Research on type 2 diabetes and its management. Covers nerve pain, early onset, BMI trajectories, and treatment side effects.
Researchers at the University of Virginia Health System have identified a potential way to treat obesity and type 2 diabetes in women by targeting a specific gene called KLF14. Increasing KLF14 abundance in fat cells may help alleviate metabolic abnormalities, including slower metabolic rates and less efficient triglyceride management.
A new analysis by University of Copenhagen researchers found that a Nordic diet has positive health benefits regardless of weight loss. The diet's unique fat composition, high in omega-3 and omega-6 unsaturated fats, plays a significant role in lowering blood sugar and cholesterol levels.
A rigorous randomized controlled trial found that adding a 300-calorie serving of French fries to one's diet daily for a month did not result in differential weight gain or biomarker changes compared to an isocaloric daily serving of almonds. The study measured body composition, blood sugar, and insulin levels, finding no clinically si...
A study of nearly 312,400 adults found that consuming wine with meals was associated with a lower risk of developing type 2 diabetes. The analysis suggested that moderate drinking may have health benefits for glucose metabolism, but the exact mechanism is unclear.
A new study reveals that simultaneous measurement of dozens of types of fats in the blood can predict the risk of developing type 2 diabetes and cardiovascular disease years in advance. The researchers found that individuals with a certain lipid profile are at increased risk, while those with a different profile have lower risk. This d...
A large US survey found a strong association between e-cigarette use and prediabetes, with users having higher prevalence of high-risk lifestyle factors and worse health status. The study's findings challenge the promotion of e-cigarettes as a safer smoking alternative.
A Johns Hopkins Medicine study analyzed over 3,800 patients with prediabetes and found that only 13% received formal diagnosis, nutritionist referral, or metformin prescription. The researchers recommend improved screening and treatment options to prevent disease progression.
Research from Tufts University scientists finds that opioid exposure in mothers can lead to metabolic disorders and type 2 diabetes in their sons. The study, published in Scientific Reports, suggests that even short-term use of opioids before pregnancy can have long-lasting effects on the health of future generations.
Researchers at the University of Leeds identify step-by-step changes in human islet amyloid polypeptide as it transforms into a toxic substance linked to type-2 diabetes. They also discover two compounds that can control the process, offering potential starting points for new treatments.
Researchers discovered specific ceramides in the blood are associated with unfavorable levels of diabetes-related compounds, linking unhealthy diets to increased risk. Ceramide profiling may enable more precise dietary approaches for preventing cardiometabolic diseases.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that obesity may increase the risk of end-stage kidney disease in women with type 2 diabetes. Managing blood pressure and sugar levels is not enough to slow progression, emphasizing the need for weight management.
NAFLD and diabetes are linked through subclinical inflammation, insulin resistance, and dysregulated liver-derived proteins. Integrating knowledge from childhood to older age can help personalize prevention and treatment.
A new University of Copenhagen study reveals that well-functioning fat tissue is crucial for overall health and may help prevent diseases such as type 2 diabetes, cancer, and obesity. High levels of lifelong exercise have been shown to improve mitochondrial function in fat cells, reducing oxidative stress and damage.
A study found that specific bacterial groups from the Lachnospiraceae family were associated with an increased risk of developing type 2 diabetes. The research used machine learning techniques and analyzed fecal samples from a large Finnish population cohort, identifying microbial biomarkers that predicted disease incidence.
A new study published in JAMA Network Open suggests that gastric bypass surgery is the most effective treatment option for patients with severe obesity and type 2 diabetes, leading to greater weight loss and a higher rate of remission. The study found that gastric bypass produces better results regardless of diabetes severity.
A systematic review and meta-analysis of six studies found that polycystic ovary syndrome affects 12.7% of girls with type 2 diabetes. The study suggests a higher prevalence of PCOS in pediatric patients with T2D, highlighting the need for early detection and management.
A retrospective cohort study of patients with atrial fibrillation and diabetes found that non-vitamin K antagonist oral anticoagulants (NOAC) were associated with a lower risk of diabetes complications and mortality than warfarin. The study suggests that NOAC may be a better therapeutic choice for this patient population.
A new poll found that less than half of people aged 50-80 have ever used a health-related app, with those in poor health and lower incomes being even less likely. Only 28% of current users share information with healthcare providers, highlighting the potential for apps to support health behaviors and improve outcomes.
A culinary medicine curriculum significantly improved biometric and diet-related behavioral outcomes among low-income patients with type 2 diabetes. Participants showed reduced glycosylated hemoglobin levels and increased consumption of fruits and vegetables, suggesting a positive impact on diabetes management.
A new study found that female adults who heavily used cannabis had a lower incidence of diabetes compared to those who did not use cannabis. In contrast, light cannabis use among females and male adults with any level or no cannabis use showed no association with diabetes diagnosis.
Researchers have developed a prototype insulin-loaded patch that comfortably sticks to the inside of a person's cheek, offering a less invasive way to manage blood sugar levels. The patch, activated by heat, releases insulin into the bloodstream several times faster than through skin, showing promise for diabetes treatment.
A trial found that parents bought fewer sugary drinks when products displayed pictorial warnings about type 2 diabetes or heart damage. Pictorial warnings are being explored as a strategy to reduce children's intake of sugary drinks and related health outcomes.
Researchers at Scripps Research have identified an experimental compound called IXA4 that activates a natural signaling pathway to protect against obesity-driven metabolic changes. This approach shows promise for preventing or treating type 2 diabetes.
A comprehensive review found that prediabetes is associated with an increased risk of comorbidities such as cardiovascular disease, stroke, and chronic kidney disease. The study suggests that prediabetes poses a significant threat to public health due to its rising prevalence worldwide.
A study by Michigan Medicine researchers found that people with diabetes have more macrophages in their fat tissue, particularly the anti-inflammatory CD206+ subtype. This subtype is unique in terms of gene expression and may play a role in the development of diabetes.
Researchers at University of Illinois Chicago identified changes in the gut microbiome that can lead to gestational diabetes. They found a specific metabolite, kynurenine, that is increased during pregnancy and contributes to insulin resistance.
Regular physical activity significantly changes metabolite profiles, associated with a lower risk of type 2 diabetes. The study found improved insulin secretion and reduced fasting glucose levels in physically active men.
Researchers found minority groups were less likely to start newer diabetes medications, despite needing them most. The study used data from nearly 5,000 patients with type 2 diabetes and showed Black patients were 20% less likely and American Indian or Alaskan Native patients were 50% less likely to initiate treatment.
Researchers developed a novel multi-organoid system to simulate the human liver-islet axis, enabling 3D co-culture of hiPSC-derived organoids for up to 30 days. The system exhibited cooperative interaction between liver and islet organoids, reflecting the dynamic interplay among organs in type 2 diabetes.
A randomized controlled trial found that late eating, associated with high melatonin levels, impairs blood sugar control through a defect in insulin secretion. Participants with the genetic variant in the MTNR1B gene had higher blood sugar levels, highlighting the importance of considering genetics in food timing recommendations.
Middle-aged men with high levels of anxiety and worry are at greater biological risk for developing heart disease and type 2 diabetes as they age. The study found that cardiometabolic disease risk increased with age, regardless of anxiety levels, but anxious individuals were more likely to develop the condition over time.
A study published in Diabetes Care found that walking regularly at greater intensity and taking more steps can lower the risk of developing Type 2 diabetes among adults aged 65 and older. For every 1,000 additional steps per day, the risk is reduced by 6%, with a 12% reduction possible if an average adult takes 2,000 more steps daily.
A new federally funded study will use machine learning to create a first-of-its-kind algorithm predicting individual responses to food and dietary routines. The National Institutes of Health's All of Us Research Program will recruit 10,000 participants nationwide.
Researchers discovered that Black women have a greater relative abundance of Actinobacteria, associated with reduced insulin sensitivity and elevated inflammation. The study highlights the importance of understanding the role of gut microbiome in cardiometabolic health disparities among Black women.
Researchers found that adolescent arterial stiffness may be a causal risk factor for hyperinsulinaemia and insulin resistance in young adulthood. Arterial stiffness also temporally precedes low HDL-cholesterol in young adults, with a positive association with triglyceride levels.
Researchers found a key role for Tmem120a in promoting expression of fat genes and shutting off muscle genes in fat tissue. This mechanism may explain why metabolic diseases like diabetes appear under certain circumstances, such as high-calorie diets. The discovery has implications for other metabolic diseases and muscle disorders.
Researchers at UNIGE found that fat can aid pancreatic beta cells in adapting to excess sugar levels. The study reveals a dynamic cycle of fat storage and mobilization allows cells to maintain near-normal insulin secretion. Regular physical activity may help give this beneficial cycle a chance to be active.
New American Heart Association scientific statement highlights gap between existing evidence on reducing cardiovascular risk and reality for people living with T2D. Available therapies can help when combined with new approaches addressing social determinants of health and other barriers to care.
A global study found that death rates for people with type 2 diabetes are declining in high-income countries, including Asia. The study showed a narrowing life expectancy gap between those with and without diabetes in many jurisdictions.
A new study from Brigham and Women's Hospital identified the activation of PIEZO1 as a key trigger for thrombosis in patients with type 2 diabetes. Inhibiting PIEZO1 prevented clot formation, suggesting its potential as a therapeutic target for preventing thrombosis.
A new study aims to improve diabetes management in rural and urban communities with a low-cost, psychological intervention called episodic future thinking. The technique helps patients value future rewards over immediate gratification, leading to healthier lifestyle changes and improved disease management.
A study of over 1,300 patients found that Mild Autonomous Cortisol Secretion (MACS) is much more prevalent than previously reported, with almost every second patient having MACS. The condition was linked to an increased risk of high blood pressure and type 2 diabetes, particularly in older women.
A cross-sectional study found that mild autonomous cortisol secretion (MACS) predominantly affects women, increasing the frequency and severity of hypertension and type 2 diabetes compared to nonfunctioning adrenal tumors. Patients with MACS carried an increased cardiometabolic burden similar to Cushing Syndrome, even without typical f...
Individuals with high-risk prediabetes significantly improved their blood glucose levels through more exercise and healthy eating behavior, while those at low risk showed limited benefits from conventional lifestyle intervention. The study's findings support personalized interventions tailored to each patient's risk profile for effecti...
Researchers found that SGLT2 inhibitor empagliflozin can improve insulin sensitivity in the brain, leading to better glucose control and reduced liver fat content. This breakthrough discovery positions SGLT2 inhibitors as a potential treatment for insulin resistance in the brain.
Exercise modifies the adaptation of the liver to increased energy intake, regulating enzymes for glucose and fructose degradation. Regular physical activity also improves glucose control and reduces fat storage in the liver, offering a comprehensive insight into molecular adaptations to high-energy diets.
A University of Birmingham-led study found that patients with a recorded history of gum disease are at higher risk of developing mental ill-health (37%), autoimmune diseases (33%), cardiovascular disease (18%), and cardiometabolic disorders, particularly Type 2 diabetes (26%). The study used UK primary care data to explore the associat...
A new study published in Frontiers in Endocrinology has identified a promising target for an anti-hypoglycaemia drug by boosting the brain's AMPK fuel gauge. The researchers found that the compound increases the release of glucagon from the pancreas, defending against hypoglycaemia.
A recent study found significant inequities in the use of GLP-1 receptor agonists (GLP-1 RA), a medication typically used for treating diabetes, among different racial and ethnic groups. The study, published in JAMA Health Forum, showed that Black patients were 19% less likely to have a GLP-1 RA prescription compared to white patients.
A study of 1.1 million patients with type 2 diabetes found disparities in the use of GLP-1 receptor agonists by racial and ethnic groups, as well as by sex and socioeconomic status. The findings highlight concerns about unequal access to effective diabetes care.
Researchers discovered a new hormone, fabkin, that regulates metabolism and controls insulin production in pancreatic beta cells. Blocking fabkin's activity prevented the development of both forms of diabetes in mice, suggesting its potential as a therapeutic target.
A University of Gothenburg study found that bariatric surgery lowers cancer risk by 60% in obese patients with type 2 diabetes, particularly those achieving and maintaining normal glucose control. The research highlights the importance of glucose control in preventing cancer in this high-risk population.
Researchers examined the risk of developing diabetes-associated eye disorders among children diagnosed with type 1 or type 2 diabetes. The study found a significant association between diabetes diagnosis and increased risk of diabetic retinopathy and glaucoma in childhood.
The study found that people with sleep disorders had the highest rates of type 2 diabetes, with 40% of subjects having the disease. Prevalence of T2D was lower among individuals with intellectual disability, with only 8% having the disease.
Researchers found that video-based, telehealth-delivered exercise and weight loss programs improved pain and function in people with knee osteoarthritis and overweight or obesity. The intervention with dietary component led to substantial weight loss and additional benefits.
Research from Harvard University reveals that physical activity later in life shifts energy towards mechanisms that extend health, reducing chronic illnesses. The study highlights the importance of staying physically active as we age to allocate energy to physiological processes that slow down deterioration.
Researchers at UConn Health have discovered that eliminating senescent cells in human fat tissue can alleviate signs of diabetes and improve insulin sensitivity. The study suggests that clearing away these dysfunctional cells could lead to game-changing new treatments for Type 2 diabetes.
A new study from the University of Eastern Finland found that patients with type 2 diabetes often do not receive adequate cholesterol-lowering treatment, despite guidelines recommending statin prescriptions for elevated LDL-C levels. Women tend to have higher average LDL-C levels and receive less statin treatment than men.
A Swedish twin study discovered epigenetic differences in twins with one developing type 2 diabetes. The researchers found lower levels of microRNA-30, a gene that regulates glucose uptake, in the affected twins' fatty tissue.
A study using anonymized health data found that people with poorly managed long-term glycemic control are nearly 50% more likely to require ICU treatment if they contract COVID-19. Metformin, insulin, and corticosteroids may also reduce the risk of severe COVID-19.