Articles tagged with Type 2 Diabetes
A large-scale genome-wide study has identified 301 distinct genetic signals associated with type 2 diabetes in East Asians. The research highlights the importance of studying different ancestries and expands the number of genetic variants linked to the disease, providing new insights into its pathophysiology.
A study published by The BMJ found that childhood body size is associated with an increased risk of coronary artery disease and type 2 diabetes in later life. However, a larger early life body size may help protect women against breast cancer. The study suggests that maintaining a normal body mass index (BMI) in adulthood can reduce th...
Researchers evaluated teens with normal weight and those with obesity, type 2 diabetes or high blood pressure to assess carotid artery health. Teens with these conditions were found to have thicker and stiffer arteries, increasing the risk of early heart attacks and strokes.
A new study from the University of Copenhagen suggests that transplanted intestinal contents could be effective against obesity and type 2 diabetes. Researchers found that obese mice with unhealthy lifestyles gained significantly less weight and avoided type 2 diabetes when they received viruses transplanted from the stool of lean mice.
A 20-year study by the Endocrine Society found that cardiovascular complications among individuals with diabetes have declined. Meanwhile, mortality rates remain higher than those in the general population, highlighting ongoing concerns about cancer and dementia risks for people with diabetes.
A study found that SGLT2 inhibitors reduce serious renal events in type 2 diabetes patients, with a 58% lower relative risk compared to DPP-4 inhibitors. The findings provide further support for the use of SGLT2 inhibitors in patients at risk of kidney disease.
Researchers found that lixisenatide significantly reduced neuroinflammation in the retina and optic nerve head of mice with early type 2 diabetes. The study suggests a novel therapeutic strategy for preventing visual deterioration in diabetic retinopathy before its clinical manifestation.
Type 2 diabetes patients exhibit elevated glucagon levels due to α-cell resistance to insulin. Glucagon counteracts insulin's effects, exacerbating high blood sugar levels.
Research published in Diabetologia found that obesity increases type 2 diabetes risk by at least 6 times, even among those with low genetic risk. The study highlights the importance of weight management and healthy lifestyle in preventing type 2 diabetes across all genetic risk groups.
A study published by The Endocrine Society highlights shared disease pathways between COVID-19 and type 2 diabetes, requiring new approaches in treatment for hospitalized patients. Commonly used diabetes medications may pose risks in severe coronavirus infections.
This observational study examines postoperative death and hospital readmission among adults with type 2 diabetes who had a prescription for metformin before major surgery. The results suggest that preoperative metformin use is associated with improved surgical outcomes in patients with type 2 diabetes.
A new study identifies consistent grip strength cut points relative to body weight, gender, and age group in a large nationally representative sample of participants. Researchers found that assessing normalized grip strength can routinely screen for type 2 diabetes in apparently healthy adults.
A new study finds that a wearable device called V-Go can safely deliver regular human insulin (RHI) to patients with type 2 diabetes, achieving good blood sugar control. The study, which compared RHI to rapid acting insulin (RAI) analogs, showed improvements in hemoglobin A1c levels and met its primary endpoint of noninferiority.
New research finds that SGLT2 inhibitors and GLP-1 receptor agonists are similarly effective in reducing major cardiovascular events, such as heart attack and stroke. Hospitalization for heart failure is also reduced with SGLT2 inhibitors, especially in those with severe cardiovascular risk.
The REVITA-2 study found that Revita DMR therapy significantly improved blood glucose levels, insulin sensitivity, and liver measures in patients with poorly controlled type 2 diabetes. The treatment, which involves duodenal mucosal resurfacing, reduced insulin resistance and improved metabolic health.
Patients with type 2 diabetes who underwent supervised exercise training showed significantly improved heart function and increased cardiovascular fitness compared to those on a low-energy diet. A low-energy diet, however, led to favourable effects on the structure of the heart and reversal of diabetes in 83% of participants.
A study suggests that boys who enter puberty at an early age are more likely to develop type 2 diabetes as adults, with a 16% increased risk per year earlier puberty occurred. Early pubertal growth spurt was also associated with a higher risk of insulin-dependent type 2 diabetes.
Research found that individuals with type 2 diabetes who participate in online support groups have worse health outcomes and higher levels of disease-related complications. In contrast, users with type 1 diabetes did not show a significant correlation between forum participation and health outcomes.
The FAST algorithm is a collaborative diabetes management tool that empowers diabetic patients who fast with Ramadan-specific educational materials and encouragement of active self-monitoring. The tool showed significant reductions in hemoglobin A1c levels among participants.
Researchers examined associations between two common weight-loss surgeries and type 2 diabetes outcomes, finding improved glycemic control and weight loss after five years. The study included 9,700 adults who underwent Roux-en-Y gastric bypass or sleeve gastrectomy, suggesting these procedures may help achieve diabetes remission.
A systematic review suggests that dental teams can play a vital role in identifying individuals at high risk of developing Type 2 diabetes. By using risk assessment tools and point-of-care blood testing, dental professionals can help detect early signs of the condition, potentially leading to better management and outcomes for patients.
A recent study published in Obesity Reviews reveals that obesity can lead to premature aging, causing DNA damage, weakened immune systems, and increased risk of diseases like cancer, cardiovascular disease, and Alzheimer's. Researchers argue that obesity should be considered a form of premature aging.
Scientists from UNIGE and HUG identify monogenic diabetes in 42% of pediatric patients, enabling tailored treatments. The study highlights the need for precision medicine to address chronic hyperglycemia, suggesting a systematic diagnosis approach to minimize long-term complications.
A new study found that people with Type 2 diabetes in the US often receive treatment that is too aggressive or not aggressive enough, with those who are most likely to benefit from intensive therapy being underserved. The study suggests a fine line between effective treatment and increased risk of hypoglycemia.
Research suggests a genetic profile may predict the risk of developing type 2 diabetes in women who have had gestational diabetes. A study analyzing data from 2,434 women found that those with a larger proportion of certain gene variants were at higher risk.
A study of 677 participants found higher abdominal fat was associated with lower scores on memory and language tasks. Visceral adiposity may impact cognitive decline in older patients with diabetes, emphasizing the importance of targeted interventions.
A large meta-analysis of SGLT2 inhibitor trials found consistent cardiovascular benefits in diverse subsets of patients with type 2 diabetes, including those without established cardiovascular disease. The study showed a significant reduction in major adverse cardiac events, cardiovascular deaths, and hospitalizations for heart failure.
Scientists have obtained a high-resolution view of glucagon-like peptide-1 receptors (GLP1R), which play a crucial role in regulating blood sugar levels. The study provides new insights into GLP1R function and its potential as a target for treating conditions like type 2 diabetes.
A 15-year study found that dysfunctional pancreatic beta-cells, independent of body weight, are the earliest event leading to pre-diabetes in children. The study also linked this condition to genetic factors associated with type 2 diabetes in adults.
A recent study published in Annals of Internal Medicine found that adults with type 2 diabetes who were newly prescribed SGLT2 inhibitors had a lower rate of gout compared to those prescribed GLP1 agonists. This suggests that SGLT2 inhibitors may be effective in reducing the risk of gout among patients with type 2 diabetes.
Researchers conducted the largest study on weight loss surgery in a Chinese population with obesity and type 2 diabetes. Surgery provided substantial effects on weight, blood sugar, and cholesterol over five years, with restrictive surgeries being slightly more effective in diabetes remission.
Researchers found that a ketone monoester drink can help participants with Type 2 diabetes and pre-diabetes better control their blood sugar levels without insulin changes. The study's lead author notes that while ketone supplements are not a magic bullet, they may be another strategy for managing the disease.
Scientists have observed people developing Type 2 diabetes due to liver fat over-spilling into the pancreas. A study showed that individuals can reverse the condition through diet and weight loss, with nearly nine out of ten participants achieving remission.
Research suggests that longer exposure to obesity and earlier development of obesity are linked to an increased risk of type 2 diabetes. Women who experienced rapid weight gain from young adulthood had a higher risk of developing the disease compared to those who remained stable.
Researchers used lipidomics and machine learning to identify a blood lipid profile linked to type 2 diabetes risk, which improved prediction over traditional methods. Lifestyle factors such as diet and physical activity also played a role in modulating the blood lipid profile.
A recent review suggests that artificial sweeteners, commonly used to aid weight loss, may actually contribute to the development of type 2 diabetes and weight gain. According to UniSA Professor Peter Clifton, consuming large quantities of artificial sweeteners can alter gut bacteria and lead to increased calorie intake.
Researchers found that filtered coffee reduces the risk of developing type 2 diabetes by up to 60%, but boiled coffee does not have this effect. The study used a novel method called metabolomics to identify specific molecules in blood samples, which indicate coffee intake and its impact on metabolism.
Good aerobic fitness is not linked to lower risk of insulin resistance in obese children. Instead, more physical activity and less sedentary time were associated with reduced insulin resistance regardless of body fat percentage. The study suggests that more physical activity plays a key role in preventing type 2 diabetes in childhood.
A large web-based study cohort in France explored associations between ultraprocessed food consumption and the risk of type 2 diabetes. The study found that higher consumption of ultraprocessed foods was associated with an increased risk of developing type 2 diabetes.
The Endocrine Society and Avalere Health introduced quality measures to assess healthcare providers' ability to identify and care for older adults at risk of hypoglycemia. The measures focus on outpatient treatment for adults aged 65 and older with type 2 diabetes, highlighting key risk factors and emphasizing education to prevent futu...
A study by Karolinska Institutet researchers identifies a molecular mechanism linking ALS and type 2 diabetes, where immunoglobulin G antibodies target calcium channels in pancreatic beta cells, leading to cell death. The findings suggest altered humoral immunity may be a generalized phenomenon for other neurodegenerative diseases.
New research reveals a significant association between preterm birth and an increased risk of developing type 1 and type 2 diabetes in children and young adults. Women born preterm are particularly at higher risk, with a 30% increase in type 2 diabetes risk and a 60% increase in type 1 diabetes risk compared to their male counterparts.
A study by Carnegie Mellon University found that age affects the well-being of newly diagnosed Type 2 diabetes patients. Younger individuals experience higher diabetes-related and psychological stress. Older adults tend to have less psychological stress and better self-care, blood sugar control, and medication adherence.
Researchers at Weill Cornell Medicine discovered that higher levels of protein adipsin in the blood protect against type 2 diabetes. Adipsin helps shield pancreatic beta cells, improving insulin production and preventing cell death.
Researchers investigated the effect of vitamin D and omega-3 supplements on chronic kidney disease (CKD) development or progression in adults with type 2 diabetes. The study found no significant difference in CKD progression between supplementation groups.
A study of 71,892 children born between 2007-2011 found strong associations between pre-pregnancy obesity in mothers and their children's high body mass index between ages two and six. Modest links were also identified with maternal diabetes and excessive weight gain during pregnancy.
A new calculator developed by Cleveland Clinic researchers can estimate a patient's risk of developing major health complications over the next 10 years depending on their treatment choice. The calculator provides personalized evidence-based information on heart disease, stroke, and other risks with usual care versus surgical treatment.
A new study published in Diabetes Care found that bariatric surgery significantly decreased the rate of diabetic kidney disease among severely obese teens with type 2 diabetes, compared to medical treatment alone. The five-year study also showed improvements in hyperfiltration, urinary albumin excretion, and blood pressure.
A new web-based calculator predicts a patient's likelihood of dying from complications or experiencing serious health issues due to type 2 diabetes and obesity, whether they undergo metabolic surgery or continue with standard medical therapy. The Individualized Diabetes Complication Risk Calculator provides a personalized risk score ba...
A recent study has identified the gene function that protects against type 2 diabetes, revealing a zinc transporter's role in insulin secretion. The research found that individuals with a specific mutation in the SLC30A8 gene have enhanced glucose-stimulated insulin secretion and reduced blood sugar levels.
Researchers found a crucial link between nicotine, type 2 diabetes and a diabetes-associated gene called Tcf7l2. Variation in this gene may influence both tobacco addiction and the development of tobacco-associated type 2 diabetes.
A new medical device called Sleeveballoon has been tested in rodents and produced impressive results on body weight, fatty liver, and diabetes control. The device reduces food intake by 60% and blood glucose levels by 65%, mimicking the effects of traditional bariatric surgery with a minimally invasive approach.
Researchers found that individuals who lost a significant amount of weight and then maintained 75% of their weight loss had improved risk factors, such as cholesterol levels and blood pressure. However, those who regained weight saw deteriorated benefits, highlighting the importance of long-term maintenance.
Research found black individuals were 50% less likely than white individuals to be prescribed newer medications for Type 2 diabetes. Monitoring of patients' conditions was also lower among ethnic minorities and those from disadvantaged backgrounds.
A new study from Harvard T.H. Chan School of Public Health found that increasing consumption of sugary beverages is associated with a higher risk of type 2 diabetes. Replacing one daily serving of sugary drinks with water, coffee, or tea reduces the risk by 2-10%.
A new metabolic discovery by researchers at Cornell University may hold the key to fighting heart disease and Type 2 diabetes. The study identifies two enzymes that convert glucose to erythritol, a sugar alcohol, in human metabolism.
Researchers at Joslin Diabetes Center have made a breakthrough in identifying diseased beta cells in type 2 diabetes by uncovering the role of m6A mRNA methylation. The discovery has significant research and therapeutic implications, offering new insights into how the disease progresses.
Researchers at the University of Cambridge found that people who achieve weight loss of 10% or more within five years after diagnosis are more than twice as likely to go into remission. This suggests that significant calorie restriction and weight loss can reverse type 2 diabetes.
A new observational study published in JAMA sheds light on the use of metformin for patients with Type 2 diabetes and impaired kidney function. The study found that metformin is associated with a 20% decreased risk of major adverse cardiovascular events compared to sulfonylureas.
A survey of elderly patients with type 2 diabetes found that many long-time patients downplay medical and social factors in favor of more aggressive treatment. The study's findings suggest that patients' perceptions of their care diverge from professional recommendations, highlighting the need for better physician-patient communications.