Research on disease-causing bacteria and how they spread. Covers waterborne bacteria, Lyme disease ecology, pathogenic genetics, and biofilm treatments.
A genetic study has identified the origins of cavity-causing bacteria Bifidobacterium dentium Bd1, revealing its genetic adaptations for oral survival. The study found that the genome sequence of this bacterium has evolved through only a few horizontal gene acquisition events, highlighting the narrow boundary between beneficial and pat...
Scientists discovered that membrane ruffles are not essential for Salmonella to penetrate host cell membranes. A new factor called WASH promotes bacterial invasion by contributing to cytoskeletal filament formation.
A new DNA-based microarray platform has been developed to identify bacterial species rapidly and accurately, with a clinical sensitivity of 95% and specificity of 99%. The assay is 18 hours faster than the current gold-standard system, which could lead to improved clinical outcomes by allowing species-specific therapy to be started early.
Researchers have identified three chemicals – betaine, glutamate, and succinate – produced by a bacterium that cause coral bleaching. These substances are involved in the transformation of harmless marine bacteria into killers that choke off corals' energy supply.
Structural biologists reveal how internalin B dimer activates human receptor Met, allowing Listeria to infect cells. The discovery may lead to therapeutics for improved wound healing and treatment of listeriosis.
Researchers use cryo-electron tomography to elucidate molecular architecture of Treponema pallidum, shedding light on cellular structure and movement. The study provides new understanding of how the bacterium attaches to human cells and moves with its flagella.
Researchers describe molecular anatomy of Mycoplasma pneumoniae, a small bacterium that can survive on its own. The study reveals intricate networks and multifunctional molecules, challenging the idea of a 'minimal' cell.
A team of scientists has discovered how bacteria defend themselves from viruses and other invaders, unlocking opportunities for targeted antibiotics, gene function studies, and stable bacterial cultures. The CRISPR-Cas system, a dynamic duo of RNA and proteins, recognizes and neutralizes invader RNAs.
Scientists have crystallized a protein that enables beneficial bacteria to bind to the gut lining, interacting with cells and exerting their activity. The discovery opens new avenues of research into gut health and highlights the importance of molecular design in selecting probiotics.
A new study found that cigarettes are contaminated with numerous human bacterial pathogens, including Acinetobacter, Bacillus, Burkholderia, Clostridium, Klebsiella, and Pseudomonas aeruginosa. These bacteria may contribute to both infectious and chronic illnesses in smokers and secondhand smoke exposed individuals.
A recent study by Mitchell S. V. Elkind and colleagues found a possible link between cumulative exposure to five common infection-causing pathogens and an increased risk of stroke. The study followed 1,625 adults over a median of 7.6 years, with 67 participants experiencing strokes during the follow-up period.
A new imaging technique developed by a team of researchers could lead to the discovery of new antibiotics, antifungal, antiviral, and anti-cancer drugs. The method uses mass spectrometry to analyze chemical communication between microorganisms.
Researchers have developed thin films of silver and copper that can kill bacteria, potentially helping to reduce hospital infections. The antimicrobial properties of these metals have been known for centuries, and a recent study found that combining them may work synergistically to better eliminate microbes.
Scientists have observed the emergence of a new adaptation strategy in bacteria Pseudomonas fluorescens, where variable offspring can survive in different environments. This bet-hedging strategy allows for species survival under rapidly changing environmental conditions.
A team of scientists analyzed the DNA of ancient remains to discover that Mycobacterium leprae, the leprosy bacterium, has colonized the entire earth due to human travels. The study found that the bacteria's four strains are distributed according to historical population movements.
New research suggests that prolonged space travel weakens human immune systems, making astronauts more susceptible to disease. The study also found that microorganisms such as bacteria can grow more rapidly in space conditions, increasing the risk of contamination and serious infection.
A Mayo Clinic study found that Clostridium difficile infections are rising in outpatient settings, with a higher proportion of cases in younger populations. The study suggests that antibiotic use may be contributing to the increased incidence and severity of C. difficile infections.
Researchers at the University of Edinburgh discovered a strain of Staphylococcus aureus bacteria jumping from humans to chickens, marking the first clear evidence of bacterial pathogens crossing from humans to animals since domestication. This finding has significant implications for poultry farming and food security.
Researchers discovered a crucial immune system quirk that can lead to effective vaccines against tularemia infection of the lungs. By targeting IL-17 cytokine responses, scientists hope to develop better vaccines that can prevent lung infections.
Researchers found that chlorhexidine-soaked wipes did not reduce neonatal sepsis or vertical transmission of group B streptococcus. The study suggests that other interventions are needed to target child mortality and achieve the Millennium Development Goal of reducing childhood mortality.
Researchers used a novel high-throughput analysis technique to study every gene in Salmonella Typhi, revealing that only 356 genes are necessary for its survival. The TraDIS method has the potential to accelerate the discovery of new targets for treatment and improve our understanding of bacterial disease.
New evidence suggests that a select few beneficial bacteria, such as segmented filamentous bacteria (SFB), can induce accumulation of a highly specific branch of the immune system. SFB stimulate particular types of helper T cells, known as Th17 cells, which are involved in autoimmune diseases like Crohn's disease and psoriasis.
Researchers have discovered a unique bacterial species that can stimulate specialized immune cells in mice, potentially providing insights into human gut-dwelling microbes. This finding could lead to new understanding of how beneficial bacteria protect against pathogenic invaders.
Researchers at the University of Gothenburg have identified a protein called MUC1 as an important part of the body's defense against Helicobacter pylori. Genetic variations in MUC1 molecules may contribute to why some people are more ill than others with stomach ulcers and stomach cancer.
Intracellular pathogens like Chlamydia and Legionella exploit host cell biology to escape destruction. Researchers found that SNARE-like proteins expressed by the bacteria inhibit membrane fusion with lysosomes, allowing them to remain in cells.
Researchers will investigate the activation of TLR4 and responses inside human cornea cells, with a goal to identify potential targets for anti-inflammatory intervention. The study aims to discover specific toll-like receptor antagonists to regulate corneal inflammation, potentially leading to novel medication alternatives.
A UBC research team has identified dendritic cells as a crucial part of the immune system's defense against bacterial infections. The study reveals that dendritic cells use cross-presentation to activate the immune system, and deactivating this process can lead to severe compromise in fighting Listeria infections.
Virginia Tech's CyberInfrastructure Group receives funding to integrate pathogen data, provide key resources and tools, and analyze genomic and proteomic data. The Pathogen Portal will serve as a centralized gateway for biomedical researchers.
Research found that light and photosynthesis aid in bacterial internalization within lettuce leaves. This makes the bacteria impervious to washing and food sanitizers. The study suggests that the increased internalization is due to open stomata allowing nutrient uptake during photosynthesis.
Research finds that pathogenic E. coli are common in Michigan and Indiana streams, even with low fecal indicator bacteria concentrations. The study suggests that current methods for determining water quality may not accurately predict the presence of harmful pathogens.
Rice University biochemists are developing a system of 'evolutionary forecasting' to better understand the mechanisms of antibiotic resistance. By sequencing genomes and analyzing molecular changes, they hope to identify patterns and rules governing how bacteria evolve to become drug-resistant.
Researchers discovered a previously unknown mechanism that aids in the spread of Listeria monocytogenes, a deadly bacterium causing listeriosis and severe illnesses.
A CU-Boulder study found that 30% of showerheads harbor significant levels of Mycobacterium avium, a pathogen linked to pulmonary disease. The researchers discovered biofilms on the inside of showerheads containing high loads of M. avium and related pathogens.
Researchers at NYU Langone Health have found a mechanism that makes human pathogens like MRSA and anthrax resistant to numerous antibiotics. By eliminating the oxidative stress caused by many antibiotics, NO can be neutralized, rendering existing antibiotics more potent at lower doses.
A new study found that bean plants' natural defenses against bacterial infections cause the bacteria to exchange DNA, potentially leading to the emergence of more pathogenic strains. This process could have significant implications for understanding the relationship between pathogens and their hosts.
Scientists have discovered how salmonella kills tumors by migrating into cancerous tissues and triggering a strong inflammatory response. The inflammatory response causes blood vessels in the tumor to become permeable, allowing salmonella to spread and ultimately kill the tumor.
A new biosensor developed by researchers at Rovira i Virgili University can detect extremely low levels of Salmonella typhi, the bacteria that causes typhoid fever, immediately and reliably. The technique uses carbon nanotubes and synthetic DNA fragments to activate an electric signal when they link up with the pathogen.
Scientists attach light-emitting genes to Listeria monocytogenes bacteria to detect their movement in real-time, revealing path of infection. The technology indicates which bacterial genes are switched on during infection and has potential for vaccine and DNA-delivery vectors.
Researchers found that pathogenic E. coli strains can survive modern food processing methods and exploit different food sources than laboratory strains. They demonstrated differences in growth characteristics, antimicrobial resistance, and reaction to environmental stresses.
Researchers have designed probiotics that can bind toxins in the gut, preventing them from interacting with host intestinal cells. These receptor-mimic probiotics offer a promising treatment for diseases such as cholera and traveller's diarrhoea, and may also be used to prevent outbreaks following natural disasters.
A large-scale study has reconstructed a key molecular circuit in mammalian immune cells, identifying over 100 regulators that work together to distinguish viruses from bacteria. The research provides a deeper understanding of immune biology and could inspire novel ways to treat disease and design better vaccines.
Researchers suggest engineering attenuated pathogens to mimic live viruses, inducing potent cellular response. The study identifies key immune patterns that distinguish pathogenic from non-pathogenic microbes.
Researchers at Sanford Burnham Prebys have identified a key enzyme in bacteria that can be targeted to kill dangerous pathogens. Chemical compounds have been discovered to inhibit this enzyme, showing promise for developing new antibacterial agents.
Researchers found that commensal bacteria in the human gut activate the immune system against Toxoplasma gondii by releasing signaling molecules, inducing inflammatory responses. The study suggests looking at gut bacteria to understand susceptibility to infectious diseases and developing novel probiotic strategies.
Researchers have identified a key protein, NanA, that allows pneumococcus bacteria to penetrate the brain, leading to meningitis. Removing or modifying this protein can prevent bacterial entry, offering potential new avenues for developing more effective vaccines.
Researchers have discovered a natural food preservative in mango seeds, which can inhibit the growth of deadly bacteria like Listeria. This breakthrough could help prevent outbreaks and save lives, as well as reduce waste by recycling fruit kernels.
New research by USGS scientists finds that ingesting beach sand can lead to gastrointestinal illness, with children more susceptible. Hand washing or sanitizing significantly reduces the risk of infection.
Researchers have identified a genomic 'signature' in circulating blood that reveals exposure to common upper respiratory viruses, such as the cold or flu. This signature reflects subtle but robust changes in genes activated by the body's response to infection, allowing for accurate diagnosis and personalized care.
Researchers at Duke University have solved the structure of Ramoplanin A2, a candidate antibiotic that can kill pathogenic bacteria by interrupting cell membrane formation. The molecule forms U-shaped structures that bind to Lipid II, preventing its participation in membrane synthesis and leading to bacterial death.
UT Southwestern Medical Center researchers have found that autophagy prevents harmful bacteria like Salmonella from becoming successful pathogens. Decreases in autophagy may lead to abnormalities in the intestinal tract's response to bacterial infections.
A new study finds that administration of a novel small molecule effectively disrupts quorum sensing in bacteria, protecting animal hosts from infection. The research offers a potential alternative to traditional antibiotics and may lead to more effective treatments for bacterial infections.
Researchers at VIB have determined the structure and operating mechanism of a deadly toxin-antitoxin system found in bacteria. The discovery provides new avenues for developing a class of antibiotics to combat bacterial threats.
Scientists at the University of Bath and University of Exeter have developed a technique to study bacterial infections in real-time with living organisms. They used fruit fly embryos to track bacterial movement and interaction with the immune system.
In a study mapping the gene profiles of children with severe Staphylococcus aureus infections, researchers found that the innate immune response is overactivated while the adaptive immune system is suppressed. This knowledge could lead to better patient outcomes and more effective therapies.
Researchers at TUM have identified a unique pathway in aggressive microorganisms, such as tuberculosis and malaria pathogens, that may be vulnerable to custom-tailored antibiotics. The discovery opens a promising approach for developing new reaction steps vital to microorganisms but irrelevant in humans.
Researchers discovered that GBS fools the immune system by reducing production of antibiotic molecules, allowing the bacteria to survive and proliferate. This understanding may lead to new targets for medical therapy to boost the immune system and clear GBS infection in critically ill newborns.
Researchers observed chemical changes in Desulfovibrio vulgaris cells as they endured air exposure, enabling some to survive through orchestrated metabolic events. This study provides a new window into bacterial adaptation and processes.
Researchers developed a new diagnostic method using tandem repeats in bacterial genomes to distinguish between pathogens like Vibrio cholerae and Vibrio parahaemolyticus. This technique can identify hundreds of bacteria strains quickly and accurately, helping track disease outbreaks and inform preventive measures.
Researchers at Scripps Research Institute have identified three proteins called Toll-like receptors as necessary for the autodestruction that occurs in autoimmune diseases like lupus. The study suggests that these TLRs may be good targets for therapy, potentially leading to new treatments for lupus and other autoimmune diseases.
Researchers at Ohio State University used mathematical modeling to determine the optimal timing of the immune response to tuberculosis, finding that introducing interferon gamma during early stages could shorten the switching time and reduce bacterial load. The study suggests a cocktail approach to new TB therapies.