Articles tagged with Genome Sequencing
Researchers at Stanford Medicine have used a healthy person's complete genome sequence to predict their risk for dozens of diseases and how they will respond to common medications. The study provides a cumulative risk report that can help physicians make concrete clinical recommendations, improving the efficiency of medicine.
A study by scientists at Stanford and Harvard Universities analyzed a patient's full genome to identify disease risks and unusual drug responses. The analysis revealed variants associated with diseases in the patient's family and conditions not inherited, highlighting the potential of whole-genome sequencing for personalized medicine.
A Purdue University scientist has discovered a long-sought gene that controls soybean stem growth, allowing for the creation of new plant varieties with desirable characteristics. The gene, Dt1, was found to be responsible for determining whether a soybean's stem continues to grow after flowering.
The study provides genomic information that suggests possible intervention targets for further experimental investigation. The genome sequences of the two new bacterial strains will help researchers zero in on the molecular basis of citrus canker, shedding light on why one strain is more virulent than its counterparts.
Researchers analyzed genetic evidence from 139 killer whales and found clear differences among species in the Antarctic and North Pacific. The study suggests that two types of killer whales are separate species, with additional analysis needed to confirm other possible species.
Researchers have identified a gene regulating appetite and explored thyroid-stimulating hormone receptor protein to understand domestication's impact on chickens. The study provides a model for exploring the molecular basis of animal domestication.
Researchers identified a novel sequence bias that regulates genomic expression rates, providing insights into how cells respond to injuries and poisons. This discovery could lead to more efficient production of therapeutic agents and research reagents.
Researchers used high-performance computing to locate small genes missed by scientists, uncovering 380 families of undetected gene families. The study used an ephemeral supercomputer to perform an all-to-all sequence search, reducing the search time from nearly 90 years to just 12 hours.
Researchers analyzed the zebra finch genome, finding large and complex gene regulatory networks in the brain activated by song communication. The study also discovered non-coding RNAs play a crucial role in regulating gene expression.
The Australian zebra finch's genome reveals a complex system for singing, with over 800 genes regulated by the action of singing. The findings may help scientists understand how humans learn language and identify genetic origins of speech disorders like autism, stroke, and stuttering.
A team of researchers has developed a way to identify genetic markers in grapevines that can be linked with specific traits, such as fruit quality and disease resistance. The technology uses modern sequencing approaches to speed up the traditional breeding process, making it more efficient and cost-effective.
UC Irvine researchers have sequenced the Hydra genome, discovering genes linked to Huntington's disease and beta-amyloid plaque formation in Alzheimer's. The genome sequencing advances research on regeneration, stem cells, and patterning, offering potential new treatments for various injuries and diseases.
The completed genome of Naegleria gruberi sheds light on the transition from prokaryotes to eukaryotes, showcasing a single-celled organism with multiple identities. The analysis reveals genes associated with cellular movement and energy production, providing insights into the evolution of eukaryotic organisms.
Researchers sequenced ancient genome from a rare fossil, confirming polar bears are an evolutionarily young species that split from brown bears 150,000 years ago. The study found polar bears adapted rapidly to past climate changes, but their adaptability is uncertain in the face of current and future climate change.
A rare ancient polar bear fossil has yielded essential information about the species' evolutionary history and response to past climate changes. The research confirms that polar bears evolved recently and adapted quickly, with a split from brown bears around 150,000 years ago.
Researchers have identified genomic regions that enabled an ocean-dwelling fish to adapt to freshwater environments in several independently evolved populations. The study, combining new technologies, found similar gene regions across different lakes and populations.
The Pea Aphid's genome sequence provides valuable tools for understanding aphid biology, speciation, and ecological interactions. The sequencing also sheds light on the relationship between aphids and plant viruses, revealing surprising gaps in the insect immune system.
A new DNA sequencing study has shed light on the evolution of flowering plants, revealing relationships between 70% of all plant species and two major groups that split apart over 111 million years ago. The study provides a clearer picture of the deep divergence that led to speciation in these plants.
The genome sequencing of three parasitoid wasp species offers new insights into the genetic mechanisms of evolution and their importance in controlling agricultural pests. The study identifies key genes responsible for venom production and reveals that these proteins have important physiological effects on host cells.
The International Brachypodium Initiative has sequenced the genome of the wild grass Brachypodium distachyon, which shares features with major grass genomes. This provides a genomic navigation system for studying agronomic traits in wheat and barley genomes.
Cold Spring Harbor Protocols presents high-throughput methods for mapping active gene regulatory elements using DNase-seq, and analyzing DNA synthesis with BrdU-IP-chip. These techniques enable genome-wide identification of genetic regulatory elements and analysis of DNA metabolism.
The sequencing of parasitic wasp genomes has revealed over 7,000 genes with recognizable counterparts in humans, offering a new genetic system for studying genetics and evolution. The discovery also highlights the potential of these wasps in controlling pests and producing artificial diets for mass rearing.
Scientists from CSHL and Hebrew University Medical Center use next-gen sequencing to rapidly identify the mutated TMEM216 gene as the cause of Joubert Syndrome. The study reveals a high carrier rate of 1:92 among Ashkenazi Jews, making it possible to prevent the disease through premarital genetic screening.
Scientists sequenced the soybean genome to understand its genes and improve characteristics. However, duplicated genes present a challenge, with many copies shuffled, making prediction difficult. Genome sequencing eliminates this issue, enabling faster research advancements.
Researchers have sequenced 85% of the soybean genome, providing critical information to improve crop yields, disease resistance, and nutritional content. The discovery includes genes conferring resistance to a devastating disease and mutations that enhance digestibility and phosphorus absorption.
The soybean genome shows evidence of two polyploid events, 59 million and 13 million years ago, which resulted in the plant's unusual ability to produce proteins and oils. Most genes are duplicated at chromosome ends, where recombination occurs, and these duplicates have evolved into new genes.
The soybean genome sequence provides a parts list of what it takes to make a soybean plant, identifying genes essential for agronomic traits like protein and oil content. The analysis also revealed targets for modifying output to bolster biodiesel production.
A new research project will sequence and annotate the sunflower genome to locate genes responsible for agriculturally important traits. The goal is to develop a hybrid variety of sunflower that can thrive in challenging environments, making it suitable for subsistence agriculture in Africa and North America.
Researchers discovered that human chromosomes can reorganize their territories surprisingly quickly, taking up to 15 minutes to complete, when transitioning from proliferation to quiescence. This rapid process is driven by an energy-driven mechanism involving nuclear actin-myosin motor function.
The Genomic Encyclopedia of Bacteria and Archaea (GEBA) project explores the vast unknown realm of microbes, sequencing genomes to advance discovery science. The initial volume reveals novel enzymes and biochemical pathways, shedding light on complex microbial processes and their role in biofuels production and bioremediation.
The study, called the Genomic Encyclopedia of Bacteria and Archaea (GEBA), describes the first 56 genomes from a diverse set of microorganisms. It reveals that phylogeny plays a key role in determining where new genes appear and how they spread.
Researchers at Boston University have developed a new DNA sequencing method that reduces the amount of DNA required for analysis, eliminating the need for time-consuming and error-prone DNA amplification. This breakthrough allows for faster and cheaper genome sequencing, enabling the analysis of long DNA strands in one swipe.
Researchers studying the model organism Daphnia pulex found that introns are inserted into the genome far more frequently than predicted, with many sequences of unknown origin. The study identified 'hot spots' for intron insertion and discovered parallel intron gains in independent genotypes.
Microbiologist Louis Tisa received nearly $500,000 to explore the symbiotic relationship between bacteria Frankia and actinorhizal plant Casuarina. The USDA grant aims to enhance the performance of these trees, providing a sustainable solution to soil enrichment.
The USDA has awarded a two-year grant of $908,280 to Virginia Tech and the University of Minnesota to complete sequencing the genome of the domesticated turkey. The project aims to identify genes and functions in the final genome sequence, providing invaluable information for disease prevention.
Researchers at the University of Washington successfully used exome sequencing to identify a previously unknown gene responsible for Miller syndrome, a mendelian disorder. This breakthrough study demonstrates the efficiency and potential of this strategy in discovering the genetic basis of rare diseases, which could lead to new therapies.
Researchers developed a statistical technique to scan genomes for specific gene-regulatory regions without prior knowledge of transcription factors. The approach has been experimentally validated in mouse and fruit fly genomes.
The maize genome is a complex sequence of DNA that has been analyzed using a unique optical mapping facility at UW-Madison. The research advances knowledge of corn's ancestry and guides breeders in extracting increased productivity from the crop.
Researchers from UA and collaborating institutions deciphered the complete genetic code of maize, providing a comprehensive foundation to systematically study maize biology. The achievement aims to breed higher yielding, disease-resistant, and drought-tolerant cultivars.
Research published in Genome Biology found that Mexicans prioritize partners with Native American and European ancestry, while Puerto Ricans prefer those with African and European heritage. Ancestry has a stronger influence on romance than previously thought, with non-random associations of genes across generations.
A team co-led by CSHL scientists published a reference genome of maize, revealing its complex DNA sequence and 'wonderful diversity'. The 2.3 billion base-pair sequence contains over 32,500 genes and provides a detailed reference manual for annotating the genome.
A $1 million project aims to develop computational tools using next-generation petascale computers to analyze genome rearrangements. The team plans to test their new algorithms on a collection of fruit fly genomes, which will provide insights into the mechanisms underlying gene order diversity.
Researchers develop new algorithms using petascale computers to infer ancestral genome rearrangement events, enabling faster analysis of large genomes. The new methods will help understand the mechanisms and rate of gene rearrangements in genomes.
A new initiative aims to sequence the genomes of 10,000 vertebrates, including whales, dolphins, and porpoises, to gain better understanding of species diversity, evolution, and conservation. The project, called Genome 10K, has the potential to revolutionize our knowledge of cetaceans and inform effective conservation strategies.
The cucumber genome has been sequenced, offering a platform for studying the cucurbit family and plant biology. The genome will aid in understanding disease and pest-resistance, flavor traits, and sex expression, with potential applications in agriculture.
A Vanderbilt biologist is using genomic data from over two dozen yeast species to identify reliable methods for determining evolutionary relationships. The goal is to apply these principles to other clades, including mammals.
Researchers at Duke University Medical Center have sequenced the genome of a biofuels yeast that thrives on turning sugar cane into ethanol. The findings could lead to more efficient biofuel production and aid research into converting cellulose from non-food crops like switchgrass into biofuel.
A team of scientists, led by MSU's Robin Buell, has sequenced the potato genome, estimating it to be 840 million base pairs. The draft sequence will help breeders improve yield, quality, and disease resistance in potatoes.
A new study uses genome sequencing to profile genetic diversity among M. ulcerans isolates, showing clonal relationships but distinct single nucleotide polymorphisms. The findings suggest a focal transmission pattern for Buruli ulcer, with local genetic variants not quickly spread over long distances.
The study found that the pathogen's genome is unusually large and has a unique structure, enabling rapid evolution of genes involved in plant infection. The 'two-speed' genomic strategy allows different parts of the genome to evolve at different rates, potentially making it harder for plants to resist infection.
Researchers have sequenced the genome of Phytophthora infestans, the cause of the Irish potato famine, to aid in its control and development of chemical-free methods. The pathogen's unique genetic traits, including repetitive DNA sequences, play a key role in its virulence and adaptability.
Scientists have decoded the genome of Phytophthora infestans, the cause of late blight, which destroyed potato crops in the 19th century and is now affecting tomatoes. The genome contains a massive amount of repetitive DNA, thought to be key to its adaptability and effectiveness as a plant pathogen.
Researchers at UC Riverside will advance their work on sequencing the barley genome and breeding new barley varieties with a two-year $1 million grant. They aim to sequence all barley genes and make information available to the public, with potential benefits for farmers, markets, and consumers.
A new genomic model defines microorganisms by their dietary habits, providing a tool for tracking environmental changes. The researchers analyzed the genomes of two bacteria with distinct lifestyles and developed a predictive model that successfully identified the habitats of dozens of bacterial samples.
A study identifies three genetic variants accounting for the wide range of dog coat textures, from poodles to beagles. The findings have implications for understanding complex human diseases, such as cancer and heart disease.
Researchers discovered a set of genes that respond inappropriately to amphetamine in 'drug-proof' zebrafish mutants, which do not experience the drug's pleasurable effects. This finding suggests a link between adult neurogenesis and addiction, with potential implications for understanding susceptibility.
Researchers at Rockefeller University discovered that telomeres resemble fragile sites in DNA, where replication can stall. A protein called TRF1 helps prevent this by removing unusual structures from telomeric DNA, allowing smooth progression of DNA replication.
Emory researchers are using DNA sequencing technology to study the genomics of agricultural ant societies, which could lead to breakthroughs in waste processing and agriculture. The project aims to understand how ants have evolved to process huge amounts of organic material over millions of years.
The DOE JGI has selected 71 new genomic sequencing projects for its 2010 Community Sequencing Program, focused on bioenergy, climate, and environmental applications. The program aims to improve the clean energy pathways and understanding of the global carbon cycle.
The Joint Genome Institute will sequence four species of labyrinthulomycetes, shedding light on their ecological role and potential applications. The organisms are single-celled marine decomposers that play a crucial part in the marine carbon cycle.