Articles tagged with Genome Sequencing
The FANTOM4 consortium has published several milestone papers in Nature Genetics and BioMed Central journals, providing new data on genomic regulatory blocks and chromatin conformation signatures. These findings have the potential to revolutionize our understanding of gene regulation and cell differentiation.
A University of Iowa biologist is studying how picoeukaryotes, tiny ocean plants, adapt to changing environments in response to climate change. The research found that despite sharing similar morphology, these organisms have distinct gene pools and unique genetic features that allow them to thrive in different ocean regions.
Researchers have decoded the genomes of two tiny algal strains, highlighting their genes that enable them to capture carbon and maintain its delicate balance in the oceans. The study also sheds light on how these algae may cope with environmental change.
Scientists discovered variable ribosomal RNA genes in yeast, which are essential to all Earth's organisms. The genes show surprise variation despite being vital for cell function, and hybridization of two yeasts re-set their clocks, providing clues on evolutionary history.
The Genome Analysis Centre (TGAC) will analyse plant, animal, and microbial genomes to improve food security and combat exotic animal diseases. It will also develop new ways to kill superbugs and contribute to the UK's economic and social wellbeing.
Researchers discovered that second chromosomes in bacteria are formed from plasmids, challenging current understanding of genome evolution. The study provides a general model for how multichromosomal architectures evolved in the Rhizobiaceae family.
Researchers have identified 10 common variants of genes that modify the timing of heart contraction, known as the QT interval. These genetic variations are associated with an increased risk of sudden cardiac death, which claims over a quarter million Americans annually.
Researchers have identified three genes - VKORC1, CYP2C9, and CYP4F2 - responsible for over 40% of warfarin dose variability. The study provides a comprehensive overview of the genetic landscape influencing dose variability, paving the way for more accurate warfarin dosing and reduced patient risk.
Over 200,000 genetically modified rice mutant lines are now available for researchers to study the function of approximately 57,000 genes in Oryza sativa. The vast repository is expected to accelerate the understanding of gene function and biological processes in rice and other commercially important grasses.
Researchers sequence genomes of 99 known cold virus strains, exposing vulnerabilities that could lead to effective remedies. The study's findings also shed light on the genetic composition of rhinovirus A and B, as well as emerging species C, which is more virulent.
The study reveals that humans have domesticated yeast strains at many points in history from diverse sources, challenging traditional views on the Tree of Life. The analysis also provides insights into yeast probiotics' contribution to gut health and potential applications for cancer treatment.
A new study reveals that large structural DNA changes, known as copy number variants, may be responsible for schizophrenia. Researchers found eight deletions in patients' genomes, two of which were newly identified, suggesting that these rare variations could be causative.
Researchers from DOE/JGI and FPL have deciphered the genetic mechanisms behind brown-rot fungi's ability to break down cellulose in wood. This breakthrough may lead to more efficient, cost-effective, and environmentally-friendly strategies for biofuels production.
Researchers compared four different strains of Coxiella burnetii to build a comprehensive picture of its genetic architecture and content. They found that strain virulence was associated with a smaller genome and the loss of genes, possibly due to pseudogene formation.
Researchers at Helmholtz Zentrum München sequenced sorghum's genome, gaining insights into its drought tolerance and C4 photosynthesis. The analysis provides new information on the evolution of crop plant genomes.
The sorghum genome sequence reveals its drought-tolerant properties and offers tools to breed more resilient crops. The genetic code is also being used to improve biofuel crops like sugarcane and Miscanthus, enhancing the efficiency of cellulosic ethanol production.
Researchers sequenced mitochondrial and nuclear DNA from museum specimens of the thylacine, a marsupial that was declared extinct in 1936. The study found little genetic variation between the two specimens, indicating the species was on the brink of extinction when it became extinct.
A team of scientists has successfully sequenced the genes of the Tasmanian Tiger from its hair, revealing insights into mammal extinction and potential ways to prevent it. The study also opens up new possibilities for analyzing museum specimens and could potentially lead to the revival of extinct species.
Researchers have identified genes controlling snail shell handedness, similar to those used by humans to set up left-right asymmetry. These findings suggest that the same genetic pathway has been responsible for establishing left-right symmetry in animals for 500-650 million years.
A study found that variations within Acinetobacter baumannii bacteria can affect its response to antibiotics, highlighting the need for targeted therapy in infectious disease. The analysis of six genomes revealed unique sets of genes among isolates, with some genes shared but others specific to different subsets.
A new genomic tool has been developed to identify gene function in soybeans, a key step towards improving crop performance. By analyzing transposon mutations, researchers can pinpoint specific genes associated with desirable traits such as seed composition and root growth.
The turkey genome will be assembled using shotgun fragments and paired-end reads, providing benefits for researchers studying commercially important sources of food. The project aims to sequence over 95% of the turkey genome, offering tools for improving commercial breeds and understanding disease development.
The discovery of Bundibugyo ebolavirus represents a significant addition to the puzzle of the Ebola virus genus. The new virus is genetically distinct from all other known Ebola virus species, differing by more than 30% at the genetic level. This finding has implications for the development of diagnostics, antivirals, and vaccines.
A new microbe, discovered in the open ocean, lacks genes needed for photosynthesis, yet provides natural fertilizer to the oceans by fixing nitrogen. Its unique metabolism may have implications for understanding carbon and nitrogen cycles in ocean ecosystems.
A new platform has been developed to study how specialized proteins regulate RNA in living, intact cells. By identifying every sequence within every strand of RNA to which proteins bind, researchers can now address questions about how differences in RNA explain the vast differences between humans and worms.
Researchers found a unique microorganism, Desulforudis audaxviator, living in complete isolation with no sunlight, oxygen, and extreme heat. The bacterium survives by harnessing energy from hydrogen and sulfate produced by radioactive decay of uranium, and has a remarkable genome with 2,157 protein-coding genes.
The genome sequence of Plasmodium knowlesi has been defined, providing new research opportunities for comparisons with P. vivax. Establishing similarities and differences between the parasites' genomes will assist in the selection of genetic targets for vaccine and drug development.
Researchers have deciphered the complete genetic sequence of Plasmodium vivax, the leading cause of relapsing malaria. The findings provide new insights into the biology of vivax malaria and may lead to new tools for prevention and treatment.
Researchers have discovered unique genes in the genome of Plasmodium vivax, a parasite responsible for 25% of global malaria cases. The findings could lead to the development of new drugs and vaccines against this debilitating disease.
The study completes the genome sequence and genetic map of Meloidogyne hapla, a microscopic worm causing significant crop damage. The research provides a powerful platform for understanding parasitism and developing eco-friendly management strategies.
Researchers sequenced the genome of Cyanobacterium ATCC 51142, revealing a rare linear chromosome containing genes for pyruvate metabolism. The discovery provides a framework for understanding this organism's ability to produce lactate and other compounds.
The U.S. Department of Energy Joint Genome Institute has updated the Integrated Microbial Genome System with new microbial genomes, improving its capabilities for analyzing metagenomic data. The system now includes tools for exploring gene cassettes conservation and examining functional annotation of genomes.
Researchers at Iowa State University have contributed to the release of the annotated genome of Meloidogyne incognita, a destructive nematode responsible for $157 billion in agricultural damage annually. The sequencing achievement provides a resource for understanding and controlling this widespread pest.
Researchers characterize grapevine transposons, finding they capture and amplify gene sequences, influencing gene evolution. The study also reveals 'domesticated' transposons with cellular roles, contributing to genetic diversity.
A new resource called Proteopedia links written information with interactive 3D images of biomacromolecules, enabling easy creation and editing by users. By integrating 3D structures with descriptive text, Proteopedia aims to make complex structural information comprehensible to all.
Researchers have successfully sequenced the complete genome of a microbe that eats methylamine, a form of ammonia, using lake mud as a sample. The study showcases a new method for discovering unknown organisms and has significant implications for understanding ecological cycles and monitoring microbial population shifts.
A novel approach extracts single genomes and discerns specific microbial capabilities from mixed community sequence data. The research team characterized biochemical pathways associated with nitrogen cycling and methane utilization in Lake Washington sediments, revealing novel versions of metabolism.
Researchers have discovered that broken sections of chromosomes can recombine to form new types of chromosomes, leading to genome diversification. This process is mediated by repeated DNA sequences, which account for half of the human genome.
IGV integrates multiple types of genomic data, allowing for rapid analysis and visualization. The tool provides flexible zooming and panning across all resolution scales.
A multi-disciplinary group proposes ten principles to guide the use of racial and ethnic categories in genetic research, minimizing misinterpretation and misuse of human genetic variation. The guidelines recognize that racial and ethnic categories are socio-political constructs that change over time.
Recent advancements in genome technologies and molecular-biology techniques offer new hope for microbial bioenergy applications. Microbes can convert biomass into useful energy forms, such as methane, hydrogen, or electricity, and capture sunlight to produce liquid fuels.
Researchers sequenced duckweed's genome to unlock its ability to absorb atmospheric carbon dioxide, reducing greenhouse gas emissions and alleviating world hunger. The plant can extract pollutants from wastewater, producing biomass faster than any other flowering plant.
A team of undergraduate students from UC San Diego has developed a new area of bioinformatics called comparative proteogenomics, which analyzes multiple genomes and proteomes simultaneously. This approach improves genomic and proteomic annotations, unlocking biological mysteries and addressing difficult problems in the field.
Scientists are sequencing ancient maize landraces to recapture the full genetic diversity of this complex crop. The Palomero genome is about 22% smaller than B73, revealing a large pool of unexplored genetic diversity.
Scientists have unraveled plant architecture at the molecular level using genomic data, shedding light on flower and grain development in maize. They characterized key gene networks and biochemical pathways, providing insights into plant construction and evolutionary conservation.
Researchers have discovered insights into vertebrate origins and the evolution of immune systems, nervous system development, and cell signaling through the analysis of the amphioxus genome. The study reveals conserved genes and DNA elements between amphioxus and humans, suggesting a common ancestor with vertebrates.
Researchers at the Genome Institute of Singapore have identified over 3,000 genomic hotspots critical for maintaining embryonic stem cell state. These findings may lead to the development of an inexhaustible source of clinically useful cells for regenerative medicine.
Researchers have discovered a group of 24 linked to virulence in Brucella abortus strain S19, which has been used as a vaccine for cattle. The study's findings may explain why other strains cause disease and trigger abortion in livestock. This understanding could aid in combating brucellosis and its potential applications in bioterrorism.
Researchers have discovered that a fundamental building block in flowering plants evolved independently from lycophytes, an ancient plant group. This finding has significant implications for understanding plant biology and developing more efficient biofuel production methods.
Researchers can now contribute to large-scale community protein annotation, enhancing comprehensive coverage of biomedical knowledge. WikiProteins combines existing authoritative databases with mined scientific papers, creating over one million concept clouds called 'Knowlets', which can be annotated by experts.
Researchers have successfully sequenced the papaya genome, revealing a complex evolutionary history and providing valuable insights into fruit tree biology. The study also identified genetic mechanisms underlying arboreal development and seed dispersal, with potential implications for other crops in the Brassicales order.
Researchers at Hebrew University of Jerusalem demonstrate the exact mechanism by which embryonic stem cells develop into specific cell types. The study reveals that ES cells express a large proportion of their genome in an 'open and active' state, enabling them to become any cell type before undergoing global genetic silencing.
A consortium of scientists including CSHL's Gregory J. Hannon report findings about mammalian evolution gleaned from comparative study of small-RNA function in platypus, revealing unique characteristics such as egg-laying and venom delivery. The platypus genome also shows conserved small-RNA roles across species.
The platypus genome sequence published by UK researchers reveals a mix of mammalian, bird-like and reptilian features in the species' genetic blueprint. The analysis found that platypus venom is a cocktail of proteins originally with different functions, similar to those in reptile venom.
The platypus genome provides insights into the evolution of venom components and a bird-like sex-determination system in mammalian ancestors. Researchers have found that platypus venom genes evolved by gene duplication of antimicrobial beta-defensins, mirroring an independent evolutionary pathway in reptiles.
Researchers have completed the first analysis of platypus DNA, revealing insights into gene regulation and immune systems that may lead to advances in human disease prevention. The study's findings also provide new perspectives on mammalian evolution and conservation efforts.
The genome of Steno, a newly emerging superbug, has been sequenced, revealing an organism with exceptional drug resistance. Understanding its genetic makeup may help researchers develop biochemical compounds to combat this resistance.
The genome sequence of Podospora anserina shows the fungus has a large set of genes involved in breaking down complex carbon sources, including cellulose and lignin. This discovery may lead to novel regulatory mechanisms during growth and reproduction, with potential applications in biotechnology.
Researchers analyzed genomic data to reveal the evolution of rickettsial genomes and their diversity. The study provides an ideal resource for developing vaccines, diagnostics, and therapeutics for Rickettsia diseases.
A broad collaboration has produced a first draft of the papaya genome, offering insights into its evolutionary path and genetic changes that make it resistant to the papaya ringspot virus. The findings indicate that papaya diverged from Arabidopsis 72 million years ago, taking a different evolutionary path.