Articles tagged with Intestinal Mucosa
Researchers found that intestinal bacteria and their metabolites can accelerate blood vessel aging and trigger cardiovascular disease. The breakdown product of phenylalanine, phenylacetic acid, accumulates with age and leads to senescence of endothelial cells.
Researchers find inhibiting TMEM219 signaling restores mucosal healing in inflammatory bowel diseases and protects intestinal stem cells from death. The study suggests TMEM219 overactivation induces intestinal stem cell death, preventing mucosal renewal during inflammation.
Researchers have developed a highly versatile 3D bioprinted gut-on-chip model with integrated electrodes, capable of simulating the formation of the intestinal barrier in real-time. This innovative device has potential applications in disease modeling and drug screening.
A new analysis has found evidence supporting the use of treatments to enhance mucosal healing and reduce inflammation in the gut, leading to improved outcomes for children with malnutrition. The study identified that a short course of treatment can restore mucosal integrity, reducing intestinal damage and systemic inflammation.
A recent study led by Dr Rachael Rigby from Lancaster University found that delays in stoma reversal surgery do not impact on risk of complications or commensal microflora loss, atrophy, or scarring. However, a higher degree of microflora loss is associated with an increased risk of complications.
Scientists discover that increased levels of enzyme alpha 1-6 fucosyltransferase (FUT8) in the colon may lead to ulcerative colitis by altering mucous layer properties, making it more permeable and sticky. Researchers believe this allows bacteria to reach epithelial cells, triggering inflammation.
Researchers found that innate effector cells can acquire a memory to strengthen gut mucosal defenses against repeated infections over time. This discovery demonstrates a new antibacterial immune defense mechanism and could lead to novel therapeutic approaches to treat intestinal diseases.
An international research team discovered that intestinal bacteria can distribute their metabolic products throughout the body via the bloodstream using membrane vesicles. The study found that these vesicles can overcome the blood-brain barrier and enter brain cells, suggesting a new method for delivering drugs or vaccines.
Researchers design theragrippers, tiny star-shaped devices that latch onto intestinal mucosa and release drugs. The devices stay in the intestine for a desired duration, solving a long-sought goal in medicine.
Researchers found that the unfolded protein response (UPR) signaling cascade plays a crucial role in protecting intestinal cells from damage. However, an overactive UPR caused by the CHOP protein can slow down tissue repair and lead to chronic inflammation.
A study explores the connection between intestinal mucosa barrier function and nonalcoholic steatohepatitis (NASH), finding that impaired barrier function may contribute to the disease's pathogenesis. The research suggests that lipid peroxidation reactions in intestinal tissue could be a key factor in NASH.