Articles tagged with Type 2 Diabetes
Researchers at Klick Applied Sciences have created a machine learning model to predict diabetes onset in patients using just 12 hours of data from continuous glucose monitors. The study showed high accuracy in identifying prediabetes, healthy patients, and those with Type 2 diabetes, offering a potential tool for early disease prevention.
A study of over 1000 Australian adults found that people with trouble sleeping were more likely to have indicators of poor cardiometabolic health, including inflammatory markers, cholesterol, and body weight. Prioritizing a good night's sleep is crucial for maintaining good health, according to researcher Dr Lisa Matricciani.
A UK Biobank study found that screening all adults aged 40-70 years for type 2 diabetes using HbA1c could detect up to 250,000 undiagnosed cases, bringing diagnoses forward by 2.2 years on average.
A study found that South Asian women with genes associated with type 2 diabetes are at a higher risk of developing gestational diabetes during pregnancy. The researchers identified genetic signatures linked with type 2 diabetes risk as strongly and independently associated with gestational diabetes in this population.
A new survey by the European Federation of Dietitians supports moderate coffee consumption as having clear health benefits, including improved alertness and sports performance. The study involved 585 dietitians from across 26 European countries.
Researchers explore the interactions between adipose tissues and surrounding blood vessels in connection with lipid metabolism and associated diseases. Targeting angiogenesis may provide a gateway for treating obesity, while its inhibition or promotion depends on the specific disease context.
Researchers found that individuals with CYP8B1 loss-of-function mutations have improved insulin sensitivity and better glucose regulation, reducing the risk of developing Type 2 diabetes. The study suggests a potential new treatment approach using bile acid modulators to target this gene.
A study published in PLOS ONE found that adults with type 2 diabetes taking metformin had a 45% lower risk of needing a breathing machine or dying from COVID-19 compared to those not taking the medication. The research team analyzed data from a large database and suggested metformin may be an effective treatment option for reducing COV...
Researchers found that a genetic mutation associated with liver disease confers different levels of risk depending on a patient's diabetic status. In diabetic patients, the mutation predisposes them to nonalcoholic fatty liver disease, but in nondiabetic patients, it protects against liver disease.
A new study by Cedars-Sinai investigators has identified risk factors for developing diabetes in people with chronic pancreatitis, including smoking and being overweight. The findings suggest that models can be built to predict diabetes risk, allowing clinicians to connect patients with weight loss or smoking cessation programs.
A study of 11,945 people found that those with type 2 diabetes are more likely to be diagnosed with advanced cancer if the condition is not screened for routinely. Researchers identified a 26% increased risk of metastasis in patients with pre-existing type 2 diabetes.
A new study published in the Journal of Clinical Endocrinology & Metabolism reveals that pancreas transplantation can provide up to 90% of recipients with diabetes freedom from insulin therapy and glucose monitoring. Despite high success rates, transplant numbers have declined due to lack of consensus criteria, education, and resource ...
A novel HNF1A gene variant has been found to cause monogenic diabetes, affecting almost seven percent of all cases in Greenland. This discovery may pave the way for precision treatment using tablet therapy with sulphonylurea, offering a simpler and cheaper alternative to insulin.
The USPSTF recommends against routine screening for obstructive sleep apnea (OSA) in asymptomatic adults and those with unrecognized symptoms. OSA is linked to various adverse health outcomes, including cardiovascular disease and cognitive impairment.
Scientists identified a three-protein signature in the blood that can improve detection of isolated impaired glucose tolerance, a form of prediabetes. The new test reduces the number of individuals who need to undergo oral glucose tolerance testing.
A high-quality Nile rat genome sequence has been assembled, expanding its potential as a model organism for studying type 2 diabetes and disorders associated with disrupted circadian rhythms. The genome's long contigs and completeness make it suitable for investigating the genetic factors contributing to disease, including epigenetics.
Researchers at Technical University of Munich developed synthetic peptides that bind to proteins forming amyloids, preventing their aggregation. These peptides could be valuable candidates for treating both diseases, with potential for medical application.
Regular use of cholesterol-lowering and diabetes-control drugs may lessen the risk of age-related macular degeneration (AMD) in European populations. The pooled data analysis involved 38,694 participants and showed a 15% lower prevalence of any type of AMD with these medications.
A new study has shown that SGLT-2 inhibitors, a type of diabetes medication, can decrease cardiovascular risk in adults with chronic kidney disease. The meta-analysis included results from 13 major clinical trials and found a 28% lower risk of worsening kidney disease and death from cardiovascular disease.
A new medication, pemafibrate, lowered triglyceride levels among adults with Type 2 diabetes, but did not decrease their cardiovascular risk. The study found that lowering triglyceride levels may not protect against cardiovascular disease in people with Type 2 diabetes.
A study found that living in a food desert increases the risk of heart attack, stroke, and early death for people with PAD. People with PAD living in food deserts were 17% more likely to experience a major cardiac event compared to those with better nutrition access.
Research found social vulnerabilities such as poverty and minority status linked to increased cardiometabolic risk during pregnancy. The study analyzed nearly 19 million pregnancies in US counties from 2016-2020 and found that four leading cardiometabolic risk factors were associated with some social vulnerability.
A study of over 1.3 million young Asian American adults hospitalized for atrial fibrillation found a significant increase in obesity and other modifiable cardiovascular disease risk factors. Young adults with at least one cardiovascular risk factor were almost three times more likely to be hospitalized for atrial fibrillation.
A one-year lifestyle intervention with a digital app and group counselling improved diet quality, reduced abdominal obesity and insulin resistance among 2907 Finnish adults at risk of type 2 diabetes. The study suggests that commitment to lifestyle counselling supports positive changes.
A team of researchers at USC is launching a comprehensive study to investigate the connection between type 2 diabetes and dementia in adults with Hispanic ancestry. The five-year study will examine brain structure and activity, blood flow, blood glucose and insulin levels, and cognitive functioning in 200 participants.
Researchers at Tulane University have discovered that following a low-carbohydrate diet can lead to reduced hemoglobin A1c levels and improved fasting glucose levels among individuals with unmedicated diabetes and prediabetes. The study suggests that a low-carb diet may be a useful approach for preventing and treating Type 2 diabetes.
A 6-month randomized clinical trial found that a low-carbohydrate diet intervention resulted in larger reductions in hemoglobin A1c (HbA1c) levels compared to usual diet among adults with elevated untreated HbA1c. The study suggests that this dietary approach may be useful for preventing and treating type 2 diabetes.
A recent review study highlights the potential of GDF15 as a therapeutic target for type 2 diabetes, citing its beneficial effects on metabolism and weight loss. The study reveals that GDF15 can activate mechanisms to counteract processes like inflammation and insulin resistance.
A study published in Diabetes Care found that trigger finger is more prevalent among individuals with diabetes, particularly those with poorly regulated blood sugar. The risk of trigger finger increases with poor HbA1C levels, highlighting the potential link between blood sugar dysregulation and this condition.
Helmholtz Munich researchers identified a novel strategy to alter glucagon receptor signaling by changing its intracellular localization. This approach offers therapeutic potential for treating type 2 diabetes by uncoupling glucose and lipid metabolism-related effects.
A team of scientists at Scripps Research and Calibr discovered a naturally occurring metabolite called myristoylglycine that can convert white fat cells into brown fat cells, potentially treating obesity and related diseases. The breakthrough uses a novel drug discovery method to identify endogenous metabolites with therapeutic potential.
A recent study published in the Journal of Nutritional Science found that consuming potatoes has no increased risk of cardiometabolic disorders. In fact, those who ate more potatoes also consumed more fruits and vegetables, meeting dietary guidelines recommendations.
A long-term study found that older patients with type 2 diabetes treated with glitazones had a 22% lower risk of developing dementia. These drugs may effectively prevent dementia in high-risk patients and are now worth prioritizing for future clinical studies.
Researchers identified protein levels that were higher or lower than normal in tissues from individuals at different stages of type 2 diabetes. The study found a correlation between metabolic pathway disturbances and disease progression, suggesting new potential causal mechanisms for the disease.
A large clinical trial found that insulin glargine and liraglutide were superior to other diabetes drugs in controlling blood sugars. The study, published in the New England Journal of Medicine, compared four common medications used to treat type 2 diabetes when added to metformin.
A study published in the Journal of the American Geriatrics Society found that individuals with type 2 diabetes who exhibit psychological resilience experience fewer hospitalizations, better physical functioning, and a lower likelihood of becoming frail. Psychological resilience also appears to mitigate aging-related concerns.
A new study by Queen Mary University of London reveals that children and young adults with Down Syndrome are four times more likely to be diagnosed with type 2 diabetes. The research, which examined over 9,000 individuals with Down Syndrome, found a 10-fold increased risk of developing the condition in those aged five-14.
A study at Michigan Medicine found multiple lipid biomarkers linked to diabetic neuropathy in patients with type 2 diabetes. High scores for neuropathy were associated with changes in lipids reflecting impaired energy metabolism, suggesting a potential target for testing and managing the condition.
Researchers found that all mind-body practices led to significant reductions in blood sugar levels, with yoga providing the largest benefit. The study suggests that these practices could be used as a complementary nonpharmacological treatment or preventive measure for type 2 diabetes.
A new study found that feelings of loneliness are strongly associated with a higher risk of developing type 2 diabetes. Individuals who reported feeling lonely were twice as likely to develop T2D than those who did not feel lonely.
Researchers found that knocking out TXNIP in alpha cells improves diabetes-associated hyperglycemia and hyperglucagonemia. This discovery suggests a new potential treatment for Type 1 diabetes.
A cohort study of nearly 200,000 people found that intentional weight loss reduces the risk of type 2 diabetes for those who are overweight or obese. However, for lean individuals, weight loss attempts are associated with longer-term weight gain and higher risks of type 2 diabetes.
A study found that building trust with community health workers (promotores) can lead to long-term self-care in type 2 diabetes patients. 32.4% of participants achieved 'self-care generativity,' while 40.5% progressed to 'stabilization.' The model, called Nosotros, could be replicated to improve chronic disease management.
A new study found that placing a monthly cap on out-of-pocket costs for commercially insured patients could lower their highest monthly healthcare bills by 50-60%. A $500 monthly limit would affect about 25% of enrollees and reduce in-network OOP costs over a year by 46%, while a $250 limit would show a 51% reduction.
Researchers found that nerve damage in the cornea increases with glucose metabolism impairment and blood sugar levels, suggesting early detection may delay or prevent complications. The study suggests high blood sugar levels can begin to damage corneal nerves long before type 2 diabetes develops.
Women who underwent a hysterectomy before age 45 have a 52% increased risk of developing incident type 2 diabetes, according to a study of over 83,000 French women. The risk remains even if ovaries are not removed and is unrelated to diet and physical activity.
A study published in The BMJ found that adopting a healthy lifestyle can reduce the risk of type 2 diabetes by up to 90% in women with a history of gestational diabetes. Women who adhered to five key lifestyle factors had a significantly lower risk of developing type 2 diabetes, regardless of their weight or genetic risk.
Repeated cold-induced shivering improves glucose tolerance, decreases fasting blood sugar, and reduces blood fat levels in overweight adults. It also markedly lowers blood pressure and has a beneficial effect on triglycerides and free-fatty acids.
Researchers have genetically engineered human muscle cells to take up more sugar from the blood, reducing blood glucose levels by 20% in diabetic mice. The new tissue also shows promise for a single injection of tissue providing long-lasting glucose control.
Researchers at the University of Houston have discovered a way to activate the soleus muscle, which can sustain elevated oxidative metabolism and improve blood glucose regulation for hours. The 'soleus pushup' movement has been shown to increase oxygen consumption and reduce insulin requirements.
A pioneering behavioural diagnostic tool, SPUR, has been developed to improve medication adherence in type 2 diabetes patients. The study found that the tool can reliably identify patients struggling with their medicines and the reasons why.
Research found that 'night owls' are more insulin resistant, favoring carbohydrates over fats as an energy source. In contrast, 'early birds' are more active and use more fat for energy, reducing their risk of type 2 diabetes and cardiovascular disease.
Research at Karolinska Institutet shows that people with diabetes have lower levels of psoriasin, a key peptide that weakens the bladder's protective barrier function. This increases the risk of urinary tract infections. Oestrogen therapy may help regulate the immune response to UTIs in patients with diabetes.
A new study reveals that type 2 diabetes significantly shortens the life expectancy of women, younger individuals, and smokers, with a 60% increased risk of early death among women. The research also shows that diagnosis at an earlier age and smoking have a substantial impact on mortality rates.
A study by the University of Geneva team shows that disrupted circadian clocks lead to a rigidity in the membrane of pancreatic endocrine cells, affecting their function. The researchers also found that lipid profiles oscillate more during the day than previously thought, particularly in phospholipids and sphingolipids.
A systematic review and meta-analysis of 19 cohort studies involving over 1 million adults found that moderate tea consumption is associated with a lower risk of developing type 2 diabetes. Drinking at least four cups of tea a day may reduce the risk by 17%.
Researchers found that a healthy lifestyle can almost halve the likelihood of developing dementia in people with type 2 diabetes. The study followed 445,364 participants and found that those with diabetes who had an unhealthy lifestyle were 65% more likely to develop dementia than those with the healthiest lifestyle.
A new study of over half a million people with type 2 diabetes found that smoking and low physical activity significantly increase the risk of premature death. Individuals with type 2 diabetes who develop cancer are more likely to die in seven years if they are smokers or physically inactive.
Italian researchers found that dairy products, particularly low-fat ones and yogurt, are associated with a lower risk of developing type 2 diabetes. Red and processed meat were linked to an increased risk, but moderate amounts of fish and eggs could be eaten in their place.
Researchers investigated direction of attentional focus in prosthetic training to improve motor learning in individuals with lower limb loss. The study suggests that current practice can be refined to enhance rehabilitation outcomes for amputees.