Articles tagged with Type 2 Diabetes
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A study of 677 participants found higher abdominal fat was associated with lower scores on memory and language tasks. Visceral adiposity may impact cognitive decline in older patients with diabetes, emphasizing the importance of targeted interventions.
A large meta-analysis of SGLT2 inhibitor trials found consistent cardiovascular benefits in diverse subsets of patients with type 2 diabetes, including those without established cardiovascular disease. The study showed a significant reduction in major adverse cardiac events, cardiovascular deaths, and hospitalizations for heart failure.
Scientists have obtained a high-resolution view of glucagon-like peptide-1 receptors (GLP1R), which play a crucial role in regulating blood sugar levels. The study provides new insights into GLP1R function and its potential as a target for treating conditions like type 2 diabetes.
A 15-year study found that dysfunctional pancreatic beta-cells, independent of body weight, are the earliest event leading to pre-diabetes in children. The study also linked this condition to genetic factors associated with type 2 diabetes in adults.
A recent study published in Annals of Internal Medicine found that adults with type 2 diabetes who were newly prescribed SGLT2 inhibitors had a lower rate of gout compared to those prescribed GLP1 agonists. This suggests that SGLT2 inhibitors may be effective in reducing the risk of gout among patients with type 2 diabetes.
Researchers conducted the largest study on weight loss surgery in a Chinese population with obesity and type 2 diabetes. Surgery provided substantial effects on weight, blood sugar, and cholesterol over five years, with restrictive surgeries being slightly more effective in diabetes remission.
Researchers found that a ketone monoester drink can help participants with Type 2 diabetes and pre-diabetes better control their blood sugar levels without insulin changes. The study's lead author notes that while ketone supplements are not a magic bullet, they may be another strategy for managing the disease.
Scientists have observed people developing Type 2 diabetes due to liver fat over-spilling into the pancreas. A study showed that individuals can reverse the condition through diet and weight loss, with nearly nine out of ten participants achieving remission.
Research suggests that longer exposure to obesity and earlier development of obesity are linked to an increased risk of type 2 diabetes. Women who experienced rapid weight gain from young adulthood had a higher risk of developing the disease compared to those who remained stable.
Good aerobic fitness is not linked to lower risk of insulin resistance in obese children. Instead, more physical activity and less sedentary time were associated with reduced insulin resistance regardless of body fat percentage. The study suggests that more physical activity plays a key role in preventing type 2 diabetes in childhood.
Researchers used lipidomics and machine learning to identify a blood lipid profile linked to type 2 diabetes risk, which improved prediction over traditional methods. Lifestyle factors such as diet and physical activity also played a role in modulating the blood lipid profile.
A recent review suggests that artificial sweeteners, commonly used to aid weight loss, may actually contribute to the development of type 2 diabetes and weight gain. According to UniSA Professor Peter Clifton, consuming large quantities of artificial sweeteners can alter gut bacteria and lead to increased calorie intake.
Researchers found that filtered coffee reduces the risk of developing type 2 diabetes by up to 60%, but boiled coffee does not have this effect. The study used a novel method called metabolomics to identify specific molecules in blood samples, which indicate coffee intake and its impact on metabolism.
A large web-based study cohort in France explored associations between ultraprocessed food consumption and the risk of type 2 diabetes. The study found that higher consumption of ultraprocessed foods was associated with an increased risk of developing type 2 diabetes.
The Endocrine Society and Avalere Health introduced quality measures to assess healthcare providers' ability to identify and care for older adults at risk of hypoglycemia. The measures focus on outpatient treatment for adults aged 65 and older with type 2 diabetes, highlighting key risk factors and emphasizing education to prevent futu...
A study by Karolinska Institutet researchers identifies a molecular mechanism linking ALS and type 2 diabetes, where immunoglobulin G antibodies target calcium channels in pancreatic beta cells, leading to cell death. The findings suggest altered humoral immunity may be a generalized phenomenon for other neurodegenerative diseases.
New research reveals a significant association between preterm birth and an increased risk of developing type 1 and type 2 diabetes in children and young adults. Women born preterm are particularly at higher risk, with a 30% increase in type 2 diabetes risk and a 60% increase in type 1 diabetes risk compared to their male counterparts.
A study by Carnegie Mellon University found that age affects the well-being of newly diagnosed Type 2 diabetes patients. Younger individuals experience higher diabetes-related and psychological stress. Older adults tend to have less psychological stress and better self-care, blood sugar control, and medication adherence.
Researchers investigated the effect of vitamin D and omega-3 supplements on chronic kidney disease (CKD) development or progression in adults with type 2 diabetes. The study found no significant difference in CKD progression between supplementation groups.
Researchers at Weill Cornell Medicine discovered that higher levels of protein adipsin in the blood protect against type 2 diabetes. Adipsin helps shield pancreatic beta cells, improving insulin production and preventing cell death.
A study of 71,892 children born between 2007-2011 found strong associations between pre-pregnancy obesity in mothers and their children's high body mass index between ages two and six. Modest links were also identified with maternal diabetes and excessive weight gain during pregnancy.
A new web-based calculator predicts a patient's likelihood of dying from complications or experiencing serious health issues due to type 2 diabetes and obesity, whether they undergo metabolic surgery or continue with standard medical therapy. The Individualized Diabetes Complication Risk Calculator provides a personalized risk score ba...
A new calculator developed by Cleveland Clinic researchers can estimate a patient's risk of developing major health complications over the next 10 years depending on their treatment choice. The calculator provides personalized evidence-based information on heart disease, stroke, and other risks with usual care versus surgical treatment.
A new study published in Diabetes Care found that bariatric surgery significantly decreased the rate of diabetic kidney disease among severely obese teens with type 2 diabetes, compared to medical treatment alone. The five-year study also showed improvements in hyperfiltration, urinary albumin excretion, and blood pressure.
A recent study has identified the gene function that protects against type 2 diabetes, revealing a zinc transporter's role in insulin secretion. The research found that individuals with a specific mutation in the SLC30A8 gene have enhanced glucose-stimulated insulin secretion and reduced blood sugar levels.
Researchers found a crucial link between nicotine, type 2 diabetes and a diabetes-associated gene called Tcf7l2. Variation in this gene may influence both tobacco addiction and the development of tobacco-associated type 2 diabetes.
A new medical device called Sleeveballoon has been tested in rodents and produced impressive results on body weight, fatty liver, and diabetes control. The device reduces food intake by 60% and blood glucose levels by 65%, mimicking the effects of traditional bariatric surgery with a minimally invasive approach.
Researchers found that individuals who lost a significant amount of weight and then maintained 75% of their weight loss had improved risk factors, such as cholesterol levels and blood pressure. However, those who regained weight saw deteriorated benefits, highlighting the importance of long-term maintenance.
Research found black individuals were 50% less likely than white individuals to be prescribed newer medications for Type 2 diabetes. Monitoring of patients' conditions was also lower among ethnic minorities and those from disadvantaged backgrounds.
A new study from Harvard T.H. Chan School of Public Health found that increasing consumption of sugary beverages is associated with a higher risk of type 2 diabetes. Replacing one daily serving of sugary drinks with water, coffee, or tea reduces the risk by 2-10%.
A new metabolic discovery by researchers at Cornell University may hold the key to fighting heart disease and Type 2 diabetes. The study identifies two enzymes that convert glucose to erythritol, a sugar alcohol, in human metabolism.
Researchers at Joslin Diabetes Center have made a breakthrough in identifying diseased beta cells in type 2 diabetes by uncovering the role of m6A mRNA methylation. The discovery has significant research and therapeutic implications, offering new insights into how the disease progresses.
Researchers at the University of Cambridge found that people who achieve weight loss of 10% or more within five years after diagnosis are more than twice as likely to go into remission. This suggests that significant calorie restriction and weight loss can reverse type 2 diabetes.
A new observational study published in JAMA sheds light on the use of metformin for patients with Type 2 diabetes and impaired kidney function. The study found that metformin is associated with a 20% decreased risk of major adverse cardiovascular events compared to sulfonylureas.
A survey of elderly patients with type 2 diabetes found that many long-time patients downplay medical and social factors in favor of more aggressive treatment. The study's findings suggest that patients' perceptions of their care diverge from professional recommendations, highlighting the need for better physician-patient communications.
A new study found that fat mass index is associated with a higher risk of cardiovascular events in people with type 2 diabetes. Researchers analyzed data from the ACCORD study and found that participants with higher fat mass were at increased risk, while lean body mass did not provide protection.
A study found that patients with poor health were more likely to continue taking insulin after age 75, despite guidelines recommending reduced treatment intensity. Discontinuing insulin may outweigh its benefits for older adults, especially those with multiple health conditions.
Hurricanes Katrina and Rita had a significant impact on the mortality rate of seniors with diabetes, even ten years later. Those who lived in affected areas experienced a 40% higher one-month mortality rate compared to unaffected counties.
A new study found that using ACE inhibitors to lower blood pressure is associated with a 24% reduced risk of developing type 2 diabetes. Natural genetic variations in ACE concentrations are also linked to lower T2D risk. The researchers used Mendelian randomization to infer the causal effects of ACE inhibition on T2D risk.
A randomized clinical trial of 6,000 patients with type 2 diabetes compared the cardiovascular outcomes of linagliptin and glimepiride. The results suggest that linagliptin may be associated with reduced cardiovascular risk.
Researchers at Uppsala University have identified a previously unknown protein, Sac2, that regulates insulin secretion from β-cells. Lowering Sac2 levels leads to reduced insulin secretion, highlighting the importance of fat composition on secretory granule function.
A new study found that early combination therapy using vildagliptin and metformin leads to better blood sugar control and reduced treatment failure rates compared to metformin alone. The study showed a significant reduction in the risk of losing blood sugar control over a 5-year period.
A new study reveals that poor diabetes control leads to significant excess hospital costs, with people with type 1 and type 2 diabetes experiencing five-fold to eight-fold higher costs for elective and emergency care. The NHS in England spends £3 billion annually on avoidable hospital treatment related to diabetes.
Babies born weighing under 3.6kg are more likely to develop type 2 diabetes by 50.0 years vs 51.3 years, with lower BMI and higher HDL cholesterol at diagnosis. Low birthweight affects risk of developing type 2 diabetes in the same way irrespective of BMI and HDL cholesterol.
A UK study found that the proportion of younger adults diagnosed with type 2 diabetes has increased since the start of the century. Younger cases have a more aggressive metabolic profile, including higher BMI, blood glucose levels, and cholesterol levels. This trend is associated with a higher risk of cardiovascular disease and mortality.
Researchers identified early metabolic features that can predict susceptibility to type 2 diabetes in children, including low HDL cholesterol and chronic inflammation. These findings may help prevent young people from developing the disease.
A new study found that socioeconomic factors significantly impact mortality and hospital readmission rates for patients with type 2 diabetes, but not type 1 diabetes. Patients from areas of high deprivation were more likely to die within six months of discharge.
A meta-analysis found that drinking light to moderate amounts of alcohol decreases triglyceride levels and insulin in people with T2DM. The study suggests that further research is needed to evaluate the effects of alcohol consumption on blood sugar management
A new study found that obesity increases the risk of type 2 diabetes by 5.8-fold, while genetic predisposition and unfavorable lifestyle factors contribute less to the risk, but still play a role in its development. Lifestyle interventions can help delay the onset of T2D among high-risk subjects.
Researchers found increased AGE levels in eyes of people with type 2 diabetes and prediabetes, indicating potential for early detection through lens autofluorescence measurement. A new biomicroscope can detect these levels without invasive procedures.
Recent studies indicate a potential decrease in the rate of new type 2 diabetes cases, although overall prevalence continues to rise. The decline is attributed to improved care and longer survival rates, suggesting that public health initiatives may be contributing to the trend.
A new study developed a machine-learning derived model that can predict future heart failure among patients with diabetes. The WATCH-DM risk score is based on 10 variables, including weight, age, and diabetes control, and identifies patients at high risk of heart failure.
A national survey of primary care physicians reveals significant knowledge gaps about prediabetes risk factors, diagnostic criteria, and management practices. The study highlights the need for improved healthcare education and reimbursement systems to prioritize preventive measures over treatment.
Researchers from Trinity College Dublin isolated a family of proteins linked to better control of blood sugar levels in type 2 diabetes patients. These IL-36 cytokines alter the intestinal microbiome, potentially mitigating insulin resistance and glucose build-up.
A new study in Diabetologia reveals that shorter individuals are at a higher risk of developing type 2 diabetes. The research found that for every 10cm increase in height, the risk of type 2 diabetes decreased by 41% in men and 33% in women, adjusted for age and other factors.
A new meta-analysis found that SGLT2 inhibitors can reduce the risk of dialysis, transplantation, or death due to kidney disease by about 30% and also reduce the risk of acute kidney injury. The results are encouraging for people with diabetic kidney disease, offering a new treatment option to halt disease progression.
A new study confirms that SGLT2 inhibitors can prevent loss of kidney function and kidney failure in people with type 2 diabetes, reducing the risk by about 30%. The findings provide further strong support for the key role of SGLT2 inhibition in kidney protection.
A healthy lifestyle is associated with a 75% lower risk of developing type 2 diabetes, compared to the least healthy lifestyle. In individuals with type 2 diabetes, a healthy lifestyle also reduces cardiovascular disease and death risk by 56% and 52%, respectively.
Research found college students with diabetes experience high levels of distress, leading to poorer self-care behaviors and lower quality of life. Universities can offer resources such as diabetes education and accommodations to support these students.
Researchers analyzed 83 randomized controlled trials involving 121,070 people with and without diabetes. They found that increasing long-chain omega-3 fats had little or no effect on likelihood of diabetes diagnosis or glucose metabolism. In contrast, higher doses of long-chain omega-3 may have negative effects on diabetes risk.