Researchers developed a new method to study long-distance DNA regulation in rare immune cells, uncovering previously hidden connections relevant to autoimmune diseases. The approach prioritized over 100 candidate genes linked to Crohn's disease risk, including CLN3, which was not typically associated with the condition.
SourceCincinnati Children's Hospital Medical Center·JournalNature Genetics·TypeData/statistical analysis·DateAug 4, 2026
The study found that population-based pathogenic variant testing reveals different subsets of high-risk women than clinical risk factors and polygenic risk scores. This highlights the importance of incorporating PV testing into risk-based screening for breast cancer.
Researchers have identified two genes, RNF144B and ENPP1, that cause calcium pyrophosphate deposition disease in Americans of European and African descent. This discovery opens up promising new avenues for targeted prevention and treatment of CPPD disease, which is currently lacking effective options.
SourceElsevier·JournalAnnals of the Rheumatic Diseases·TypeData/statistical analysis·DateMay 28, 2025
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Researchers used genetic data and computational tools to identify genetic variants associated with asthma, finding differences between childhood- and adult-onset forms of the disease. The study provides insights into potential treatment targets for both types of asthma.
SourceUniversity of Chicago·JournalGenome Medicine·TypeData/statistical analysis·DateApr 10, 2025
Research from the Long Life Family Study found individuals from long-lived families have significantly better vascular health than the general population. The study identified key risk factors and four genomic regions linked to PAD risk, providing novel insight into underlying mechanisms.
SourceImpact Journals LLC·JournalAging-US·TypeNews article·DateMar 12, 2025
Researchers have identified over 2000 protein-coding genes that change significantly between summer and winter in the starfish's reproductive process. This study provides a promising breakthrough in understanding how crown-of-thorns starfish communicate during reproduction, which could lead to the development of natural pest control me...
SourceUniversity of Queensland·JournalPLOS Biology·DateMay 14, 2024
A new study found that people with high genetic stress sensitivity are more likely to experience heart attacks during stressful periods, such as holidays and elections. Those who also have anxiety or depression are at even higher risk, with their likelihood tripled.
A new study of early Bronze Age examples from Luxembourg and Britain provides insights into family relationships in prehistoric communities. Genetic evidence reveals that children were buried with their biological mothers, suggesting a patrilineal descent system.
SourceJohannes Gutenberg Universitaet Mainz·JournalScientific Reports·DateJan 25, 2024
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Researchers discuss a new approach integrating genomic, epigenomic, transcriptomic, and machine learning methods to identify functional genetic variants and characterize their mode of action in regulating target genes. This method aims to improve understanding of disease etiology and prioritize causative inherited genetic variants.
SourceImpact Journals LLC·JournalOncotarget·TypeData/statistical analysis·DateNov 20, 2023
Researchers have discovered that HER3 plays a crucial role in promoting cell survival in metastatic colorectal and pancreatic cancer. The surrounding liver microenvironment activates HER3, making it an emerging therapeutic target for these types of cancer.
SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateMay 24, 2023
A team of researchers from Ritsumeikan University in Japan has elucidated the mechanism behind the liquid-solid phase transition of FUS protein that leads to ALS. They discovered a new therapeutic target, arginine, which suppresses FUS aggregation and could delay ALS progression.
SourceRitsumeikan University·JournalPhysical Chemistry Chemical Physics·TypeExperimental study·DateAug 29, 2022
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Sky & Telescope Pocket Sky Atlas, 2nd Edition is a durable star atlas for planning sessions, identifying targets, and teaching celestial navigation.
Scientists have discovered that the genomes of marine invertebrates have been surprisingly stable across deep time. The study found that chromosomes are remarkably similar among sponges, jellyfish, scallops, and even humans, with some genes traveling together for almost a billion years.
SourceOkinawa Institute of Science and Technology (OIST) Graduate University·JournalScience Advances·TypeExperimental study·DateFeb 3, 2022
A large family study has pinpointed genetic linkage in drug addiction, identifying genes that influence opioid dependence and its symptom cluster traits. The study provides a foundation for further research on the genetic factors contributing to substance dependence risk.
SourceYale University·JournalAmerican Journal of Human Genetics·DateApr 10, 2006
A study by UW researchers found that genetic taste markers do not affect the enjoyment of chocolate, and that sweetness and fat can mask bitter flavors. The study showed that women who were more sensitive to bitter tastes preferred lattes over straight espresso coffee.
SourceUniversity of Washington·JournalChemical Senses·DateJan 31, 2001
A genetic mutation in the tau gene has been identified as the cause of a 20-hour day in hamsters. The discovery reveals that the enzyme CK1ε plays a crucial role in regulating the circadian rhythm, and offers new opportunities for developing drugs to control the biological clock in humans.
SourceHoward Hughes Medical Institute·JournalScience·DateApr 20, 2000
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Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
The completion of a high-density integrated genetic linkage and radiation hybrid map for the laboratory rat is a landmark in genomic science. The maps provide an integrated reference to more than 3,000 genes and ESTs, enabling researchers to connect disorders to their underlying genetic components.
SourceCold Spring Harbor Laboratory·JournalGenome Research·DateApr 30, 1999
Researchers have identified three genes connected to stroke in hypertensive rats, with two protecting against the disease and one predisposing it. The study sheds light on the complex nature of stroke, which is influenced by multiple genetic factors beyond well-known risk factors.
SourceNIH/National Heart, Lung and Blood Institute·DateJul 30, 1996