Research on type 2 diabetes and its management. Covers nerve pain, early onset, BMI trajectories, and treatment side effects.
The USPSTF has lowered the recommended starting age of screening for type 2 diabetes from 40 to 35. Screening is now recommended for adults with prediabetes or type 2 diabetes, particularly those aged 35-70 who are overweight or obese. This recommendation aims to detect and treat these conditions earlier.
The prevalence of type 1 and type 2 diabetes among US children and teens rose significantly from 2001 to 2017. Researchers estimated an increase in diabetes cases across all age groups during this period, with the largest increases seen among younger populations.
A new study by Salk scientists found that time-restricted eating (TRE) confers multiple health benefits, including reduced risk of type 2 diabetes, fatty liver disease, and sepsis, regardless of age and sex. TRE may also protect against infectious diseases like COVID-19 and improve insulin resistance.
A new study published in Diabetologia found that children of mothers with diabetes before or during pregnancy are more likely to develop high refractive error (RE), including long and short-sightedness. The study analyzed data from over 2.4 million births in Denmark and found a significant association between maternal diabetes and an i...
A new study examining the association between type 2 diabetes mellitus and skin diseases reveals a strong link between the two conditions. The research, published in Chinese Medical Journal, found that 93.5% of individuals with T2DM had skin problems, including over 47 types of comorbid skin diseases.
Researchers have determined the structure of human leukotriene B4 receptor 1 (hBLT1), a protein involved in inflammation and disease. The analysis reveals how the receptor recognizes its binding partners and interacts with them, opening up avenues for designing better drugs.
Researchers at Karolinska Institutet discovered three different subtypes of mature fat cells in white adipose tissue, with only one subtype, Adipo PLIN, responding to insulin. The study suggests that changes in this specific subtype may contribute to metabolic diseases like Type 2 diabetes.
A study found that a body mass index of 25.0 kg/m2 is the cutoff point for developing type 2 diabetes, with elevated liver enzymes increasing the risk. The research suggests a stronger association between BMI and T2DM when liver enzymes are high, likely due to insulin resistance caused by non-alcoholic fatty liver disease.
A new artificial pancreas has been successfully trialled in outpatients with type 2 diabetes, showing improved blood sugar control and reduced risk of low blood sugar levels. The device can automate insulin delivery using digital technology, allowing for more effective management of the condition.
A low glycaemic diet has been shown to produce small but meaningful improvements in blood sugar levels, cholesterol, weight, and other risk factors in people with diabetes. The findings are based on a systematic review of 27 randomised controlled trials involving 1,617 participants with type 1 or 2 diabetes.
Scientists discovered impaired leptin transport to the brain via LepR receptors leads to pre-diabetic state and exhausted insulin secretion. Reintroducing leptin restores pancreatic function-promoting action, suggesting a crucial brain role in type 2 diabetes management.
A recent study published in Frontiers in Nutrition found that consuming millet as part of a daily diet can reduce blood glucose levels by 12-15% and help manage diabetes. The research, which analyzed data from over 1,000 human subjects across 11 countries, also found that millets have a lower glycemic index compared to other grains.
A new study published in Nutrients highlights the importance of adequate protein intake for adults living with diabetes. The research found that nearly half of US adults with diabetes did not meet the daily recommended protein intake, leading to greater physical limitations and potentially increasing the risk of muscle loss.
Researchers found a steady decline in blood glucose control over 15 years, with certain participants developing multiple complications. Minority groups and those with high blood pressure and dyslipidemia were at higher risk for developing complications.
A study by Anglia Ruskin University found that younger people with diabetes are significantly more concerned about COVID-19 risks and have a higher likelihood of reporting worries. Social support from family, friends, and healthcare teams plays a crucial role in managing these concerns.
A new study finds that youth-onset type 2 diabetes increases the risk of developing serious complications by young adulthood. Within 15 years of diagnosis, nearly a third of participants had two or more complications, including heart disease, kidney disease, and eye disease.
Patients who underwent bariatric surgery reported improved physical health, energy, and reduced body pain compared to those on medical therapy alone. Significant weight loss and insulin independence drove these improvements in general health measures and quality of life.
A study from the University of Gothenburg and Oxford found that early blood sugar control in type 2 diabetes significantly impacts future heart attack and death risks. Targeting levels below 52 mmol/mol reduces mortality risk by 20%, while delayed control offers only a 3% benefit.
Researchers discovered 47 lipids significantly different between rapid and slow kidney function decliners, providing a platform for risk stratification. The study's findings also suggest the underlying mechanism of progressive kidney disease, which could be a future target for therapeutic intervention.
Scientists at the University of Cambridge have discovered rare genetic variants that substantially increase susceptibility to type 2 diabetes. These variants are carried by one in 3,000 people and significantly increase an individual's risk of developing the condition, six-fold.
The COVID-19 pandemic had a substantial effect on diabetes care in the US, with a decrease in health services received by patients with type 2 diabetes. This decrease was particularly pronounced among low-income individuals, highlighting the need for targeted support and resources.
A new pathway to treating type 2 diabetes has been discovered by researchers at the University of Arizona, focusing on the liver's role in insulin sensitivity. The study found that fat in the liver increases the release of GABA, a neurotransmitter that decreases nerve activity.
People of South Asian and African/African Caribbean ethnicity are less likely to be prescribed guideline-indicated statins for type 2 diabetes, a finding that could prevent up to 12,600 heart attacks and strokes in the UK. The study suggests that targeted education and prescribing interventions may help address these disparities.
A study published in iScience has identified dozens of muscle proteins with decreased quantities in individuals with prediabetes and type 2 diabetes. The findings highlight the significance of mitochondrial energy metabolism in the progression from prediabetes to type 2 diabetes.
Researchers at Tohoku University have identified a new gene, CCDC152 (L-IST RNA), which inhibits selenoprotein P (SeP) levels, reducing insulin resistance and glucose metabolism issues associated with type 2 diabetes. EGCG supplements may help increase L-IST, offering potential treatment options for diabetic patients.
A study by National University of Ireland Galway found that nearly half of adults with diabetes attending a dedicated clinic have signs of established chronic kidney disease. The research suggests that careful medical management is not enough to prevent the development of kidney disease in people with diabetes.
Researchers found a direct link between placental mTOR and an infant's birthweight, with implications for obesity and Type 2 diabetes in adulthood. The study suggests that manipulating mTOR in the placenta can cause permanent impact on offspring health.
Researchers found that autologous bone marrow stromal stem cells can lower blood glucose levels and reduce medication doses in non-obese Type 2 diabetes patients with a short disease duration. The study's results are promising for the potential treatment of this chronic disease.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that consuming two servings of whole fruits per day significantly lowers the risk of developing type 2 diabetes. The research, which analyzed data from over 7,700 participants, suggests that a healthy diet and lifestyle, including frui...
The study found that continuous glucose monitors reduced emergency department visits and hospitalizations for hypoglycemia, improving blood sugar control in selected insulin-treated type 2 diabetes patients. The monitors also showed comparable results to a new diabetes medication in terms of blood sugar control.
Eating at least two serves of fruit daily has been found to lower the risk of developing type 2 diabetes by 36%. The study suggests that whole fruits, not juice, contribute to improved insulin sensitivity and reduced blood glucose levels. Higher consumption of fruits rich in phytochemicals and fibre may also play a role.
A global collaboration has identified 24 new loci linked to glycemic traits, improving our understanding of type 2 diabetes and its impact on different ancestries. This study highlights the importance of including diverse populations in genetic research, yielding better results and enabling more precise diagnosis and treatment.
A weight management program has been shown to lower blood pressure and reduce the need for anti-hypertensive medications in people with type 2 diabetes. The program, developed by researchers at Universities of Glasgow and Newcastle, induces substantial weight loss and leads to remission of type 2 diabetes in 8 out of 10 participants.
A new class of diabetes medication, GLP-1 receptor agonists, has been shown to improve asthma symptoms and reduce lung inflammation in patients with type 2 diabetes. The study found that these medications can help control asthma exacerbations and reduce breathing symptoms.
Researchers from Kumamoto University have discovered that cysteinylated albumin can be used as an early diagnostic marker for diabetic kidney disease. The study found that serum oxidized albumin reflects renal pathology earlier than urinary albumin and predicts disease progression.
A new study published in The Lancet Diabetes & Endocrinology found that BMI cut-offs used by the World Health Organization and UK's National Institute for Health and Care Excellence are not suitable for adults from Black Asian and Minority Ethnic backgrounds. The research, which included over 1.5 million people, shows that these groups...
A cluster-randomized controlled trial found that individuals with type 2 diabetes who received primary care-based oral health support experienced a significant increase in self-reported oral health quality of life. The study's authors conclude that patients with diabetes can benefit from extra attention to oral health, highlighting the...
A study found that consuming two cans of sardines a week reduced the risk of developing type 2 diabetes by 31% in elderly patients with prediabetes. The nutrient-rich fish helped lower insulin resistance, increase HDL cholesterol and improve glucose metabolism.
Andrew T. Hattersley, a renowned diabetes researcher, has been awarded the 2021 Harold Hamm International Prize for Biomedical Research in Diabetes. The prize recognizes his lifelong contributions to the field of diabetes research and his singular advances that promote curative potential.
A new study suggests that an hour of daily exercise can help Arctic Inuit people with a faulty TBC1D4 gene control their high blood sugar levels. This finding has the potential to improve the lives of thousands across the Arctic region, providing a positive outlook for those living with type 2 diabetes.
A study by Sansum Diabetes Research Institute and Rice University found wearable devices that continuously monitor blood sugar levels provide new insights into the progression of Type 2 diabetes among at-risk Hispanic/Latino adults. The results point to new directions for improved diabetes care, particularly in underserved populations.
A recent study examined the association between age at diabetes onset and subsequent dementia risk. The research found that younger individuals with type 2 diabetes were more likely to develop dementia compared to those who developed diabetes at an older age.
A new study from Children's Hospital Los Angeles finds a surge of patients presenting with diabetic ketoacidosis, a life-threatening complication of type 2 diabetes. Insulin levels in the blood may drop too low for too long due to COVID-19, causing DKA.
Scientists at Lund University discovered a key role for the VPS39 gene in regulating muscle stem cells' ability to create new mature muscle cells. The study found that individuals with type 2 diabetes have altered epigenetic patterns and impaired sugar uptake, leading to compromised muscle function.
A new once-a-week injectable insulin therapy has proven safe and as effective as daily insulin injections in two international clinical trials. The treatment may provide a convenient alternative to the burden of daily insulin shots for diabetes patients, improving long-term adherence and glucose control.
Low-volume HIIT (less than 20 minutes total exercise time) yields comparable improvements to longer interventions despite requiring significantly less time. This approach is especially beneficial for individuals with busy schedules who struggle to meet current physical activity guidelines.
A clinical practice review article by Rita Kalyani provides a systematic approach for treating patients with diabetes and cardiovascular disease. The article recommends using GLP-1 receptor agonists and SGLT2 inhibitors, particularly for patients with heart or blood vessel disease, to reduce the risk of major cardiovascular events.
Researchers found that body fat percentage is a key predictor of exercise capacity and cardiovascular disease risk in individuals with Type II diabetes. Machine learning approaches were used to analyze data and make accurate predictions.
A new approach has led to the discovery of a small molecule that may help regulate cholesterol levels in the brain, making it a potential therapeutic target for Alzheimer's disease. Increasing the activity of ABCA1 is expected to positively influence insulin signaling and reduce inflammation in the brain.
A new once-weekly basal insulin injection demonstrated similar efficacy and safety to daily basal insulin in patients with type 2 diabetes, achieving comparable blood glucose control and lower rates of hypoglycemia
A recent study presented at ENDO 2021 found that women with polycystic ovarian syndrome (PCOS) who are obese have a more than three-fold increased risk of developing type 2 diabetes during their lifetime. The risk was not observed in normal-weight women with PCOS.
Researchers have identified a way to reverse high blood sugar and muscle loss by targeting liver metabolism, which is disrupted in people with obesity-related type 2 diabetes. The study found that selectively silencing enzymes breaks down alanine can restore skeletal muscle protein synthesis, leading to improved muscle size and strength.
Researchers at the University of Gothenburg found that free fatty acids in the blood trigger insulin release even at normal blood-sugar levels, contradicting the long-held hypothesis. The study suggests that obesity and excess fat tissue contribute to increased FFAs, which may be an early sign of incipient type 2 diabetes.
A study found lifestyle interventions reduced cardiovascular harm and optimized benefits for 85% of participants. However, it increased the risk of major cardiovascular events in those with poor blood sugar control, suggesting alternative options like glucose-lowering drugs may be necessary.
A study by the University of South Australia found that women with gestational diabetes are ten times more likely to develop type 2 diabetes. However, only a third of these women understand they are at high risk due to lack of education and lifestyle changes.
Research from Queen Mary University of London has concluded that type 2 diabetes is associated with an increased risk of Parkinson's disease and may contribute to faster disease progression. Treating people with type 2 diabetes medications may reduce Parkinson's risk and slow its progression.
A new study published in Diabetologia found that regular physical activity significantly reduces the risk of type 2 diabetes for people living in polluted regions. The research, conducted in Taiwan, investigated the combined effects of physical activity and air pollution on type 2 diabetes risk.
A research review recommends physicians conduct regular screenings, adopt a high level of suspicion, and intervene early with families at risk for pediatric Type 2 diabetes. The study highlights the importance of addressing underlying factors such as weight issues, food insecurity, and stress to slow the youth diabetes epidemic.
A new study published in The Lancet found that patients with type 2 diabetes treated with Semaglutide achieved significant weight loss and improved blood glucose control. Two-thirds of patients lost at least 5% of their body weight, while over a quarter lost more than 15%.
Research found a strong association between birthweight of 2.5kg or more and lower IGF-1 levels, which are linked to an increased risk of developing type 2 diabetes in adulthood. The study involved 112,736 women and 68,354 men from the UK Biobank study.