Articles tagged with Kidney
A cohort study of 120 women who gave birth after receiving a kidney transplant found no differences in kidney function or patient survival compared to those who did not have children. The study's findings provide good news for kidney transplant women who fear getting pregnant due to concerns about their health and lifespan.
A study found that childhood minimal change nephrotic syndrome can lead to lasting health effects, including osteoporosis and hypertension in adults. The condition may also cause reproductive problems, such as low sperm count and defective sperm.
A study published by the American Society of Nephrology found that weight loss through diet and exercise can reduce proteinuria and slow down kidney function decline in obese patients with kidney disease. Surgical interventions also show promise in normalizing kidney filtration rates.
A new study found that extending preventive treatment for CMV infection post-kidney transplant reduces the risk of disease by nearly two-thirds. This approach also proves cost-effective, offsetting increased costs with reduced cases of CMV disease.
A new study from St. Michael's Hospital reveals that patients with acute kidney injury requiring in-hospital dialysis are three times more likely to need long-term dialysis later in life. Early medical surveillance and intervention may prevent progression to irreversible end-stage kidney disease.
A study found that hospitalized patients with acute kidney injury requiring dialysis have a higher risk of chronic dialysis, but not increased mortality rates. Patients who survive hospitalization complicated by acute kidney injury requiring dialysis remain at high risk of needing dialysis for 3-5 years.
The ERC is funding top researchers, including Sanna Lehtonen's group, to study the development of albuminuria and diabetic nephropathy. They aim to identify novel drug leads to treat insulin resistance and combat early stages of kidney disease.
Researchers at UT Southwestern Medical Center found a significant link between depression and early-stage chronic kidney disease, with 57 out of 272 participants identified as depressed. The study suggests that depression screening should be considered for patients in the early stages of chronic kidney disease.
Concomitant kidney dysfunction and worsening renal function in heart failure patients are associated with a poor prognosis. New treatments target improving renal function and preventing its deterioration during hospitalizations for acute heart failure.
Researchers found that retrieving kidneys from uncontrolled non-heart-beating donors after sudden out-of-hospital cardiac arrests can lead to a 10% increase in transplantation rates. The procedure, which raises ethical concerns, has the potential to alleviate organ shortages.
A study of 1,239 patients found that night home hem dialysis can extend life expectancy similar to a kidney transplant from deceased donors. The treatment allows patients to live longer and maintain independence. Night home hemodialysis may be suitable for high-risk patients or those waiting for a transplant.
A new study finds that single kidneys from very young deceased donors can maintain the health of an adult with kidney failure. The research suggests that this practice is safe and effective, offering an alternative to traditional organ allocation methods.
Researchers have developed a Wearable Artificial Kidney that provides continuous dialysis 24/7, reducing hospitalization rates and improving quality of life. The device is powered by two nine-volt batteries and weighs about 10 pounds.
A DASH-style diet high in calcium, potassium, and magnesium, and low in sodium, was found to reduce the risk of kidney stone formation. Participants with higher scores on this dietary approach were between 40-45% less likely to develop kidney stones than those with lower scores.
A study found that female recipients of male donor kidneys have a higher risk of transplant failure in the first year after transplantation. However, this increased risk is reversed after ten years. The study suggests that H-Y antigens on male cells may elicit an immune response in female kidney transplant recipients.
A new laboratory test called urine neutrophil gelatinase associated lipocalin (NGAL) has been found to help predict acute kidney injury (AKI) in intensive care patients. NGAL levels are also higher in patients with HIV-associated nephropathy, a complication of HIV affecting African Americans and black Africans.
Researchers at Columbia University Medical Center have discovered a protein called NGAL that can help diagnose kidney disease caused by HIV. High levels of the protein in urine may indicate the presence of HIV-associated nephropathy, allowing for earlier intervention and potentially preventing kidney failure.
A daily supplement of potassium citrate has been found to prevent kidney stones in children on the high-fat ketogenic diet, a common treatment for epilepsy. The study, published in Pediatrics, showed that those who received potassium citrate twice daily were seven times less likely to develop kidney stones.
A daily dose of sodium bicarbonate slows the decline of kidney function in patients with advanced chronic kidney disease, reducing the rate of progression by about two-thirds. Patients taking baking soda also experience improvements in nutrition and are less likely to develop end-stage renal disease.
A new procedure called CESA combines endovascular and surgical approaches to treat high-risk aortic aneurysms. The technique has shown excellent results in the first 20 high-risk patients with complex aortic pathology treated with CESA, with a cumulative survival rate of 76% at two years.
Scientists have identified PLA2R, a protein found in normal human glomeruli, as the target antigen in idiopathic membranous nephropathy. This discovery holds promise for developing a blood test to replace kidney biopsies and determining which patients are most likely to benefit from immunosuppressive treatment.
Researchers have found that the circadian clock protein Period 1 regulates expression of the renal epithelial sodium channel in mice, leading to decreased sodium loss in urine. Additionally, a study on gene therapy revealed that TLR9-MyD88 pathway is critical for adaptive immune responses to AAV vectors. Another study on kidney repair ...
A treatment that significantly slows the progression of eye injury in people with type 1 diabetes has been found. The treatment uses an antihypertensive medication commonly prescribed to treat high blood pressure, and was shown to slow diabetic eye damage in over 65% of participants.
A recent study found that contrast-induced kidney damage from medical imaging procedures increases the risk of having a stroke or heart attack over the next year or two. Patients who developed this damage had twice as many long-term negative health effects compared to those whose kidneys were not damaged.
Almost half of older kidney transplant candidates (over 60) will die before receiving a transplant due to increased wait times. Researchers urge these patients to consider live-donor options to improve survival chances.
A new study reveals that medical insurers' reimbursement documents can provide insights into the long-term health of kidney transplant patients. The research found that combined use of Medicare billing claims from both Part A and Part B accurately documented cardiovascular events after transplantation, with a high sensitivity rate.
A new study projects that nearly half of older patients currently on the kidney transplant waiting list will die before receiving an organ from a deceased donor. The study found significant variations in mortality rates across different transplant regions and patient groups, including African Americans and those aged 70 or older.
A new study by Johns Hopkins Medicine finds that Roux-en-Y weight loss surgery nearly doubles the risk of developing kidney stones, with an overall risk of around 8 percent. The researchers suggest that doctors can help prevent kidney stones through calcium supplements and other interventions.
Researchers at Mayo Clinic have found a peptide that preserves and improves kidney function during heart failure, potentially reducing the risk of kidney damage. The new compound has been tested in laboratory and animal models and is expected to move into clinical trials next year.
A new DNA vaccine using IL-10 has been shown to prevent kidney damage in mice with systemic lupus erythematosus (SLE) by inducing antigen-specific tolerance. The study found lower levels of anti-Sm antibodies and significant proteinuria were less common in the vaccinated group compared to the control group.
A new study demonstrates the effectiveness of eculizumab in preventing antibody-mediated rejection in positive crossmatch kidney transplant patients. The treatment, which blocks the immune system's activation of the complement system, showed promising results with none of the treated patients developing antibody-mediated rejection.
Researchers identified microRNAs that can predict transplant rejection with high accuracy. Additionally, a new gene-based urine test has been developed to diagnose common kidney transplant complications. The study also explores increasing transplantation through donor chains and transplanting single kidneys from pediatric donors.
Researchers at MCG report breakthrough in treating acute renal failure by blocking mitochondrial fragmentation caused by vascular obstruction, trauma, chemotherapy, and toxins. This can prevent kidney cells from committing suicide and lead to acute renal failure.
A 3D kidney atlas has been created to help diagnose and treat renal diseases more effectively. The atlas, part of the European Renal Genome Project, will aid in understanding genes that play a key role in renal diseases and other data on anatomy.
Researchers have identified a potential genetic link to vesicoureteric reflux (VUR), a common cause of urinary tract infections and kidney failure in children. The study found that the VUR susceptibility gene is located on chromosome 12 and may be inherited in an autosomal recessive fashion.
Even mild acute kidney injury is associated with reduced patient and graft survival, while the strictest definition linked to poor outcomes including cardiovascular events and end-stage renal disease.
A gene test can help predict patients' risk of shock and kidney failure after heart surgery by identifying genetic differences in the COMT enzyme. This knowledge can guide treatment to prevent complications.
A new study found that men with moderate kidney disease have a 39% increased risk of developing cancer compared to those with normal kidney function. The risk is highest for lung and urinary tract cancers, but not prostate cancer. Maintaining kidney function may help prevent cancer in the general population.
A study of nearly 6,900 patients found that simultaneous pancreas-kidney (SPK) transplantation resulted in a 89% long-term survival rate compared to 80% for kidney-only transplants and 65% for deceased donor transplants. SPK recipients were also more likely to die during the first year after transplantation.
A new study found that donor-related risk factors, yet to be identified, contribute measurably to the success or failure of kidney transplants. The study examined pairs of recipients who received kidneys from the same deceased donor and found significant correlations between unmeasured risk factors and delayed graft function and kidney...
UT Southwestern researchers have discovered a link between immune cell malfunction and kidney damage in lupus patients. They also found that certain genes, such as kallikreins, appear to protect the kidneys from immune attack, suggesting potential new treatments for the disease.
A recent study by Marcello Tonelli and colleagues found no correlation between remote or rural residence and increased time to kidney transplantation in the US. The likelihood of receiving a transplant from a deceased or living donor was similar among patients dwelling farther away, suggesting disparities may not be solely due to location
A study of 298 black and 945 white male patients found that blacks with moderate and advanced chronic kidney disease lived longer than whites once they reached later stages. Blacks had a lower prevalence of cardiovascular disease, which contributed to their better survival rates.
A study published in the Journal of the American Society of Nephrology found that enzyme replacement therapy with agalsidase alfa slows kidney function decline in men with Fabry disease. The therapy showed promise when initiated early, particularly for those with higher initial kidney function.
A study suggests that combining glomerular filtration rate (GFR) and urinary albumin levels can predict which patients with chronic kidney disease will develop end-stage renal disease. This combination test could help identify patients at high risk of serious kidney trouble.
A novel hemodialysis procedure called high cut-off hemodialysis has been shown to restore kidney function and increase lifespan in patients with multiple myeloma, a form of cancer that causes severe kidney failure. In a study of 19 patients who underwent the procedure while receiving chemotherapy, 70% became independent of dialysis.
A recent study found that distance from a patient's home to the nearest transplant facility has no bearing on whether an individual is placed on the transplant waiting list. However, the research identified neighborhood poverty as a key factor associated with disparities in waitlisting, particularly for black patients.
A study from the American Chemical Society reports that proteins from garden peas show promise in fighting high blood pressure and chronic kidney disease. The researchers found a 20% drop in blood pressure in rats with polycystic kidney disease when fed small daily doses of pea protein hydrolysate.
A study found that proteinuria levels are higher in children with low glomerular filtration rates and non-Caucasian race, suggesting genetic or environmental factors. The study also found that patients taking renin-angiotensin system antagonizing drugs had lower levels of proteinuria compared to those not on these medications.
A new risk score identifies patients who are likely to receive a survival benefit from combined heart and kidney transplants, based on factors such as peripheral vascular disease, age, and kidney function. The study found that low-risk patients with combined kidney failure and heart failure may benefit from combined transplantation.
Researchers at Yale University have discovered a previously undescribed syndrome associated with seizures, developmental delay, and hearing loss. The syndrome, named SeSAME, is caused by mutations in the KCNJ10 gene, which affects potassium channels in the brain, inner ear, and kidney.
Researchers identify LIPG gene mutations that result in elevated HDL-C levels, potentially increasing cardiovascular risk. Meanwhile, a new study suggests intermittent IL-7 therapy may boost CD4+ T cell counts in HIV-infected patients.
A debate between world-leading experts reveals conflicting views on blood pressure control, with some arguing the kidneys play a key role and others pointing to the brain's influence. The discussion highlights major issues in blood pressure control and will guide future studies.
Researchers developed computer-generated chains of kidney transplantations that start with altruistic donors, providing a viable alternative to paired donations. The models assign values to donor characteristics, generating pairings based on similar scores and overcoming issues in the matching market.
A new study by Kaiser Permanente researchers found that chronic kidney disease independently increases the risk of ischemic stroke in patients with atrial fibrillation. Kidney function may provide an additional clue about how to best assess stroke risk and decide upon the best prevention strategy for patients with AF.
A new Clinical Research Chair in Transplantation has been established at the University of Western Ontario to improve organ transplant outcomes for patients like Pat Davis, who received a kidney transplant after being told it was impossible.
A new calculation eliminates obstacles in measuring kidney function in children, relying on various blood tests that can be performed in a clinical setting. The study's findings suggest an accurate estimate is crucial to properly treat children with acute and chronic kidney problems.
Marshall Lindheimer, a renowned expert in kidney function and blood pressure control during pregnancy, has made significant contributions to the understanding of preeclampsia. His research has led to the development of treatments for transient diabetes insipidus during pregnancy.
A new immune-system 'atlas' will improve doctors' ability to monitor transplanted organs and shed light on the mechanisms of gradual, cumulative kidney malfunction after transplant. The atlas allows for inexpensive, noninvasive blood tests that show whether a donated kidney is infected or accruing chronic injuries.
A new study found that patients waiting for a kidney transplant who receive care at centers with shorter wait times tend to live longer. The research analyzed data from nearly 109,000 patients and found that waiting time had the strongest effect on survival, with patients at centers with long waits having a higher risk of death.