Research on type 2 diabetes and its management. Covers nerve pain, early onset, BMI trajectories, and treatment side effects.
A study using anonymized health data found that people with poorly managed long-term glycemic control are nearly 50% more likely to require ICU treatment if they contract COVID-19. Metformin, insulin, and corticosteroids may also reduce the risk of severe COVID-19.
A new study found that low energy diets with formula meal replacements are the most effective methods for weight management and remission in adults with type 2 diabetes. Formula meal replacements achieved greater weight loss compared to food-based low-energy diets.
A new study from Intermountain Healthcare found that low-frequency intermittent fasting raises galectin-3 levels, a protein tied to inflammatory response, and lowers rates of insulin resistance and metabolic syndrome. This suggests that even occasional fasting may have positive health effects.
A recent study led by Okayama University scientists found that metformin activates a subset of immune cells called CD8+ T-lymphocytes to attack and kill tumor cells. The study revealed that metformin increases the production of reactive oxygen species in these cells, which activates growth pathways and allows for proliferation.
A large study published in Nature Communications has identified a protein in the blood, follistatin, which can predict type 2 diabetes up to 19 years before diagnosis. The study found that higher levels of follistatin circulating in the blood are associated with an increased risk of developing the disease.
Research found that adults with type 1 or type 2 diabetes and atrial fibrillation were less likely to notice irregular heartbeat symptoms, had a lower quality of life, and experienced more co-occurring health conditions than those without diabetes. This delay in diagnosis may lead to more complications such as stroke.
A study by Karolinska Institutet found that low levels of microRNA-210 in red blood cells cause vascular damage in type 2 diabetes. The reduction in microRNA-210 levels impaired blood vessel endothelial cell function and led to increased risk of cardiovascular disease.
Research associates elevated galectin-1 levels with increased risk of type 2 diabetes, while offering kidney protection in high-risk patients. Galectin-1's role in disease development and progression is a new clue in understanding the link between obesity and type 2 diabetes.
Researchers have discovered that a low-dose oral compound, HBI-002, can safely reduce oxidative stress and inflammation in the retina, common causes of diabetic retinopathy. The study suggests that small amounts of carbon monoxide may help protect vision in diabetes patients.
Researchers found that around 5% of patients with type 2 diabetes in Scotland are in remission, suggesting a need for updated guidelines to support clinicians. Individuals in remission tend to be older and have lower blood sugar levels at diagnosis, and often achieve remission after weight loss since their diagnosis
New research from the University of South Australia finds that the 5:2 diet is just as effective as a continuous energy-restricted diet in achieving weight loss and preventing type 2 diabetes in women with a previous diagnosis of gestational diabetes. The study suggests that this diet offers greater choice and flexibility for women loo...
A nationwide study found that living in areas with high fast-food outlets increases the risk of developing type 2 diabetes. In contrast, a greater presence of supermarkets is associated with lower T2D incidence, particularly in suburban and rural communities.
A five-year study aims to identify hormone responses in a population of Mexican Americans with prediabetes, Type 2 diabetes, and obesity. The research uses genetic data and physiologic testing to guide optimal treatments for diabetes, prediabetes, and related diseases.
A recent study by the University of California - San Diego team discovered that glycogen regulates and promotes fat metabolism, helping to balance energy intake and expenditure. The research suggests modulating glycogen metabolism in fat cells could provide new approaches for weight loss and improved metabolic health.
A recent study by the University of Eastern Finland suggests that consuming one serving of whole grains daily can reduce type 2 diabetes incidence and associated costs in Finland. The potential cost savings could be up to €1 billion over ten years, leading to healthier years for individuals.
Researchers found that excess carbohydrates can lead to metabolic distress by blocking the synthesis of important antioxidants and increasing insulin levels. This study provides new insights into the relationship between carbohydrate overfeeding and metabolic health.
A VCU study found that people with advanced liver scarring caused by obesity and diabetes are dying from liver disease, underscoring the need for new treatments. The research provides a roadmap for future therapies to prevent liver transplants and save lives.
A team of international scientists has shown that skeletal muscle cells from people with type 2 diabetes have a different circadian rhythm, leading to altered mitochondrial metabolism. The study suggests that considering cellular rhythms when prescribing treatments for type 2 diabetes could optimize their effectiveness.
A large population-based cohort study found that combined oral contraceptives reduce the risk of type 2 diabetes and pre-diabetes in women with PCOS by 26%. Women with PCOS have twice the risk of developing type 2 diabetes or pre-diabetes, highlighting the need for treatments to reduce this risk.
A large Swedish cohort study found that obese patients (BMI >35 kg/m2) were twice as likely to experience a prolonged ICU stay or die from COVID-19. The study also showed that obesity is an independent risk factor for severe outcomes, suggesting closer monitoring for individuals with obesity hospitalized for COVID-19.
A new center will address individual, familial, societal and environmental factors contributing to health disparities in the Latino/a/x community. The center will support research projects and interventions aimed at reducing obesity and chronic disease risk in Latino/a/x families.
New research identifies SGK as a key driver of insulin resistance in the liver, which can be targeted to prevent type 2 diabetes. Inhibiting SGK activity restores normal insulin action and helps block fat buildup in the liver.
Researchers found that poorly controlled type 2 diabetes is associated with an increased risk of developing preclinical dementia, which can progress to full-blown dementia. The study also suggests that controlling blood glucose levels may be key to preventing cognitive decline.
Researchers identified a pattern that links the accumulation of amyloid beta (Aβ) proteins with a reduction of serotonin, which may help predict who will develop late-life depression. The study found that individuals expressing this pattern had more severe depressive symptoms.
A study by Karolinska Institutet reveals that enlarged fat cells cause inflammation and pathology in adipose tissue, increasing the risk of type 2 diabetes. Researchers found that blocking the formation of senescent fat cells reduced pro-inflammatory factors, paving the way for novel treatment strategies.
A multidisciplinary taskforce developed a Clinical Care Pathway for NAFLD/NASH, outlining practical guidance from screening to patient care management. The pathway aims to provide efficient, safe, and value-based care for patients with NAFLD and NASH, highlighting the importance of early interventions and shared decision-making.
A new strategy proposes that weight loss of 15% or more should be the main treatment focus for patients with type 2 diabetes, with potential to slow progress and reverse cases. This approach aims to address not just high blood sugar but other obesity-related complications.
A new analysis of COVID-19-diabetes studies confirms that patients with advanced diabetes have a higher risk of death when infected with SARS-CoV-2. The study found associations between characteristics such as age, sex, obesity, and pre-existing conditions, as well as medication use, and increased risk of COVID-19-related death.
A recent US survey highlights substantial deficiencies in diabetes care and management, compromising optimal health outcomes among those with type 1 and type 2 diabetes. The study found significant disruptions in routine care, psychosocial stress, and challenges accessing essential medications and testing supplies.
People with diabetes who have survived COVID-19 require closer monitoring due to increased risk of complications and mortality. Routine care, including risk factor assessment and self-management education, is crucial to mitigate these risks.
A new study found that men with young-onset type 2 diabetes are more likely to develop retinopathy than those diagnosed at an older age. The study also suggests that early detection and treatment can reduce the risk of complications.
A new study found that nearly three in ten people with type 2 diabetes in Scotland were prescribed antidepressants before their diagnosis. Additionally, one in ten individuals received antipsychotic prescriptions prior to T2D diagnosis. These findings suggest a link between mental health and the development of type 2 diabetes.
A new study found that every extra 1cm in waist circumference increases the odds of advanced fibrosis by 5% in people with type 2 diabetes. Advanced fibrosis is a late stage of non-alcoholic fatty liver disease (NAFLD), which can lead to serious liver damage.
A comprehensive analysis of 33 studies reveals that COVID-19 lockdowns lead to improved blood sugar control in individuals with type 1 diabetes, while glycaemic control deteriorates and weight gain increases among those with type 2 diabetes. The study suggests that lockdown measures may have allowed people with type 1 diabetes to bette...
A new study reveals marked socio-economic inequalities in Scotland's type 2 diabetes prevalence, with the gap widening over time. Women in the most deprived areas are almost 2.5 times more likely to have type 2 diabetes than those in the least deprived areas.
A large study of over 88,000 participants found that addressing key risk factors such as smoking, diet, and blood pressure can lower dementia risk in those with type 2 diabetes. The study also showed improvements in cognitive function and brain structure with greater adherence to treatment targets.
Glyscend Therapeutics has initiated a phase 1 clinical trial in Australia investigating an oral polymer therapy that improves glucose homeostasis with weight loss in nonclinical models. The therapy targets mechanisms underlying bariatric surgery and aims to replicate its benefits without the need for surgery.
A new USC study found that artificial sweeteners like sucralose can trick the brain into feeling hungry, leading to increased calorie consumption. This study, one of the largest to-date on artificial sweeteners, suggests that females and people with obesity may be more sensitive to these sweeteners.
A new study found that maintaining healthy lifestyle habits and having a healthy body weight can significantly lower the lifetime risk of type 2 diabetes in middle-aged adults. The research included over 5,993 participants and analyzed the relationship between cardiovascular health and genetic predisposition to type 2 diabetes.
A study found type 2 diabetes linked to higher mortality risk in hospitalised COVID patients than type 1; older age and high CRP also associated with increased risk. A model can predict which patients are at higher risk of death using age and CRP as variables.
A new low-dose whey protein microgel shot taken 15 minutes before meals reduces post-meal blood sugar spikes and improves insulin response in people with type 2 diabetes. Glucose levels were reduced by 22% and insulin responses were higher in the whey protein group.
A new study found that people of normal weight with type 2 diabetes can achieve remission by losing weight. Eight out of 12 participants achieved remission after losing 10-15% of their body weight, with levels of fat in the liver and pancreas falling substantially and insulin-producing cells restored. The study supports the idea that e...
Researchers found that liver fat is higher in people with type 2 diabetes, even at seemingly healthy levels, and that weight loss induced remission reduces intra-organ fat. A significant proportion of participants achieved remission of their T2D after a weight management programme.
A study of over 19,000 bariatric surgery patients found men are five times as likely to die within 30 days after the procedure compared to women. Men's long-term mortality is also almost three times higher due to comorbidities such as cardiovascular disease and type 2 diabetes.
A recent US study found that major weight loss can reverse most cardiovascular risks associated with obesity. The study analyzed data from over 20,000 adults and found that the risk of high blood pressure and dyslipidemia was similar in those who lost weight and those who never had obesity.
An international study involving almost 10,000 patients with type 2 diabetes found that women are less likely to reach recommended treatment targets for cardiovascular prevention, such as statins and blood pressure medications. However, women were less likely to experience adverse cardiovascular outcomes apart from stroke.
A new study found that alendronate, a widely used osteoporosis treatment, may reduce the risk of developing type 2 diabetes by 34% compared to non-users. The study, published in Diabetologia, also suggests that longer treatment duration is associated with lower risk of type 2 diabetes.
A study of over 100,000 people with type 2 diabetes found that insulin resistance is associated with a greater risk of stroke. Those with lower insulin resistance were 40% less likely to have a stroke than those with higher insulin resistance.
A serum biomarker, polyubiquitinated phosphatase and tensin homolog (PTEN), was associated with a four-fold higher risk of kidney function decline. This modified form of PTEN was linked to severity of lesions in kidney structure, indicating early manifestations of diabetic kidney disease.
A two-hour glucose tolerance test is linked to cognitive decline in a 10-year follow-up study. Higher blood glucose levels measured in the test were associated with weaker performance in a memory test and a greater decline in results.
Research by University of Arizona Health Sciences identifies chronic arsenic exposure as a risk factor for developing insulin resistance and glucose intolerance. The study found that prolonged activation of NRF2 protein leads to shifts in metabolic pathways, increasing glucose production in the liver.
A 12-week study showed that a low-calorie, low-carbohydrate diet managed by pharmacists can eliminate Type 2 diabetes medications and improve glucose control for over one-third of participants. This approach promotes Type 2 diabetes remission and highlights the potential role of community pharmacists in overall diabetes care.
A Finnish study discovered a positive association between standing and improved insulin sensitivity in adults with increased risk of type 2 diabetes and cardiovascular diseases. The researchers found that increasing daily standing time can help prevent chronic diseases, even if physical activity recommendations are not met.
A new study found that non-Hispanic Black and Mexican American adults are diagnosed with type 2 diabetes at an average age of 46-47 years old, four to seven years earlier than non-Hispanic white adults. Preventive measures such as nutrition counseling and physical-activity programs can prevent or delay the onset of diabetes.
A large-scale review of clinical evidence suggests that losing significant weight through diet or surgery can bring about type 2 diabetes remission. Meal-replacement diets and low-carbohydrate diets were found to be effective in achieving remission, with people who lost the most weight being more likely to succeed.
A study of rural schoolchildren found that behaviors leading to obesity decreased on school days compared to non-school days, while activity levels increased. The researchers recommend structured programs or schedules for children on non-school days to combat obesogenic behaviors.
A new USC study found a link between 'forever chemicals' and changes in glucose metabolism in Latina girls, potentially increasing their risk of developing type 2 diabetes. Researchers measured the impact of PFAS on glucose metabolism over time among adolescents and young adults.
A University of California, Davis study found that consuming sucrose and high fructose corn syrup can increase liver fat and decrease insulin sensitivity, highlighting the need for consumers to read labels carefully. The study also found no significant differences between the effects of sucrose and high fructose corn syrup.
Researchers found that certain peptides associated with migraine pain can regulate insulin production in mice, potentially preventing type 2 diabetes. The study suggests that these peptides could be developed into therapeutic strategies to control blood sugar levels, while minimizing the risk of migraines.
The U.S. Preventive Services Task Force recommends screening for prediabetes and type 2 diabetes, particularly in high-risk individuals. The guidelines aim to detect and prevent these conditions through early detection and intervention.