Articles tagged with Parkinsons Disease
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Researchers have identified neuroimaging techniques that can predict Parkinson's disease in patients with REM sleep disturbances, enabling early neuroprotective treatment strategies. A study found that 19% of patients developed a neurodegenerative disorder within two and a half years, with 5 cases of Parkinson's disease among those sho...
Researchers have identified neuroimaging abnormalities in patients with rapid-eye-movement sleep behaviour disorder that predict the development of neurodegenerative diseases. The study found decreased striatal dopamine transporters uptake and midbrain hyperechogenicity to be risk factors for developing Parkinson's disease, dementia wi...
Researchers at Columbia University Irving Medical Center have identified a novel molecular pathway underlying Parkinson's disease, which involves polyamines and toxic proteins in neurons. The study suggests that polyamine-lowering drugs may be able to slow the disease's progression and potentially lead to early detection tests.
Researchers are uncovering the molecular basis of Parkinson's disease by studying alpha-synuclein in yeast cells, which could lead to new therapeutic drugs. Small compounds found effective in preventing Parkinson's disease in worms and blocking toxic effects in rat neurons may form the basis of future treatments.
Parkinson's disease affects brain circuitry that impacts cognitive functions like planning and decision-making. Researchers discovered patients can perform automated tasks better than non-patients, yet struggle to adapt to changing behaviors.
Moussa B.H. Youdim, a renowned neuroscientist, receives the 2010 ECNP Lifetime Achievement Award for his groundbreaking work on neuroprotective therapies for Parkinson's disease and Alzheimer's disease. His research focuses on the role of monoamine oxidase enzymes in neurotransmitter metabolism and brain iron metabolism.
A genome-wide association study has revealed a strong link between a gene in the human leukocyte antigen region and Parkinson's disease, implicating the immune system. The study suggests that inflammation is involved in the origin of the disease, not just a symptom.
Researchers at Johns Hopkins have identified two drugs that can protect nerve cells in mice from the lethal effects of Parkinson's disease by blocking the overactive LRRK2 protein. This finding suggests a promising target for developing treatments against Parkinson's disease.
A team of researchers has discovered a genetic link between the immune system and Parkinson's disease, finding a new association with the HLA region. The study, which analyzed over 2,000 patients and healthy volunteers, suggests that immune function may play a role in the development and progression of Parkinson's disease.
Individuals with Parkinson's disease who were told they had a higher chance of receiving an active drug showed a stronger neurochemical response to placebo. The expectation of symptom improvement is associated with the release of dopamine in patients with Parkinson's disease and can affect motor performance.
Researchers found that a gaseous molecule called nitric oxide can trigger brain cell death in neurodegenerative diseases. The study discovered a new molecular pathway that leads to cellular suicide, offering new potential for diagnosis and treatment.
Scientists at Stanford University School of Medicine have identified a molecular pathway responsible for the death of key nerve cells whose loss causes Parkinson's disease. The study found that a genetic mutation linked to Parkinson's causes impaired activity of microRNAs, leading to premature cell death.
A recent study found that REM sleep behavior disorder can be an early warning sign of dementia or Parkinson's disease, with some patients experiencing symptoms for up to 50 years before diagnosis. The research suggests that the brain may be actively affected by these disorders for an extended period.
Researchers are investigating how parkin protein can rescue certain neurons from injury induced by Parkinson's disease. The study aims to understand the steps underlying parkin's ability to promote neuron recovery and identify targets for therapies.
Researchers discovered that specific brain circuits in the basal ganglia signal the start and stop of new actions, a process compromised in Parkinson's and Huntington's patients. Genetic manipulation of these circuits in mice impaired sequence learning, echoing human patients' struggles with movement initiation and termination.
Researchers are using induced pluripotent stem cells from skin tissue to grow dopamine neurons and study Parkinson's disease. The goal is to better understand the cause of the disease by comparing healthy cells with those affected by Parkinson's.
Researchers identify pedunculopontine nucleus as key brain region in Parkinson's disease-related gait disorders. Targeting acetylcholine-producing nerve cells may alleviate falls and improve walking abilities.
A study published in JCI Online found that targeting acetylcholine-producing nerve cells in the pedunculopontine nucleus may alleviate gait disorders and falls in Parkinson's disease patients. Meanwhile, another study suggests that blocking TIM-1 protein could provide therapeutic benefits for asthma patients.
A 29-year follow-up study of Finnish men and women found that individuals with higher vitamin D levels had a significantly lower risk of developing Parkinson's disease. The study suggests a potential link between chronic inadequacy of vitamin D and the development of Parkinson's disease.
A new study reveals that low vitamin D levels can predict the development of Parkinson's disease, with individuals having the lowest levels being three times more likely to develop the condition. Researchers are calling for public health authorities to consider raising the target vitamin D level above the current recommended level.
Researchers at Gladstone Institutes establish a connection between brain circuits and Parkinson's disease symptoms, identifying a potential treatment strategy. By activating specific pathways, they can mimic Parkinson's-like symptoms and even restore motor function in mice with dopamine deficiency.
The Parkinson's Disease Foundation has announced $1.2 million in research awards to support scientists studying the cause of and potential treatments for Parkinson's disease. Funding will go towards projects exploring dopamine regulation, tobacco compounds, and more.
A study published in Neuron reveals that the loss of Nna proteins causes mitochondrial dysfunction, leading to severe cell death in mice and fly models. Researchers believe this discovery could provide insights into human neurodegenerative disorders like Parkinson's disease.
A study published in Neurology found that a combination of tests can predict falls in people with Parkinson's disease. The tests evaluated overall symptoms, balance, and mobility, showing a sensitivity of 78% and specificity of 84%. Implementing these tests can help identify those at risk of falling and prevent injuries.
Researchers found that Parkinson's patients with impulsive-compulsive spectrum behaviors have impaired self-control, but normal motivation. They prefer smaller immediate payments over larger delayed ones.
A study found that genetic mutations and pesticide exposure interact to increase men's risk for Parkinson's disease. Individuals with two variant alleles of the ABCB1 gene who were exposed to organochlorine insecticides had a stronger association with Parkinson's disease.
Researchers at Rhode Island Hospital tested spinal cord stimulation in a single patient with Parkinson's disease, finding that low-frequency SCS worsened symptoms while high-frequency SCS improved motor function. Further studies are needed to confirm these findings and explore potential benefits of this approach for PD patients.
A major study found that patients with Parkinson's disease respond similarly to deep brain stimulation (DBS) at two different brain targets, challenging current beliefs. Motor symptoms such as tremor and stiffness improved equally in both groups.
A major study published in the New England Journal of Medicine has found that deep brain stimulation (DBS) is an effective treatment for Parkinson's disease, with similar improvements in motor function regardless of the targeted region. The study also revealed small differences in non-motor effects such as mood and cognitive function.
Researchers have developed a real-time wireless monitoring system to track vital signs of patients with debilitating conditions like Parkinson's disease and COPD. The system uses wearable sensors and a web portal for medical personnel to receive alerts in case of life-threatening events.
Researchers identified a previously unknown brainstem pathway in vertebrates, which stimulates neural activity and locomotion. This finding suggests new research directions for treating Parkinson's disease, particularly targeting the neurotransmitter acetylcholine.
A randomized trial found that pramipexole significantly improved depressive symptoms and functioning in patients with mild-to-moderate Parkinson's disease. The study also showed that the antidepressant effect of pramipexole was largely independent of its effect on motor symptoms.
Researchers successfully transplanted endometrial stem cells into the brains of mice with a Parkinson-like condition, restoring partially dopamine levels. This finding raises the possibility of women serving as their own stem cell donors and banks being established for men and women with Parkinson's disease.
Researchers at Yale University have discovered that endometrial stem cells can repair brain cells damaged by Parkinson's disease, potentially treating women with the condition. The study, published in Journal of Cellular and Molecular Medicine, found that these stem cells can differentiate into dopamine-producing nerve cells.
Researchers at UCSF have created a transgenic mouse model that displays the earliest signs of Parkinson's disease, including constipation and gastrointestinal problems. The model is significant as it validates a theory suggesting the neurological component of Parkinson's is a late-stage effect of a larger systemic problem.
A recent study published in The Lancet Neurology found that deep brain stimulation improves quality of life, mobility, and activities of daily living in advanced Parkinson's disease patients, while also reducing dyskinesia and off time. However, the procedure carried a higher risk of serious adverse events.
Researchers at the Genome Institute of Singapore have developed a zebrafish model to study Parkinson's disease, which can aid in drug development and screening. The model demonstrates that zebrafish can be used to study human diseases, including PD, and has potential for large-scale drug screening.
Parkin and PINK1 genes play a critical role in Parkinson's disease. The study found that PINK1 is rapidly degraded under healthy conditions, but its accumulation stabilizes at low membrane potential. Parkin is recruited to mitochondria with low potential to dispose of damaged organelles.
A new book by NASA climatologist Claire Parkinson examines the coming climate crisis, drawing on 4.6 billion years of Earth's climate history. The book highlights the limitations of computer models and warns of unintended consequences of geoengineering, instead advocating for alternative approaches to reduce climate change.
New data from the RECOVER study showed that Neupro (Rotigotine Transdermal System) effectively improved both motor and non-motor symptoms of Parkinson's disease, including sleep quality, mood, cognition, and pain. The treatment also translated into significant improvements in quality of life for patients.
New data presented at the American Academy of Neurology annual meeting showed that patients with moderate to severe RLS using rotigotine achieved sustained improvements in symptoms over 5 years. The study confirmed the safety and efficacy of rotigotine, with over a third of patients remaining symptom-free after 5 years.
Scientists at the Max Planck Institute of Neurobiology have demonstrated using a new animal model that nerve cells do not begin to die until three conditions are met in Parkinson's disease. This finding is an important step forward in understanding this illness and may offer a potential new direction for therapy.
Scientists at UCSF have developed a novel cell-based strategy to treat Parkinson's disease by transplanting embryonic neurons into the striatum, improving motor function and balance in rats. The approach may offer a more precise effect than traditional strategies and has implications for other neurodegenerative diseases.
A new guideline recommends treatments to help people with Parkinson's disease manage sleep disorders, constipation and sexual problems. The guideline suggests medications like sildenafil citrate and isosmotic macrogol to improve erectile dysfunction and constipation.
A study of over 305,000 people found that those who smoked for 40+ years were 46% less likely to develop Parkinson's disease. However, the risk did not decrease with the number of cigarettes smoked per day.
University of Alabama scientists find that ampicillin enhances the normal function of torsinA protein in cells affected by dystonia and Parkinson's disease. The drug restored normal movement to mice and improved cellular protection against stress, leading to potential new treatments for these debilitating conditions.
People with Parkinson's disease struggle to recognize emotions in others' faces and voices. Deep brain stimulation appears to exacerbate this issue, particularly with fear and sadness expressions.
A study of 136,474 participants found that regular ibuprofen users were 40% less likely to develop Parkinson's disease. Higher doses of ibuprofen also showed a reduced risk of developing the disease.
Researchers at McGill University discover a molecular link between Parkinson's disease and impaired nerve cell communication. They found that parkin protein binds to endophilin-A, affecting synaptic transmission and potentially leading to dopamine neuron death.
A population-based study confirms exposure to TCE increases the risk of Parkinson's disease, with workers five and a half times more likely to develop the condition than those not exposed. The study used twins to evaluate environmental risk factors and found significant associations between TCE exposure and Parkinson's disease.
Research reveals that people with Parkinson's disease are often isolated and stigmatized based on their communication style. The study shows that negative perceptions of speech patterns can limit opportunities for social interaction and reduce full participation in society.
Researchers are testing whether simulation driving can improve Parkinson's patients' driving skills and reduce their threefold increased risk of car accidents. The five-week training program involves simulator-based driving tests and on-road evaluations to assess the impact of cognitive-improving activities.
Parkinson's disease is more common in the Midwest and Northeast, with twice as likely to affect whites and Hispanics compared to blacks and Asians. Environmental factors, such as chemical exposure in farming and agriculture, are considered a major contributor to the disease.
Researchers at Emory University School of Medicine have identified a novel compound, 7,8-dihydroxyflavone, that mimics the brain's growth factor and protects against neurological disease damage. The flavonoid compound shows potential as a new class of brain-protecting drugs with low chronic toxicity.
A large-scale population-based study found that specific sub-class of dihydropyridine cardiovascular medications decreased the risk of Parkinson's disease by 26-30%. The study suggests that these medications' ability to cross the blood-brain barrier may be key to their neuroprotective effects.
Researchers developed a brain-based model to understand how Parkinson's affects learning and attention, highlighting the role of dopamine in non-motor symptoms. The study shows that dopamine medications enhance attentional performance in patients.
Treadmill training can improve walking movements and reduce gait hypokinesia in Parkinson's patients. The systematic review found positive effects on walking speed, stride length, and walking distance but no improvement in cadence.
A study reveals a genetic variant that increases the risk of Parkinson's disease, affecting vitamin B6 metabolism and dopamine production. This interaction with dietary habits may aid in developing individualized therapies.
Researchers found that pathological gamblers with Parkinson's Disease exhibited poor decision-making and abnormal social behavior. They performed poorly in the Iowa Gambling Task and showed difficulties in forming close relationships.
Researchers identified dopamine agonist withdrawal syndrome (DAWS) in patients with Parkinson's disease who reduced their medication dosage. DAWS causes anxiety, panic attacks, depression, and other symptoms that are not alleviated by other treatments.