Articles tagged with Type 2 Diabetes
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Researchers found that poorer blood sugar control, as measured by haemoglobin A1c, was associated with higher core body temperature and increased heart rate during exercise in a heated chamber. This suggests that people with type 2 diabetes may be at greater risk of heat-related stress and heat-related injuries.
Researchers found that continuous glucose monitors and wearable devices pose challenges for patients and caregivers, including issues with hardware, software, and device use. Nearly three-quarters of participants experienced low blood sugar levels, highlighting the need for improved technology to manage diabetes effectively.
A diabetes screening program in an urban emergency department found high rates of undiagnosed prediabetes and type 2 diabetes among racial and ethnic minority individuals and low-income patients. The study suggests that targeted outreach to those with higher hemoglobin A1c levels may be more cost-effective.
A study by Brigham and Women's Hospital investigators found early signs of eye damage before type 2 diabetes onset, suggesting pre-diabetic complications. They discovered immune cells migrating to the lens, causing cellular changes that compromise lens function.
Researchers have identified serine as a key contributor to peripheral neuropathy in diabetes, a condition that affects approximately half of people with type 1 or type 2 diabetes. Supplementing diabetic mice with serine alleviated neuropathy symptoms, suggesting a potential treatment option.
A UK study found that people with type 2 diabetes have substantially higher cancer mortality rates than the general population. Breast cancer mortality in younger women with T2D is rising, highlighting the need for extended screening, better management of diabetes and its complications, and improved cancer treatments.
A six-year study published in the Journal of the American Heart Association found that reducing overall calorie intake was a stronger determinant of weight change than meal timing. The research suggests that limiting total eating window during the day may not be as effective for controlling weight as previously thought.
A large cohort study found an association between dietary nitrite intake and increased risk of type 2 diabetes. The study, which included over 104,000 participants, suggests that limiting the use of nitrite additives in processed meats may be necessary to reduce this risk.
A new twin study by Karolinska Institutet suggests that the same genes may be behind both cardiometabolic diseases and dementia. The study found that individuals with multiple cardiometabolic conditions had a significantly increased risk of developing dementia.
A new study by the University of Coimbra found that higher coffee intake is associated with reduced NAFLD severity in overweight people with T2D. Caffeine and polyphenols in coffee may help alleviate liver fibrosis and improve glucose homeostasis.
Researchers at WashU Medicine discovered a link between obesity and diabetes, highlighting the importance of an enzyme in fatty acid processing. The study suggests that defects in this enzyme contribute to insulin hypersecretion and beta cell failure, paving the way for potential therapeutic interventions.
Researchers at the University of Cambridge developed an artificial pancreas that can help maintain healthy glucose levels in type 2 diabetes patients. The device doubled the time spent in the target range for glucose and halved the time spent with high glucose levels, reducing average glucose levels and glycated haemoglobin levels.
A new study uses machine learning to predict poor glycemic control in patients with type 2 diabetes, identifying key factors such as prior glucose levels and anti-diabetic medicines. The findings suggest that data routinely collected for diabetes monitoring can reliably identify patients at risk of hyperglycemia.
Researchers found that people with higher levels of Coprococcus tended to have higher insulin sensitivity, while those with Flavonifractor had lower insulin sensitivity. The study aimed to understand the relationship between microbiome composition and diabetes development.
Researchers found that xanthan gum-based fluid thickener decreases postprandial blood glucose levels by increasing Glp1 and Glp1r expression in the ileum. Additionally, the study reveals alterations in gut microbiome composition, favoring beneficial bacteria that produce short-chain fatty acids to protect intestinal cells.
A new study found that drinking two or more cups of coffee daily may increase the risk of cardiovascular disease mortality among people with severe hypertension. In contrast, moderate green tea consumption did not show a significant association with increased risk, suggesting potential benefits of polyphenols in reducing mortality.
A study published in Circulation found that walking between 6,000 and 9,000 steps per day significantly lowers the risk of a cardiovascular event in older adults. For those who are least active, even small increases in daily step count can have a substantial impact on heart health.
Research published in Developmental Medicine & Child Neurology reveals a link between maternal diabetes and neurodevelopmental disorders such as autism, ADHD, and intellectual disability in children. Type 1 and type 2 diabetes were associated with increased risks of these conditions, while gestational diabetes was linked to autism spec...
Researchers developed a new epigenetic biomarker, GrimAge version 2, which leverages two DNAm-based estimators of plasma proteins to predict mortality risk. The study found that GrimAge 2 outperforms existing clinical biomarkers in predicting mortality across multiple racial/ethnic groups and associations with age-related conditions.
A study found that metformin use significantly reduces the risk of total knee and hip replacements in patients with type 2 diabetes. The researchers analyzed data from over 69,000 participants and discovered a significant association between metformin use and lower joint replacement rates.
A study in wild mice reveals that metformin's antidiabetic effects depend on the presence of GDF15, a protein that responds to cellular stress. GDF15 activates AMPK, a metabolic sensor involved in energy balance, and its levels increase with metformin treatment.
A systematic review and meta-analysis of 53 studies found that obesity is not a universal phenotype in children with type 2 diabetes. Further studies are needed to understand the mechanisms driving this condition in children with type 2 diabetes.
A new study found that a machine learning-based blood test can accurately predict an individual's entire diet over 19 food groups, outperforming traditional methods. The test, which uses molecular profiling, also identifies who is more likely to develop diabetes and cardiovascular disease based on each food group.
A new study found that intermittent fasting can lead to complete diabetes remission in people with type 2 diabetes, with 55% of participants discontinuing their medication and maintaining it for at least a year. The study also showed that diabetes medications costs decreased by 77% after intermittent fasting.
Women who take more steps per day have a lower risk of developing type 2 diabetes, with those taking 10,700 steps daily being 44% less likely to develop the condition. The study analyzed over 5,700 participants and found a significant correlation between physical activity and reduced diabetes risk.
A study found that drinking caffeinated coffee daily can reduce the risk of type 2 diabetes by 10-53% in women who had gestational diabetes during pregnancy. Replacing sugary drinks with coffee also shows a 10-17% reduced risk.
A randomized controlled trial found that a low-carbohydrate, high-fat diet helped patients with type 2 diabetes achieve better weight loss and glucose control over a 6-month intervention compared to a high-carb, low-fat diet. However, changes were not sustained 3 months after the intervention.
Global rates of type 2 diabetes in adolescents and young adults have increased significantly between 1990 and 2019, with countries with lower socioeconomic development and women under 30 showing the largest increases. High body mass index is the main contributing factor to this trend.
A retrospective cohort study of 1,404 subjects with type 2 diabetes found that metformin use reduced the risk of delirium by 50% and decreased 3-year mortality rates. The study suggests that metformin may be a potential benefit for patients with diabetes, particularly in reducing age-related disorders such as dementia.
Researchers have developed a preventative therapeutic approach that prevents stress-induced cell death in pancreatic cells, a hallmark of type 1 diabetes. The treatment targets the GLIS3-MANF pathway common to both major types of diabetes.
A new study allows people with type 2 diabetes to choose their own medication after trying three different drugs in succession. The approach resulted in better glucose control and fewer side effects compared to other methods. Researchers conclude that patients should try before choosing a treatment for optimal results.
A study published in the Hypertension journal suggests that bromocriptine, a Parkinson's disease medication, may help prevent heart disease in youth with Type 1 diabetes. The research found that teens with Type 1 diabetes who took bromocriptine had lower blood pressure and less stiff arteries after one month of treatment.
A new University of Otago study found that only half of women with gestational diabetes were tested for type 2 diabetes within six months of giving birth. The study also highlighted ethnic and regional disparities in testing rates, with Māori women being particularly under-tested.
A study of over one million Medicaid beneficiaries found that more than half experienced significant lapses in coverage, with only 25% continuously enrolled throughout the period. The authors recommend increasing investments to improve long-term health outcomes.
A recent study found that consuming the most vegetables, including leafy greens and cruciferous veggies, was associated with a lower risk of developing Type 2 diabetes. Meanwhile, potatoes may not have the same benefits but aren't bad if prepared in a healthy way.
Researchers at Klick Applied Sciences have created a machine learning model to predict diabetes onset in patients using just 12 hours of data from continuous glucose monitors. The study showed high accuracy in identifying prediabetes, healthy patients, and those with Type 2 diabetes, offering a potential tool for early disease prevention.
A study of over 1000 Australian adults found that people with trouble sleeping were more likely to have indicators of poor cardiometabolic health, including inflammatory markers, cholesterol, and body weight. Prioritizing a good night's sleep is crucial for maintaining good health, according to researcher Dr Lisa Matricciani.
A study found that South Asian women with genes associated with type 2 diabetes are at a higher risk of developing gestational diabetes during pregnancy. The researchers identified genetic signatures linked with type 2 diabetes risk as strongly and independently associated with gestational diabetes in this population.
A new survey by the European Federation of Dietitians supports moderate coffee consumption as having clear health benefits, including improved alertness and sports performance. The study involved 585 dietitians from across 26 European countries.
Researchers explore the interactions between adipose tissues and surrounding blood vessels in connection with lipid metabolism and associated diseases. Targeting angiogenesis may provide a gateway for treating obesity, while its inhibition or promotion depends on the specific disease context.
A UK Biobank study found that screening all adults aged 40-70 years for type 2 diabetes using HbA1c could detect up to 250,000 undiagnosed cases, bringing diagnoses forward by 2.2 years on average.
A study published in PLOS ONE found that adults with type 2 diabetes taking metformin had a 45% lower risk of needing a breathing machine or dying from COVID-19 compared to those not taking the medication. The research team analyzed data from a large database and suggested metformin may be an effective treatment option for reducing COV...
Researchers found that a genetic mutation associated with liver disease confers different levels of risk depending on a patient's diabetic status. In diabetic patients, the mutation predisposes them to nonalcoholic fatty liver disease, but in nondiabetic patients, it protects against liver disease.
Researchers found that individuals with CYP8B1 loss-of-function mutations have improved insulin sensitivity and better glucose regulation, reducing the risk of developing Type 2 diabetes. The study suggests a potential new treatment approach using bile acid modulators to target this gene.
A new study by Cedars-Sinai investigators has identified risk factors for developing diabetes in people with chronic pancreatitis, including smoking and being overweight. The findings suggest that models can be built to predict diabetes risk, allowing clinicians to connect patients with weight loss or smoking cessation programs.
A new study published in the Journal of Clinical Endocrinology & Metabolism reveals that pancreas transplantation can provide up to 90% of recipients with diabetes freedom from insulin therapy and glucose monitoring. Despite high success rates, transplant numbers have declined due to lack of consensus criteria, education, and resource ...
A novel HNF1A gene variant has been found to cause monogenic diabetes, affecting almost seven percent of all cases in Greenland. This discovery may pave the way for precision treatment using tablet therapy with sulphonylurea, offering a simpler and cheaper alternative to insulin.
The USPSTF recommends against routine screening for obstructive sleep apnea (OSA) in asymptomatic adults and those with unrecognized symptoms. OSA is linked to various adverse health outcomes, including cardiovascular disease and cognitive impairment.
A study of 11,945 people found that those with type 2 diabetes are more likely to be diagnosed with advanced cancer if the condition is not screened for routinely. Researchers identified a 26% increased risk of metastasis in patients with pre-existing type 2 diabetes.
Scientists identified a three-protein signature in the blood that can improve detection of isolated impaired glucose tolerance, a form of prediabetes. The new test reduces the number of individuals who need to undergo oral glucose tolerance testing.
Researchers at Technical University of Munich developed synthetic peptides that bind to proteins forming amyloids, preventing their aggregation. These peptides could be valuable candidates for treating both diseases, with potential for medical application.
A high-quality Nile rat genome sequence has been assembled, expanding its potential as a model organism for studying type 2 diabetes and disorders associated with disrupted circadian rhythms. The genome's long contigs and completeness make it suitable for investigating the genetic factors contributing to disease, including epigenetics.
Regular use of cholesterol-lowering and diabetes-control drugs may lessen the risk of age-related macular degeneration (AMD) in European populations. The pooled data analysis involved 38,694 participants and showed a 15% lower prevalence of any type of AMD with these medications.
A new medication, pemafibrate, lowered triglyceride levels among adults with Type 2 diabetes, but did not decrease their cardiovascular risk. The study found that lowering triglyceride levels may not protect against cardiovascular disease in people with Type 2 diabetes.
A new study has shown that SGLT-2 inhibitors, a type of diabetes medication, can decrease cardiovascular risk in adults with chronic kidney disease. The meta-analysis included results from 13 major clinical trials and found a 28% lower risk of worsening kidney disease and death from cardiovascular disease.
A study of over 1.3 million young Asian American adults hospitalized for atrial fibrillation found a significant increase in obesity and other modifiable cardiovascular disease risk factors. Young adults with at least one cardiovascular risk factor were almost three times more likely to be hospitalized for atrial fibrillation.
A study found that living in a food desert increases the risk of heart attack, stroke, and early death for people with PAD. People with PAD living in food deserts were 17% more likely to experience a major cardiac event compared to those with better nutrition access.
Research found social vulnerabilities such as poverty and minority status linked to increased cardiometabolic risk during pregnancy. The study analyzed nearly 19 million pregnancies in US counties from 2016-2020 and found that four leading cardiometabolic risk factors were associated with some social vulnerability.
A one-year lifestyle intervention with a digital app and group counselling improved diet quality, reduced abdominal obesity and insulin resistance among 2907 Finnish adults at risk of type 2 diabetes. The study suggests that commitment to lifestyle counselling supports positive changes.
A team of researchers at USC is launching a comprehensive study to investigate the connection between type 2 diabetes and dementia in adults with Hispanic ancestry. The five-year study will examine brain structure and activity, blood flow, blood glucose and insulin levels, and cognitive functioning in 200 participants.