Articles tagged with Bacterial Pathogens
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Researchers have discovered that Mycobacterium tuberculosis stimulates macrophages to accumulate fat droplets, turning them into 'foamy' cells that can reawaken the latent TB infection. This cellular transformation allows the bacteria to leak out into the airways and progressively destroy lung tissue.
Researchers have identified a molecule that blocks a key signaling pathway in pathogenic gut bacteria, reducing toxin production and preventing infection. This breakthrough discovery represents a novel class of antimicrobial agents with broad-spectrum efficacy.
Scientists at Sainsbury Laboratory have discovered a new way to produce crops with broad-spectrum disease resistance using pattern recognition receptors. This breakthrough could lead to enhanced resistance in various crops, reducing yield losses and pesticide use.
Researchers found that periodontal pathogens activate HIV-1 promoters in T-cells, monocytes/macrophages, and dendritic cells. TLR2 and TLR9 play a key role in this response.
A study by Beth Israel Deaconess Medical Center suggests that mitochondria released into the bloodstream following physical injury elicit a sepsis-like immune response. This finding could lead to new strategies for managing trauma and developing tests to differentiate between infective and non-infective inflammation.
Scientists have identified a specific N-glycan that enables arabidopsis plants to recognize and resist bacterial infections. This discovery could lead to the development of new plant varieties with built-in immunity against diseases.
Dr. Diggle's research focuses on the ability of pathogenic bacteria to coordinate cooperative behaviours to exploit their hosts. His work has been published in top journals Nature and Current Biology, and he will deliver a key lecture at the Society for General Microbiology Spring Meeting
A new study published in the Journal of Leukocyte Biology suggests that simvastatin impairs immune cells' ability to kill pathogens and enhances inflammation. Researchers found that simvastatin also increases cytokine production, which triggers and sustains inflammation.
Thalassemia Foundation of Canada awards Concordia University professor Dr. Peter Pawelek a two-year grant to study a receptor protein found on the surface of a lethal bacterial pathogen that can 'hijack' thalassemia treatment drugs. The research aims to develop new antibiotics to combat opportunistic infections in thalassemia patients.
Beewolves have evolved a symbiotic relationship with bacteria of the genus Streptomyces that produce nine different antibiotics, providing effective protection against various pathogens. This natural defense mechanism, known as combination prophylaxis, has been used by beewolves for millions of years to safeguard their offspring.
Researchers from Catholic University of Rome discover that a non-pathogenic bacterium can trigger an autoimmune disease similar to multiple sclerosis in mice. The study suggests that environmental factors may play a role in the development of the disease, and could potentially lead to the development of a vaccine.
A team at Washington University in St. Louis has identified a link between white-tailed deer populations and emerging tick-borne diseases, including human ehrlichiosis and southern tick-associated rash illness (STARI). The study used a sophisticated DNA assay to track the transmission of pathogens from wildlife to ticks.
A recent study suggests that nitric oxide synthase inhibition may be a promising approach to treating neonatal meningitis caused by Escherichia coli K1. The research found that inhibiting inducible nitric oxide synthase enhanced phagocytosis of the bacteria, reducing pathogen load and brain damage.
Researchers have identified 60 small RNA particles (sRNAs) in Helicobacter pylori, a surprising finding given the pathogen's previously thought lack of sRNAs. The discovery could provide new insights into gene regulation and potentially lead to the development of a vaccine against H. pylori.
Researchers have discovered that aphids lack critical immune genes, instead relying on reproduction to protect themselves. This finding could lead to new methods for controlling these pests and better understanding human health.
Dr. Kim Orth's pioneering work focuses on mechanisms bacteria use to cause disease, expanding the frontiers of chemistry through innovative research. Her discoveries have important implications in medicine, especially in understanding and treating infectious diseases.
Researchers at National Jewish Health have discovered how Listeria monocytogenes triggers an endogenous pathway that dampens the host's own immune response. The bacteria makes infected immune cells release interferon-αβ, which reduces immune resistance to infection and causes food poisoning. This finding highlights the crosstalk betwee...
One-third of analyzed milk samples exceed EU microbe contamination limits, according to a study by researchers from the University of Valencia. The experts advise against keeping milk in jugs and recommend better cleaning practices for utensils.
Researchers discover that beneficial gut bacteria play a crucial role in priming the immune system to combat future infections. The study found that these 'good' bacteria influence neutrophils, white blood cells that help fight infection, and suggest that prolonged antibiotic use may compromise immune function.
A new study suggests that flu can increase susceptibility to secondary bacterial super-infections, which can lead to high mortality rates. The research found a lethal synergy between the influenza virus and Haemophilus influenzae, mediated by innate immunity, and highlights the need for early antiviral and antibiotic treatment.
Researchers found that firing low temperature plasma beams at dentin reduced the amount of dental bacteria by up to 10,000-fold. The technology could be used to remove infected tissue in tooth cavities, replacing conventional drilling methods.
Researchers at the University of Illinois have developed a new visible light photocatalyst that can kill bacteria and viruses, even after the light is turned off. The catalyst's unique catalytic memory effect allows it to continue killing pathogens for up to 24 hours.
Researchers developed a rapid-acting disinfectant that kills bacteria, viruses and fungi on surgical instruments, including those resistant to conventional disinfectants. The new formula is safer, cheaper and more effective than existing treatments against prions, which cause deadly illnesses.
A study published by The Translational Genomics Research Institute found that circumcision significantly alters the bacterial communities of the penis, reducing anaerobic bacteria and increasing aerobic bacteria. This change may contribute to lower HIV risk and protection against bacterial vaginosis in women.
Researchers at Binghamton University identified specific types of chronic wound bacteria producing cell-cell signaling molecules AI-2 and AHLs. The 'good' bacteria produce AI-2, while pathogenic species produce AHLs, which can be targeted to improve wound healing.
Researchers at UNC have discovered a single calcium atom controls bacterial motility required for infection. By blocking this site, the bacteria can't move, stopping its ability to establish infections like meningitis. The finding identifies a key step in bacterial infection and could lead to new drug targets.
A genetic study has identified the origins of cavity-causing bacteria Bifidobacterium dentium Bd1, revealing its genetic adaptations for oral survival. The study found that the genome sequence of this bacterium has evolved through only a few horizontal gene acquisition events, highlighting the narrow boundary between beneficial and pat...
Scientists discovered that membrane ruffles are not essential for Salmonella to penetrate host cell membranes. A new factor called WASH promotes bacterial invasion by contributing to cytoskeletal filament formation.
A new DNA-based microarray platform has been developed to identify bacterial species rapidly and accurately, with a clinical sensitivity of 95% and specificity of 99%. The assay is 18 hours faster than the current gold-standard system, which could lead to improved clinical outcomes by allowing species-specific therapy to be started early.
Researchers have identified three chemicals – betaine, glutamate, and succinate – produced by a bacterium that cause coral bleaching. These substances are involved in the transformation of harmless marine bacteria into killers that choke off corals' energy supply.
Researchers use cryo-electron tomography to elucidate molecular architecture of Treponema pallidum, shedding light on cellular structure and movement. The study provides new understanding of how the bacterium attaches to human cells and moves with its flagella.
Structural biologists reveal how internalin B dimer activates human receptor Met, allowing Listeria to infect cells. The discovery may lead to therapeutics for improved wound healing and treatment of listeriosis.
Researchers describe molecular anatomy of Mycoplasma pneumoniae, a small bacterium that can survive on its own. The study reveals intricate networks and multifunctional molecules, challenging the idea of a 'minimal' cell.
A team of scientists has discovered how bacteria defend themselves from viruses and other invaders, unlocking opportunities for targeted antibiotics, gene function studies, and stable bacterial cultures. The CRISPR-Cas system, a dynamic duo of RNA and proteins, recognizes and neutralizes invader RNAs.
Scientists have crystallized a protein that enables beneficial bacteria to bind to the gut lining, interacting with cells and exerting their activity. The discovery opens new avenues of research into gut health and highlights the importance of molecular design in selecting probiotics.
A new study found that cigarettes are contaminated with numerous human bacterial pathogens, including Acinetobacter, Bacillus, Burkholderia, Clostridium, Klebsiella, and Pseudomonas aeruginosa. These bacteria may contribute to both infectious and chronic illnesses in smokers and secondhand smoke exposed individuals.
Researchers have developed thin films of silver and copper that can kill bacteria, potentially helping to reduce hospital infections. The antimicrobial properties of these metals have been known for centuries, and a recent study found that combining them may work synergistically to better eliminate microbes.
A recent study by Mitchell S. V. Elkind and colleagues found a possible link between cumulative exposure to five common infection-causing pathogens and an increased risk of stroke. The study followed 1,625 adults over a median of 7.6 years, with 67 participants experiencing strokes during the follow-up period.
A new imaging technique developed by a team of researchers could lead to the discovery of new antibiotics, antifungal, antiviral, and anti-cancer drugs. The method uses mass spectrometry to analyze chemical communication between microorganisms.
Scientists have observed the emergence of a new adaptation strategy in bacteria Pseudomonas fluorescens, where variable offspring can survive in different environments. This bet-hedging strategy allows for species survival under rapidly changing environmental conditions.
A team of scientists analyzed the DNA of ancient remains to discover that Mycobacterium leprae, the leprosy bacterium, has colonized the entire earth due to human travels. The study found that the bacteria's four strains are distributed according to historical population movements.
New research suggests that prolonged space travel weakens human immune systems, making astronauts more susceptible to disease. The study also found that microorganisms such as bacteria can grow more rapidly in space conditions, increasing the risk of contamination and serious infection.
Researchers at the University of Edinburgh discovered a strain of Staphylococcus aureus bacteria jumping from humans to chickens, marking the first clear evidence of bacterial pathogens crossing from humans to animals since domestication. This finding has significant implications for poultry farming and food security.
A Mayo Clinic study found that Clostridium difficile infections are rising in outpatient settings, with a higher proportion of cases in younger populations. The study suggests that antibiotic use may be contributing to the increased incidence and severity of C. difficile infections.
Researchers discovered a crucial immune system quirk that can lead to effective vaccines against tularemia infection of the lungs. By targeting IL-17 cytokine responses, scientists hope to develop better vaccines that can prevent lung infections.
Researchers found that chlorhexidine-soaked wipes did not reduce neonatal sepsis or vertical transmission of group B streptococcus. The study suggests that other interventions are needed to target child mortality and achieve the Millennium Development Goal of reducing childhood mortality.
Researchers used a novel high-throughput analysis technique to study every gene in Salmonella Typhi, revealing that only 356 genes are necessary for its survival. The TraDIS method has the potential to accelerate the discovery of new targets for treatment and improve our understanding of bacterial disease.
Researchers have discovered a unique bacterial species that can stimulate specialized immune cells in mice, potentially providing insights into human gut-dwelling microbes. This finding could lead to new understanding of how beneficial bacteria protect against pathogenic invaders.
New evidence suggests that a select few beneficial bacteria, such as segmented filamentous bacteria (SFB), can induce accumulation of a highly specific branch of the immune system. SFB stimulate particular types of helper T cells, known as Th17 cells, which are involved in autoimmune diseases like Crohn's disease and psoriasis.
Researchers at the University of Gothenburg have identified a protein called MUC1 as an important part of the body's defense against Helicobacter pylori. Genetic variations in MUC1 molecules may contribute to why some people are more ill than others with stomach ulcers and stomach cancer.
Intracellular pathogens like Chlamydia and Legionella exploit host cell biology to escape destruction. Researchers found that SNARE-like proteins expressed by the bacteria inhibit membrane fusion with lysosomes, allowing them to remain in cells.
Researchers will investigate the activation of TLR4 and responses inside human cornea cells, with a goal to identify potential targets for anti-inflammatory intervention. The study aims to discover specific toll-like receptor antagonists to regulate corneal inflammation, potentially leading to novel medication alternatives.
Virginia Tech's CyberInfrastructure Group receives funding to integrate pathogen data, provide key resources and tools, and analyze genomic and proteomic data. The Pathogen Portal will serve as a centralized gateway for biomedical researchers.
A UBC research team has identified dendritic cells as a crucial part of the immune system's defense against bacterial infections. The study reveals that dendritic cells use cross-presentation to activate the immune system, and deactivating this process can lead to severe compromise in fighting Listeria infections.
Research found that light and photosynthesis aid in bacterial internalization within lettuce leaves. This makes the bacteria impervious to washing and food sanitizers. The study suggests that the increased internalization is due to open stomata allowing nutrient uptake during photosynthesis.
Research finds that pathogenic E. coli are common in Michigan and Indiana streams, even with low fecal indicator bacteria concentrations. The study suggests that current methods for determining water quality may not accurately predict the presence of harmful pathogens.
Rice University biochemists are developing a system of 'evolutionary forecasting' to better understand the mechanisms of antibiotic resistance. By sequencing genomes and analyzing molecular changes, they hope to identify patterns and rules governing how bacteria evolve to become drug-resistant.
Researchers discovered a previously unknown mechanism that aids in the spread of Listeria monocytogenes, a deadly bacterium causing listeriosis and severe illnesses.
A CU-Boulder study found that 30% of showerheads harbor significant levels of Mycobacterium avium, a pathogen linked to pulmonary disease. The researchers discovered biofilms on the inside of showerheads containing high loads of M. avium and related pathogens.
A new study found that bean plants' natural defenses against bacterial infections cause the bacteria to exchange DNA, potentially leading to the emergence of more pathogenic strains. This process could have significant implications for understanding the relationship between pathogens and their hosts.