Articles tagged with Parkinsons Disease
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A study using positron emission tomography (PET) brain scans identified different forms of Parkinsonism with high accuracy. The research found that image-based classification had excellent specificity and positive predictive value for idiopathic Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy.
A large-scale study demonstrates that transplanted cells produced dopamine, leading to improved motor symptoms and brain function. Long-term clinical outcomes revealed sustained improvements over a four-year period.
Researchers discovered four small molecules capable of protecting cells from alpha-synuclein toxicity, a hallmark of Parkinson's disease. The compounds improved protein trafficking and decreased mitochondrial damage in multiple models, suggesting potential therapeutic avenues for the disease.
Scientists have found that activating Retinoid X Receptor (RXR) increases dopamine cell survival in models of Parkinson's disease, providing a novel strategy for treating the condition. The study used two cellular models to explore the neuroprotective function of RXR ligands LG268 and XCT.
Researchers studied gait to identify physical signs of Parkinson's disease in its early stages. The team found that people with Parkinson's had significantly asymmetrical arm swings compared to those without the disease.
Researchers at the Muhammad Ali Parkinson Center are conducting a study to determine if simple exercise can help protect neurons in the brain from Parkinson's disease. Participants will follow a structured exercise program called pole-striding, which involves walking with ski-like poles, for 12 weeks.
Researchers found that ghrelin is protective of dopamine neurons and can slow the development of Parkinson's disease. Ghrelin supplementation in mice showed increased dopamine production and reduced loss compared to controls.
Dr. Larisch's research links Parkin and ARTS proteins to excess brain cell death in PD, a progressive neurodegenerative disorder. This discovery may lead to better treatment of patients suffering from Parkinson's Disease.
Scientists at Garvan Institute of Medical Research developed a mathematical model and microscopy method to reveal mechanisms behind dopamine release. The study found that dopamine release is regulated by factors such as the frequency of nerve impulses, making it possible to develop more effective treatments.
ISU researchers have discovered a compound that neutralizes the cell-killing kinase-C and allows dopamine-producing cells to survive and function. This finding brings hope for a possible cure for Parkinson's disease by targeting the protein responsible for killing these cells.
Stereotactic radiosurgery is an effective and safe method for eliminating tremors caused by Parkinson's disease and essential tremor. Long-term results show that SRS favorsably compares to deep brain stimulation and radiofrequency treatments in terms of tremor relief and complications.
Researchers found that simvastatin reverses biochemical changes caused by Parkinson's disease in mice. The drug blocks the activity of p21Ras protein and protects neurons, normalizing neurotransmitter levels and improving motor functions.
A new study found that carriers of Gaucher disease face a significantly higher risk of developing Parkinson's disease, with the risk being 5 times greater than the general public. The study also found that GBA alterations increase the likelihood of early disease onset.
Researchers from Yerkes National Primate Research Center are presenting on various topics, including Alzheimer's disease, Parkinson's disease, and memory function. The study aims to improve human health by understanding the evolutionary specializations of the human brain and its relationship with neurological disorders.
Michigan State University has been awarded a $6.2 million Morris K. Udall Center of Excellence for Parkinson's disease research grant. The grant makes MSU's College of Human Medicine a major player in research of the degenerative disease, with eight investigators expected to join the center by next summer.
Research identifies opposing roles for phosphorylated alpha-synuclein amino acids in Parkinson's disease. Phosphorylation at Tyr125 protects nerve cells from alpha-synuclein toxicity, whereas Ser129 phosphorylation increases toxic oligomers.
Researchers confirm association between higher blood urate levels and slower disease progression in Parkinson's patients. The study suggests that elevated urate levels may have a protective influence on brain cells, but the exact mechanism is unclear.
Scientists found that Parkinson's disease progresses more slowly in participants with the highest levels of urate. This discovery supports the idea that patients and doctors may be able to better predict the course of the illness.
Higher urate levels in patients with early Parkinson's disease are associated with slower clinical decline. The study found that elevated urate levels in the cerebrospinal fluid were inversely related to disease progression.
A study funded by NIH found that individuals with higher urate levels in their blood and cerebrospinal fluid have a slower rate of disease progression. A clinical trial is underway to examine the safety and benefits of supplemental urate elevation for recently diagnosed patients.
A driving simulation test involving 67 people with mild to moderate Parkinson's disease and 51 healthy individuals found that those with Parkinson's were more likely to crash in foggy conditions. Their reaction time was also longer, averaging 2.7 seconds compared to 2.1 seconds for healthy drivers.
A large-scale clinical trial aims to determine if high doses of coenzyme Q10 can slow Parkinson's disease progression. Studies have shown that Parkinson's patients have impaired mitochondrial function and low levels of coenzyme Q10, which can be protected by the enzyme.
A new study found that occupational pesticide exposure is associated with an increased risk of developing Parkinson's disease. The study, published in Archives of Neurology, investigated the link between pesticide use and parkinsonism, and found that certain pesticides more than doubled the risk of the disease.
Researchers at Mayo Clinic have discovered a single gene promoting development of essential tremor in some patients and Parkinson's disease in others. The study found a significant association between the LINGO1 gene variant identified in Iceland to both disorders, with mutations potentially responsible for five percent of patients.
Researchers have identified a new nerve growth factor, MANF, that can halt the progress of Parkinson's disease and restore damaged cells in rats. The study shows promising results, suggesting that MANF may be a highly significant finding in respect to growth factor therapy for PD.
Researchers have discovered a way to regulate gene therapy for Parkinson's disease by introducing an 'off switch' using the antibiotic doxycycline. This breakthrough addresses safety concerns and paves the way for safer treatment options.
Researchers developed a new technology using ambient sound to aid Parkinson's patients speaking louder and more clearly. The system, which plays background babble noise when the patient begins to speak, shows significant improvement in speech changes after eight weeks of training.
Parkinson-associated genes PINK1 and Parkin functionally interact to maintain mitochondrial function, impairing neuron loss
A landmark study will follow 200 people with PD for at least two years to examine the impact of disease progression on day-to-day function and quality of life. The research aims to advance understanding of how interventions like exercise affect changes in quality of life and mobility over time.
Researchers found that H5N1 flu infection causes a 17% loss of dopamine-producing cells and accumulation of alpha-synuclein protein, key findings linked to Parkinson's disease. The study suggests the virus primes the brain for further damage from environmental toxins or other infections.
A study published in Cortex found that Parkinson's patients struggle with grammatically complex sentences due to degeneration of dopamine-secreting neurons. Eye-tracking data revealed slower response times when processing relative clauses, but not at the end of sentences.
Researchers created a fly model to study Parkinson's-associated dementia, finding that sleep loss caused long-lasting cognitive impairments. Curcumin blocked this effect, restoring normal learning abilities in genetically modified flies.
The study reveals that alpha-synuclein aggregates can pass to new, healthy cells, contributing to the progression of Parkinson's disease. The researchers found that cell-to-cell transmission of alpha-synuclein occurs through endocytosis and is linked to impaired quality-control systems in recipient cells.
Researchers at UT Southwestern Medical Center found people with Parkinson's disease have significantly higher blood levels of a particular pesticide than healthy individuals. The study may provide the basis for a beta-HCH blood test to identify those at risk for developing the disease.
Researchers at Queen's University have created eye movement tests to aid in understanding childhood brain development, healthy aging, and the diagnosis of Attention Deficit Hyperactivity Disorder (ADHD) and Parkinson's disease. The study found that children scored low on these tests, while those with ADHD showed decreased normal brain ...
A rapid and inexpensive drug-screening method developed by Whitehead Institute scientists uses baker's yeast to synthesize and screen molecules, cutting testing time to weeks. The technique targets protein-protein interactions found in cellular processes, offering new potential for treating diseases like Parkinson's.
Individuals with higher levels of education and significant impairment by Parkinson's disease require treatment earlier than others. Higher education is independently associated with an increased need for symptomatic treatment.
Researchers have developed a novel drug discovery tool that uses baker's yeast to rapidly search for drugs to treat Parkinson's disease. The tool identifies cyclic peptides with protective effects on yeast cells and neurons in an animal model of the disease, offering new hope for treatment breakthroughs.
Researchers present findings on stimulating metabotropic glutamate receptors to stop glutamate release in brain cells, potentially reversing Parkinson's disease symptoms. Current treatments only alleviate symptoms, but new approach aims to protect and repair dying cells.
A new class of pulsars detected by NASA's Fermi Gamma-ray Space Telescope reveals the existence of a large population of radio-quiet gamma-ray pulsars. The study identifies 16 pulsars using computational techniques developed to analyze data from the Fermi Large Area Telescope.
Researchers found that Parkinson's patients exhibit a selective impairment in learning from reward, but not from negative outcomes. Treatment with dopamine agonists improves learning from positive outcomes, but impairs learning from negative outcomes.
Researchers at UT Southwestern Medical Center have identified a protein called CHIP that binds to the mutated protein LRRK2, promoting its breakdown. This finding provides a potential therapeutic target for treatments to halt the action of the mutated protein.
The University of Texas Health Science Center at Houston has received a two-year, $412,500 federal stimulus grant to support research on developing a therapeutic vaccine for Parkinson's disease. Researchers aim to target alpha-synuclein, a protein associated with the disease, and potentially slow its progression.
A genetically engineered mouse reproduces many of the non-motor symptoms associated with Parkinson's disease, including digestive problems and loss of sense of smell. The mice have delayed emptying of the stomach, fall asleep more quickly, and display signs of depression in tests.
A telemedicine project at the University of Rochester Medical Center has improved quality of life and motor function for Parkinson's patients in nursing homes. The system, utilizing a laptop, software, and web camera, enables specialists to conduct virtual visits with trained nurses, reducing travel burden and costs.
Four University of Miami Marine Biology and Fisheries students have received recognition from the National Science Foundation for their research on coral reefs. Ross Cunning and John Parkinson were awarded fellowships, while Sean Bignami and Kevin V. Brix received Honorable Mentions.
Researchers found significant improvements in rigidity, movement, fine motor skills, and energy levels among Parkinson's patients playing Wii games. Most participants experienced a decrease in depression levels to zero.
Researchers have identified the protein ILK as promoting growth of aggressive rhabdomyosarcoma cells and suppressing ERMS cell growth. A therapy targeting ILK may provide a tailored approach for treating the lethal form of RMS, ARMS.
Researchers at Karolinska Institutet are making rapid progress in stem cell therapy, with a first-in-human study initiated for Parkinson's disease. The study uses the drug product sNN0031, which has shown long-lasting recovery and new cell formation in animal models. Additionally, a treatment for ALS entered clinical trials last year.
Researchers at Columbia University Irving Medical Center have identified a protein called oct3 that plays a critical role in both Parkinson's disease and addictive drugs. The protein helps toxic chemicals reach dopamine neurons, leading to cell death in patients with Parkinson's disease.
Researchers discover organic cation transporter 3 (oct3) plays a critical role in both Parkinson's disease and drug addiction by transporting toxic chemicals into brain cells that die in patients with the condition. Oct3 helps astrocytes remove excess dopamine, leading to feelings of euphoria but also potential brain damage.
Researchers at Columbia University Medical Center found that dopamine, a calcium channel, and alpha-synuclein act together to kill brain cells in Parkinson's disease. The discovery gives hope for saving neurons and stopping the progression of the disease by targeting just one of the three factors.
Researchers found a 75% increased risk of Parkinson's disease among Central Valley residents exposed to maneb and paraquat between 1974 and 1999. Earlier exposure, particularly in childhood or adolescence, significantly increased the risk, especially for those diagnosed at age 60 or younger.
A study by Dr. Nicolas Bazan at LSU Health Sciences Center has found that an omega three fatty acid called docosahexaenoic acid (DHA) protects brain cells from misfolding proteins associated with Parkinson's disease and other neurodegenerative disorders.
Researchers have identified a group of cells as direct targets of deep brain stimulation (DBS) using optogenetics, which reduces disease symptoms by preferentially activating neurons linked to the subthalamic nucleus region. The technique allows precise stimulation and measurement of treatment effects simultaneously in animals with Par...
A new study at the Mayo Clinic found that one in six patients taking therapeutic doses of dopamine agonist medications for Parkinson's disease developed new-onset compulsive gambling or hypersexuality. Researchers analyzed medical records of patients and found no such cases in those taking low doses or other treatments.
Researchers found that a gene called Nurr1 limits pro-inflammatory neurotoxic mediators in microglia and astrocytes, suggesting a link between inflammation and Parkinson's disease progression. The study may point to new avenues for therapy and anti-inflammatory treatments to combat the disease.
A study published in Physical Therapy found that directing attention to external effects of movement improves postural stability in patients with Parkinson's disease. This strategy may help reduce falls and improve mobility for those affected.
Researchers have developed a non-invasive brain scanning technique that may help diagnose Parkinson's disease and track its progression. The technique uses diffusion tensor imaging to examine the substantia nigra region of the brain, which produces dopamine.
Researchers discovered that GDNF delivery to specific brain areas can cause unwanted weight loss in Parkinson patients. The finding suggests that gene therapy techniques in the brain potentially could control obesity and highlights the importance of placing therapy in the correct region.