Articles tagged with Type 2 Diabetes
A meta-analysis of clinical trials found that SGLT2 inhibitors, like dapagliflozin and empagliflozin, reduce cardiovascular death and hospitalization in patients with mildly reduced or preserved ejection fraction heart failure. These drugs may benefit a wide range of patients, regardless of age, sex, or medical history.
Researchers have combined tesaglitazar and GLP-1 in a new hormone combination for type 2 diabetes treatment, improving glucose metabolism with minimal doses. The new drug has shown promise in animal studies, reducing kidney damage and increasing insulin sensitivity.
A study by Children's Hospital Colorado reveals a 77% surge in newly diagnosed youth-onset type 2 diabetes cases during the COVID-19 pandemic. The increasing prevalence of obesity and unhealthy habits since the pandemic's onset are thought to contribute to this rise.
A recent study by Johns Hopkins Children's Center researchers found a significant rise in type 2 diabetes cases among children during the COVID-19 pandemic. The increase was largely attributed to reduced physical activity and weight gain due to lockdowns and virtual learning.
Researchers found that participants who received cooking education showed improvements in eating more vegetables, fewer carbohydrates, and lower A1C levels. The study also highlighted the importance of addressing food insecurity in diabetes management.
A new study identifies PDIA3 as a molecule targeted by the immune system in response to stress, contributing to liver damage in type 2 diabetes and obesity. Elevated levels of antibodies for PDIA3 have been found in people with these conditions, but improving diet and weight can reverse this liver condition.
Using standing desks alongside other measures reduced office workers' sitting time by about an hour a day over one year, leading to small improvements in stress, well-being, and energy levels. A height-adjustable desk was three times more effective than the standard SWAL intervention in reducing sitting time.
Researchers discovered a rare genetic mutation that may lead to better diabetes treatments for patients, regardless of whether they inherited the mutation. The study found that carriers of the mutation had lower levels of adiponectin and higher levels of ceramides in their blood.
A new study suggests that the true figure of undiagnosed diabetes in the US is significantly lower than current government estimates, with a prevalence rate of around 9.5% of the total diabetes burden. Disparities in access to healthcare and screening contribute to higher rates in older adults, racial/ethnic minorities, and those witho...
A UCI-led study found that Rhodiola rosea extract improved glucose homeostasis, modulated the gut microbiome, and reduced inflammatory biomarkers in a mouse model of type 2 diabetes. The results suggest potential benefits for treating the condition through changes in the microbiome.
Researchers developed an AI algorithm using individual ECG heartbeats to accurately predict diabetes and pre-diabetes. The DiaBeats algorithm detected the diseases with an overall accuracy of 97%, irrespective of factors like age, gender, and coexisting metabolic disorders.
A world-first study reveals a direct link between low vitamin D and high inflammation, providing a biomarker for those at risk of chronic illnesses. Boosting vitamin D in people with deficiencies may reduce chronic inflammation.
Researchers have developed a novel approach to engineering live bacterial therapeutics by using native microbes that can survive in the gut. This method overcomes previous limitations of introducing engineered bacteria into the gut, demonstrating potential for long-term therapy and reversal of disease pathologies in mouse models.
A team of researchers at Mount Sinai discovered a molecular mechanism involving carbohydrate response-element binding protein (ChREBP) that plays a key role in glucose toxicity and beta-cell death. Increasing expression of an alternate form of ChREBP or activating nuclear factor-erythroid factor 2 can preserve beta-cell mass.
A new study from Edith Cowan University found that acupuncture therapy significantly improved fasting plasma glucose, two-hour plasma glucose, and glycated haemoglobin levels in people with prediabetes. The therapy also showed a greater decline in the incidence of prediabetes without adverse reactions.
The Women's Preventive Services Initiative issues guidelines for preventing obesity in midlife women, recommending counseling on healthy eating and physical activity. The guideline aims to mitigate concerns about weight stigma by normalizing counseling among all midlife women, regardless of BMI status.
A recent JAMA study found a positive association between high insulin dosage and cancer incidence among patients with type 1 diabetes. The study suggests that clinicians may need to balance cancer risk when treating patients on high insulin doses, with improving insulin sensitivity potentially being a preferred approach.
A recent study published in Nutrients suggests that regular quinoa consumption can help prevent type 2 diabetes. Researchers replaced carbohydrate-rich foods with quinoa and found a significant reduction in post-meal blood sugar spikes. By mitigating this spike, quinoa may play a crucial role in preventing the progression of type 2 dia...
Researchers found that lactating mothers expose their pups to triclosan, leading to early signs of liver damage that can progress to nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Exposure to triclosan in early life may lay the groundwork for future development of fatty liver disease.
Arterial stiffness in adolescence is a novel risk factor for hypertension, insulin resistance, and type 2 diabetes in young adulthood and mid-adulthood. Risk factors include maternal smoking habits, early life smoking patterns, high salt intake, genetic inheritance, obesity, and elevated blood pressure from childhood.
A new study published in Diabetologia finds that limiting food intake to a 10-hour window during the day improves metabolic health in adults with type 2 diabetes. The research, conducted by Prof Patrick Schrauwen and colleagues, shows a decrease in 24-hour glucose levels and an increase in time spent with normal blood glucose levels.
Researchers at Monash University have discovered a new pathway to regenerate insulin in pancreatic stem cells, which could lead to new therapies for Type 1 and Type 2 diabetes. The study uses a drug approved by the US FDA to reactivate dormant insulin-producing cells, paving the way for potential treatments.
A systematic review by Leicester researchers has explored common methods used to predict years of life lost, highlighting differences between basic and advanced methods. The study aims to provide a comprehensive guide for healthcare professionals and researchers, promoting better understanding of life expectancy metrics.
Researchers analyzed data from 11 populations of adults totaling nearly 400,000 men and women, finding no correlation between refined grain intake and the risk of developing type 2 diabetes. In contrast, total grain intake was consistently associated with a lower risk of T2D.
Scientists have developed a new class of antidiabetic drugs called Adipeutics that specifically target adipocytes to restore glucose uptake. This therapy has shown promising results in animal models and holds potential for addressing not only type 2 diabetes but also related medical conditions.
A new study by the University of Pittsburgh found that patients with diabetes on Medicare Advantage plans are more likely to receive preventive treatments, but less likely to receive newer and more expensive medications. This disparity can lead to poorer health outcomes, including higher blood pressure and worse diabetes control.
A study published in Cell Reports found that a rhythmic small intestinal microbiome prevents obesity and type 2 diabetes in mice. The researchers used mouse models to explore how diet and feeding patterns affect the gut microbiome and its impact on host health, particularly with obesity and type 2 diabetes.
Eating one avocado a day for six months improved overall diet quality by eight points and slightly decreased LDL cholesterol levels. However, avocados had no effect on belly fat or weight gain in participants with overweight or obesity.
A study of over 1000 consumers from Australia and NZ found that 27% would pay nearly double the price for 'healthy' drinks with low/no sugar, natural/no additives, or vitamins and minerals. Younger consumers (18-24 years) are more likely to be interested in healthy drinks.
Researchers at University of Basel found that the sight and smell of a meal stimulate an inflammatory response in the brain, which affects insulin secretion. In overweight individuals, this response is excessive and can impair insulin function.
The American Heart Association has revised its cardiovascular health checklist to include sleep duration as a key factor in ideal heart and brain health. The new Life's Essential 8 score replaces the previous Life's Simple 7 and assesses factors such as diet, physical activity, nicotine exposure, and blood pressure.
A University of Houston study found that 61% of Black and Hispanic adolescents have low vitamin D levels, which can lead to cardiovascular disease, certain cancers, type 2 diabetes, and renal disease. The research emphasizes the importance of raising awareness among clinicians about social determinants of health and providing culturall...
A narrative review of endoscopic sleeve gastroplasty (ESG) highlights its potential as a minimally invasive weight loss procedure. The review concludes that ESG induces significant weight loss and improves obesity-related conditions, with the technique's success attributed to delayed gastric emptying. Researchers support the use of ESG...
Research by Oregon State University has explained the biosynthetic pathway underlying the production of acarbose, a type 2 diabetes drug. The findings could lead to improvements in industrial production through biotechnological approaches.
A new study reveals that IL18 signaling is essential for β-cell development and insulin secretion, using specific receptors on acinar and β cells. This finding may provide insights into the role of IL18 in regulating islet β cell proliferation and guide future efforts to expand β cells and increase islet mass in diabetes.
A study published in Alzheimer's & Dementia found that individuals with at least two cardiometabolic diseases, such as type 2 diabetes and heart disease, double their risk of developing dementia. The study suggests that prevention of these diseases could be a strategy for reducing dementia risk.
Researchers have developed a test that measures blood levels of ceramides, a waxy substance similar to cholesterol, to predict diabetes remission in gastric bypass surgery patients. The study found that individuals with low ceramide levels prior to surgery had a higher likelihood of achieving diabetes remission two years later.
Researchers at Karolinska Institutet describe a new way of generating insulin-producing cells using a molecule that stimulates protein synthesis and boosts insulin production. The study shows promise for treating type 1 and 2 diabetes, potentially increasing the number of insulin-producing pancreatic β cells.
A new study has found that nonalcoholic fatty liver disease (NAFLD) in children significantly increases the risk of developing type 2 diabetes. The study, published in Clinical Gastroenterology and Hepatology, revealed that among 892 children with NAFLD, 6.6% developed type 2 diabetes, with the incidence rate rising by 3% annually.
Research found that patients using insulin have a higher risk of fractures compared to those using metformin, particularly in non-obese and well-controlled diabetic patients. Routine fracture risk assessments are recommended for these individuals.
A randomized controlled trial shows significant improvements in testosterone replacement therapy for men with poorly-controlled type 2 diabetes and hypogonadism. The treatment improved symptoms, libido, and quality of life, as well as delayed verbal recall, a potential early sign of dementia.
A study found that around one in 500 men carry an extra sex chromosome, putting them at increased risk of several common diseases. Men with XXY or XYY chromosomes have higher risks of reproductive problems, type 2 diabetes, and other health conditions.
A high-fat diet can lead to increased fructose metabolism in the small intestine, resulting in the release of glycerate into circulation. This can cause damage to insulin-producing pancreatic beta cells, increasing the risk of glucose tolerance disorders and Type 2 diabetes mellitus.
A comprehensive register study at the University of Gothenburg shows individuals with diabetes have a substantially increased risk of left-sided heart valve disease. Lowering blood pressure and reducing other risk factors may even reduce this risk more than current treatment targets suggest.
A new study published in Frontiers in Pharmacology found that traditional Ayurvedic medicines are effective in maintaining blood sugar levels in patients with type 2 diabetes. The review analyzed 219 articles and included 98 Ayurvedic medicines, showing benefits in glycemic control, body weight, and other diabetes-related parameters.
A new study from University of Eastern Finland indicates that telemedicine played a crucial role in maintaining essential type 2 diabetes care amid the COVID-19 pandemic. Despite reduced face-to-face appointments, remote services for diabetes management cushioned the decline and kept overall contacts only 9% lower than 2019.
A recent study reveals that patients with lower body mass indexes (BMIs) could benefit from weight-loss surgery due to its effectiveness in treating type 2 diabetes and other comorbidities. The study found that patients with Class I obesity who underwent weight-loss procedures had shorter hospital stays, fewer complications, and improv...
A customized WeightWatchers program has been shown to effectively manage Type 2 diabetes by lowering blood glucose levels and promoting significant weight loss. Participants in the six-month clinical trial experienced improved glycemic control and overall well-being, with clinically meaningful and statistically significant results.
A nationwide study found a significant association between excessive BMI in late adolescence and the development of type 1 diabetes in young adulthood. The researchers analyzed data from over 1.4 million adolescents and found that those with obesity had double the risk of developing type 1 diabetes compared to those with optimal BMI.
Researchers at Oregon State University have developed a new analytical method that reveals why some obese patients develop type 2 diabetes while others don't. The study found that a particular type of gut microbe leads to insulin resistance, and treatments targeting microbiota may be a new therapeutic strategy for the disease.
A new study finds that cancer patients are at a greater risk of developing diabetes, particularly those with lung, pancreatic, breast, brain, urinary tract, or uterine cancers. The study also shows that cancer patients who develop diabetes die sooner than survivors without diabetes.
A new study found that sodium-glucose co-transporter 2 inhibitors (SGLT-2i) decreased the risk of hospitalization for heart failure in adults with type 2 diabetes. SGLT-2i showed similar cardiovascular outcomes to metformin but a lower risk of heart failure hospitalization.
The US healthcare system faces a significant challenge in providing high-quality, personalized obesity care due to lack of insurance coverage for effective medications and societal stigma. Recent efforts aim to address this issue through framework development and policy changes, which may lead to improved patient outcomes and cost savi...
Research describes how breast cancer cells impair pancreatic islet function to suppress insulin production, leading to diabetes and increased tumor growth. The study identifies microRNA-122 as a key player in this process.
A small protein supplement taken before meals can help people with type 2 diabetes control their blood sugars for two extra hours a day. The study found daily glucose levels were also 0.6 mmol/L lower when taking the supplement.
A new study at Lund University found distinct epigenetic differences between subgroups of patients with type 2 diabetes, associated with different risks of developing common complications. Epigenetic biomarkers can be used to predict complications and tailor treatments for individual patients.
A large Japanese trial found that daily vitamin D supplements had no clinically meaningful effect on preventing type 2 diabetes in people at high risk of the condition. However, results suggested a potential benefit for those with insufficient insulin secretion, warranting further research.
A recent study published in the Journal of Endocrinology suggests that lowering blood glucose levels can partially restore reproductive hormone levels and ovulation in female mice with obesity. The study used dapagliflozin, a common type 2 diabetes medication, to treat the mice, resulting in improved fertility outcomes.
Researchers discovered Empa, an FDA-approved diabetes medication, improved blood vessel function and reduced arterial stiffness in aged male mice. The study suggests SGLT2 inhibition may be a therapeutic tool to delay or reverse vascular aging in humans.
A landmark trial found that a widely used diabetes drug, metformin, is not effective against the most common forms of early-stage breast cancer. However, researchers discovered a potential benefit for individuals with HER2-positive breast cancer, which accounts for about 20% of all breast cancers.