Add BrightSurf on Google Email

Gene therapy treats first disease affecting multiple organ systems in a large animal

Researchers have developed a gene therapy approach to treat mucopolysaccharidosis VII, a disorder affecting multiple organ systems, in dogs. The treatment involves four intravenous injections of a retroviral vector expressing canine beta-glucuronidase, resulting in normal enzyme activity and near-normal mobility in treated dogs.

SourceUniversity of Pennsylvania·JournalProceedings of the National Academy of Sciences·DateSep 9, 2002

Dog collars could prevent parasitic disease in children

A recent study found that dog collars fitted with deltamethrin resulted in a 42% reduction in transmission of zoonotic visceral leishmaniasis to children and a 54% drop in infection rates among dogs. This alternative control method is more practical and effective than current methods, such as dog culling and spraying insecticide.

SourceThe Lancet_DELETED·JournalThe Lancet·DateAug 1, 2002

Dog 'model' for studying inherited human blindness

Researchers have discovered genetic mutations in dogs that mirror the genetic mutations of humans with inherited blindness, providing new insights into photoreceptor cell degeneration. The study has potential implications for treating both canine and human retinal diseases, including progressive retinitis pigmentosa.

SourceCornell University·JournalHuman Molecular Genetics·DateMay 7, 2002

Mastiffs could aid treatment of retinitis pigmentosa

Researchers have discovered a genetic mutation in English mastiffs that causes retinal dysfunction and degeneration, mirroring human dominant retinitis pigmentosa. The study aims to find treatments and cures for inherited forms of blindness in humans by testing therapies first in dogs.

SourceCornell University·JournalProceedings of the National Academy of Sciences·DateApr 29, 2002

Italian wolves haven't gone to the dogs--yet

A new study has revealed that Italian wolves have maintained a pure population despite facing threats such as competition for food and space. The researchers analyzed mitochondrial DNA samples from over 100 Italian wolves, finding unique sequences that indicate the species has remained genetically distinct from feral dogs.

SourceSociety for Conservation Biology·JournalConservation Biology·DateApr 12, 2000

Enzyme Presence Could Be Key Factor In Wolf Health, Study Suggests

Researchers found that three out of 11 wild wolves carried the enzyme corticosteroid-induced alkaline phosphatase, which is also found in dogs. This enzyme reflects long-term stress and indicates the presence of hepatic disease in the wolves. In contrast, captive wolves had no enzyme, suggesting they are healthier.

SourceUniversity of Illinois at Urbana-Champaign, News Bureau·JournalJournal of Zoo and Wildlife Medicine·DateMay 6, 1999

Puppy Parasites

Researchers discovered Cryptosporidium and Giardia parasites in 7.3% and 11.7% of stool samples from dogs, with puppies under 30 weeks old most affected. Despite no visible symptoms, these parasites can cause serious illness in humans.

SourceNew Scientist·JournalThe New Scientist·DateMay 28, 1998

Dog Blindness Gene May Help Humans

Researchers at Cornell University have discovered a genetic correlation between dog blindness and a similar human disease, potentially leading to new treatments for human eye disorders. The study identifies the canine version of the human RP17 gene defect, which could lead to gene therapy methods for both dogs and humans.

SourceCornell University·JournalProceedings of the National Academy of Sciences·DateMar 16, 1998