Researchers at Cold Spring Harbor Laboratory discovered how dehydration enables calcium to pass through the NMDAR channel, revealing key molecular mechanisms underlying learning and memory. This finding has implications for brain development and disease, including GRIN disorders that cause severe developmental disabilities.
Researchers discovered that water fleas use chemoreceptors to detect predator signals, involving ionotropic receptors IR25a and IR93a. Without these co-receptors, Daphnia lose their defense mechanisms against predators.
Researchers have identified a monoacylglycerol acyltransferase (MGAT)-coding gene named bishu-1 that maintains the expression level of thermal receptors and modulates cool temperature sensation and avoidance behavior. The discovery could promote the development of lipid-mediated treatments for maintaining thermosensation in humans.
Researchers have mapped mosquito cells that can fine-tune their ability to detect attractive human odors. The discovery may lead to the development of more effective repellents to combat mosquito-borne diseases.
Research reveals that glutamate receptors, key mediators of brain cell communication, form tetramers similar to voltage-gated potassium channels. The discovery challenges previous theories on how ligand-gated receptors become activated by neurotransmitters.