Articles tagged with Parkinsons Disease
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Researchers developed a prosthetic device that applies electrical stimulation to the dorsal column in the spinal cord, improving movement in dopamine-depleted animals. The device was found to be effective and less invasive than other alternatives to medication, with potential for widespread use.
A Stanford study found that stimulating neural wires rather than cells in the subthalamic nucleus can improve Parkinson's symptoms, offering new insights into the disease and possible treatments. The researchers used optogenetics to activate specific types of cells in rodents, revealing a key role for axons in transmitting signals.
Researchers use single-molecule fluorescence resonance energy transfer to observe alpha-synuclein proteins changing shape in response to different binding partners, revealing unprecedented twists and turns. This ability could play a significant role in regulating disease-related aggregates.
Researchers found that DBS in either brain target effectively treated motor symptoms, but produced unique effects on mood and mental sharpness. The discovery may impact the selection of DBS patients, especially those with pre-existing memory or cognitive disabilities.
Patients with early Parkinson's disease show similar overall levels of disability after six years of levodopa or dopamine agonist treatment. Persistent differences are seen in motor symptoms, fluid build-up, and sleepiness.
A study compared two common drugs used to treat early-stage Parkinson's disease and found that their long-term impact is similar. The research showed that patients on different treatment regimens experience roughly the same level of disability and quality of life over time.
Scientists at Whitehead Institute have successfully removed cancer-causing genes from human skin cells reprogrammed into embryonic-stem-cell-like state, creating patient-specific stem cells. These cells can be matured into dopamine-producing neurons, which degenerate in Parkinson's disease patients.
A new study found that women with a longer fertile lifespan, resulting in higher levels of naturally produced estrogen, had a lower risk of developing Parkinson's disease. However, hormone therapy did not offer protection against the disease, and may even have harmful neurological effects.
Researchers at McGill University found that Parkinson's patients who develop addictions have elevated dopamine levels, promoting addictive behaviours. Adjusting medication dosage resolved symptoms, suggesting hereditary factors contribute to addiction vulnerability.
A new study found that women with a longer fertile lifespan and more years of exposure to their own sex hormones may be protected from Parkinson's disease. Women with four or more pregnancies were at greater risk of developing the disease compared to those with fewer pregnancies.
Claire Parkinson, Marc Kuchner, and Neil Gehrels received recognition for their leadership in understanding sea-ice changes through satellite measurements and detecting extra-solar planets. The scientists' research has greatly advanced astronomers' understanding of climate change, exoplanet formation, and gamma-ray bursts.
Researchers have created an algorithm that analyzes gene expression and protein production to identify genes and pathways that can affect cell survival. The new method, ResponseNet, has led to new insights into the connection between alpha-synuclein toxicity and basic cell processes.
The Parkinson's Disease Foundation has awarded $300,000 in emergency bridge funding to four leading scientists working on novel research projects. The grants will support studies focused on improving gastrointestinal motility and targeting alpha-synuclein protein misfolding, among others.
Researchers at UT Health Science Center are developing a vaccine targeting alpha-synuclein to prevent Parkinson's disease progression. The vaccine has the potential to slow symptom onset, a current challenge in treatment.
A study of nearly 157,000 people found that those with a family history of melanoma were nearly twice as likely to develop Parkinson's disease. Researchers suggest that the two diseases may share common genetic components.
Researchers at Diamond Light Source have developed a new technique using X-ray eyes to map metal distribution in brain tissue, which could lead to early diagnosis and treatment of Parkinson's disease. By studying the distribution of metal ions in affected regions, scientists hope to improve MRI detection and diagnosis.
Researchers discovered that adding extra copies of a gene makes a protective protein neutralize toxic chemicals in the brain, preventing cell death. This breakthrough could offer profound protection against neurodegenerative diseases like Alzheimer's and ALS.
A Penn study found a genetic link between Parkinson's disease genes and manganese poisoning, with the PARK9 protein protecting cells from toxic effects. Manganese poisoning is an environmental risk factor for a Parkinson's-like syndrome.
Researchers at MIT have identified two genes that are altered in the brains of animals with L-DOPA-induced dyskinesias. The study found that regulating these CalDAG-GEF molecules could have therapeutic value for treating the involuntary movements associated with Parkinson's disease.
Researchers at the University of Cincinnati are developing new imaging technologies to help accurately pinpoint deep-brain stimulation electrodes in patients with Parkinson's disease. The study aims to reduce complications and improve patient outcomes by utilizing advanced MRI sequences and diffusion tensor imaging.
A new study found that patients starting rasagiline earlier experienced less progression of Parkinson's disease symptoms and signs, including rigidity and activities of daily living. The long-term study showed a 16% less progression in the early-start group compared to those who delayed treatment for six months.
A Mayo Clinic-led international consortium discovered a genetic defect in the dynactin complex that may help explain neurodegenerative diseases like Parkinson's and amyotrophic lateral sclerosis. The mechanism implicated in Perry syndrome, a rare disorder, may also shed light on common depression and sleep disorders.
Patients with advanced Parkinson's disease who received deep brain stimulation treatment had significant improvements in movement skills and quality of life after six months. However, the treatment was also associated with a higher risk of serious adverse events, including surgical site infections and nervous system disorders.
Researchers at Emory University School of Medicine have discovered that the protein alpha-synuclein interferes with the cell's recycling of MEF2D, leading to cell death. The study suggests that targeting MEF2D could be a potential way to regulate brain cells' response to toxic stresses.
A study published in Neurology found that people with REM sleep behavior disorder have an increased risk of developing neurodegenerative diseases like dementia and Parkinson's. The five-year risk was estimated to be 18%, while the 10-year and 12-year risks were 41% and 52%, respectively.
Researchers developed a method to analyze genetic variations in HCV-infected patients, predicting their response to antiviral therapy. This approach may lead to a test that identifies targets for new antiviral drugs.
Researchers found that CD4+ T cells play a significant role in Parkinson's disease progression. Infiltration of these immune cells in the brain contributes to neurodegeneration. Targeting the immune system might offer a new therapeutic approach.
A recent study found that older antidepressants targeting both serotonin and norepinephrine are more effective in treating depression in people with Parkinson's disease. This is a significant finding, as depression affects up to 50% of individuals with the condition.
Researchers are investigating the correlation between a fading sense of smell and the onset of Parkinson's disease. The study, which draws from research demonstrating that first-degree family members have a slight increase in risk, will monitor relatives 50 years or older for early detection.
Levodopa is recommended for treating both early and advanced stages of Parkinson's disease, improving motor skills, speech, and gait. The treatment can also confirm a suspected diagnosis of Parkinson's disease, providing relief from tremors and other symptoms.
Parkin protein prompts neuronal survival by clearing damaged mitochondria. Researchers found that Parkin translocates to mitochondria upon damage, sending them to autophagosomes for degradation. This process prevents damaged mitochondria from triggering cell death.
Researchers at Southern Methodist University identified four potent chemical compounds that slow neuron degeneration, a key cause of old-age diseases like Alzheimer's and Parkinson's. The compounds, called 3-substituted indolin-2-one derivatives, are non-toxic even at high doses, offering hope for halting neurodegenerative diseases.
A recent clinical trial has shown remarkable results for patients with obsessive-compulsive disorder (OCD), with 7 out of 10 participants experiencing a substantial reduction in symptoms after deep cerebral stimulation. The treatment, which involves targeting the subthalamic nucleus in the brain, offers a promising alternative to tradi...
Researchers will investigate new ways of developing clinical trials for Alzheimer's disease and Parkinson's disease. The study aims to improve the speed, cost-effectiveness, and relevance of treatments, benefiting patients and their carers.
The Parkinson's Disease Foundation has awarded $150,000 to study the potential of individualized stem cell therapy for treating Parkinson's disease. Researchers will investigate using transformed adult skin cells to replace damaged dopamine neurons in the brains of people with Parkinson's.
A study published in Archives of Neurology found that individuals with Parkinson's disease are more likely to be vitamin D deficient compared to healthy adults and those with Alzheimer's disease. The average vitamin D concentration in the group with Parkinson's disease was lower than both groups.
A new study from Emory University School of Medicine found that 55 percent of Parkinson's disease patients had insufficient levels of vitamin D. The study also showed a higher fraction of patients with the lowest levels of vitamin D, described as deficiency, in the Parkinson's group compared to Alzheimer's and healthy groups.
Stuart A. Lipton will lead a center studying potential environmental causes of Parkinson's disease, examining chemical reactions that alter protein function and screening compounds to prevent disease progression. The center represents a collaborative effort between scientists at Burnham and other institutions.
The National Institute of Environmental Health Sciences is awarding three new grants to investigate the role of environmental factors in Parkinson's disease and other neurodegenerative disorders. The research will focus on identifying mechanisms that link pesticide exposure, mitochondrial damage, and altered dopamine storage to the dev...
A study of 402 Parkinson's disease patients found that 69.9% experienced pain, compared to 62.8% in healthy controls. Pain types included cramping and central neuropathic pain, suggesting a link between brain structures and pain processing.
Researchers have discovered unique hybrid protein complexes that form when Abeta amyloid and a-synuclein interact, altering neuronal activity. This study provides a model for developing new drugs to treat these devastating neurological diseases.
Researchers used an engineered virus to deliver a glowing protein into newborn brain cells in an animal model of Parkinson's disease, revealing most cells are glial and do not form neurons. Further gene delivery experiments showed no effect on neuron formation but increased the number of oligodendrocytes supporting neurons.
Researchers at the University of Cincinnati have found that deep brain stimulation can halt the progression of dopamine-cell loss in animal models. The study suggests that stimulating neurons with electrodes boosts the amount of BDNF, a protein that promotes neuronal growth.
A new brain imaging study reveals that there are optimal times for multitasking, allowing individuals to be more efficient. The research found that certain brain regions show higher activity when people are performing well under multiple tasks.
A team of University of Cincinnati researchers is studying the relationship between depression and Parkinson's disease to gain insight into possible treatments. In pilot models, they found that stress-induced depression exacerbates problems with movement and causes brain cells to die faster.
A study published in JCI Journals suggests that a yeast protein called Hsp104 may hold the key to treating Parkinson's disease. The protein was found to inhibit alpha-synuclein aggregation, which is thought to contribute to PD pathology.
Researchers at the University of Pennsylvania School of Medicine have identified a baker's yeast protein, Hsp104, that can reverse protein aggregation in animal models of Parkinson's disease. This breakthrough finding holds promise for developing new treatments for the condition.
Researchers found that dopamine strengthens the 'go' circuit and weakens the 'stop' circuit in the brain, leading to compulsive behavior and addictive tendencies. The study also shows how Parkinson's patients' reduced dopamine levels lead to frozen motor skills.
The Michael J. Fox Foundation has awarded $1.1 million for 15 high-risk, high-reward research projects to explore new approaches to treating Parkinson's disease using gene silencing techniques and induced pluripotent stem cell technology. The funding aims to develop transformative treatments and a cure for PD.
A team of scientists found that genes controlling heme synthesis in red blood cells also control a gene and protein causing Parkinson's disease. The study suggests that targeting the GATA-1 and GATA-2 proteins may lead to new treatments for the neurological disorder.
The Michael J. Fox Foundation has awarded $2.4 million to nine research teams to validate potential therapeutic targets for Parkinson's disease. The funding aims to accumulate evidence and reduce the risk of investment for industry, ultimately accelerating PD drug development.
Jülich scientists have discovered the mechanism behind Parkinsonian tremor and developed a new deep brain pacemaker to disrupt it. The device influences disturbed neurons in the core region of the brain, causing irregular rhythms that break down diseased modes.
The Parkinson's Disease Foundation has awarded $950,000 in seed grants to 19 researchers, including Matthew Goldberg and Sandra M. Lynch, to explore new treatments for Parkinson's disease. The funding will support the development of animal models and antibody-based therapies.
Researchers at the University of Alberta found that sprinters closest to the starter pistol had significantly lower reaction times than those farther away. The study suggests that procedures used in Olympic sprint events may give runners closer to the starter an advantage.
Researchers have found that adult stem cells from Parkinson's patients' noses can differentiate into dopamine-producing brain cells when transplanted into the brain of a rat. This breakthrough has significant implications for treating the debilitating symptoms of Parkinson's disease.
A Binghamton University researcher will receive a $1.33 million NIH grant to study the side effects of Parkinson's disease treatment, with a focus on reducing dyskinesia and suppressing abnormal motor movements. The research aims to develop new treatments that can address these issues and improve patient outcomes.
Researchers at Goethe University Frankfurt have discovered two gatekeeper proteins, Rpn13 and an ubiquitin receptor, on the proteasome. This finding has significant implications for cancer research, as it may lead to the development of targeted drugs that can block protein breakdown and prevent tumor cell proliferation.
Researchers found that activating the c-Jun gene in cultured neurons with Schwann cells promotes dedifferentiation and speeds nerve healing. The study suggests a new potential target for understanding and treating diseases like Charcot-Marie Tooth disease and Guillain-Barre syndrome.
A study of seven patients with Parkinson's disease found that re-implanting electrodes to correct placement can improve symptoms and reduce medication doses for those who had poor results after initial implantation. The procedure led to significant improvements in motor function scores and reduced levodopa medication doses.
The American Society for Neural Therapy and Repair (ASNTR) has awarded neuroscientist Paul M. Carvey for his groundbreaking research on Parkinson's Disease, while recognizing patient advocate Joan Samuelson for her tireless advocacy efforts.