Articles tagged with Genetically Engineered Viruses
Researchers from The University of Osaka developed a new technique using mass photometry to detect and quantify components of rAAV particles. This method can distinguish between full and empty particles, streamlining gene therapy manufacturing and improving clinical effectiveness.
Researchers at Tel Aviv University discovered a variant of TMEM16F protein that enhances the spread of Parkinson's pathology, potentially leading to new treatments. The study found that cells with the mutation secrete more pathological α-synuclein, which can form Lewy bodies and damage brain cells.
Researchers developed a compact 'gene scissor' tool, TnpB, which shows a 4.4-fold increase in efficiency of modifying DNA, making it more effective as a gene editing tool. The tool can be used to treat patients with familial hypercholesterolemia, reducing cholesterol levels by nearly 80%.
In a mouse model of multiple system atrophy, alpha-synuclein overexpression induces neuroinflammation, demyelination, and neurodegeneration. IFNγ produced by infiltrating CD4+ T-cells mediates these changes. The study suggests that IFNγ is a potential future disease-modifying therapeutic target.
Researchers have developed an oncolytic virus that can 'warm up' cold tumors and improve immunotherapy outcomes. The virus was engineered to carry a gene encoding a TGF-β inhibitor, which greatly increased survival rates in mice with aggressive melanoma and other cancers.
Researchers from IMBA identify a family of virus-like transposons called Mavericks that facilitate horizontal gene transfer (HGT) between reproductively isolated worm species. The study reveals the role of Mavericks in overcoming the species barrier, with potential applications in pathogen control and genomic innovation.
Researchers found that combining radiation with a genetically engineered oncolytic vaccinia virus improved treatment outcomes for glioblastoma brain tumors in mice. The combination showed a 15% cure rate and 62% rejection of new cancer cells, outperforming radiation alone.
A Dartmouth study reveals that disruptions in the mTORC1 pathway can rescue neuronal overgrowth and synapse function dysregulated by Pten loss, potentially offering new treatments for autism spectrum disorders. The research team also found that administering Rapamycin to children showed some benefit to symptoms of autism.
Researchers at the University of Bologna have developed a new targeted cancer therapy based on a genetically modified phage that selectively eliminates tumour cells. The virus is engineered to transport a drug activated by light to target tumour cells, reducing side effects.
Researchers are exploring how an engineered adeno-associated virus (AAV) can compensate for missing protein or swap out genetic mutations that cause vision problems. AAV has been found to be beneficial and is being used as a tool to deliver genes that work as they should.
Isaac Hilton is using non-integrating episomal DNA viruses to create a new platform technology for cell and gene therapies. He aims to hijack these viruses to safely program medicinal functions in human cells.
Scientists have engineered mosquitoes that can't spread all four types of the dengue virus, a major breakthrough in controlling the disease. This development has the potential to limit human suffering and mortality from dengue, which affects over 390 million people annually.
A US defense agency program aims to genetically modify crops using infectious viruses, sparking concerns about its potential military applications and the risk of creating new biological weapons. The approach, known as HEGAAs, would deliver the viruses through insects, raising questions about transparency and public deliberation.
Researchers genetically engineered a Zika virus infectious cDNA clone, enabling rapid vaccine development and exploration of the virus's evolution and transmission. The study unlocks insights into why the Zika virus causes severe diseases and epidemics.
Researchers at MIT have found a way to add genetically modified viruses to the production of nanowires, which can serve as one of a battery's electrodes. This increases the surface area, allowing for more efficient charging and discharging.
Princeton University researchers are developing a new method for studying brain connectivity using genetically engineered viruses. The viruses, designed by Lynn Enquist's team, travel through the nervous system, tracing connections between neurons and reporting on their activity. This approach has significant implications for understan...
Researchers discovered a genetically engineered herpes simplex virus reduces smooth muscle cell proliferation and restores endothelial layer in arteries following angioplasty. This study provides an important step towards treating vascular disease with genetically engineered viruses.
Researchers at the University of Rochester and UCLA have discovered a novel way to target HIV by genetically engineering a mutant tRNA primer that disrupts the virus's replication process. The approach, which has been patented, opens up new avenues for gene therapy in AIDS treatment.