Articles tagged with Glutamate Receptors
Researchers at Carnegie Mellon have modeled the molecular changes that occur when glutamate docks with a receptor on a neuron, enabling computer simulation of binding-site closure and opening. This breakthrough could lead to the development of drug therapies for disorders such as epilepsy and Alzheimer’s disease.
Researchers found that cocaine affects dopamine and glutamate receptors, interfering with normal activation of glutamate receptors. This interaction between D2R and NR2B subunits is critical for mediating cocaine's effect on motor responses.
Researchers at the University of Leicester have made a breakthrough in understanding the cause of brain damage and its link to various neurological diseases. The study identified glutamate receptors as the culprit behind oligodendrocyte damage, paving the way for potential treatments to block these receptors and prevent injury.
A new targeted drug has been developed to prevent long-term changes in brain cells that contribute to addiction. The peptide works by tricking cellular machinery into pulling the glutamate receptor back onto the surface, restoring normal communication between neurons.
Researchers have identified a receptor for the fifth taste, amino acid, which may aid understanding of how animals regulate nutritional intake. The discovery also has potential applications in the food industry, such as formulating new products with specific tastes.
A study by Hopkins researcher Jane McGowan found that hypoglycemia altered the ability of certain neurotransmitter receptors to bind glutamate, a key molecule for normal brain function. The research suggests that hypoglycemia may impact the brain's ability to develop normally, particularly in regards to learning and memory.
Neurons control connection strength by removing or inserting receptors for glutamate, a key neurotransmitter. The discovery reveals a 'shuttle' system that rapidly regulates receptor numbers, allowing neurons to adjust connection strength.
Scientists have identified a network of cellular receptors in the spinal cord that transmits sensations of chronic pain. Blocking their activity may provide a new strategy for pain management. The discovery suggests that pain can be caused by pathways normally not painful.
Researchers have discovered plant glutamate receptors, which work similarly to human receptors in the brain. This finding suggests that plants possess a signaling system for neurotransmitters, enabling potential use as a model system to study neurological functions.
Researchers found genes encoding for glutamate receptors in plants, indicating a common cell-to-cell communication system between plants and animals. This discovery may explain why certain plants produce neuroactive compounds that activate human brain receptors.
Researchers at Emory University have identified a potential new approach for alleviating Parkinson's disease symptoms by blocking glutamate receptors in the brain. This could lead to combination therapies that improve treatment outcomes and reduce side effects.
A new study suggests that blocking glutamate activity may prevent schizophrenia-like behavior in rats. Using an experimental compound, researchers found that doses of PCP no longer triggered behavioral abnormalities when glutamate levels were normalized.
Research reveals that glutamate receptors, key mediators of brain cell communication, form tetramers similar to voltage-gated potassium channels. The discovery challenges previous theories on how ligand-gated receptors become activated by neurotransmitters.
Scientists have discovered a crucial region on nerve cells that may be essential for the actions of inhaled anesthetics, potentially leading to safer, more potent pain medications. The finding also provides insight into the genetics of alcohol addiction and may help develop new treatments.
A mutated gene in the glutamate receptor family causes faulty nerve cells to die due to false detection of neurotransmitters. The discovery may help understand how to slow down or stop this process, preserving neurons.
Researchers at Johns Hopkins Medicine have identified a protein called GRIP that clusters neurotransmitter receptors together on brain cells, enabling faster and stronger communication between nerve cells. This discovery has the potential to play a role in learning and memory.
Scientists created a 3D computer model of a glutamate receptor, which can be used to develop new drugs for Alzheimer's disease and other disorders. The model accurately represents the receptor's structure and behavior.
Researchers at Johns Hopkins Medicine discovered a peptide that closes an NMDA glutamate receptor, potentially aiding the development of stroke treatment drugs. The peptide, known as Mag-1.5, can help regulate communication between nerve cells and may provide insights for potential new therapies.