Articles tagged with Parkinsons Disease
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A new study from Mayo Clinic researchers reveals that the joint effects of common DNA variations in several genes within a well-defined biological pathway largely explain why some people develop Parkinson’s disease. The findings also predict with great accuracy at what age people might develop their first symptoms.
Researchers have found that Isradipine slows the destruction of dopamine-producing neurons in a mouse model, potentially preventing Parkinson's disease or slowing its progression. The study aims to develop clinical trials in humans to test the drug's efficacy.
Researchers from Yale University and others report that injecting human neural stem cells into primates with severe Parkinson's disease improved symptoms such as tremors and motor function. The study found that the stem cells survived, migrated, and had a functional impact, suggesting a potential therapeutic value.
Researchers at Northwestern University have discovered a drug that slows and may halt the progression of Parkinson's disease by rejuvenating aging dopamine cells. Isradipine, a widely used hypertension medication, restores stressed-out dopamine neurons to their youthful state, potentially extending the time L-DOPA works effectively.
A study found that exposure to pesticides increases the risk of Parkinson's disease, as does traumatic head injury, with higher levels of exposure associated with greater risk. The two factors are potentially modifiable, suggesting opportunities for prevention and reduction.
Scientists have successfully implanted dopamine generators in brain cells, leading to improved symptoms in Parkinson's disease in non-human primates. The treatment involves injecting fragments of the carotid body into the striate area of the brain, which boosts the production of dopaminergic cells and increases dopamine release.
Researchers at Mayo Clinic have discovered a correlation between violent rapid eye movement sleep behavior disorder and eventual onset of parkinsonism or dementia. Patients with the disorder may be exhibiting early signs of an evolving neurodegenerative disease caused by abnormal synuclein protein clumps.
A new study from USC researchers found that treadmill exercise can improve balance and stability in patients with Parkinson's Disease. The study, published in the Journal of Neuroscience, suggests that exercise may help the brain work more efficiently by allowing remaining dopamine-producing neurons to function harder.
A randomized clinical trial found that a 300-milligram dose of CoQ10 did not improve Parkinson's disease symptoms in patients. However, the treatment was well-tolerated and increased blood levels of CoQ10, suggesting potential benefits at higher doses.
Parkinson's disease and narcolepsy share symptoms due to damage in the same small group of neurons. Researchers found that Parkinson's patients have severe loss of hypocretin cells, which may be reversible with treatments aimed at reversing this deficit.
Researchers found people taking antidepressant medications were nearly twice as likely to develop Parkinson's disease than those not taking the medication. Depression was identified as an early symptom of Parkinson's, appearing in the year before diagnosis.
Researchers found people taking levodopa were 95% more likely to choose symbols associated with higher monetary gains than those on haloperidol. Dopamine depletion may lead to lack of motivation in Parkinson's disease patients.
Research found that individuals with moderate to vigorous exercise levels were 40% less likely to develop Parkinson's disease than those with low activity levels. The study of over 143,000 people suggested a potential benefit of regular physical activity in reducing the risk of this debilitating condition.
Researchers are developing nanotechnology to stimulate the body's healing abilities, enabling damaged organs to repair themselves. Early results show paralyzed lab mice regaining mobility after receiving a nanomaterial injection, offering hope for treating intractable diseases.
A novel video-imaging system reveals that slow component-b proteins, involved in Parkinson's and Alzheimer's diseases, exhibit rapid bursts of movement followed by pauses. Multiple slow proteins are also transported together as 'packets,' piggy-backing on molecular motors, suggesting a potential carpooling mechanism.
Research reveals a strong link between stroke damage to brain region putamen and motor neglect, a condition causing slow movement on the left side. Treatment targeting dopamine-like compounds may ease this disability in patients with Parkinson's disease.
A study found that people who smoked and drank coffee were less likely to develop Parkinson's disease, which may be due to genetic or environmental factors. However, the risks of smoking and caffeine consumption should not be taken to avoid the disease.
Individuals with Parkinson's disease are less likely to smoke or consume high doses of caffeine than their family members. Smoking, caffeine consumption, and NSAID use were found to be inversely associated with Parkinson's disease, with no link between NSAID use observed.
Research highlights the role of pesticides, toxic agents, and inflammation in Parkinson's development, while also exploring potential neuroprotective agents like nicotine. The findings aim to better understand the disease process and develop preventive measures.
Researchers found that taking the prolonged release version of ropinirole with levodopa significantly reduced daily 'off' time by 2.1 hours compared to the placebo group. Additionally, those taking ropinirole showed improvements in troublesome Parkinson symptoms, quality of life, and motor function.
The NIH is launching a large-scale clinical trial to explore the potential of creatine as a treatment for Parkinson's disease. The study aims to slow the progression of the disease and improve quality of life for patients.
Researchers used massive computer-simulation power to model protein aggregation and its role in Parkinson's and Alzheimer's diseases. They found that beta-synuclein blocks harmful structures caused by alpha-synuclein, offering a potential treatment for debilitating diseases.
A two-year study found that the drug risedronate reduced hip fractures in people with Parkinson disease by three times compared to placebo. Risedronate also increased bone mineral density and decreased biomarkers for bone loss, effectively controlling osteoporosis progression.
A study by Max-Planck-Gesellschaft researchers found that disabling Ret-receptors in mice leads to earlier death of dopaminergic neurons, similar to Parkinson's disease. The loss of these neurons is a hallmark of the disease, and the study suggests that preserving this function may be crucial for preventing neurodegeneration.
Researchers at the University of Kentucky are exploring a novel gene therapy approach using DNA nanoparticles to deliver proteins beneficial to brain cells. This technology has shown potential in rescuing dormant brain cells, causing them to produce dopamine, and improving symptoms in animal models of Parkinson's disease.
Patients with Parkinson's disease who develop the condition at a younger age and have a history of alcohol abuse are more likely to experience pathological gambling as a side effect of dopamine agonist medications. Behavioral characteristics such as impulsivity and risk-taking behavior may also play a role in this increased risk.
A Stanford University study suggests that boosting endocannabinoid levels in the brain may be a new treatment approach for Parkinson's disease. Researchers combined a drug with an experimental compound to trigger improved movement in mice with a condition similar to Parkinson's, showing promising results.
GST pi is a critical enzyme that stands at the crossroads of several biochemical pathways leading to Parkinson's disease. It prevents both externally provoked cell death and internally initiated suicide by blocking the formation of free radicals, which cause cell damage.
Researchers have developed a new model of Parkinson's disease in fruit flies, confirming the link between dopamine and a mutant form of the parkin protein. The study found that a single copy of the mutation was toxic to dopaminergic neurons, leading to motor dysfunction.
The number of individuals with Parkinson's disease is projected to nearly double globally by 2030, with the majority of growth occurring in developing countries in Asia. This growth will be driven by increasing life expectancy and growing economies, which will lead to increased healthcare spending and a greater burden on societies.
A study published in Neurology found that zonisamide significantly improved tremors and dyskinesias in Parkinson disease patients. The medication was effective at 50mg/day, with a nearly 40% improvement in symptoms.
A study by Dr. Xuemei Huang found that participants with lower LDL cholesterol had a 3.5-fold higher occurrence of Parkinson's disease compared to those with higher LDL levels. The results suggest a link between low LDL cholesterol and an increased risk of developing the neurodegenerative disorder.
Researchers have discovered that transplanted neural stem cells can survive, differentiate into neurons, and form synapses with host tissue, potentially offering a new treatment for Parkinson's disease. The study shows promise in reducing the destruction of dopaminergic cells and replacing those lost to the disease.
A groundbreaking study by neurologist Steven Goldman and his team used stem cells to treat Parkinson's disease in rats, achieving a remarkable improvement in symptoms. However, brain tumors appeared due to the stem cells' uncontrolled growth, prompting an urgent need to find solutions.
A study published in Neurology found that people with Parkinson disease were more likely to make safety mistakes during a driving test than those without neurological disorders. The study involved an on-road driving test of participants with mild to moderate Parkinson disease and those of similar age without neurological disorders.
An alliance is being formed in India to conduct Parkinson's disease clinical trials, which will aid in the development of new treatments and slow down disease progression. The initiative aims to bring attention to the condition in India, where only a few neurologists specialize in movement disorders.
The Parkinson Study Group has received a $200,000 grant from the Parkinson's Disease Foundation to fund innovative programs supporting clinical research. The grant will support retrospective data-mining projects and mentorship for young researchers, aiming to accelerate treatment development.
Neuroscientists at Duke University Medical Center discovered that critical nerve cells in mice fire all at the same time, overwhelming the brain's ability to control movement. This finding contradicts current theories behind Parkinson's disease and may help develop new therapeutics.
Researchers found that dopamine deficiency in Parkinson's causes loss of muscle control and paralysis due to disruption of coordinated activity in a particular neural circuitry. A new treatment pathway aims to restore this dopamine-regulated circuitry coordination.
The Phase I trial demonstrated statistically significant clinical efficacy and neuro-imaging results, with patients showing a 25% improvement in Unified Parkinson's Disease Rating Scale scores. PET scan data revealed a significant improvement in brain metabolism on the treated side of the brain compared to the untreated side.
A Phase 1 study of CERE-120, a gene therapy product, demonstrated significant symptom reduction in patients with advanced Parkinson's disease, reducing UPDRS motor 'off' scores by approximately 40%. The treatment also showed promising results in improving 'on' time and reducing 'off' time.
Researchers found that dopamine plays a critical role in regulating sleep and brain activity associated with dreaming. Animal models of Parkinson's disease and schizophrenia exhibited sleep disturbances when dopamine levels were reduced or increased, suggesting a link between dopamine imbalances and sleep problems in these conditions.
Research found that Parkinson's disease patients developing impulse control disorders show increased rates of depression, appetite changes, and irritability compared to those without the disorder. The study identified nine patients with impulse control disorders, including pathological gambling, hypersexuality, and excessive shopping.
A large collaborative effort has made publicly available genetic data for Parkinson's research, providing new opportunities for future studies. The data includes genotypes from hundred of patients and healthy controls, which may help identify common genetic variability that results in minor and moderate risk for disease.
A team of researchers used a sophisticated laser system to gain evidence that neuromelanin, a dark brown pigment accumulating in brains, consists of layers of two other pigments: eumelanin and pheomelanin. This structural arrangement may play a critical role in the neurodegenerative cascade behind Parkinson's disease.
Researchers found accelerated brain changes in people with Parkinson's, while mice exposed to pesticides showed increased oxidative stress and reduced dopamine uptake. Exposure to banned pesticides like dieldrin may increase the risk of developing Parkinson's earlier in life.
UT Southwestern researchers found that blocking tumor necrosis factor, an inflammatory molecule, reduces dopamine neuron death in rats with Parkinson's disease. The study suggests that TNF-dependent inflammation may contribute to the progression of the disease.
Researchers investigated the impact of two copies of the G2019S Parkinson's gene mutation on disease severity. They found no observable differences in symptoms, age of onset, or life expectancy between those with two copies and those with only one copy.
Researchers discovered that dopamine neurons in manganese-exposed animals don't release dopamine when stimulated, suggesting a dysfunctional dopamine system. The study found effects of manganese exposure at high blood concentrations, similar to those in children and adults with environmental or occupational exposure.
The University of Pittsburgh has been designated as an American Parkinson Disease Association Advanced Center for Parkinson's Disease Research. The center will focus on developing early diagnosis methods and understanding iron accumulation in the PD brain. Dr. J. Timothy Greenamyre will direct the center.
A large international study provides strong evidence that common genetic variants in the alpha-synuclein gene contribute to Parkinson's disease worldwide. Variability in this gene is associated with a 1.5 times greater risk for the disease, highlighting potential therapies to reduce alpha-synuclein protein production.
Research found that SNCA gene variability is associated with an increased risk of Parkinson disease, explaining approximately 3% of the population's susceptibility. The study also suggests that this variation may be a common factor in the development of the disease.
Researchers at Mayo Clinic have discovered an association between allergic rhinitis and the development of Parkinson's disease. The study found that people with allergic rhinitis are 2.9 times more likely to develop Parkinson's, highlighting a potential link between inflammation and the disease.
A five-year study by The Parkinson's Institute suggests that nicotine treatment can reduce dopamine cell damage in Parkinson's disease. This protective effect may explain the lower incidence of Parkinson's among smokers, and could potentially lead to new therapy options for early-stage patients.
Researchers at the Montreal Neurological Institute have made a groundbreaking discovery about the parkin gene, which plays a novel role in nerve cell survival. This finding may help identify potential treatment targets for Parkinson's disease and other neurodegenerative disorders.
Researchers have created a new genetic model for Parkinson's disease using mice with a deleted TFAM gene, which mimics the human condition. The study shows that dopamine-producing nerve cells in the brain stem degenerate slowly, similar to humans with Parkinson's disease.
A study found that alterations in the glucocerebrosidase (GBA) gene contribute to dementia with Lewy bodies (DLB), a common neurodegenerative disease. Researchers sequenced DNA from autopsy samples and identified mutations in the GBA gene in nearly 40% of DLB patients.
A recent study found that apathy is a core feature of Parkinson's disease and may occur in up to 51% of patients. Apathy with no depression was also present in 29% of those with Parkinson's disease, highlighting the need for accurate diagnosis and treatment.
Researchers found that direct neurologist involvement improves Parkinson's disease symptoms for patients undergoing deep brain stimulation, leading to reduced tremors and medication dosages. This study emphasizes the importance of personalized care by experts in movement disorders and deep brain stimulation.
A study by Emory University researchers found a connection between developmental exposure to the pesticide dieldrin and an increased risk of developing Parkinson's disease. The study suggests that early life exposures may contribute to neurodegeneration later in life.