Articles tagged with Type 2 Diabetes
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The COVID-19 pandemic had a substantial effect on diabetes care in the US, with a decrease in health services received by patients with type 2 diabetes. This decrease was particularly pronounced among low-income individuals, highlighting the need for targeted support and resources.
A study published in iScience has identified dozens of muscle proteins with decreased quantities in individuals with prediabetes and type 2 diabetes. The findings highlight the significance of mitochondrial energy metabolism in the progression from prediabetes to type 2 diabetes.
A new pathway to treating type 2 diabetes has been discovered by researchers at the University of Arizona, focusing on the liver's role in insulin sensitivity. The study found that fat in the liver increases the release of GABA, a neurotransmitter that decreases nerve activity.
People of South Asian and African/African Caribbean ethnicity are less likely to be prescribed guideline-indicated statins for type 2 diabetes, a finding that could prevent up to 12,600 heart attacks and strokes in the UK. The study suggests that targeted education and prescribing interventions may help address these disparities.
Researchers at Tohoku University have identified a new gene, CCDC152 (L-IST RNA), which inhibits selenoprotein P (SeP) levels, reducing insulin resistance and glucose metabolism issues associated with type 2 diabetes. EGCG supplements may help increase L-IST, offering potential treatment options for diabetic patients.
A study by National University of Ireland Galway found that nearly half of adults with diabetes attending a dedicated clinic have signs of established chronic kidney disease. The research suggests that careful medical management is not enough to prevent the development of kidney disease in people with diabetes.
Researchers found a direct link between placental mTOR and an infant's birthweight, with implications for obesity and Type 2 diabetes in adulthood. The study suggests that manipulating mTOR in the placenta can cause permanent impact on offspring health.
Researchers found that autologous bone marrow stromal stem cells can lower blood glucose levels and reduce medication doses in non-obese Type 2 diabetes patients with a short disease duration. The study's results are promising for the potential treatment of this chronic disease.
The study found that continuous glucose monitors reduced emergency department visits and hospitalizations for hypoglycemia, improving blood sugar control in selected insulin-treated type 2 diabetes patients. The monitors also showed comparable results to a new diabetes medication in terms of blood sugar control.
Eating at least two serves of fruit daily has been found to lower the risk of developing type 2 diabetes by 36%. The study suggests that whole fruits, not juice, contribute to improved insulin sensitivity and reduced blood glucose levels. Higher consumption of fruits rich in phytochemicals and fibre may also play a role.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that consuming two servings of whole fruits per day significantly lowers the risk of developing type 2 diabetes. The research, which analyzed data from over 7,700 participants, suggests that a healthy diet and lifestyle, including frui...
A weight management program has been shown to lower blood pressure and reduce the need for anti-hypertensive medications in people with type 2 diabetes. The program, developed by researchers at Universities of Glasgow and Newcastle, induces substantial weight loss and leads to remission of type 2 diabetes in 8 out of 10 participants.
A global collaboration has identified 24 new loci linked to glycemic traits, improving our understanding of type 2 diabetes and its impact on different ancestries. This study highlights the importance of including diverse populations in genetic research, yielding better results and enabling more precise diagnosis and treatment.
A new class of diabetes medication, GLP-1 receptor agonists, has been shown to improve asthma symptoms and reduce lung inflammation in patients with type 2 diabetes. The study found that these medications can help control asthma exacerbations and reduce breathing symptoms.
Researchers from Kumamoto University have discovered that cysteinylated albumin can be used as an early diagnostic marker for diabetic kidney disease. The study found that serum oxidized albumin reflects renal pathology earlier than urinary albumin and predicts disease progression.
A cluster-randomized controlled trial found that individuals with type 2 diabetes who received primary care-based oral health support experienced a significant increase in self-reported oral health quality of life. The study's authors conclude that patients with diabetes can benefit from extra attention to oral health, highlighting the...
A new study published in The Lancet Diabetes & Endocrinology found that BMI cut-offs used by the World Health Organization and UK's National Institute for Health and Care Excellence are not suitable for adults from Black Asian and Minority Ethnic backgrounds. The research, which included over 1.5 million people, shows that these groups...
A study found that consuming two cans of sardines a week reduced the risk of developing type 2 diabetes by 31% in elderly patients with prediabetes. The nutrient-rich fish helped lower insulin resistance, increase HDL cholesterol and improve glucose metabolism.
Andrew T. Hattersley, a renowned diabetes researcher, has been awarded the 2021 Harold Hamm International Prize for Biomedical Research in Diabetes. The prize recognizes his lifelong contributions to the field of diabetes research and his singular advances that promote curative potential.
A new study suggests that an hour of daily exercise can help Arctic Inuit people with a faulty TBC1D4 gene control their high blood sugar levels. This finding has the potential to improve the lives of thousands across the Arctic region, providing a positive outlook for those living with type 2 diabetes.
A study by Sansum Diabetes Research Institute and Rice University found wearable devices that continuously monitor blood sugar levels provide new insights into the progression of Type 2 diabetes among at-risk Hispanic/Latino adults. The results point to new directions for improved diabetes care, particularly in underserved populations.
A recent study examined the association between age at diabetes onset and subsequent dementia risk. The research found that younger individuals with type 2 diabetes were more likely to develop dementia compared to those who developed diabetes at an older age.
A new study from Children's Hospital Los Angeles finds a surge of patients presenting with diabetic ketoacidosis, a life-threatening complication of type 2 diabetes. Insulin levels in the blood may drop too low for too long due to COVID-19, causing DKA.
Scientists at Lund University discovered a key role for the VPS39 gene in regulating muscle stem cells' ability to create new mature muscle cells. The study found that individuals with type 2 diabetes have altered epigenetic patterns and impaired sugar uptake, leading to compromised muscle function.
A new once-a-week injectable insulin therapy has proven safe and as effective as daily insulin injections in two international clinical trials. The treatment may provide a convenient alternative to the burden of daily insulin shots for diabetes patients, improving long-term adherence and glucose control.
Low-volume HIIT (less than 20 minutes total exercise time) yields comparable improvements to longer interventions despite requiring significantly less time. This approach is especially beneficial for individuals with busy schedules who struggle to meet current physical activity guidelines.
A clinical practice review article by Rita Kalyani provides a systematic approach for treating patients with diabetes and cardiovascular disease. The article recommends using GLP-1 receptor agonists and SGLT2 inhibitors, particularly for patients with heart or blood vessel disease, to reduce the risk of major cardiovascular events.
Researchers found that body fat percentage is a key predictor of exercise capacity and cardiovascular disease risk in individuals with Type II diabetes. Machine learning approaches were used to analyze data and make accurate predictions.
A new approach has led to the discovery of a small molecule that may help regulate cholesterol levels in the brain, making it a potential therapeutic target for Alzheimer's disease. Increasing the activity of ABCA1 is expected to positively influence insulin signaling and reduce inflammation in the brain.
A new once-weekly basal insulin injection demonstrated similar efficacy and safety to daily basal insulin in patients with type 2 diabetes, achieving comparable blood glucose control and lower rates of hypoglycemia
A recent study presented at ENDO 2021 found that women with polycystic ovarian syndrome (PCOS) who are obese have a more than three-fold increased risk of developing type 2 diabetes during their lifetime. The risk was not observed in normal-weight women with PCOS.
Researchers have identified a way to reverse high blood sugar and muscle loss by targeting liver metabolism, which is disrupted in people with obesity-related type 2 diabetes. The study found that selectively silencing enzymes breaks down alanine can restore skeletal muscle protein synthesis, leading to improved muscle size and strength.
Researchers at the University of Gothenburg found that free fatty acids in the blood trigger insulin release even at normal blood-sugar levels, contradicting the long-held hypothesis. The study suggests that obesity and excess fat tissue contribute to increased FFAs, which may be an early sign of incipient type 2 diabetes.
A study found lifestyle interventions reduced cardiovascular harm and optimized benefits for 85% of participants. However, it increased the risk of major cardiovascular events in those with poor blood sugar control, suggesting alternative options like glucose-lowering drugs may be necessary.
A study by the University of South Australia found that women with gestational diabetes are ten times more likely to develop type 2 diabetes. However, only a third of these women understand they are at high risk due to lack of education and lifestyle changes.
Research from Queen Mary University of London has concluded that type 2 diabetes is associated with an increased risk of Parkinson's disease and may contribute to faster disease progression. Treating people with type 2 diabetes medications may reduce Parkinson's risk and slow its progression.
A new study published in Diabetologia found that regular physical activity significantly reduces the risk of type 2 diabetes for people living in polluted regions. The research, conducted in Taiwan, investigated the combined effects of physical activity and air pollution on type 2 diabetes risk.
A new study published in The Lancet found that patients with type 2 diabetes treated with Semaglutide achieved significant weight loss and improved blood glucose control. Two-thirds of patients lost at least 5% of their body weight, while over a quarter lost more than 15%.
A research review recommends physicians conduct regular screenings, adopt a high level of suspicion, and intervene early with families at risk for pediatric Type 2 diabetes. The study highlights the importance of addressing underlying factors such as weight issues, food insecurity, and stress to slow the youth diabetes epidemic.
Research found a strong association between birthweight of 2.5kg or more and lower IGF-1 levels, which are linked to an increased risk of developing type 2 diabetes in adulthood. The study involved 112,736 women and 68,354 men from the UK Biobank study.
A study found that the gut microbiome can predict changes in glucose regulation, particularly related to insulin levels and secretion. The study suggests that certain microbes may be useful for predicting disease progression and informs future research.
Research found that morning exercise was associated with higher risks of developing coronary heart disease in men, while midday exercise had lower cardiorespiratory fitness levels. The study suggests that timing of physical activity may play a role in cardiovascular health outcomes for individuals with type 2 diabetes.
A recent study published in the Journal of the American Heart Association found that obesity contributes to up to half of new Type 2 diabetes cases annually in the United States. The research suggests that reducing obesity could prevent or delay the onset of type 2 diabetes, with public health efforts supporting healthy lifestyles pote...
A large study found that older adults with moderately elevated blood sugar levels do not frequently develop full-blown diabetes. Instead, many improve their blood glucose levels or die from other causes, suggesting that the 'prediabetes' diagnosis is less useful in this age group.
A large-scale analysis found a disproportionately higher COVID-19 death risk in middle-aged people with type 2 diabetes. The study suggests that vaccine prioritization strategies across Europe should consider the relative risk of COVID-19 mortality in this population.
Patients with extreme blood sugar swings between doctor visits face higher risk of heart disease, study finds. Wide variations in blood sugar levels are associated with poor health outcomes and even death, researchers suggest.
Researchers used machine learning models to identify metabolites in walnuts associated with a reduced risk of type 2 diabetes and cardiovascular disease. The study found a 17% lower risk of type 2 diabetes and 29% lower risk of cardiovascular disease, contributing to our understanding of the health benefits of walnuts.
Research published in the American Heart Association's Circulation Journal found that women with a history of gestational diabetes during pregnancy have a two-fold higher risk of coronary artery calcification, a strong predictor of heart disease. Attaining healthy blood sugar levels after pregnancy does not decrease this risk.
A team of researchers found that immature beta-cells can contribute to proper insulin release when paired with more mature counterparts. By balancing the proportion of 'weak' and 'strong' beta-cells, islet function can be restored under conditions of metabolic stress.
A study of 44,541 women found that taking metformin to treat type 2 diabetes may protect against developing ER-positive breast cancer. However, the risk of triple negative breast cancer was increased by 74% among those treated with metformin. The link between type 2 diabetes and breast cancer varied by breast cancer subtype.
A new study published in The Lancet found that metabolic surgery is more effective than medications and lifestyle interventions in controlling severe type 2 diabetes. Over 37.5% of surgically-treated patients achieved diabetes remission for the entire 10-year study period.
A large observational study published in Diabetologia found that obesity is associated with a higher risk of microvascular complications in people with type 2 diabetes. The study suggests that maintaining a healthy body mass index (BMI) before and after a diabetes diagnosis can help prevent these complications. Furthermore, the researc...
Researchers are investigating whether changing mealtimes to earlier or later in the day can reduce the risk of developing Type 2 diabetes. The study, led by Dr Denise Robertson and Professor Jonathan Johnston, aims to explore the impact on participants' blood pressure, waist and hip circumferences, and food preferences.
A recent study found that patients taking metformin before COVID-19 diagnosis had a threefold decrease in mortality. The study also suggests that metformin's anti-inflammatory and anti-thrombotic effects may be responsible for this benefit.
A new study confirms that treatment with Bimagrumab is safe and effective for treating excess adiposity and metabolic disturbances in adult patients with obesity and type 2 diabetes. The medication achieved a nearly 21% decrease in body fat and a 6.5% reduction in body weight, along with a gain of lean mass.
A low-carb diet may lead to higher rates of type 2 diabetes remission in the short term, with benefits diminishing at 12 months. The study found that low-carb diets increased weight loss and reduced medication use, but also showed worsening quality of life and cholesterol levels at longer term.
Researchers have identified six distinct subtypes of prediabetes, differing in disease development and risk. These subtypes can be used to predict individual risk of developing diabetes and secondary diseases, enabling targeted prevention measures.
Researchers at Oregon State University found that specific beneficial microbes can improve glucose metabolism and reduce obesity risk in mice fed a western diet. The study identified four bacterial species with potential therapeutic applications for type 2 diabetes, opening new avenues for probiotic treatments.
Researchers found that intensive glycemic control reduced CAN risk in individuals with no history of cardiovascular disease by 17%, while intensive blood pressure control reduced risks by 22%. Intensive glucose treatment was more effective in individuals without a history of CVD, whereas blood pressure lowering was more effective in ol...
A study of 1.3 million people reveals that younger adults with type 2 diabetes diagnosis are associated with a higher risk of mortality and cardiovascular disease. Early interventions to improve blood glucose levels and cardiovascular risk profiles are essential to reduce ill health and mortality.