Articles tagged with Kidney
The Declaration of Istanbul sets forth recommendations to prevent organ trafficking, including programs to prevent organ failure and maximize deceased donation. Organ trafficking has been linked to increased post-transplant complications and a higher incidence of acute rejection and severe infections.
A study of 2025 women who donated kidneys found that female kidney donors do not face increased risks of miscarriage, premature birth or gestational diabetes. While post-donation pregnancies had higher rates of certain health conditions, these were comparable to those in the general population.
Researchers at the American Society of Nephrology's Annual Meeting found that stent placement does not improve kidney function or blood pressure in patients with atherosclerotic renovascular disease. The ASTRAL trial, involving over 800 patients, showed no clinically worthwhile benefits from revascularization.
A newly developed equation estimates glomerular filtration rate (GFR) more accurately than the widely used Modification of Diet in Renal Disease (MDRD) Study equation, especially at higher GFR levels. The CKD-EPI equation was validated using data from over 8,000 patients and shows lower bias compared to the MDRD equation.
Individuals with kidney stones are at a 60% greater risk of developing chronic kidney disease (CKD), according to a new study. Researchers recommend careful monitoring of stone formers and appropriate treatment when needed.
A study of over 5,300 live kidney donors found that obesity was common among donors, particularly those from African- and Hispanic-American backgrounds. Obese donors were more likely to develop hypertension prior to and after donation, but did not experience worse kidney function compared to non-obese donors.
Kidney transplant wait times vary widely across the US, with some patients waiting just one year and others up to 10 years. Experts will discuss issues and possible solutions for these inequities in organ allocation policies.
Researchers found improved cognitive function in transplant patients, particularly in verbal learning and memory. In contrast, dialysis patients showed declining test scores over time. The study suggests that kidney transplantation may have a beneficial effect on patients' mental function.
A study found that African-Americans in Canada have better health outcomes after receiving a kidney transplant compared to their US counterparts. Despite lower access to transplants, African-American Canadians experienced similar kidney survival rates and longer overall survival rates than Caucasians.
Researchers have identified molecular signals causing abnormal changes in the peritoneum, a lining used in peritoneal dialysis. Disrupting these signals may help maintain PD's effectiveness and offer new hope for former PD patients seeking alternative treatments.
A polymeric drug developed by University of Alberta researcher David Bundle binds to the E. coli toxin, preventing it from affecting the kidneys and causing life-threatening damage.
Researchers propose new ultrasound screening criteria to diagnose autosomal dominant polycystic kidney disease (ADPKD), which may misdiagnose individuals with the milder form of the disease. The new criteria improve detection in individuals with mutations in either PKD1 or PKD2 genes.
A new study by researchers at the University of Cincinnati shows that eliminating steroid therapy as early as seven days following a transplant surgery maintains kidney function. The study found reduction in steroid-related complications, even when prednisone was given in very low doses.
A study found that US residents traveling abroad for kidney transplants experienced higher rates of acute rejection and severe infections. The study, which included 33 transplant tourists and 66 comparison patients, noted significant differences in infection types and severities.
A study of 1,500 kidney cancer patients suggests that tissue-sparing surgery may improve overall survival in patients with reduced kidney function. The finding highlights the underuse of this option and raises concerns about the potential harm of removing healthy kidney tissue.
Research found that kidneys from older donors exhibit a 32% depression in glomerular filtration rate, leading to shortened survival after transplantation. The study suggests that selecting organs with more functioning glomeruli could improve graft survival rates.
Kidney transplant specialists at Cedars-Sinai Medical Center have developed innovative laboratory techniques to improve opportunities for highly sensitized patients. The new technology uses solid phase assays to predict patient risk and improve transplant success rates.
Researchers investigate how high blood pressure affects tiny kidney filters, known as glomeruli. They believe that damaged kidney filters worsen hypertension and that inflammation plays a crucial role in the process.
Scientists have identified a site where sodium regulates specific potassium ion channels, which could lead to new approaches in drug design. The findings may help understand the mechanisms involved in ion channel gating and its relevance to hypertension.
Researchers at Penn School of Medicine have created a highly specific inhibitor, TPNLQ, that selectively blocks potassium channels in kidneys, opening a new avenue for treating hypertension. This breakthrough could provide a potential new approach to reducing salt reabsorption and lower blood pressure.
Dialysis patients with depression are nearly twice as likely to be hospitalized or die within a year compared to those without depression. The study found that more than 80% of depressed patients died or were hospitalized, while only 43% of non-depressed patients experienced these outcomes.
A study published in JAMA found that using sodium bicarbonate for hydration during coronary angiography does not reduce the risk of developing serious kidney problems compared to using sodium chloride. The results suggest that there is little difference in outcomes between the two hydration strategies.
A new study found that combining two commonly used blood pressure medications, ACE inhibitors and ARBs, reduces urine protein levels more than taking either medication alone. However, it also causes more kidney damage and a higher risk of death among high-risk patients.
A study found that rituximab significantly reduces kidney injury in patients with membranous nephropathy, reversing functional and biological abnormalities. The treatment achieved complete remission in 10 patients, including significant healing of kidney damage.
Researchers have developed a groundbreaking procedure using tailor-made regulatory cells to avoid lifelong drug use for transplant patients. The technique shows promising findings and has been tested in clinical trials on 17 kidney transplant patients, with encouraging results.
The American Society of Nephrology discusses the merits of using eGFR for early detection and treatment of CKD, highlighting concerns about misclassification and universal screening. Experts emphasize the need for education and proper use of eGFR to ensure accurate diagnosis and management.
Black patients receiving kidneys from black cardiac donors showed better long-term survival compared to those receiving non-black donor kidneys. The study suggests that increased utilization of kidneys donated after cardiac death can help reduce racial disparities in kidney transplantation.
A study found that patients receiving kidney transplants who took statin drugs had better survival rates compared to those who did not. Statin therapy was associated with a 36% lower risk of death in renal transplant recipients.
A new therapy developed at Cedars-Sinai Medical Center improves transplant rates and outcomes for patients awaiting living- and deceased-donor kidney transplantation. The combination of IVIG and rituximab offers superior benefits to IVIG alone, improving transplant rates to 80 percent of treated patients.
A recent study challenges previous findings on iodinated contrast material's effect on kidney function. It found that serum creatinine levels change frequently in patients without receiving contrast material, rendering prior studies' conclusions questionable.
Researchers at UT Southwestern Medical Center predict that global warming will cause a 30% growth in kidney-stone cases by 2050, with an additional 1.6-2.2 million new cases. Dehydration is a major risk factor for kidney stones, and warmer temperatures are expected to exacerbate this effect.
A new design for an automated, wearable artificial kidney eliminates complications of traditional dialysis. The device functions continuously, providing cleansing and fluid balance on a continuous basis, and regenerates and reuses spent dialysate to minimize protein loss.
A study found that patients with chronic kidney disease (CKD) or end-stage renal disease (ESRD) were less likely to use recommended medications after a heart attack, but 1-year adherence rates were similar for both groups. Rates of medication use varied significantly among different types of drugs.
A new analysis of kidney transplant data found that male kidneys function better in men than women, who have a higher risk of rejection. The study, based on almost 200,000 cases, suggests that gender should be considered when allocating donor kidneys.
A retrospective cohort study found complex gender interactions in kidney transplantation outcomes, with female donors having a higher rate of graft loss and female recipients experiencing a lower rate of graft failure. The study suggests considering sex in future studies and decisions on organ allocation to optimize transplant success.
A study published in the Journal of the American College of Surgeons found that morbidly obese patients undergoing Roux-en-Y gastric bypass surgery are at an increased risk of developing kidney stones as early as three months post-operation. The study suggests a possible link between the surgical procedure and changes in urinary electr...
Researchers found that adults who consumed at least one serving of lowfat milk or milk products daily had 37% lower odds of poor kidney function linked to heart disease. A diet rich in lowfat milk and whole grains, fruits, and vegetables was also associated with a reduced risk.
Withdrawing calcineurin inhibitors after kidney transplantation can prolong survival, improve kidney function, and save money compared to lifelong medication use. The study found that treatment with sirolimus plus steroids may be more efficacious and less costly than regimens using calcineurin inhibitors.
A new study found that boiling cubed or shredded potato samples reduced potassium levels by 50% and 75%, respectively. Leaching had little effect on mineral content. Boiling thinly sliced potatoes can help renal failure patients reduce their mineral intake while maintaining other nutritional qualities.
Researchers have discovered a new kidney protein, NGAL, that can diagnose sudden kidney failure days sooner than current tests. A simple urine test for NGAL can help emergency department physicians accurately diagnose kidney failure and make evidence-based treatment decisions.
Researchers found that sirolimus can help protect against rejection in non-compliant kidney transplant patients, potentially extending their organ's lifespan. The study used an assay to measure immune function at 'trough' levels of immunosuppressive drugs.
A large US study found that sirolimus increases the risk of new-onset diabetes in kidney transplant recipients. The risk is higher when combined with other anti-rejection drugs and appears to be independent of other factors.
Patients with systolic dysfunction are nearly twice as likely to die than those without the condition, according to a study analyzing 2,718 kidney transplant candidates. This increased mortality risk is similar to that seen in patients with cardiac ischemia.
Researchers predict a rise in kidney stone disease due to global warming, with a potential cost of $1 billion annually by 2050. The southern US is expected to see an expansion of the
Leptospirosis is a major public health problem in South East Asia and South America, with over 500,000 severe cases every year. Researchers have discovered that bacteria can form biofilms, which protect them against harsh conditions and make them more resistant to antibiotics.
Researchers have identified genes that can cause enlarged hearts and kidney inflammation, leading to heart attacks and kidney failure. Understanding these genetic links may lead to new treatments for common heart diseases.
Research by Johns Hopkins Medicine found that African-American patients with chronic kidney disease continue to lose kidney function despite strict blood pressure control. The study suggests that treating CKD in this population may require a more comprehensive approach, considering other factors beyond just blood pressure.
Research by Tufts University biologists reveals that early exposure to atrazine leads to deformed hearts, impaired kidneys, and digestive systems in tadpoles. The study found a significant increase in abnormalities in organs after 48 hours of exposure, with 57% of tadpoles having smaller-than-normal hearts.
A 10-year retrospective study found that even small increases in serum creatinine levels during hospitalization raise the risk of end-stage renal disease and mortality in elderly patients. The study also identified that larger changes in creatinine levels were associated with higher risks.
Researchers found septic acute kidney injury (AKI) patients have higher acuity of illness, lower blood pressure, and worse pulmonary function compared to non-septic AKI. The study suggests septic AKI requires specific clinical interventions to reduce injury and promote kidney recovery.
Women with poor kidney filtering ability are at increased risk of sudden cardiac death, according to a new study published by the American Heart Association. The research found that those with advanced kidney dysfunction had a 3.16 times higher risk of SCD than women with normal kidney function.
Physiologists investigate nanoparticles' potential to cause diseases like atherosclerosis and kidney stones. Researchers are exploring how nanoparticles interact with cells and tissues to understand their role in these conditions.
Researchers identified two classes of small-molecule CFTR inhibitors that slowed cyst growth by over 80% and preserved kidney function. In mouse models, these inhibitors reduced cyst expansion and kidney enlargement.
A new study found that an iso-osmolar X-ray dye did not reduce the risk of kidney damage during percutaneous coronary intervention (PCI) in patients with chronic renal failure. The study compared two types of contrast medium and found no significant difference in rates of kidney injury or need for dialysis.
A new surgical approach, called bilateral nephron-sparing surgery, has shown promise in saving both kidneys of children with bilateral Wilms tumor. This procedure involves removing the malignant tumor while sparing as much healthy kidney tissue as possible.
A study found that elevated uric acid levels can precede significant changes in urine albumin levels, suggesting a potential early sign of diabetic kidney disease. Higher uric acid levels are associated with lower kidney function in patients with type 1 diabetes.
Researchers at Albert Einstein College of Medicine found that aberrant Notch signaling plays a role in diabetic nephropathy and focal segmental glomerulosclerosis, two major causes of end-stage renal disease. They discovered that gamma secretase inhibitors can protect against kidney disease, sparking hope for new treatment options.
A simple laboratory test measures a biomarker called NGAL to predict acute kidney injury (AKI) risk up to three days before symptoms appear. The test has been shown to be highly accurate in identifying patients at risk of AKI and may enable timely treatment to prevent or improve outcomes.
Researchers at Emory and Children's Healthcare of Atlanta are partnering with UCLA and Stanford hospitals to develop new ways to make kidney transplants more tolerable for children. The goal is to create a simple blood or urine test to inform doctors whether kidney rejection is 'revving up,' possibly avoiding painful biopsies.
Researchers have discovered a link between the bacteria Oxalobacter formigenes and a reduced risk of recurrent kidney stones. The study found that O. formigenes can metabolize oxalate, reducing the risk of calcium oxalate stone formation by up to 70%.