Articles tagged with Mrna Expression
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers have identified a genetic mechanism in bacteria that could lead to the development of new antibiotics. The preQ1 riboswitch regulates gene expression by controlling the availability of queuosine, a molecule essential for bacterial survival and human disease.
A recent study by Kristian E. Baker and Ambro van Hoof directly challenged the 'faux 3' UTR model of mRNA decay, revealing a critical flaw in the existing understanding of this process. This breakthrough discovery has significant implications for gene expression regulation and potential therapeutic strategies for genetic diseases.
High levels of CD200 expression in melanomas represses activation of antitumor T cell immune responses by dendritic cells. Targeting the interaction between CD200 and its receptor may provide a new treatment approach for metastatic melanoma.
The discovery of microRNAs in the unicellular green alga Chlamydomonas reinhardtii expands our understanding of small RNA regulation and challenges existing dogma. The researchers found functional characteristics between plant and animal miRNAs, suggesting a potential role in regulating sexual reproduction.
Researchers found that microRNA let-7 binds to HMGA2 mRNA transcript, suppressing its expression and preventing tumorigenesis. This establishes HMGA2 as a target of let-7, highlighting the potential role of microRNAs in cancer prevention.
Researchers at UCSD identified a novel gene called Nxf1 that restores function to mutated genes by increasing normal product production, alleviating abnormalities in mouse mutations. This discovery offers hope for controlling human disorders caused by retrovirus insertion mutations.
Researchers found that measuring Mcm5 levels in urine could detect bladder cancer with higher sensitivity than current tests. Additionally, a study linked effective DNA repair capacity to poorer survival rates in NSCLC patients treated with chemotherapy.
Researchers investigated post-transcriptional regulation of COX2 in tumor cells. They found that microRNA-21 plays a crucial role in modulating COX2 expression by targeting its mRNA for degradation.
Human microvascular endothelial cells express CXCR3 receptor in response to cell cycle regulation, leading to antiproliferative effect. This mechanism provides an additional pathway for controlling angiogenesis, potentially blocking tumor growth.
Researchers at MGH/Harvard discovered a tiny RNA gene controlling developmental timing in animals, including fish, sea urchins, and humans. The gene is conserved across bilaterally symmetric animals but not in more primitive or plant species.
Researchers link destruction of proteins to destruction of messenger RNA, a breakthrough that could lead to development of pharmaceuticals to control protein production.
Researchers at Duke University have identified 31 genes that react to cadmium exposure, including 22 previously unknown genes. These findings offer new insights into the toxic effects of cadmium and potential biomarkers for monitoring contamination.
A new study in Saccharomyces cerevisiae, also known as Brewer's yeast, indicates that mRNA localization regulates differential gene expression in the organism. The localization of a protein called ASH1 to the tip of budding daughter cells controls its expression.