Articles tagged with Parkinsons Disease
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A novel cell therapy using retinal pigment epithelial cells attached to gelatin bead microcarriers has shown promising results in patients with moderate to advanced Parkinson's disease. The therapy, Spheramine, has been well-tolerated and has improved symptoms such as tremor, rigidity, and balance issues for several years.
Two studies from the University at Buffalo use advanced MRI technologies to identify brain regions linked to Parkinson's disease. The research found that white matter hyperintensities are associated with lower scores on mental tests, suggesting a possible explanation for cognitive impairment in PD.
A new study by University of Minnesota researchers identifies unit burst generators in the spinal cord that control rhythmic movements such as walking. The discovery may help lead to treatments for Parkinson's disease and spinal cord injuries.
Recent research has identified seven LRRK2 gene mutations associated with Parkinson's disease, including a rare mutation that doubles the risk in ethnic Chinese. The findings suggest that genetic influences passed down through generations can significantly increase susceptibility to the disease.
The Michael J. Fox Foundation has awarded $5.6 million for a Phase 2 clinical trial investigating the potential of inosine to slow or stop Parkinson's disease progression. The study will determine the safety of using inosine to raise urate levels and assess optimal dosage for therapeutic effect.
A study of 804 individuals with early Parkinson's disease found that those with higher blood urate levels were less likely to progress and required dopaminergic therapy. The association suggests that urate may protect dopamine-producing neurons, potentially leading to the development of new therapies.
Researchers found that high urate levels among recently diagnosed Parkinson's patients slowed disease progression during a two-year study period. Elevated urate levels have been linked to reduced risk of developing Parkinson's disease, and may offer new treatment strategies for the disorder.
A study by Medical College of Georgia found that occupational therapy using Nintendo Wii can slow disease progression, decrease medication needs, and increase function in Parkinson's patients. The therapy helps participants improve daily activities like dressing, walking, and fine motor skills.
Scientists have identified 'mother cells' that produce dopamine-producing neurons affected by Parkinson's disease. These radial glia-like cells could be used to grow replacement neurons in the lab, potentially leading to new treatments for the disease.
A recent study published in Nature Medicine found that fetal cells implanted in patients with Parkinson's disease can develop Lewy body pathology, a defining characteristic of the disease. The study suggests that cell replacement strategies for Parkinson's disease may not be effective in the long-term.
Researchers at Yale University have successfully created new neurons using uterine stem cells, which increased dopamine levels and partially corrected Parkinson's disease symptoms in mice. This breakthrough has significant implications for the development of a potential human treatment.
A study of 42 amateur boxers found microhemorrhages in three cases, a potential precursor to Parkinson's disease and dementia. However, the differences were not statistically significant, leaving conclusive statements unclear. Further research on professional boxers is planned to assess intensive exposure to blows.
A family-based study found a significant association between pesticide use, particularly herbicides and insecticides, and an increased risk of developing Parkinson's disease. The research team recruited 319 patients and over 200 relatives to analyze the relationship between pesticide exposure and Parkinson's disease development.
Researchers at Memorial Sloan-Kettering Cancer Center have successfully used therapeutic cloning to treat Parkinson's disease in mice. The method involves generating customized dopamine neurons from the patient's own skin cells and transplanting them into the mouse, resulting in neurological improvement.
Scientists have identified genes and processes that may underlie the susceptibility to Parkinson's disease. The study found that the gene sir-2.1 has a significant effect on protein formation, which is thought to play a role in the aging process and the development of the disease.
Researchers found that impaired sense of smell can precede the development of Parkinson's disease (PD) in men by at least four years. Smell impairment was associated with an increased risk of PD, even after adjusting for other factors such as age and cognitive function.
A genetic clue has been uncovered for Parkinson's disease, a progressive movement disorder affecting millions worldwide. GIGYF2 mutations have been found to be directly linked to the development of Parkinson's in people with a family history of the disease.
Scripps Research will develop a compound to treat neurodegeneration in Parkinson's disease using a classical pharmaceutical approach. The goal is to bring the potential treatment to human clinical studies, aiming to have a safe and efficacious compound with sufficient preclinical safety data.
A reliable blood test for Parkinson's disease could revolutionize care and research, according to a new study. The test uses a 'metabolomic profile' to identify unique changes in dozens of small molecules in serum that are linked to the disease.
Researchers discovered a protein imbalance in Parkinson's disease patients and found that adding a phosphate group can reduce toxicity. The study suggests alpha-synuclein protein plays a key role in brain cell communication and may be a potential target for therapy.
A new study by Buck Institute researchers finds that high levels of MAO-B enzyme in mice lead to Parkinson-like symptoms. The findings suggest that humans with high MAO-B levels may be at risk for the disease and could benefit from preventive treatment.
A study of 7,374 participants found that those taking calcium channel blockers for high blood pressure had a lower risk of developing Parkinson's disease. The medication was shown to cut the risk by 23% compared to non-users, but not other high blood pressure medications.
Researchers found that manipulating serotonin receptors can block L-DOPA-induced side effects in advanced Parkinson's disease. The discovery suggests a new approach for developing treatments for this disorder, which is the second most common neurodegenerative disease after Alzheimer's.
A new guideline from the American Academy of Neurology highlights individuals at risk of falling due to conditions like stroke, dementia, Parkinson's disease, and vision loss. Regular screening and preventive measures can help prevent fall-related injuries and deaths.
Researchers developed MAPAS to predict protein contact surfaces, which can guide new treatments for devastating diseases. The tool uses supercomputers to analyze protein shapes and energy, revealing key details of membrane interactions.
The Michael J. Fox Foundation has awarded up to $3 million in funding to four industry teams as part of its Therapeutics Development Initiative, focusing on treatments targeting alpha-synuclein toxicity, chronic inflammation, trophic factors, and mitochondrial dysfunction. The grants aim to accelerate the development and delivery of tr...
A new Mayo Clinic study identified several gene variations that predict people at high risk for ALS and Parkinson's disease. The researchers found a high-risk prediction factor for ALS (2,000 times greater than average) and for Parkinson's disease (nearly 400 times greater than average).
A new study found trichloroethylene to be a risk factor for parkinsonism, a group of nervous disorders with symptoms similar to Parkinson's disease. The study showed that chronic exposure to TCE can lead to degenerative changes in the brain, including reduced mitochondrial function and dopamine neuron damage.
A study by Einstein researchers suggests that impaired autophagy may contribute to the development of Parkinson's disease. The team found that dopamine-altered alpha-synuclein molecules interfere with lysosomal digestion, leading to toxic compound accumulation and cell death.
Researchers found that green tea polyphenols protect dopamine neurons and inhibit the ROS-NO pathway, which contributes to cell death in Parkinson's disease. The study suggests green tea polyphenols may be developed into a safe and easily administrable drug for Parkinson's disease treatment.
A recent study by Mayo Clinic found that relatives of patients with Parkinson's disease are at increased risk for developing depression and anxiety disorders. The risk is particularly elevated in families where the patient develops Parkinson's before age 75.
Researchers at Université Laval discovered that a diet rich in omega-3 fatty acids protects the brain against Parkinson's disease. The study found that mice fed an omega-3 rich diet were immune to the toxic compound MPTP, which causes damage to dopamine-producing neurons.
A recent study using PET scans shows that an experimental gene therapy can normalize brain function in Parkinson's patients. The treatment was found to alter brain activity in a favorable way, primarily affecting motor networks.
Regular use of non-aspirin NSAIDs reduced Parkinson's disease risk by up to 60% compared to non-users. Women who regularly used aspirin also showed a 40% reduced risk, especially after two years of use.
Researchers at Saint Louis University School of Medicine discovered a key brain chemical that causes Parkinson’s disease. They found that dopamine itself is converted into DOPAL, which triggers the death of dopamine-producing cells and leads to Parkinson’s.
Researchers found that Deep Brain Stimulation (DBS) actually speeds up decision-making in Parkinson's patients, contrary to expectations. The study suggests that DBS affects the brain's ability to deliberate on complicated decisions by interrupting the 'hold-your-horses' signal.
Research at The Parkinson's Institute and Clinical Center found that intermittent nicotine treatment reduces medication-induced dyskinesias in Parkinson's disease models. This could lead to more effective and long-term treatment options for patients suffering from the condition.
First-degree relatives of patients with Parkinson's disease are at increased risk of developing dementia and cognitive impairment, particularly those with younger age of onset. The study suggests shared familial susceptibility factors may be driving this association.
Researchers at ESRF and CNRS used chemical nano-imaging to visualize iron distribution in dopaminergic neurons. They found that iron is stored within dopamine vesicles, which helps explain the molecular mechanisms involved in Parkinson's disease.
Researchers analyzed genes of 278 people with Parkinson's disease and found a higher prevalence of mutations in the GBA gene among those diagnosed before age 50. The study suggests that Jewish ancestry may be an important risk factor for younger-onset Parkinson's disease due to the increased presence of GBA gene mutations in this group.
Researchers have created 'pro-chelators' that can selectively bind to potentially destructive forms of iron in the brain, reducing oxidative stress and cell damage associated with these diseases. The iron-binding agents are designed to target only harmful iron species, allowing benign forms to carry out vital functions.
Researchers found a link between the loss of norepinephrine and dopamine neurons and delayed Parkinson's symptoms. The study showed that both types of neurons are necessary for normal motor function.
A study published in BMC Medicine found that simvastatin is associated with a lower incidence of dementia and Parkinson's disease. The researchers analyzed data from over 700,000 simvastatin users and more than 50,000 atorvastatin users to confirm the benefits of simvastatin on these conditions.
Researchers found that transplanted stem cells triggered the brain's self-repair mechanisms by boosting nerve survival and blood vessel development. The study suggests that stem cells may be more effective at repairing damaged brain tissue than previously thought.
Researchers have identified two separate brain networks affected by Parkinson's disease, one regulating movement and the other cognitive function. The study found that standard treatments alter the motor network but not the cognitive network, highlighting the need for new treatments to target cognition.
Researchers identified risk factors for hallucinations, sleepiness and swelling in people with early Parkinson's disease, including being male, having multiple health problems and taking certain medications. The study found nearly half of participants developed swelling within four years of treatment.
A pooled analysis of data from previous studies suggests that cigarette smoking is associated with a reduced risk for developing Parkinson’s disease. Current and long-term smokers had the lowest risk, while those who quit smoking up to 25 years prior to diagnosis also showed a significant decrease in risk.
A recent study reveals that depression is common in early Parkinson's disease diagnosis, with 27% of subjects screening positive for depression. Untreated depression can significantly impact daily life activities and overall quality of life.
In mice and human patients, researchers found that crippling of protective enzyme Prx2 leads to death of dopamine-producing neurons in Parkinson's disease. Activating Prx2 prevents neuronal loss, suggesting it as a beneficial target for PD treatment.
Researchers at University of Helsinki discover novel neurotrophic factor CDNF that protects and rescues damaged dopamine neurons, recovering function after experimental lesion. This breakthrough may lead to new treatment strategies for Parkinson's disease.
The Parkinson's Institute has received a $1 million grant from the Valley Foundation to support its STOP PD program, which aims to identify compounds to halt Parkinson's disease progression. The new facility will enable expanded research and patient services, offering improved care for those diagnosed with Parkinson's.
The Penn Udall Center will focus on dementia and Parkinson's disease, with objectives including developing a new rating scale for activities of daily living and studying the neural basis of cognitive deficits in Parkinson's disease. The center aims to improve care and treatment for patients and train physicians.
A novel gene therapy technique has been found safe and effective in reducing worsening symptoms of Parkinson's disease in advanced patients. The treatment, which involves injecting genes into one side of the brain to restore a critical neurotransmitter called GABA, showed a 27% improvement in symptoms among participants.
A large-scale study found that high levels of urate in the blood are strongly associated with a reduced risk of Parkinson's disease. Urate, a normal component of blood, may have beneficial effects due to its antioxidant properties.
A new gene therapy clinical trial has reported promising results in improving motor function for patients with Parkinson's disease. The study found significant improvements in both the off-state and on-medication phases, with some patients showing impressive gains of up to 65 percent.
A Phase 1 study using an adeno-associated virus vector to deliver an inhibitory gene to the subthalamic nucleus demonstrated a lack of adverse events and statistically significant improvements in clinical symptoms and brain metabolism. The treated side showed notable improvement, with sustained benefits observed over 12 months.
A study published in The Lancet found that gene therapy can safely alleviate symptoms of Parkinson's disease, with significant improvements seen in movement and motor scores. The treatment involves injecting genetic information directly into brain cells, eliminating the need for indwelling hardware associated with deep-brain stimulation.
Scientists have discovered a potential new treatment for Parkinson's disease by inhibiting the action of an enzyme called SIRT2. Blocking this pathway is believed to protect neurons damaged in Parkinson's from the toxic effects of alpha-synuclein, a protein that accumulates in the brains of patients.
A novel signaling pathway has been identified as being altered by genetic mutations in Parkinson's disease, affecting cellular function and potentially leading to new therapeutic targets. The research found that mitochondrial protein PINK1 plays a crucial role in protecting cells from oxidative stress and promoting cell survival.
The study reveals a novel anti-apoptotic signaling pathway disrupted by PINK1 mutations, suggesting a potential target for therapeutic intervention in Parkinson's disease. Increasing evidence links single-copy mutations in PINK1 to the development of later-onset PD.