Articles tagged with Type 2 Diabetes
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A new center will address individual, familial, societal and environmental factors contributing to health disparities in the Latino/a/x community. The center will support research projects and interventions aimed at reducing obesity and chronic disease risk in Latino/a/x families.
New research identifies SGK as a key driver of insulin resistance in the liver, which can be targeted to prevent type 2 diabetes. Inhibiting SGK activity restores normal insulin action and helps block fat buildup in the liver.
Researchers found that poorly controlled type 2 diabetes is associated with an increased risk of developing preclinical dementia, which can progress to full-blown dementia. The study also suggests that controlling blood glucose levels may be key to preventing cognitive decline.
Researchers identified a pattern that links the accumulation of amyloid beta (Aβ) proteins with a reduction of serotonin, which may help predict who will develop late-life depression. The study found that individuals expressing this pattern had more severe depressive symptoms.
A study by Karolinska Institutet reveals that enlarged fat cells cause inflammation and pathology in adipose tissue, increasing the risk of type 2 diabetes. Researchers found that blocking the formation of senescent fat cells reduced pro-inflammatory factors, paving the way for novel treatment strategies.
A multidisciplinary taskforce developed a Clinical Care Pathway for NAFLD/NASH, outlining practical guidance from screening to patient care management. The pathway aims to provide efficient, safe, and value-based care for patients with NAFLD and NASH, highlighting the importance of early interventions and shared decision-making.
A new strategy proposes that weight loss of 15% or more should be the main treatment focus for patients with type 2 diabetes, with potential to slow progress and reverse cases. This approach aims to address not just high blood sugar but other obesity-related complications.
A new analysis of COVID-19-diabetes studies confirms that patients with advanced diabetes have a higher risk of death when infected with SARS-CoV-2. The study found associations between characteristics such as age, sex, obesity, and pre-existing conditions, as well as medication use, and increased risk of COVID-19-related death.
A recent US survey highlights substantial deficiencies in diabetes care and management, compromising optimal health outcomes among those with type 1 and type 2 diabetes. The study found significant disruptions in routine care, psychosocial stress, and challenges accessing essential medications and testing supplies.
People with diabetes who have survived COVID-19 require closer monitoring due to increased risk of complications and mortality. Routine care, including risk factor assessment and self-management education, is crucial to mitigate these risks.
A new study found that men with young-onset type 2 diabetes are more likely to develop retinopathy than those diagnosed at an older age. The study also suggests that early detection and treatment can reduce the risk of complications.
A new study found that nearly three in ten people with type 2 diabetes in Scotland were prescribed antidepressants before their diagnosis. Additionally, one in ten individuals received antipsychotic prescriptions prior to T2D diagnosis. These findings suggest a link between mental health and the development of type 2 diabetes.
A new study found that every extra 1cm in waist circumference increases the odds of advanced fibrosis by 5% in people with type 2 diabetes. Advanced fibrosis is a late stage of non-alcoholic fatty liver disease (NAFLD), which can lead to serious liver damage.
A comprehensive analysis of 33 studies reveals that COVID-19 lockdowns lead to improved blood sugar control in individuals with type 1 diabetes, while glycaemic control deteriorates and weight gain increases among those with type 2 diabetes. The study suggests that lockdown measures may have allowed people with type 1 diabetes to bette...
A new study reveals marked socio-economic inequalities in Scotland's type 2 diabetes prevalence, with the gap widening over time. Women in the most deprived areas are almost 2.5 times more likely to have type 2 diabetes than those in the least deprived areas.
A large study of over 88,000 participants found that addressing key risk factors such as smoking, diet, and blood pressure can lower dementia risk in those with type 2 diabetes. The study also showed improvements in cognitive function and brain structure with greater adherence to treatment targets.
Glyscend Therapeutics has initiated a phase 1 clinical trial in Australia investigating an oral polymer therapy that improves glucose homeostasis with weight loss in nonclinical models. The therapy targets mechanisms underlying bariatric surgery and aims to replicate its benefits without the need for surgery.
A new USC study found that artificial sweeteners like sucralose can trick the brain into feeling hungry, leading to increased calorie consumption. This study, one of the largest to-date on artificial sweeteners, suggests that females and people with obesity may be more sensitive to these sweeteners.
A new study found that maintaining healthy lifestyle habits and having a healthy body weight can significantly lower the lifetime risk of type 2 diabetes in middle-aged adults. The research included over 5,993 participants and analyzed the relationship between cardiovascular health and genetic predisposition to type 2 diabetes.
A study found type 2 diabetes linked to higher mortality risk in hospitalised COVID patients than type 1; older age and high CRP also associated with increased risk. A model can predict which patients are at higher risk of death using age and CRP as variables.
A new low-dose whey protein microgel shot taken 15 minutes before meals reduces post-meal blood sugar spikes and improves insulin response in people with type 2 diabetes. Glucose levels were reduced by 22% and insulin responses were higher in the whey protein group.
A new study found that people of normal weight with type 2 diabetes can achieve remission by losing weight. Eight out of 12 participants achieved remission after losing 10-15% of their body weight, with levels of fat in the liver and pancreas falling substantially and insulin-producing cells restored. The study supports the idea that e...
Researchers found that liver fat is higher in people with type 2 diabetes, even at seemingly healthy levels, and that weight loss induced remission reduces intra-organ fat. A significant proportion of participants achieved remission of their T2D after a weight management programme.
A study of over 19,000 bariatric surgery patients found men are five times as likely to die within 30 days after the procedure compared to women. Men's long-term mortality is also almost three times higher due to comorbidities such as cardiovascular disease and type 2 diabetes.
A recent US study found that major weight loss can reverse most cardiovascular risks associated with obesity. The study analyzed data from over 20,000 adults and found that the risk of high blood pressure and dyslipidemia was similar in those who lost weight and those who never had obesity.
An international study involving almost 10,000 patients with type 2 diabetes found that women are less likely to reach recommended treatment targets for cardiovascular prevention, such as statins and blood pressure medications. However, women were less likely to experience adverse cardiovascular outcomes apart from stroke.
A new study found that alendronate, a widely used osteoporosis treatment, may reduce the risk of developing type 2 diabetes by 34% compared to non-users. The study, published in Diabetologia, also suggests that longer treatment duration is associated with lower risk of type 2 diabetes.
A study of over 100,000 people with type 2 diabetes found that insulin resistance is associated with a greater risk of stroke. Those with lower insulin resistance were 40% less likely to have a stroke than those with higher insulin resistance.
A serum biomarker, polyubiquitinated phosphatase and tensin homolog (PTEN), was associated with a four-fold higher risk of kidney function decline. This modified form of PTEN was linked to severity of lesions in kidney structure, indicating early manifestations of diabetic kidney disease.
A two-hour glucose tolerance test is linked to cognitive decline in a 10-year follow-up study. Higher blood glucose levels measured in the test were associated with weaker performance in a memory test and a greater decline in results.
Research by University of Arizona Health Sciences identifies chronic arsenic exposure as a risk factor for developing insulin resistance and glucose intolerance. The study found that prolonged activation of NRF2 protein leads to shifts in metabolic pathways, increasing glucose production in the liver.
A 12-week study showed that a low-calorie, low-carbohydrate diet managed by pharmacists can eliminate Type 2 diabetes medications and improve glucose control for over one-third of participants. This approach promotes Type 2 diabetes remission and highlights the potential role of community pharmacists in overall diabetes care.
A Finnish study discovered a positive association between standing and improved insulin sensitivity in adults with increased risk of type 2 diabetes and cardiovascular diseases. The researchers found that increasing daily standing time can help prevent chronic diseases, even if physical activity recommendations are not met.
A new study found that non-Hispanic Black and Mexican American adults are diagnosed with type 2 diabetes at an average age of 46-47 years old, four to seven years earlier than non-Hispanic white adults. Preventive measures such as nutrition counseling and physical-activity programs can prevent or delay the onset of diabetes.
A large-scale review of clinical evidence suggests that losing significant weight through diet or surgery can bring about type 2 diabetes remission. Meal-replacement diets and low-carbohydrate diets were found to be effective in achieving remission, with people who lost the most weight being more likely to succeed.
A study of rural schoolchildren found that behaviors leading to obesity decreased on school days compared to non-school days, while activity levels increased. The researchers recommend structured programs or schedules for children on non-school days to combat obesogenic behaviors.
A new USC study found a link between 'forever chemicals' and changes in glucose metabolism in Latina girls, potentially increasing their risk of developing type 2 diabetes. Researchers measured the impact of PFAS on glucose metabolism over time among adolescents and young adults.
A University of California, Davis study found that consuming sucrose and high fructose corn syrup can increase liver fat and decrease insulin sensitivity, highlighting the need for consumers to read labels carefully. The study also found no significant differences between the effects of sucrose and high fructose corn syrup.
Researchers found that certain peptides associated with migraine pain can regulate insulin production in mice, potentially preventing type 2 diabetes. The study suggests that these peptides could be developed into therapeutic strategies to control blood sugar levels, while minimizing the risk of migraines.
The U.S. Preventive Services Task Force recommends screening for prediabetes and type 2 diabetes, particularly in high-risk individuals. The guidelines aim to detect and prevent these conditions through early detection and intervention.
The USPSTF has lowered the recommended starting age of screening for type 2 diabetes from 40 to 35. Screening is now recommended for adults with prediabetes or type 2 diabetes, particularly those aged 35-70 who are overweight or obese. This recommendation aims to detect and treat these conditions earlier.
The prevalence of type 1 and type 2 diabetes among US children and teens rose significantly from 2001 to 2017. Researchers estimated an increase in diabetes cases across all age groups during this period, with the largest increases seen among younger populations.
A new study by Salk scientists found that time-restricted eating (TRE) confers multiple health benefits, including reduced risk of type 2 diabetes, fatty liver disease, and sepsis, regardless of age and sex. TRE may also protect against infectious diseases like COVID-19 and improve insulin resistance.
A new study published in Diabetologia found that children of mothers with diabetes before or during pregnancy are more likely to develop high refractive error (RE), including long and short-sightedness. The study analyzed data from over 2.4 million births in Denmark and found a significant association between maternal diabetes and an i...
A new study examining the association between type 2 diabetes mellitus and skin diseases reveals a strong link between the two conditions. The research, published in Chinese Medical Journal, found that 93.5% of individuals with T2DM had skin problems, including over 47 types of comorbid skin diseases.
Researchers have determined the structure of human leukotriene B4 receptor 1 (hBLT1), a protein involved in inflammation and disease. The analysis reveals how the receptor recognizes its binding partners and interacts with them, opening up avenues for designing better drugs.
Researchers at Karolinska Institutet discovered three different subtypes of mature fat cells in white adipose tissue, with only one subtype, Adipo PLIN, responding to insulin. The study suggests that changes in this specific subtype may contribute to metabolic diseases like Type 2 diabetes.
A study found that a body mass index of 25.0 kg/m2 is the cutoff point for developing type 2 diabetes, with elevated liver enzymes increasing the risk. The research suggests a stronger association between BMI and T2DM when liver enzymes are high, likely due to insulin resistance caused by non-alcoholic fatty liver disease.
A new artificial pancreas has been successfully trialled in outpatients with type 2 diabetes, showing improved blood sugar control and reduced risk of low blood sugar levels. The device can automate insulin delivery using digital technology, allowing for more effective management of the condition.
A low glycaemic diet has been shown to produce small but meaningful improvements in blood sugar levels, cholesterol, weight, and other risk factors in people with diabetes. The findings are based on a systematic review of 27 randomised controlled trials involving 1,617 participants with type 1 or 2 diabetes.
Scientists discovered impaired leptin transport to the brain via LepR receptors leads to pre-diabetic state and exhausted insulin secretion. Reintroducing leptin restores pancreatic function-promoting action, suggesting a crucial brain role in type 2 diabetes management.
A new study published in Nutrients highlights the importance of adequate protein intake for adults living with diabetes. The research found that nearly half of US adults with diabetes did not meet the daily recommended protein intake, leading to greater physical limitations and potentially increasing the risk of muscle loss.
A recent study published in Frontiers in Nutrition found that consuming millet as part of a daily diet can reduce blood glucose levels by 12-15% and help manage diabetes. The research, which analyzed data from over 1,000 human subjects across 11 countries, also found that millets have a lower glycemic index compared to other grains.
A new study finds that youth-onset type 2 diabetes increases the risk of developing serious complications by young adulthood. Within 15 years of diagnosis, nearly a third of participants had two or more complications, including heart disease, kidney disease, and eye disease.
Researchers found a steady decline in blood glucose control over 15 years, with certain participants developing multiple complications. Minority groups and those with high blood pressure and dyslipidemia were at higher risk for developing complications.
A study by Anglia Ruskin University found that younger people with diabetes are significantly more concerned about COVID-19 risks and have a higher likelihood of reporting worries. Social support from family, friends, and healthcare teams plays a crucial role in managing these concerns.
Patients who underwent bariatric surgery reported improved physical health, energy, and reduced body pain compared to those on medical therapy alone. Significant weight loss and insulin independence drove these improvements in general health measures and quality of life.
A study from the University of Gothenburg and Oxford found that early blood sugar control in type 2 diabetes significantly impacts future heart attack and death risks. Targeting levels below 52 mmol/mol reduces mortality risk by 20%, while delayed control offers only a 3% benefit.
Researchers discovered 47 lipids significantly different between rapid and slow kidney function decliners, providing a platform for risk stratification. The study's findings also suggest the underlying mechanism of progressive kidney disease, which could be a future target for therapeutic intervention.
Scientists at the University of Cambridge have discovered rare genetic variants that substantially increase susceptibility to type 2 diabetes. These variants are carried by one in 3,000 people and significantly increase an individual's risk of developing the condition, six-fold.