Articles tagged with Type 2 Diabetes
Italian researchers found that dairy products, particularly low-fat ones and yogurt, are associated with a lower risk of developing type 2 diabetes. Red and processed meat were linked to an increased risk, but moderate amounts of fish and eggs could be eaten in their place.
A six-country European survey found that people with diabetes living in Italy and the UK, women, and those younger than 45 have the highest prevalence of anxiety. The study also suggests a link between blood sugar management and anxiety severity.
Tirzepatide, a new type 2 diabetes drug, has been shown to achieve blood glucose targets 4-12 weeks sooner than existing treatments. Additionally, tirzepatide was found to promote weight loss goals faster than semaglutide, with an average time of 8-24 weeks to reach target weight loss.
A study published in Neurology found that people with type 2 diabetes who followed seven healthy lifestyle habits had a lower risk of dementia. The habits included getting enough sleep, exercising regularly and having frequent social contact.
Researchers are using in vitro skeletal muscle models to study Type 2 diabetes and its treatment. These models enable the exploration of disease characteristics and discovery of new medicines tailored to individual patients' muscles.
The US Preventive Services Task Force (USPSTF) states that screening for type 2 diabetes in asymptomatic children and adolescents under 18 has insufficient evidence to support a recommendation. As of 2018, approximately 23,000 children and adolescents had type 2 diabetes, with incidence rates rising.
A study led by Arizona State University Professor Gabriel Shaibi found that a community-based program combining education and exercise significantly improves the health of Latino children at risk for diabetes. The program, which included 117 families from around the Valley, provided culturally focused lessons on healthy eating and phys...
Weekly injections of semaglutide reduce type 2 diabetes risk by over 60%, mirroring significant weight loss. Sustained treatment is necessary to maintain the benefit.
A new study reveals a widening gap in diabetes-related mortality between urban and rural areas in the USA, with significant disparities seen in male and younger patients. The study found that reductions in mortality rates in urban areas were mainly limited to female and older patients, while outcomes worsened for male and younger indiv...
A new study found that tighter blood sugar control for women with gestational diabetes reduced infant death, trauma, and shoulder dystocia by half. However, it also increased the risk of serious health complications for the mother, such as major postpartum hemorrhage.
Researchers found that early weight loss is strongly associated with short and medium-term success in weight management programmes. Those who fail to lose at least 0.5% of their body weight after three sessions are unlikely to succeed. The threshold of failing to achieve 0.5% body weight loss was 95% accurate at identifying participant...
Studies investigate lifestyle interventions to achieve nutritional ketosis and its impact on chronic illness, sleep, and cardiovascular disease in the military. Researchers aim to understand how ketogenic diet, ketone-based beverages, and their effects on clinical outcomes will benefit soldiers' health.
A new study of 1.9 million adults found that young-onset type 2 diabetes is associated with a substantially higher relative risk of cardiovascular disease and death. Individuals diagnosed with early-onset T2D aged 40 or younger had five times more likelihood to develop heart disease, seven times more likely to be hospitalized with hear...
Researchers from Children's Hospital of Philadelphia used advanced mapping techniques to identify causal genes and target pairings in the pancreas linked to type 2 diabetes. The study revealed alpha and acinar cells play a greater role in disease development than previously thought.
Researchers found that people with type 2 diabetes are being admitted to hospital at greater frequency for non-traditional complications, including infections and mental health disorders. These emerging complications pose a significant burden on healthcare systems and may require changes to diabetes management.
A study by University of Basel researchers found that insufficient insulin production contributes to overweight, challenging the long-held belief that poor nutrition and lack of exercise cause weight gain. The research revealed a key enzyme's role in hormone activation, leading to severe hunger and obesity.
Researchers at CeMM have discovered that targeting SMNDC1 in alpha cells can induce insulin production, a potential new approach for treating diabetes. The study identified a key molecular mechanism regulating insulin hormone production and its essential role in the treatment of diabetes.
Diabetes-resistant mice develop a protective beta cell cluster with reduced glucose uptake and increased beta cell division, while diabetic-prone mice experience metabolic stress and beta cell failure. This study reveals the key role of adaptive gene expression in protecting against type 2 diabetes.
A study published in Cell found that a Western-style diet high in sugar alters the gut microbiome, leading to metabolic disease, pre-diabetes, and weight gain. Eliminating sugar from the diet restored the protective effects of Th17 immune cells, which were depleted by the sugar.
A meta-analysis of clinical trials found that SGLT2 inhibitors, like dapagliflozin and empagliflozin, reduce cardiovascular death and hospitalization in patients with mildly reduced or preserved ejection fraction heart failure. These drugs may benefit a wide range of patients, regardless of age, sex, or medical history.
Researchers have combined tesaglitazar and GLP-1 in a new hormone combination for type 2 diabetes treatment, improving glucose metabolism with minimal doses. The new drug has shown promise in animal studies, reducing kidney damage and increasing insulin sensitivity.
A study by Children's Hospital Colorado reveals a 77% surge in newly diagnosed youth-onset type 2 diabetes cases during the COVID-19 pandemic. The increasing prevalence of obesity and unhealthy habits since the pandemic's onset are thought to contribute to this rise.
A recent study by Johns Hopkins Children's Center researchers found a significant rise in type 2 diabetes cases among children during the COVID-19 pandemic. The increase was largely attributed to reduced physical activity and weight gain due to lockdowns and virtual learning.
Researchers found that participants who received cooking education showed improvements in eating more vegetables, fewer carbohydrates, and lower A1C levels. The study also highlighted the importance of addressing food insecurity in diabetes management.
A new study identifies PDIA3 as a molecule targeted by the immune system in response to stress, contributing to liver damage in type 2 diabetes and obesity. Elevated levels of antibodies for PDIA3 have been found in people with these conditions, but improving diet and weight can reverse this liver condition.
Using standing desks alongside other measures reduced office workers' sitting time by about an hour a day over one year, leading to small improvements in stress, well-being, and energy levels. A height-adjustable desk was three times more effective than the standard SWAL intervention in reducing sitting time.
Researchers discovered a rare genetic mutation that may lead to better diabetes treatments for patients, regardless of whether they inherited the mutation. The study found that carriers of the mutation had lower levels of adiponectin and higher levels of ceramides in their blood.
A new study suggests that the true figure of undiagnosed diabetes in the US is significantly lower than current government estimates, with a prevalence rate of around 9.5% of the total diabetes burden. Disparities in access to healthcare and screening contribute to higher rates in older adults, racial/ethnic minorities, and those witho...
A UCI-led study found that Rhodiola rosea extract improved glucose homeostasis, modulated the gut microbiome, and reduced inflammatory biomarkers in a mouse model of type 2 diabetes. The results suggest potential benefits for treating the condition through changes in the microbiome.
Researchers developed an AI algorithm using individual ECG heartbeats to accurately predict diabetes and pre-diabetes. The DiaBeats algorithm detected the diseases with an overall accuracy of 97%, irrespective of factors like age, gender, and coexisting metabolic disorders.
A world-first study reveals a direct link between low vitamin D and high inflammation, providing a biomarker for those at risk of chronic illnesses. Boosting vitamin D in people with deficiencies may reduce chronic inflammation.
A team of researchers at Mount Sinai discovered a molecular mechanism involving carbohydrate response-element binding protein (ChREBP) that plays a key role in glucose toxicity and beta-cell death. Increasing expression of an alternate form of ChREBP or activating nuclear factor-erythroid factor 2 can preserve beta-cell mass.
Researchers have developed a novel approach to engineering live bacterial therapeutics by using native microbes that can survive in the gut. This method overcomes previous limitations of introducing engineered bacteria into the gut, demonstrating potential for long-term therapy and reversal of disease pathologies in mouse models.
The Women's Preventive Services Initiative issues guidelines for preventing obesity in midlife women, recommending counseling on healthy eating and physical activity. The guideline aims to mitigate concerns about weight stigma by normalizing counseling among all midlife women, regardless of BMI status.
A new study from Edith Cowan University found that acupuncture therapy significantly improved fasting plasma glucose, two-hour plasma glucose, and glycated haemoglobin levels in people with prediabetes. The therapy also showed a greater decline in the incidence of prediabetes without adverse reactions.
A recent JAMA study found a positive association between high insulin dosage and cancer incidence among patients with type 1 diabetes. The study suggests that clinicians may need to balance cancer risk when treating patients on high insulin doses, with improving insulin sensitivity potentially being a preferred approach.
A recent study published in Nutrients suggests that regular quinoa consumption can help prevent type 2 diabetes. Researchers replaced carbohydrate-rich foods with quinoa and found a significant reduction in post-meal blood sugar spikes. By mitigating this spike, quinoa may play a crucial role in preventing the progression of type 2 dia...
Researchers found that lactating mothers expose their pups to triclosan, leading to early signs of liver damage that can progress to nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Exposure to triclosan in early life may lay the groundwork for future development of fatty liver disease.
Arterial stiffness in adolescence is a novel risk factor for hypertension, insulin resistance, and type 2 diabetes in young adulthood and mid-adulthood. Risk factors include maternal smoking habits, early life smoking patterns, high salt intake, genetic inheritance, obesity, and elevated blood pressure from childhood.
A new study published in Diabetologia finds that limiting food intake to a 10-hour window during the day improves metabolic health in adults with type 2 diabetes. The research, conducted by Prof Patrick Schrauwen and colleagues, shows a decrease in 24-hour glucose levels and an increase in time spent with normal blood glucose levels.
Researchers at Monash University have discovered a new pathway to regenerate insulin in pancreatic stem cells, which could lead to new therapies for Type 1 and Type 2 diabetes. The study uses a drug approved by the US FDA to reactivate dormant insulin-producing cells, paving the way for potential treatments.
A systematic review by Leicester researchers has explored common methods used to predict years of life lost, highlighting differences between basic and advanced methods. The study aims to provide a comprehensive guide for healthcare professionals and researchers, promoting better understanding of life expectancy metrics.
Scientists have developed a new class of antidiabetic drugs called Adipeutics that specifically target adipocytes to restore glucose uptake. This therapy has shown promising results in animal models and holds potential for addressing not only type 2 diabetes but also related medical conditions.
Researchers analyzed data from 11 populations of adults totaling nearly 400,000 men and women, finding no correlation between refined grain intake and the risk of developing type 2 diabetes. In contrast, total grain intake was consistently associated with a lower risk of T2D.
A new study by the University of Pittsburgh found that patients with diabetes on Medicare Advantage plans are more likely to receive preventive treatments, but less likely to receive newer and more expensive medications. This disparity can lead to poorer health outcomes, including higher blood pressure and worse diabetes control.
Eating one avocado a day for six months improved overall diet quality by eight points and slightly decreased LDL cholesterol levels. However, avocados had no effect on belly fat or weight gain in participants with overweight or obesity.
A study published in Cell Reports found that a rhythmic small intestinal microbiome prevents obesity and type 2 diabetes in mice. The researchers used mouse models to explore how diet and feeding patterns affect the gut microbiome and its impact on host health, particularly with obesity and type 2 diabetes.
A study of over 1000 consumers from Australia and NZ found that 27% would pay nearly double the price for 'healthy' drinks with low/no sugar, natural/no additives, or vitamins and minerals. Younger consumers (18-24 years) are more likely to be interested in healthy drinks.
Researchers at University of Basel found that the sight and smell of a meal stimulate an inflammatory response in the brain, which affects insulin secretion. In overweight individuals, this response is excessive and can impair insulin function.
The American Heart Association has revised its cardiovascular health checklist to include sleep duration as a key factor in ideal heart and brain health. The new Life's Essential 8 score replaces the previous Life's Simple 7 and assesses factors such as diet, physical activity, nicotine exposure, and blood pressure.
A University of Houston study found that 61% of Black and Hispanic adolescents have low vitamin D levels, which can lead to cardiovascular disease, certain cancers, type 2 diabetes, and renal disease. The research emphasizes the importance of raising awareness among clinicians about social determinants of health and providing culturall...
A narrative review of endoscopic sleeve gastroplasty (ESG) highlights its potential as a minimally invasive weight loss procedure. The review concludes that ESG induces significant weight loss and improves obesity-related conditions, with the technique's success attributed to delayed gastric emptying. Researchers support the use of ESG...
Research by Oregon State University has explained the biosynthetic pathway underlying the production of acarbose, a type 2 diabetes drug. The findings could lead to improvements in industrial production through biotechnological approaches.
A new study reveals that IL18 signaling is essential for β-cell development and insulin secretion, using specific receptors on acinar and β cells. This finding may provide insights into the role of IL18 in regulating islet β cell proliferation and guide future efforts to expand β cells and increase islet mass in diabetes.
A study published in Alzheimer's & Dementia found that individuals with at least two cardiometabolic diseases, such as type 2 diabetes and heart disease, double their risk of developing dementia. The study suggests that prevention of these diseases could be a strategy for reducing dementia risk.
Researchers have developed a test that measures blood levels of ceramides, a waxy substance similar to cholesterol, to predict diabetes remission in gastric bypass surgery patients. The study found that individuals with low ceramide levels prior to surgery had a higher likelihood of achieving diabetes remission two years later.
A new study has found that nonalcoholic fatty liver disease (NAFLD) in children significantly increases the risk of developing type 2 diabetes. The study, published in Clinical Gastroenterology and Hepatology, revealed that among 892 children with NAFLD, 6.6% developed type 2 diabetes, with the incidence rate rising by 3% annually.
Researchers at Karolinska Institutet describe a new way of generating insulin-producing cells using a molecule that stimulates protein synthesis and boosts insulin production. The study shows promise for treating type 1 and 2 diabetes, potentially increasing the number of insulin-producing pancreatic β cells.
Research found that patients using insulin have a higher risk of fractures compared to those using metformin, particularly in non-obese and well-controlled diabetic patients. Routine fracture risk assessments are recommended for these individuals.
A randomized controlled trial shows significant improvements in testosterone replacement therapy for men with poorly-controlled type 2 diabetes and hypogonadism. The treatment improved symptoms, libido, and quality of life, as well as delayed verbal recall, a potential early sign of dementia.