Research on type 2 diabetes and its management. Covers nerve pain, early onset, BMI trajectories, and treatment side effects.
New research links diabetes to risk of COVID-19 infection and differential outcomes, highlighting the importance of optimising blood sugar control in people with type 1 and 2 diabetes. Better control appears to be an important modifier of COVID-19 severity, suggesting a therapeutic opportunity for diabetes management.
A new study suggests that people with type 1 diabetes will live almost 8 years less and those with type 2 diabetes will live almost 2 years less than the general population. The study used data from the UK National Diabetes Audit and Office for National Statistics to calculate life expectancy, finding a significant gap in mortality rat...
A large observational study suggests that individuals with type 2 diabetes are 36% more likely to develop vascular dementia and 9% more likely to be diagnosed with non-vascular dementia compared to their diabetes-free counterparts. The risk of Alzheimer's disease is not higher in those with type 2 diabetes.
A new study reveals that reversing type 2 diabetes can restore the pancreas to a normal size and shape, improving insulin function. After 2 years of weight loss, responders experienced significant growth in pancreas volume and fat reduction, while non-responders showed no change.
A study published in Diabetologia suggests that regular heat exposure through hot baths is associated with improved glycated haemoglobin levels and reduced body weight in patients with type 2 diabetes. The research found daily hot-tub bathing to have beneficial effects on cardiovascular risk factors, including blood pressure.
Research found that increased exercise capacity lowers all-cause mortality risk in T2D patients, with moderate exercise reducing risk by 25% and high-intensity exercise by 32%. The study used data from Taiwan's National Health Interview Survey and National Health Insurance research database.
Research shows spousal concordance is strongest for behavioral risk factors like diet and physical activity, while pathophysiological factors show weaker concordance. Couples with similar dietary habits and high-intensity exercise tend to have lower type 2 diabetes risk.
A study of 200,000 UK Biobank blood samples found over 2,000 undiagnosed cases of type 2 diabetes, with patients waiting on average 2.3 years for a clinical diagnosis. Population-level screening using HbA1c testing could identify cases earlier and reduce complications.
A study found that people with type 2 diabetes who go to bed early and wake up early have a significantly more active lifestyle than those who prefer late bedtimes. This research highlights the importance of sleep chronotypes in managing diabetes and suggests that adjusting bedtime can lead to improved physical activity levels.
A new study found that rheumatoid arthritis is associated with a 23% increased risk of developing type 2 diabetes. The research suggests that systemic inflammation may contribute to the development of diabetes in individuals with RA, highlighting the need for more intensive screening and management of diabetes risk factors.
A recent study published in Diabetologia reveals that people with type 1 diabetes have a 33% higher risk of falls compared to the general population, while those with type 2 diabetes face a 19% increased risk. The research also identifies various risk factors for falls and fractures in individuals with diabetes.
Researchers at Lund University have discovered biomarkers to predict how type 2 diabetes patients will respond to metformin treatment. The study, conducted on 363 participants, shows promise for personalized therapy and reducing side effects.
A study published in Diabetologia found that loneliness predicts the development of type 2 diabetes, even after accounting for other factors. The researchers analyzed data from over 4,100 adults and discovered that individuals experiencing chronic loneliness were more likely to develop type 2 diabetes over a period of 12 years.
Researchers have identified 105 epigenetic changes in blood cells that precede the onset of type 2 diabetes. These changes are associated with altered methylation activity and expression patterns in islets of Langerhans, suggesting a potential diagnostic marker for early detection.
A new study confirms insomnia as a novel risk factor for type 2 diabetes, with individuals experiencing a 17% higher likelihood of developing the condition. The research also identifies 15 protective factors, including increased total cholesterol and testosterone levels, which can help inform public health policies to prevent the disease.
Research reveals that Type 2 diabetes affects brain function in older women, leading to sensory and motor deficits. A unique fNIRS technique detects decreased oxygenated blood use in the brain, suggesting underlying mechanisms such as muscle changes and cortical dysfunction.
A novel 'disease-in-a-dish' model has been developed to study the basic molecular factors leading to type 2 diabetes. The model, using reprogrammed induced pluripotent stem cells from patients with type 2 diabetes and healthy controls, reveals defects in proteins with unknown roles in metabolism or diabetes.
A world-first study found that an engineered form of the SMOC1 protein can decrease blood glucose levels and improve metabolic health in people with type 2 diabetes. This breakthrough discovery has the potential to create a new class of treatments for the condition.
Research shows handgrip strength can predict type 2 diabetes risk by 50% per unit increase, with implications for prevention strategies. The finding is marked in women and could be used to identify individuals at high risk.
The DAPA-CKD trial found that dapagliflozin reduced the risk of worsening kidney function, death from kidney disease, or hospitalization for heart failure and cardiovascular events in patients with chronic kidney disease. The study also showed a significant reduction in all-cause mortality.
Two randomized controlled studies demonstrate that SGLT2 inhibitors can slow CKD progression across all patient groups, not just those with diabetes. The DAPA-CKD trial found a significant reduction in kidney function decline and end-stage disease with dapagliflozin treatment.
A new study published at ESC Congress 2020 suggests that body mass index (BMI) is a more powerful risk factor for developing type 2 diabetes than genetic predisposition. Researchers found that individuals with a higher BMI were more likely to develop diabetes, regardless of their genetic risk level.
Patients with type 2 diabetes experience significant reductions in heart attack risk and mortality when starting medications to prevent cardiovascular disease. The study found that the risk was reduced by 61% for heart attacks and 41% for death over a 15-year period.
A genetic variant of the DUSP8 gene impairs brain response to insulin, leading to increased risk of type 2 diabetes. Research reveals protein Dusp8's regulatory effects on hypothalamic insulin sensitivity and inflammatory processes.
Elevated NT-proBNP levels are associated with a reduced risk of developing type 2 diabetes, especially in women. However, those who develop diabetes with elevated NT-proBNP have a higher risk of macro- and microvascular complications such as heart attack, stroke, or severe damage to eyes, kidneys, or nerves.
Researchers at UCSF have developed a smartphone-based digital biomarker to detect Type 2 diabetes, providing a potential in-home alternative to blood draws and clinic-based screening tools. The algorithm correctly identified the presence of diabetes in up to 81% of patients, offering a promising solution for widespread disease screening.
Researchers at Lund University found that a strict six-week low-calorie diet had the greatest positive effect on health markers after bariatric surgery. The operation itself caused minor changes, and most effects disappeared after six weeks.
A new vaccine candidate BCG::RD1 has shown highly protective effects against tuberculosis in older mice with type 2 diabetes. The vaccine acts on multiple immune cell subsets to mount a robust response against TB-causing bacteria.
A recent analysis found that adults with rheumatoid arthritis had a lower risk of developing type 2 diabetes compared to other individuals. The study, published in Arthritis Care & Research, used a US commercial insurance database and included over 449,000 people.
A new drug candidate, SRI-37330, has been discovered to improve four detrimental characteristics of diabetes: high blood sugar, glucagon elevation, excessive glucose production by the liver, and fatty liver. The compound is non-toxic, orally bioavailable, and highly effective in human islets and mouse models.
A new study published by The Endocrine Society found that cinnamon supplementation lowered abnormal fasting glucose levels and improved response to eating carbohydrates. Cinnamon was well-tolerated without adverse effects.
Researchers found severely limited exercise capacity in adults with type 2 diabetes, increasing risk of heart failure. Subtle impairments in blood flow and heart function were detected using advanced imaging techniques.
Research reveals that both too little and too much sleep can lead to increased mortality rates, with the effect being more pronounced in people with type 2 diabetes. Sleep duration is linked to various cause-specific mortality rates, including cancer, cardiovascular disease, and stroke.
Researchers found that Cyclocarya paliurus polysaccharide modulates the gut microbiota and improves metabolic pathways, leading to a reduction in serum glucose levels and alleviating type 2 diabetes symptoms. The study provides new insights into the use of dietary polysaccharides for preventing or intervening in T2DM.
Researchers have found that an individual's gut microbiota can predict and treat type 2 diabetes, with altered gut bacteria linked to reduced butyrate production. The study suggests potential for personalized dietary changes or probiotics to prevent or treat the disease.
A new study published in Psychoneuroendocrinology documents a clear link between stress hormone cortisol and higher blood sugar levels in people with type 2 diabetes. The research suggests that sustained cortisol levels make it difficult to control blood sugar and manage the disease.
Two studies by European and US researchers found that higher consumption of these foods is associated with a lower risk of developing type 2 diabetes. Increasing fruit and vegetable intake by 66 grams per day was linked to a 25% lower risk, while whole grain consumption was also significantly related to reduced disease risk.
A study in Journal of Biological Chemistry describes a new way to determine the age of insulin-storage parcels and sheds light on how their age affects their release into the bloodstream. This finding could help experts better understand diabetes and fine-tune therapies for it.
Researchers found that certain gut bacteria not following a day-night rhythm can serve as an indicator for potential type 2 diabetes. Mathematical models also suggest this microbial risk signature helps in diagnosing diabetes, improving diagnosis and outlook of the disease.
The new guidelines emphasize the importance of early identification and management of T2D in Indigenous communities, where it is most prevalent. The guidelines recommend tighter diabetes control, transitioning adolescents to multidisciplinary care teams, and exploring newer medications for treatment.
A new study published in Circulation: Cardiovascular Quality and Outcomes journal found that people with newly diagnosed Type 2 diabetes who develop heart failure have the highest 5-year risk of death, three times higher than those without heart or kidney disease. Researchers also identified patients with cardiovascular or kidney disea...
A new study found that early signs of type 2 diabetes can be detected in children as young as 8 years old through metabolic changes measured by blood samples. The research identified subtle differences in metabolism among participants who were more genetically prone to developing the disease later in life.
Research suggests that a high amount of hip and leg fat mass is crucial to maintain metabolic health. Studies show that low visceral fat and high lower body fat may be equally important for retaining cardiometabolic health.
A new genetic risk score has been found to be effective in diagnosing type 1 diabetes in Indians, even in its current form based on European data. Genetic differences between Indian and European populations suggest that the test could be further improved to enhance outcomes.
Research by the University of Sheffield reveals people with diabetes are at a greater risk of bone fractures, especially hip fractures. Severity and length of time living with the condition also increase this risk.
A large analysis of over 200,000 people found that high-quality carbohydrates like whole grains are associated with a lower risk of type 2 diabetes. Researchers also discovered that replacing low-quality carbohydrates with saturated fats is linked to a reduced risk of developing the condition.
Scientists have mapped proinsulin's vast network of interacting proteins, revealing a key player in proper folding and insulin production. Boosting PRDX4 levels may offer a novel therapeutic approach to improving type 2 diabetes treatment.
A new blood test can identify women at risk of developing type 2 diabetes up to 10 years after delivery, allowing for potential interventions such as diet and exercise. The test uses metabolic markers that are present in the blood of women who have had gestational diabetes.
A new study published in Diabetologia found that women who experience more pregnancy losses are at a higher risk of developing type 2 diabetes. The study analyzed data from over 247,000 women and found that each additional pregnancy loss increased the risk by 18-71%. Women with no previous pregnancies also had a significantly higher risk.
Researchers found that combining rosiglitazone, a popular but abandoned diabetes treatment, with another drug called Compound A can enhance its effectiveness while reducing side effects such as weight gain and fluid retention. The study suggests that using lower doses of rosiglitazone may be sufficient to achieve similar results.
Two studies from University of Otago researchers found that a higher fibre intake can reduce premature mortality by 35% in adults with type 1 or type 2 diabetes. However, food processing may dilute the health benefits of whole grains, leading to increased blood glucose levels and weight.
Research finds that people with Type 2 diabetes experience worse cognitive performance after a stroke compared to those without the condition. However, prediabetes is not associated with similar cognitive decline, emphasizing the importance of early diagnosis and treatment.
A CNIO-led European study has confirmed that diabetes type 3c is an early manifestation of pancreatic cancer, allowing for earlier diagnosis and treatment. The study found that pancreatic cancer is the cause of the development of diabetes type 3c in 26% of cases.
Experts recommend prioritizing surgical treatment for patients with type 2 diabetes or severe obesity due to the risk of complications from their disease and COVID-19. Bariatric and metabolic surgery can lead to significant weight loss, reduced cardiovascular risk, and improved survival.
A study published by The BMJ found that childhood body size is associated with an increased risk of coronary artery disease and type 2 diabetes in later life. However, a larger early life body size may help protect women against breast cancer. The study suggests that maintaining a normal body mass index (BMI) in adulthood can reduce th...
Researchers evaluated teens with normal weight and those with obesity, type 2 diabetes or high blood pressure to assess carotid artery health. Teens with these conditions were found to have thicker and stiffer arteries, increasing the risk of early heart attacks and strokes.
A large-scale study has identified 301 distinct genetic links to type 2 diabetes among 433,540 East Asian individuals. The findings provide insight into the biological basis of the chronic metabolic disorder and highlight the importance of studying different ancestries.
A large-scale genome-wide study has identified 301 distinct genetic signals associated with type 2 diabetes in East Asians. The research highlights the importance of studying different ancestries and expands the number of genetic variants linked to the disease, providing new insights into its pathophysiology.
A new study from the University of Copenhagen suggests that transplanted intestinal contents could be effective against obesity and type 2 diabetes. Researchers found that obese mice with unhealthy lifestyles gained significantly less weight and avoided type 2 diabetes when they received viruses transplanted from the stool of lean mice.
A 20-year study by the Endocrine Society found that cardiovascular complications among individuals with diabetes have declined. Meanwhile, mortality rates remain higher than those in the general population, highlighting ongoing concerns about cancer and dementia risks for people with diabetes.