Articles tagged with Transcriptional Repression
Researchers developed RegVelo, an AI framework that models cellular dynamics and gene regulation to predict cellular fate decisions. The model traces developmental trajectories and simulates regulatory interactions, providing insights into hidden drivers of development and potential therapeutic targets.
Researchers from The University of Osaka have discovered a two-factor system that controls stem cell differentiation, involving the stabilization of the CoREST corepressor complex at gene promoters. This process prevents stem cells from drifting towards differentiation and maintaining their pluripotency.
A new study reveals that tomato plants adapt to heat stress by delaying shoot apical stem cell development, allowing for stable yields. This redox-controlled mechanism enables the plant to temporarily suspend its maturation program during adverse conditions, resulting in significant yield losses prevention.
A new study published in Aging-US has identified the p53-p16/RB-E2F-DREAM complex as a critical regulator of cellular senescence. The researchers found that this complex represses multiple target genes involved in cell cycle regulation, DNA repair, and chromatin structure, leading to the stability of the senescent arrest.
Researchers from the ALFA Score Consortium explore how nutrition and physical exercise can positively impact the aging process by modifying epigenetic changes. They find that healthy aging is associated with more tightly condensed chromatin, fewer histone post-translational modifications, and greater regulation by non-coding RNAs.
Researchers from Northwestern University discuss the multifaceted tumorigenic functions of EZH2, including its role in regulating translation and coactivating transcription. This new understanding may provide novel insights into advancing EZH2-targeting strategies for prostate cancer patients.
Researchers have identified HDAC7 as a transcriptional repressor involved in B lymphocyte generation and identity. The study reveals that HDAC7 is essential for B cell development, maintaining its lymphoid identity by silencing lineage-inappropriate genes.
The MECP2 gene, responsible for Rett syndrome, plays a multifunctional role in RNA processing, including transcriptional repression and splicing regulation. This discovery opens new avenues for understanding the disease and developing targeted therapies.