Articles tagged with Type 2 Diabetes
A novel diabetes medication, sotagliflozin, significantly reduces hospitalization for heart failure, heart attack, and stroke in patients with Type 2 diabetes and chronic kidney disease. The study found a 26% decrease in cardiovascular deaths and hospitalizations.
The SCORED and SOLOIST trials demonstrate the benefits of SGLT2 inhibitors in patients with type 2 diabetes and chronic kidney disease or recent worsening heart failure. These trials show significant reductions in cardiovascular events, including deaths, hospitalizations, and strokes.
Researchers found that people with Type 2 diabetes still have a 21% higher risk for cardiovascular disease and 31% higher risk for heart failure hospitalization. Optimizing five key cardiovascular risk factors can help reduce this impact, according to the American Heart Association.
A new study published in JAMA Internal Medicine shows that providing support for small lifestyle changes can almost halve the risk of developing Type 2 diabetes. The Norfolk Diabetes Prevention Study found that modest weight loss and increased physical activity reduced the risk by 40-47% for those with prediabetes.
A new report from The Lancet Commission on Diabetes highlights the need for evidence-based interventions to close the gap in diabetes prevention and care. Implementing six key components can reduce cardiovascular-renal events by up to 40% and prevent premature deaths.
A University of Gothenburg study shows that a molecule from gut bacteria, imidazole propionate, reduces the efficacy of metformin in lowering blood glucose. The study found high levels of imidazole propionate associated with impaired metformin action in type 2 diabetes patients.
A new study published in The Journal of the American Osteopathic Association found that increased social support reduces diabetes-related distress and improves treatment outcomes. Researchers emphasize the importance of integrating patients' family and support systems into their diabetes management plans to optimize care.
A study suggests that losing fat mass, but not lean mass, is key for heart health in obese patients with type 2 diabetes. Reducing body fat and waist circumference lowers the risk of heart failure in this population.
A new study from the University of Eastern Finland shows that physical activity and dietary counselling significantly reduces insulin resistance in normal-weight children, preventing type 2 diabetes. The intervention also boosts metabolism in skeletal muscles, adipose tissue, and the liver.
Mice fed a Western diet showed faster decline in odor detection and learning abilities compared to controls. The researchers suggest high dietary sugar content, rather than obesity or hyperglycemia, may be linked to this deterioration.
Researchers found that weight-reduction surgery significantly reduces the risk of a second heart attack, cardiovascular event, and death among severely obese patients with a prior heart attack. Patients who underwent surgery also experienced improvements in sleep apnea, hypertension, cholesterol, and Type 2 diabetes.
A new study suggests that incorporating wrinkled 'super peas' into foods, such as whole pea seeds or flour, could help tackle the global type 2 diabetes epidemic by preventing 'sugar spikes'. The research found that consuming these peas resulted in a more stable increase in blood sugar levels compared to regular peas.
A study of 4923 Japanese individuals with type 2 diabetes found that drinking 4 or more cups of green tea daily and 2 or more cups of coffee daily was associated with a 63% lower risk of death. Higher quantities of both beverages were linked to even greater reductions in mortality risk.
A new study has shown that a minimally-invasive ablation procedure can rejuvenate the lining of the duodenum, leading to significant improvements in blood glucose control and weight loss. In a pilot study, 75% of patients with type 2 diabetes who underwent the procedure were able to discontinue insulin therapy within six months.
Researchers are collecting detailed health information from people with atypical forms of diabetes to understand their causes and differences from common types. The study aims to provide critical insight into the emerging spectrum of diabetes, potentially leading to new targets for prevention and treatment.
Exposing diabetic mice to electromagnetic fields normalizes two major hallmarks of type 2 diabetes, including reduced blood sugar levels and improved insulin sensitivity. The effects are long-lasting, suggesting a potential EMF therapy for managing diabetes during sleep.
A multicenter observational study found that sitagliptin improved survival rates in diabetic patients hospitalized with COVID-19 pneumonia. The study also showed reduced inflammation and improved clinical outcomes. A new randomized, placebo-controlled trial is now enrolling patients to confirm the findings.
A Canadian study of over 290,000 children found that those exposed to diabetes in the womb had a 50-200% higher risk of developing heart disease before age 35. The study also discovered that these children were more likely to develop high blood pressure and type 2 diabetes.
Two newer diabetes medications can significantly reduce the risk of heart disease, cardiovascular events, and end-stage kidney disease. They also lower blood pressure and slow chronic kidney disease progression.
A new study finds that regular use of acid reflux drugs is associated with a heightened risk of developing type 2 diabetes. The longer these drugs are taken, the greater the risk seems to be, prompting researchers to advise blood glucose check-ups for long-term users.
A recent clinical trial found that ertugliflozin demonstrated non-inferiority on the rate of cardiovascular death, heart attack or stroke compared to placebo. The study results add to growing evidence supporting guidelines for using SGLT2 inhibitors to prevent adverse cardiovascular outcomes in type 2 diabetes patients.
A large-scale US study found that housing instability is associated with poor blood sugar control in people with type 2 diabetes. The study of over 25,000 patients revealed that frequent address changes and housing insecurity are linked to higher risk of emergency department visits and lower vaccination rates.
A Canadian study found that SGLT2 inhibitors reduce the risk of cardiovascular events, including heart attack and stroke, among patients with type 2 diabetes. The study's findings suggest that these drugs offer cardioprotective benefits in a real-world setting.
Researchers found that patients taking HIV and hepatitis B treatment had a 33% lower risk of developing diabetes. The protective effect was replicated in multiple databases, suggesting that these drugs could be repurposed to prevent type 2 diabetes.
A six-year study found metformin slowed cognitive decline and reduced dementia risk in individuals with type 2 diabetes. Researchers believe the medication may also benefit those at risk of cognitive decline without diabetes. The study suggests a potential repurposing of metformin to prevent cognitive decline in older people.
A new study found that high-intensity interval training (HIIT) combining cycling and rowing improves insulin sensitivity and reduces blood sugar levels in individuals with obesity and type 2 diabetes. The study also showed improvements in body composition, including a reduction in fat mass and an increase in muscle mass.
Research shows that maintaining good cardiovascular health can significantly reduce the risk of developing type 2 diabetes in middle-aged individuals, regardless of their genetic susceptibility. The study found that individuals with ideal CVH had a lower lifetime risk of T2D compared to those with poor or intermediate CVH.
New research links diabetes to risk of COVID-19 infection and differential outcomes, highlighting the importance of optimising blood sugar control in people with type 1 and 2 diabetes. Better control appears to be an important modifier of COVID-19 severity, suggesting a therapeutic opportunity for diabetes management.
A nationwide study in Sweden found that non-Western immigrants experienced a higher risk of death with each generation born in the country. First-generation immigrants had a survival advantage compared to native Swedes, but this reduced over time and vanished in second-generation immigrants.
A recent report found that people with type 1 diabetes had almost a 3-fold risk of death from COVID-19, while those with type 2 diabetes had an almost 2 times higher risk. High blood glucose levels are associated with poor outcomes in patients with COVID-19.
A new study reveals that reversing type 2 diabetes can restore the pancreas to a normal size and shape, improving insulin function. After 2 years of weight loss, responders experienced significant growth in pancreas volume and fat reduction, while non-responders showed no change.
A study published in Diabetologia suggests that regular heat exposure through hot baths is associated with improved glycated haemoglobin levels and reduced body weight in patients with type 2 diabetes. The research found daily hot-tub bathing to have beneficial effects on cardiovascular risk factors, including blood pressure.
A new study suggests that people with type 1 diabetes will live almost 8 years less and those with type 2 diabetes will live almost 2 years less than the general population. The study used data from the UK National Diabetes Audit and Office for National Statistics to calculate life expectancy, finding a significant gap in mortality rat...
A large observational study suggests that individuals with type 2 diabetes are 36% more likely to develop vascular dementia and 9% more likely to be diagnosed with non-vascular dementia compared to their diabetes-free counterparts. The risk of Alzheimer's disease is not higher in those with type 2 diabetes.
A new study found that rheumatoid arthritis is associated with a 23% increased risk of developing type 2 diabetes. The research suggests that systemic inflammation may contribute to the development of diabetes in individuals with RA, highlighting the need for more intensive screening and management of diabetes risk factors.
A recent study published in Diabetologia reveals that people with type 1 diabetes have a 33% higher risk of falls compared to the general population, while those with type 2 diabetes face a 19% increased risk. The research also identifies various risk factors for falls and fractures in individuals with diabetes.
Research found that increased exercise capacity lowers all-cause mortality risk in T2D patients, with moderate exercise reducing risk by 25% and high-intensity exercise by 32%. The study used data from Taiwan's National Health Interview Survey and National Health Insurance research database.
Research shows spousal concordance is strongest for behavioral risk factors like diet and physical activity, while pathophysiological factors show weaker concordance. Couples with similar dietary habits and high-intensity exercise tend to have lower type 2 diabetes risk.
A study of 200,000 UK Biobank blood samples found over 2,000 undiagnosed cases of type 2 diabetes, with patients waiting on average 2.3 years for a clinical diagnosis. Population-level screening using HbA1c testing could identify cases earlier and reduce complications.
A study found that people with type 2 diabetes who go to bed early and wake up early have a significantly more active lifestyle than those who prefer late bedtimes. This research highlights the importance of sleep chronotypes in managing diabetes and suggests that adjusting bedtime can lead to improved physical activity levels.
Researchers at Lund University have discovered biomarkers to predict how type 2 diabetes patients will respond to metformin treatment. The study, conducted on 363 participants, shows promise for personalized therapy and reducing side effects.
A study published in Diabetologia found that loneliness predicts the development of type 2 diabetes, even after accounting for other factors. The researchers analyzed data from over 4,100 adults and discovered that individuals experiencing chronic loneliness were more likely to develop type 2 diabetes over a period of 12 years.
Researchers have identified 105 epigenetic changes in blood cells that precede the onset of type 2 diabetes. These changes are associated with altered methylation activity and expression patterns in islets of Langerhans, suggesting a potential diagnostic marker for early detection.
Research reveals that Type 2 diabetes affects brain function in older women, leading to sensory and motor deficits. A unique fNIRS technique detects decreased oxygenated blood use in the brain, suggesting underlying mechanisms such as muscle changes and cortical dysfunction.
A new study confirms insomnia as a novel risk factor for type 2 diabetes, with individuals experiencing a 17% higher likelihood of developing the condition. The research also identifies 15 protective factors, including increased total cholesterol and testosterone levels, which can help inform public health policies to prevent the disease.
A novel 'disease-in-a-dish' model has been developed to study the basic molecular factors leading to type 2 diabetes. The model, using reprogrammed induced pluripotent stem cells from patients with type 2 diabetes and healthy controls, reveals defects in proteins with unknown roles in metabolism or diabetes.
Research shows handgrip strength can predict type 2 diabetes risk by 50% per unit increase, with implications for prevention strategies. The finding is marked in women and could be used to identify individuals at high risk.
A world-first study found that an engineered form of the SMOC1 protein can decrease blood glucose levels and improve metabolic health in people with type 2 diabetes. This breakthrough discovery has the potential to create a new class of treatments for the condition.
Two randomized controlled studies demonstrate that SGLT2 inhibitors can slow CKD progression across all patient groups, not just those with diabetes. The DAPA-CKD trial found a significant reduction in kidney function decline and end-stage disease with dapagliflozin treatment.
A new study published at ESC Congress 2020 suggests that body mass index (BMI) is a more powerful risk factor for developing type 2 diabetes than genetic predisposition. Researchers found that individuals with a higher BMI were more likely to develop diabetes, regardless of their genetic risk level.
The DAPA-CKD trial found that dapagliflozin reduced the risk of worsening kidney function, death from kidney disease, or hospitalization for heart failure and cardiovascular events in patients with chronic kidney disease. The study also showed a significant reduction in all-cause mortality.
Patients with type 2 diabetes experience significant reductions in heart attack risk and mortality when starting medications to prevent cardiovascular disease. The study found that the risk was reduced by 61% for heart attacks and 41% for death over a 15-year period.
A genetic variant of the DUSP8 gene impairs brain response to insulin, leading to increased risk of type 2 diabetes. Research reveals protein Dusp8's regulatory effects on hypothalamic insulin sensitivity and inflammatory processes.
Elevated NT-proBNP levels are associated with a reduced risk of developing type 2 diabetes, especially in women. However, those who develop diabetes with elevated NT-proBNP have a higher risk of macro- and microvascular complications such as heart attack, stroke, or severe damage to eyes, kidneys, or nerves.
Researchers at UCSF have developed a smartphone-based digital biomarker to detect Type 2 diabetes, providing a potential in-home alternative to blood draws and clinic-based screening tools. The algorithm correctly identified the presence of diabetes in up to 81% of patients, offering a promising solution for widespread disease screening.
Researchers at Lund University found that a strict six-week low-calorie diet had the greatest positive effect on health markers after bariatric surgery. The operation itself caused minor changes, and most effects disappeared after six weeks.
A new vaccine candidate BCG::RD1 has shown highly protective effects against tuberculosis in older mice with type 2 diabetes. The vaccine acts on multiple immune cell subsets to mount a robust response against TB-causing bacteria.
A recent analysis found that adults with rheumatoid arthritis had a lower risk of developing type 2 diabetes compared to other individuals. The study, published in Arthritis Care & Research, used a US commercial insurance database and included over 449,000 people.
A new drug candidate, SRI-37330, has been discovered to improve four detrimental characteristics of diabetes: high blood sugar, glucagon elevation, excessive glucose production by the liver, and fatty liver. The compound is non-toxic, orally bioavailable, and highly effective in human islets and mouse models.
A new study published by The Endocrine Society found that cinnamon supplementation lowered abnormal fasting glucose levels and improved response to eating carbohydrates. Cinnamon was well-tolerated without adverse effects.