Articles tagged with Genome Sequencing
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
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Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A new metagenomic study of activated sludge wastewater treatment processes reveals key players and mechanisms behind the process. The researchers were able to obtain a nearly complete genetic blueprint for Accumulibacter phosphatis, a bacterial species essential for removing excess phosphorus from wastewater.
Genomatix Software GmbH has appointed a distributor in China, Beijing ZGZ Science and Technology Development Co., Ltd., to expand its market presence. This partnership is significant for Genomatix, with over 1,800 researchers in China subscribed to its free services.
Biologists have discovered that genes can change their locations in a genome, triggering the origin of species. The 'jumping gene' theory, long disputed, has been confirmed by researchers at the University of Rochester using fruit fly species Drosophila melanogaster and Drosophila simulans.
Researchers analyzed Paulinella's plastid genome, finding it closely related to cyanobacteria and retaining ancient genetic features. The study offers insights into the establishment of plastids and the transition from single-celled hosts to complex organisms.
The genome sequences of P. ramorum and P. sojae could lead to strategies to combat these destructive plant pathogens. Phytophthora species cause significant losses in various crops, including soybeans, oak trees, and cocoa beans, resulting in hundreds of billions of dollars in economic damage annually.
Tetrahymena thermophila has two distinct nuclei, each with a different genome, and its macronuclear genome expresses genes governing behavior. The study reveals gene duplication in genes involved in sensing and responding to environment.
A new microchip-based test called FluChip can distinguish among 72 influenza strains in under 12 hours, enhancing global flu surveillance efforts. This technology has the potential to increase laboratory diagnostic capacity and provide critical information on the geographic origin of emerging viruses.
The sequenced genome of Tetrahymena thermophila encodes over 27,000 protein-coding genes and lacks centromeres, shedding light on the single-celled organism's unique biology. The discovery provides a valuable model for studying eukaryotic evolution.
Scientists have discovered a common coastal strain of cyanobacteria that thrives in choppy, polluted waters. The study found that this strain has evolved unique metal-processing biology missing in its open-ocean relative, enabling it to absorb and process essential metals.
Researchers from Max Planck Institute successfully sequenced the genome of a methane-producing Rice Cluster I Archaeon, revealing unique enzymatic mechanisms that enable them to thrive in oxygen-rich environments. This breakthrough could pave the way for developing methods to monitor and potentially reduce methane emissions from floode...
Scientists identified a genetic element that the dengue virus uses to replicate, triggering the potentially fatal illness known as dengue hemorrhagic fever. The discovery provides a model for RNA replication in flaviviruses, which cause millions of cases of human illness each year.
The Laccaria genome sequence will provide critical insights into the symbiotic relationship between trees and fungi, enabling faster-growing trees with enhanced biomass production. The study highlights the importance of mycorrhizal fungi in terrestrial ecosystems and their potential to mitigate climate change.
Scientists have uncovered the complete genome sequence of Ostreococcus tauri, a tiny eukaryote that plays a significant role in ocean climate dynamics. The study reveals the organism's complex genetic makeup and its ability to perform photosynthesis, which has major implications for carbon cycling.
A new hybrid method combines the best of old and new genome-sequencing technologies to produce better quality genomic information. The approach evaluates the utility and cost-effectiveness of two sequencing methods and finds that a hybrid method produces superior results.
The DOE JGI has released IMG 1.5, which contains 62 finished and 100 draft genomes sequenced by the institute. The release includes 38 new DOE JGI genomes and 21 new public microbial genomes, with 22 archaeal genomes featuring curated gene models.
Researchers have gained insights into the genetic mechanisms of Proteus mirabilis, a bacterium causing kidney stones and complicated urinary tract infections. The complete genome sequence, including 3,693 genes and 4.063 megabases of DNA, will help scientists identify potential targets for new vaccines.
Scientists have discovered that ancient genes, including Constans (CO) and Flowering Locus T (FT), dictate flowering and fall bud set in trees. This finding has significant implications for understanding tree maturation and adaptation to climate change, as well as speeding up tree breeding.
The VBI Microbial Database provides genome sequence and annotation data for two major plant pathogens, Phytophthora sojae and Phytophthora ramorum. The database offers powerful analytical tools and community annotation features to facilitate research on these pathogens.
A new method for targeted gene disruption has been developed for the filamentous fungus A. brassicicola, allowing for high-throughput identification of genes and their functions. This breakthrough enables researchers to dissect the pathogen's genome and establish the function of individual genes in disease development.
Researchers sequenced DNA from microbes and viruses collected at different ocean depths, discovering thousands of new genes and evidence of frequent gene exchange. This study provides a comprehensive picture of ocean microbial communities and their interactions with the environment.
A study of 135 bacteria and 16 primitive microorganisms reveals large- and small-scale organizational patterns in their genomes, which are highly nonrandom. The findings suggest that evolution of prokaryotes is constrained by both gene content and genome arrangement on chromosomes.
The DOE JGI is accepting letters of intent for new CSP projects until January 13, 2006, with a focus on advancing the nation's energy security. The institute will prioritize proposals that translate genomic information into discoveries for developing cleaner domestic energy options.
Researchers at McMaster University have successfully sequenced the woolly mammoth genome, providing a new understanding of evolution and allowing for the potential recreation of extinct hybrid animals. The discovery has significant implications for fields such as conservation and genetics.
Scientists at The Institute for Genomic Research have sequenced the genome of Aspergillus fumigatus, a fungus that can cause human infections. The 28 Mb genome consists of 8 chromosomes with over 10,000 genes, which researchers are now searching to identify unique virulence factors.
Researchers have successfully sequenced the DNA of a woolly mammoth, comparing it to African and Indian elephant genomes. The study provides unprecedented insight into the evolution and extinction of the species.
Researchers harness dog genome data to study genetic diseases, breed characteristics, and skeletal variation. The findings highlight the dog's potential as a valuable model organism in genetics and medical research.
A new microbial genome sequence shows that C. hydrogenoformans can convert water and carbon monoxide to hydrogen, making it an excellent starting point for clean fuel production. The microbe's unique protein machines allow it to use carbon monoxide in different ways, making it more efficient than other species.
Scientists suggest prioritizing organisms based on evolutionary divergence to maximize sequence diversity, offering a more efficient approach than considering multiple factors simultaneously. This 'greedy strategy' allows centers to select the best candidates one at a time without compromising overall effectiveness.
The fourth version of IMG, a collaborative effort between DOE JGI and the Lawrence Berkeley National Laboratory, adds organism phenotype characterizations and enhances comparative analysis capabilities. The update features extended Analysis Carts and improved functional profiles across organisms.
A team of researchers has identified key genes responsible for the Spanish flu's extreme virulence, which could lead to the development of effective antivirals and vaccines. The study also suggests that certain FDA-approved flu medications may be effective against future strains of the virus.
Researchers at The Institute for Genomic Research predict that infinite genomes may never be fully described due to the continuous emergence of new genes in bacteria and viruses. By analyzing eight isolates of Group B Strep, TIGR scientists discovered a core genome with an average of 1806 genes present across all strains.
The latest version of IMG, a collaborative effort between the DOE JGI and Lawrence Berkeley National Laboratory, enables users to add annotations and save analysis results. The update also features improved comparative analysis capabilities and a new training workshop designed for teachers and students.
Researchers discovered that thermophilic bacteria have an abundance of disulfide bonds, which improve protein stability and boost heat-tolerance. The study identified a specific protein, protein disulfide oxidoreductase (PDO), playing a key role in forming these bonds.
A new technique called piggyBac has been developed to systematically inactivate genes in the mouse genome, enabling researchers to understand the functions of individual genes. This method uses a reliable gene-transposing tool that can insert itself into the genomes of human and mouse cells.
The completed rice genome sequence provides a raw material for studies aimed at improving the agricultural yield of the world's most important food source. The sequence reveals some 37,500 genes on the 12 chromosomes of rice, closely related to other major cereal grasses.
The complete sequence of the rice genome has been announced, providing a genetic toolkit for breeders to develop novel strains that are highly productive, disease-resistant, and environmentally friendly. This breakthrough has significant implications for global food security and sustainable agriculture.
A recent study reveals that symbiotic bacteria, such as Blochmannia, exhibit exceptional genomic stability despite rapid protein evolution. Genome sequencing of the black carpenter ant mutualist revealed that all shared genes were completely conserved in both genomes, indicating a striking lack of genetic change over millions of years.
Researchers discover key biochemical tools that cold-adapted bacteria use to survive in subzero temperatures, including cell membranes packed with polyunsaturated fatty acids and protective solutes inside cells. The study also reveals potential industrial applications for cold-hardy enzymes found in the Colwellia psychrerythraea genome.
A large-scale genomic study found that co-circulating minor variants of the flu virus can exchange genes and create novel, epidemiologically significant strains. This process can lead to an epidemic with just one or two more mutations, challenging the traditional view of epidemic flu.
Researchers have identified gene sequences involved in the host-parasite relationship and parasite metabolism, providing potential vaccine candidates. The sequencing of trypanosome genomes has significant challenges due to repetitive sequences but promises to advance tropical medicine by helping develop new drugs against these diseases.
Researchers have discovered a shared genetic core among three deadly parasites, which could lead to the development of new drugs targeting these diseases. The genome studies found that the parasites share approximately 6,200 conserved genes, providing potential targets for treatment.
Researchers have identified 34 mutations resulting in embryonic lethality, attributing it to defects in cellular proliferation, gastrulation, and other developmental processes. The study predicts that between 13.7% and 19% of all mouse genes are necessary for embryonic viability.
Researchers found nearly equal proportions of two different sexes in a worldwide collection of 290 specimens, indicating recent evolutionary history of sexual activity. This discovery could lead to new strains with increased ability to cause disease and infect humans.
A genome study of the beneficial microbe Pseudomonas fluorescens Pf-5 has identified new chemical pathways that may help boost plant health and combat plant diseases. The research, published in Nature Biotechnology, reveals the potential for this microbe to produce new antibiotic compounds.
DOE JGI scientists have overcome major challenges to sequence DNA from ancient cave bear specimens, yielding 40,000-year-old genomic data. The breakthrough enables comparison with modern brown bears and polar bears, shedding light on human predecessors.
The new IMG 1.1 version features enhanced capabilities to improve the efficiency of genome analysis, including a function to compare gene occurrence profiles and support infrastructure for comparative organism statistics. The tool continues to be updated quarterly with new public and DOE JGI genomes.
The University of Wisconsin-Madison's Grid Laboratory of Wisconsin (GLOW) is a campus-wide distributed computing environment that harnesses spare processing power from hundreds of individual computers. This allows researchers to sort through massive DNA sequences and power simulations in a fraction of the time previously required. By a...
A study of gene expression in a microbial community found over 2,000 proteins produced by five key species, including unique enzymes that maintain protein structure in acidic conditions. The community thrives in hot, highly acidic environments, with large numbers of proteins not resembling any other known proteins.
Researchers developed Environmental Genomic Tags (EGTs) to assess environment vitality and signal progress in remediating contaminated environments. The EGT approach captures a DNA profile of a particular niche, reflecting the presence and levels of nutrients, pollutants, and other environmental features.
Researchers analyzed whale skeletons and farm soil using metagenomics, discovering specialized bacteria that thrive in these environments. The study provides a new understanding of the diversity of microbial life on earth, with potential applications in fields such as agriculture and medicine.
The study reveals novel receptors that enable the fungus to recognize its environment, as well as secreted proteins used to damage rice plants. The M. grisea genome contains retro-elements, which may contribute to its rapid evolution of new strains.
The DOE JGI has launched a public online microbial genome data clearinghouse, IMG, to facilitate the analysis and comparison of microbial genomes. The platform offers a comprehensive system for exploring and annotating DOE JGI-sequested genomes, enabling scientists to tap into the diversity of microbial environments.
Researchers have discovered three new bacterial species, Wolbachia wAna, wSim, and wMoj, in the genomes of Drosophila fruit flies. The discovery was made by scanning raw genomic data from the Trace Archive, a public repository of sequencing projects.
Scientists have found that functional forms of missing tRNA genes can be created by copying from distant DNA sequences and joining them. This discovery sheds light on the evolution of extremophiles in the Archaea kingdom.
The genome sequence of V. fischeri reveals surprising parallels with Vibrio cholerae and other pathogens, indicating toxin activity genes. The research sheds light on the connection between quorum sensing and global regulatory networks in bacterial cell communication.
A new method assigns biological functions to unknown genes, enabling genome comparison, by integrating experimental and computational analyses. This approach identifies functional proteins in 97% of hypothetical genes and provides a framework for ranking their precision and confidence.
Researchers at New York University have discovered over 150 additional genes required to make an embryo, bringing the total estimated number of genes needed to around 2,600. The study also sheds light on how these genes work in humans and provides clues for understanding human diseases.
Researchers found evidence of meiosis in Giardia intestinalis, a unicellular protist parasite, suggesting that eukaryotes have been capable of sex for a long time. The discovery provides insight into the evolution of sexual reproduction in eukaryotic cells.
Researchers have mapped the genome of Cryptococcus neoformans, a fungus that causes severe inflammation of the brain in people with HIV and those taking chemotherapy or steroid treatments. The study identified 30 new genes involved in the fungus's biosynthesis, offering potential targets for treatment.
Dehalococcoides bacteria can adapt to various environmental conditions through the use of mobile genetic elements, allowing them to degrade chlorinated pollutants. The genome sequence of Strain 195 reveals its ability to turn genes on and off in response to environmental cues.