Research on blood and what it reveals about health. Covers blood biomarkers, occupational exposure, cell-preservation for CAR-T therapy, and blood supply.
A new study published in the Journal of the American Heart Association found that elevated levels of two protein biomarkers associated with heart damage were linked to undetected or symptomless cardiovascular disease in adults with Type 2 diabetes. The study analyzed health information and blood samples from over 10,300 adults and foun...
A study of 8,269 pediatric patients reveals persistent disparities in central line–associated bloodstream infection rates for Black patients and those who speak a language other than English. Stratifying outcomes to assess for disparities may inform targeted interventions to improve equity.
Researchers discovered that vascular toxicity linked to these drugs is unrelated to angiogenesis-related genes, but rather due to changes in vascular architecture. This new understanding will help select the most effective and safe way to modulate angiogenesis in ischemic tissues or cancer.
Researchers found that a combination of amyloid burden and blood markers of abnormal astrocyte activation can predict Alzheimer's disease progression. Testing for these biomarkers may help identify patients at risk, enabling earlier diagnosis and treatment.
Researchers at the University of Gothenburg have developed a new blood test that can measure biomarkers in the blood before and after neurosurgery, correlating with the extent of brain injury. The study found that high levels of certain markers may indicate damage that could cause cognitive problems for patients in the long term.
Researchers found variability in IgA levels between blood and gut samples, suggesting IgA regulates commensal microbes to prevent immune dysregulation. Patients with normal fecal IgA were less likely to develop symptoms, while those deficient in both blood and fecal IgA showed elevated inflammatory cytokines.
Two researchers will receive $1 million each for their five-year studies on new medication-based approaches to repair damaged aortas, as well as the effects of exercise on healing heart muscle and brain tissue after a heart attack or stroke. The American Heart Association's Merit Award supports innovative research with high impact.
Increasing physical activity, particularly daily 20-minute walks, can improve cardiovascular health and reduce disparities in heart health. Despite this, only one in four American adults meet the recommended physical activity levels, with certain groups facing additional barriers to accessibility.
A new study found that lesbian and bisexual women are less likely to have ideal cardiovascular health scores compared to heterosexual women. In contrast, gay and bisexual men were more likely to have ideal cardiovascular health scores. The study highlights the need for prevention strategies among sexual minority adults in France.
A new study by researchers from the University of Edinburgh found that double testing with a faecal immunochemical test (FIT) increases the detection rate of bowel cancer to nearly 100%. This approach ensures more cases are identified and can potentially reduce demand for colonoscopies.
The study used magnetic resonance imaging (MRI) to measure acute pressure changes inside the heart, discovering that pressure increases when patients receive a specific medication called adenosine. This technology can help doctors better diagnose and monitor patients with heart disease and heart failure.
A recent study published in PLOS ONE found that pregnant and lactating dogs share similarities in certain blood metabolites with human pregnancy, including glucose and fatty acid concentrations. The research analyzed 27 dogs from 21 breeds and discovered intriguing correlations between canine metabolism and human physiological processes.
A study by UMC Utrecht shows that corona patients can measure their blood oxygen levels at home using a pulse oximeter, feeling safe and experiencing more control. This method does not increase GP visits or hospitalization but contributes to relieving caregivers and keeping healthcare affordable.
Researchers develop innovative data compression scheme to facilitate multispeckle diffuse correlation spectroscopy with high pixel resolutions, enabling non-invasive measurement of brain blood flow. The scheme uses field-programmable gate array compression to alleviate computational burdens and expand the use of SPAD cameras in biomedi...
Researchers at CU Anschutz Medical Campus used metabolomics to study elite cyclists' metabolism during training and racing. The study identified healthy metabolomic signatures that can help detect dysregulations of key areas ahead of time, potentially leading to personalized exercise-as-medicine approaches for preventing chronic diseases.
A pilot study found that high-dose tadalafil improved metabolic control and reduced hemoglobin A1c levels by 2.50 mmol/mol in patients with well-controlled type 2 diabetes. The treatment also showed increased blood flow, liver values, and metabolism.
New research published in the journal SURGERY found that obesity is associated with increased risk of complications following surgery, including infection, blood clots, and kidney complications. Patients with overweight or obesity had higher risk-adjusted odds of developing these post-operative outcomes compared to those of normal weight.
Strokes can be largely prevented through education and lifestyle changes, such as moving more, healthy eating, and managing blood pressure. The American Stroke Association is launching a digital tool to educate people on stroke warning signs and risk factors, particularly for diverse populations.
A University of Houston team has discovered new biomarkers for early detection of bladder cancer, including D-dimer and IL-8, which may identify disease progression. The study's findings could lead to a simple urine test as the new standard for bladder cancer diagnosis.
Researchers at UBC and the University of Michigan have discovered a new compound, MPI 8, that prevents blood clots without increasing bleeding risk. This breakthrough could lead to improved treatment options for patients affected by blood clots.
A two-component system designed by MIT engineers has shown promising results in stopping internal bleeding in mouse models. The system, which mimics the body's natural clotting process, uses a nanoparticle and polymer to recruit platelets and form blood clots at injury sites.
Researchers used fluid dynamics to model blood drop behavior during secondary atomization, finding smaller droplets are easier to sweep up by firearm gases. This discovery could explain how short-range shooters remain clean from blood stains.
A new study by Ohio State University researchers has made significant strides in ensuring the safe and effective transfusion of artificial blood substitutes. The key to improved safety lies in the size of the artificial blood molecule, with larger sizes reducing cardiovascular side effects.
A team of UCF College of Medicine researchers created a digital topographical map of the cardiac sympathetic neural network, controlling heart rate and 'fight-or-flight' response. The map will guide treatments like neuromodulation therapy for hypertension, sleep apnea, and heart failure.
Researchers found that correctly occluded left atrial appendages minimized left atrial flow stasis and thrombogenicity using 4D flow MRI and 3D phantoms. The study provides a clinical goal for the procedure in patients with atrial fibrillation.
Researchers at The Mount Sinai Hospital have created versatile disease models of acute myeloid leukemia (AML), allowing for accurate study of the cancer's progression and response to drugs. These models, derived from induced pluripotent stem cells, can mimic different stages of AML and are nearly identical to those found in patients.
Researchers have identified hundreds of genes with significant stroke-driven changes and likely relevance in human strokes. The study found alterations in sphingolipid production, which are involved in regulating blood vessels, and pinpointed several molecular pathways that can be targeted for stroke treatment.
A novel treatment approach called balloon pulmonary angioplasty has been shown to be effective in treating chronic blood clots in lung arteries. The procedure improves exercise capacity and quality of life, with some patients able to stop medications altogether. Refinements in technique have improved the procedure's safety and efficacy.
Researchers develop a new technique to measure blood attenuation using a fluorophore-coated guidewire, improving the accuracy of near-infrared fluorescence in cardiovascular imaging. The method provides accurate information on vessel walls and outperforms existing correction methods.
Researchers at Karolinska Institutet have discovered that a type of sugar molecule in blood is associated with the level of tau protein, a critical factor in severe dementia. Measuring blood glycan levels can predict Alzheimer's disease risk to 80% accuracy, almost a decade before symptoms appear.
A new study from Uppsala University found that patients can experience twice as much improvement in blood pressure by changing medication as they would by doubling their current dose. The study, involving 280 patients and testing four different blood pressure-lowering drugs, challenges the conventional strategy of recommending equally ...
Psychiatrists at Indiana University School of Medicine found deaths by suicide increased during the week of a full moon, especially in people over age 55. They also identified 3-4 p.m. and September as peak times for suicides.
Researchers from the London School of Hygiene & Tropical Medicine found that intramuscular administration of tranexamic acid (TXA) is safe and quickly reaches therapeutic concentrations in pregnant women. Oral TXA was also well-tolerated but took an hour to reach therapeutic blood concentrations.
Researchers found decreased lung injury, coughing up blood, and mortality rates after balloon pulmonary angioplasty between 2013 and 2022. The minimally invasive procedure is now considered a safer option for inoperable CTEPH patients.
Using image-based computational blood dynamics, researchers mimicked health conditions and investigated hemodynamic parameters to better understand how aneurysm size affects blood flow. They found that altered blood flow velocity distribution can lead to rupture, emphasizing the importance of early detection and treatment options.
A WPI researcher is leading a three-year project to investigate the effects of stretching and blood flow on cardiovascular cells in tissue-engineered heart valves. The project aims to expand understanding of mechanical forces that propel cells in the body, with potential applications in other fields like cancer and wound healing.
The article discusses concerns about the integrity of research and the well-being of participants due to financial conflicts of interest. The authors argue that disclosing these conflicts to potential participants may not achieve their intended moral goals, highlighting the need for improved policies.
A study by Johns Hopkins Medicine researchers found that certain biomarkers in urine and blood can predict the risk of developing chronic kidney disease (CKD) in patients with acute kidney injury (AKI). Higher levels of KIM-1, MCP-1, and TNFRI were associated with a increased risk of CKD progression.
A phase 3 randomised controlled trial found monthly injections of fitusiran effective in reducing bleeds in patients with severe haemophilia A or B. The study included 56 male patients with inhibitors, who experienced no bleeds after nine months on prophylactic treatment.
A study found that as alcohol consumption increased, the probability of a firearm-involved suicide also rose until a certain blood alcohol concentration was reached. Interventions focusing on heavy alcohol use may help reduce suicide mortality rates, particularly those involving firearms.
A retrospective analysis of blood samples and medical records from 270 patients found that CPS1 levels help predict which patients survive or die without a transplant. The study suggests that CPS1 could be a valuable clinical management tool for acetaminophen and other causes of liver failure.
A new study found that specific biomarkers in blood can predict PTSD likelihood, diagnose disorder, or monitor treatment response. Researchers discovered four biomarkers with significant differences between those with PTSD or sub-threshold PTSD and those with high resilience.
Scientists have found that antibodies targeting βII-spectrin on mesangial cells are the trigger for IgA nephropathy. This discovery enables blood-based diagnosis and may lead to improved treatments.
Researchers found that older adults with depression exhibit accelerated biological aging, poor physical and brain health, and worse cardiovascular health. This association suggests opportunities for preventive strategies to reduce disability associated with major depression in older adults.
A study by Max-Planck-Gesellschaft researchers found that consuming small amounts of high-fat and high-sugar foods regularly rewires the brain, leading to a preference for these types of food.
Researchers developed StarCrete, a cosmic concrete made from Martian dust, potato starch, and salt, which is twice as strong as regular concrete. The material's compressive strength reaches 72 MPa, making it suitable for space construction.
A University of Ottawa study found that almost two-thirds of Canadians with stroke experience disturbed sleep, and those affected are up to 7 times more likely to report multiple sleep problems. The study highlights the need for better awareness and guidance on managing sleep disorders in stroke patients.
Researchers discover that inhibiting a gene crucial for DNA production can significantly reduce destructive cell proliferation and disease progression in pulmonary hypertension. This finding presents a potential treatment target for the condition, which affects females aged 30-60 with limited treatment options.
A remote hypertension program, operated by Mass General Brigham, successfully supported patients through the COVID-19 pandemic in achieving their blood pressure goals. Participants who enrolled during the pandemic reached and maintained their goal blood pressures an average of two months earlier than in the pre-pandemic period.
Researchers found that increasing melanin levels in human skin reduces Cherenkov emission intensity, while blood concentration affects different color channels. The study suggests using multispectral signatures to correct attenuated signals based on patient's blood volume or skin color.
Researchers at Indiana University School of Medicine have developed a blood test for anxiety that can help identify biomarkers associated with the disorder. The test has been validated by three independent cohorts and shows promise in matching patients to effective treatments, such as medications and nutraceuticals.
Researchers developed a blood test to detect residual leukemia in AML patients before bone marrow transplant, showing that those with persistent mutations had higher risks of relapse and lower survival rates. The study supports ongoing research on precision medicine and personalized post-transplant care.
High-dose anticoagulation reduces intubations and deaths by 30% in hospitalized COVID-19 patients, especially those with ARDS. The study found a significant reduction in mortality and need for ICU care among patients treated with therapeutic anticoagulation.
A new study published in Hypertension journal found that irregular sleep patterns contribute to higher blood pressure among teens with extra belly weight. The research suggests that maintaining a regular sleep schedule may help protect adolescents from cardiovascular consequences of obesity.
A virtual care team consisting of physicians and pharmacists improved the adoption of life-saving therapies in patients with heart failure, leading to increased use of evidence-based treatments and better patient outcomes. The strategy was safe and effective, with comparable length of stay and safety events between the groups.
A new study shows that transcatheter mitral valve repair significantly reduces hospitalizations by almost 50 percent and death by nearly 30 percent in heart failure patients with severe mitral regurgitation. The procedure, using Abbott's MitraClip system, improves symptoms, reduces hospitalizations, and leads to longer survival.
The study found that transcatheter edge-to-edge repair achieved a successful repair for nearly 9 out of 10 patients and reduced valve leakage from severe to moderate or less in almost 90% of patients. Patients who underwent the procedure were half as likely to die within one year compared with those in whom the procedure was unsuccessful.
A new non-invasive diagnostic technique using smartphone photographs of the eye and face has been successfully developed to detect anaemia in children. The study, published in PLOS ONE, used images from 43 children under four to predict blood haemoglobin concentration with high accuracy.
Two studies found that adults with high cardiovascular health scores tend to live longer lives free of major chronic diseases. The research highlights the importance of maintaining ideal cardiovascular health to delay onset of age-related diseases, allowing individuals to enjoy life in their years as well as their years in life.
A new study found that walking an additional 500 steps per day was associated with a 14% lower risk of heart disease, stroke or heart failure. This benefit is significant for older adults, as most studies have focused on early-to-midlife adults.