Articles tagged with Genetic Interaction
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A recent yeast study found that combining gene deletions can lead to increased drug sensitivity, while some combinations result in hyper-resistance. Researchers used a model system to demonstrate the impact of perturbing many different gene combinations.
The proposed framework assesses multiple brain-body interactions contributing to Alzheimer's disease, including environmental and genetic factors. Gene-environment interactions are shown to shift the onset curve of dementia by 10 years in carriers of dominant Alzheimer's genes.
Scientists genetically modified mycoparasites to express Green Fluorescent Protein, revealing they can live up to 21-days on host plant surfaces without harming the environment. The study showed that these mycoparasites cannot spread in sterile soil or decomposing leaves, addressing concerns about their impact.
Artificial intelligence methods used to predict enhancer-promoter interactions may result in inflated performance measurements. The study highlights the need for careful experimental design when applying machine learning to genomic research.
Researchers at Massachusetts General Hospital found that dietary fat quality and genetic risk of diabetes work independently, and a diet high in polyunsaturated fats can reduce type 2 diabetes risk. The study's findings support the deployment of lifestyle or dietary interventions for all gradients of genetic risk.
Researchers at the University of Maryland and National Cancer Institute identified 12 distinct gene-pair relationships in tumor cells that could be targeted for cancer therapy. These relationships were associated with varying levels of expression in the two genes and correlated with cancer patient survival.
A mathematical framework describes the ecology of a microbiome-host interaction landscape, allowing for global comparisons and understanding of diverse microbiomes' associations with similar health outcomes. The framework applies equally well to traditional genetic interactions.
Researchers at UC San Diego discover a gel-like state of DNA that enables stability and responsiveness in the nucleus. The study suggests a physical principle of chromosomal organization with implications for gene expression and cell fate.
Researchers from UK and Malawi identify novel schistosome hybrids infecting children along Shire River Valley, with potential for abrupt genetic changes and increased disease transmission. A OneHealth approach is warranted to investigate inter-species combinations and zoonotic potential.
The dengue virus uses nonstructural protein 1 (NS1) to replicate in infected cells, with a key role in viral RNA replication and formation of the membranous replication organelle. A novel interaction between NS1 and NS4A-2K-4B is required for viral RNA replication but not for replication organelle formation.
Researchers have developed an algorithm that can predict synthetic lethal interactions between genes, which could lead to more targeted and effective cancer treatments. The Slant algorithm uses data from existing protein networks to identify patterns associated with these interactions.
Researchers say gene interactions are key to understanding disease risk and treatment response, but current methods lack statistical power to uncover multiple genes. Genome-wide association studies have identified thousands of mutations that contribute to disease, but environmental effects and genetic diversity complicate matters.
Researchers discovered a sex-specific obesity locus for the Lyplal1 gene, finding that females have a higher mitochondrial activity and produce more brown adipose tissue, reducing fat mass and insulin resistance. In contrast, males exhibit low mitochondrial activity and increased weight and insulin resistance.
Researchers developed SPAEML, a statistical approach that can accurately detect the underpinnings of simulated complex traits. The method was tested on datasets similar to Alzheimer's disease and flower structure in corn, identifying simulated markers and distinguishing between additive and interacting loci.
Researchers have developed new techniques to identify which of our genes are influenced by ancient viral DNA snippets, revealing complex interactions between viruses and human genetic material. The study found that a single transposon can control multiple genes, increasing the complexity of its impact on health and disease.
A new screening method, 'rec-YnH', has been developed to detect direct biomolecule interactions, enabling researchers to understand complex cellular processes. This affordable and accessible technique can be used by standard biomedical laboratories to study protein-protein and protein-RNA interactions.
Scientists at the University of Konstanz have gained detailed structural insights into DNA polymerases interacting with modified substrates. This knowledge can be used to advance genome sequencing and other areas of molecular biology-based diagnostics.
A new USC Dornsife study reveals that genetic mutations can behave unpredictably due to interactions with the environment and pre-existing genetic differences. This complexity makes it difficult to predict how these mutations will affect individuals, even for well-studied diseases.
Scientists at the University of Cambridge have developed a new technique to determine the structure and interactions of the Zika virus genome inside human cells. This technique, called COMRADES, can screen for host-virus RNA base-pairing and reveal interacting sequences, offering potential targets for anti-viral therapies.
A new study using fruit flies identifies complex gene interactions underlying a common cause of autism. The research reveals that multiple genes interact to modulate variable symptoms, challenging the traditional single-gene approach.
A study by Philipp Maass and Anja Weise found that chromosomes 12 and 17 frequently interact with each other across different individuals, resulting in recurrent patterns. This interaction is linked to a human genetic condition, brachydactyly, where the deletion of a specific gene alters chromosomal arrangements and disturbs interactions.
Researchers uncover how different genes work together to keep cells alive, revealing surprising partnerships between genes with unrelated functions. The study provides a roadmap for understanding genetic interactions in complex cells and organisms, including humans.
The study reveals that water molecules at the RNA surface perform tipping motions, known as librations, which influence the structure and dynamics of RNA. The findings show a complex scenario where water fluctuations are transferred to RNA vibrations, essential for avoiding local overheating.
A new study finds that neurons in mice with Fragile X syndrome appear normal but fail to interact properly, leading to cognitive impairments. The discovery suggests targeting neuronal interactions may be a promising approach to addressing the genetic defect.
A study published in Nature Structural & Molecular Biology reveals the mechanism by which PHF1 increases PRC2 activity, allowing for efficient gene regulation across different species. The findings suggest that stable PRC2 chromatin interactions mediated by PHF1 are key to increased lysine trimethylation and gene repression.
A large-scale study found that low physical activity and inefficient sleep patterns intensify genetic risk factors for obesity, confirming previous findings with new, more objective measurements. The study also showed a gene-activity interaction between physical activity levels and genetic variants associated with obesity.
Researchers investigate how genetic genes IRF6 and SPRY4 interact during fetal development to form the palate. Studies reveal that these two genes interact to reduce adhesion of the oral surface to the tongue, leading to cleft palate formation. The study aims to better understand this interaction to address defects in palate creation.
Scientists at the University of Pittsburgh School of Medicine have identified two genes, Sap130 and Pcdha9, that play a crucial role in causing hypoplastic left heart syndrome (HLHS). The study reveals that mutations in these genes can cause HLHS by compromising blood flow to the body.
Researchers at Cold Spring Harbor Laboratory discover that adding beneficial traits can have negative consequences due to epistasis. They find a case of negative epistasis in a tomato plant and show how to exploit this knowledge to unlock untapped yield potential by adjusting the dosage of genes responsible for different traits.
A new tool called MARGI identifies all RNA molecules interacting with a segment of DNA, as well as their locations. This breakthrough enables researchers to identify new gene functions and instructions encoded in the genome.
Researchers from Osaka University investigated how neuronal activity influences CREB dynamics and its interactions with the cAMP response element (CRE). They found that neuronal activity increases CREB-CRE interactions, leading to increased binding of CREB to specific genomic sites.
Researchers at Wayne State University School of Medicine have shown that interactions between genetic variants and environmental exposures significantly impact human traits and diseases. The study highlights the importance of precision medicine initiatives for communities with different ancestries, including urban areas.
Researchers discovered significant gene expression changes in coral when introduced to algae at four hours after the symbiotic relationship begins. This finding highlights the adaptive process of coral cells responding to the introduction of the symbiont and its impact on phagosome functionality.
Research on plant development, including cell division, differentiation, and organ formation, reveals new insights into the biosynthesis of auxins and the molecular control of stem cells. Key findings also shed light on the hormonal and transcriptional control of secondary cell wall formation and pollen wall development.
The Rutgers scientists reveal how a transcription activator protein interacts with RNA polymerase and DNA to initiate transcription. The discovery provides a molecular picture of transcription activation at a target promoter.
Researchers found that DNA molecules interact with each other in a way that depends on the sequence of the DNA and epigenetic factors. The team presented direct evidence for sequence-dependent attractive interactions between double-stranded DNA molecules.
Research resolves debate on gene interactions and adaptation by showing that the long-term response can be predicted in two scenarios: when genetic drift or selection dominate. Epistasis affects long-term response only if it changes sign during adaptation, regardless of initial trait variance components.
Researchers have identified a key gene associated with cleft lip and palate, providing a step closer to understanding the condition's causes and developing effective prevention approaches. The discovery highlights the complex interplay between genes and environmental factors in shaping fetal development.
Researchers discovered that DNA molecules interact directly with each other based on their sequence and epigenetic factors, suggesting a new mechanism for DNA organization in the cell. The study found that methyl groups play a key role in regulating these interactions, which could impact gene expression and chromosome organization.
Fruit flies develop complex nervous systems through a set of genetic control switches that interact early in development to generate dozens of types of olfactory neurons. The same gene network also plays a role in programming taste neurons, suggesting the same basic mechanism could be at work in other animals.
A new Cas9 variant, SpCas9-HF1, eliminates unwanted DNA breaks and reduces them to undetectable levels, expanding therapeutic applications. The high-fidelity variant is also important for research applications where off-target effects can confound results.
A team of scientists created a new single-molecule tool to observe enzymatic proteins at work, providing fast and reliable characterization of their interactions with DNA. This tool offers picometer-resolution nanopore tweezers, enabling detection of minute differences in protein binding and motion.
Scientists at Van Andel Research Institute have unraveled the molecular mechanism of TOPLESS, a plant protein that interacts with other molecules to regulate gene silencing. This discovery provides insights into similar pathways in humans and has significant implications for understanding diseases such as cancer.
Researchers identified 136 genes whose expression is correlated across regions within each network, suggesting a molecular basis for synchronized physiological interactions. These genes encode proteins essential for nerve cell activity and maintenance of voltage differences.
Researchers create genomic interactions catalogue to study promoter interactions, identifying genes involved in inflammatory bowel disorders. The catalogue captures over 1 million interactions, revealing new elements for turning genes on or off.
Scientists have developed a computer system that can analyze large databases of gene-activity measurements to identify genes that are turned on in specific cell types. This allows researchers to refine their analysis through thousands of measurements, providing more information about human diseases than current techniques.
The study demonstrates the use of DNA nanotechnology to position arrays of hundreds of identical silver clusters with tunable fluorescent properties. This approach enables controlled assembly of photonic arrays, opening up new possibilities for sensing and imaging applications.
A study of 19,000 individuals found that regular use of aspirin and/or NSAIDs was associated with a lower risk of colorectal cancer. However, the association differed according to specific genetic variations at chromosomes 12 and 15.
Research reveals that DNA sequences in 'gene deserts' can regulate gene activity elsewhere by forming DNA loops, increasing cancer risk through wormhole-like effects. The study provides new insights into the role of long-range genetic regulation in cancer development.
Two genetic mutations on a single gene have been found to interact and lower the risk of heart attacks in people who carry both variants. The study suggests that clinicians should test individuals with reduced activity of DBH and norepinephrine to determine if they benefit from beta blockers.
A study of Swedish teenagers found that three genetic variants interacted with environmental factors to increase the risk of delinquency, while a positive parent-child relationship decreased the risk. The research suggests that genes affect brain function and behavior by altering sensitivity to negative or positive environments.
GAS5, a long intergenic non-coding RNA, acts as a brake on steroid hormone receptors, preventing them from binding DNA. Researchers have gained insights into how GAS5 RNA interacts with steroid hormone receptors and its potential role in disease.
A new study published in Diabetologia found that children infected with enterovirus were 48% more likely to develop type 1 diabetes. The study's results suggest a positive correlation between EV infection and the incidence of type 1 diabetes, which may be driven by environmental factors in regions with high EV prevalence.
Research suggests physical activity reduces type 2 diabetes risk, but its effect may vary by genetic factors. Women at high genetic risk show weaker protective effect of physical activity compared to men.
The study developed a novel approach for evaluating the relevance of interactions using a Bayesian hierarchal mixture framework. The model successfully identified significant interactions in cutaneous melanoma and lung cancer risk by controlling false positive discovery and estimating parameters.
A UT Arlington big data team has won a three-year $600,000 NSF grant to develop an interactive database of fruit fly gene expressions, which are commonly found in humans and other species. The project aims to yield methods of analyzing data that will aid in biomedical science and engineering.
Researchers describe a new strategy that pinpoints a genetic variant predisposing individuals to schizophrenia and reveals deficits in nerve development. The study uses induced pluripotent stem cells to identify CYFIP1 as a critical gene maintaining nerve cell structure.
Researchers found that lifespan in fruit flies depended more on interactions among dietary, genetic and mitochondrial factors than on individual factors. This study suggests that looking at complex combinations can lead to a deeper understanding of the aging process.
A study of over 37,000 men and women found that eating fried foods four times a week had twice the impact on body mass index (BMI) for those with the highest genetic risk scores. Genetic variants associated with BMI and obesity also interacted with fried food consumption to influence adiposity.
The Biophysical Society has announced the winners of its Education Committee Travel Awards, which recognize students and postdoctoral fellows for their scientific merit. The award recipients will present their research during the meeting and receive a travel grant.