A team of scientists has decoded hidden DNA variations that influence digestion, immune response, and muscle control. The study maps genomic variation across ancestries with a breadth and resolution never before achieved.
Researchers at the University of Pittsburgh have discovered a novel tool to help stratify rejection risk in kidney transplantation. They found that mismatching SIRP-alpha between donors and recipients contributes to worse rejection, scarring, and graft failure in humans, suggesting improved transplant outcomes.
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers generated high-quality haplotype-resolved assemblies of the MHC region in five widely used tumor cell lines. The studies identified numerous single nucleotide polymorphisms, indels, and structural variants surrounding HLA class I and II genes, providing valuable resources for cancer immunology research.
A new study by Mass General Brigham researchers has identified a natural 'brake' within the innate immune system that can prevent organ transplant rejection. The discovery highlights a promising target for new therapies and offers hope for longer-lasting transplant success and reduced need for lifelong immunosuppression.
Researchers have identified a subset of T-cells that acts like stem cells and continuously generates effector T-cells that attack transplanted organs. Targeting the transcription factor IRF4 may lead to innovative therapies for patients with chronic infections, cancers, autoimmune diseases and transplanted organs.
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Researchers propose a new hypothesis for developing small diameter vascular grafts (SDVG) that heal in a reconstructive manner. They aim to emulate the structure and behavior of living arteries, incorporating a blood vessel network within the graft walls.
Researchers have created a humanized mouse model that can predict the best match for a living organ donor and detect early signs of transplant rejection. The model uses a combination of HLA-G and B regulatory cells to identify patients who may need less immunosuppressive therapy.
Researchers identified a biomarker that predicts kidney transplant rejection risk by analyzing immune molecule ratios. Monitoring this ratio may help clinicians identify high-risk patients and intervene with new treatments to prevent long-term organ rejection.
Researchers showcased Droplet Digital PCR's use in detecting rare mutations, including stem cell integrity and cancer-related de novo mutations. The technology also enabled the non-invasive detection of transplant rejection through cell-free DNA measurement, offering a promising alternative to invasive methods.
Researchers at the University of Pennsylvania have discovered a method to detect organ transplant rejection earlier, using a blood-based approach that targets 'transplant exosomes.' This new strategy may enable doctors to intervene sooner and reduce the risk of long-term side effects from immunosuppressive drugs.
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
Research from Tufts University reveals that hyperlipidemia, high cholesterol and high triglycerides, accelerates heart-transplant rejection in mice. The studies, published online in the American Journal of Transplantation, found that mice fed a high-fat diet rejected their transplants faster than those on a lower-fat diet.