Articles tagged with Kidney
A new device containing human kidney cells has been shown to significantly reduce the risk of death from acute kidney injury. The device, called Renal Assist Device, was tested on 40 patients and found to improve recovery rates and reduce mortality by half.
Researchers discovered that mice are more efficient at removing oxalate from the body, a crucial step in preventing kidney stones. This finding holds promise for developing improved treatments and paving the way for a mouse model of the disease.
A new screening questionnaire, SCORED, has been shown to be more accurate and efficient in identifying individuals with silent chronic kidney disease than current clinical practice guidelines. The test correctly identifies patients at risk for CKD 88-95% of the time and defines high-risk individuals 25% fewer times.
Researchers studied 317 healthy teens aged 15-18 and found higher rates of albumin in the urine of black teens compared to their white counterparts, even with normal blood pressure. This suggests that kidney damage is apparent before hypertension develops in high-risk youths.
A rare case of colon duplication was diagnosed in an adult patient with hydronephrotic atrophy of the right kidney. The mass was successfully removed during a laparotomy, revealing a continuum of the duplicated colon. This exceptional case highlights the importance of accurate pre-operative diagnosis and surgical expertise.
A new study has found that kidney donor age is associated with increased aortic stiffness in recipients, which may explain higher rates of cardiovascular disease and death. The study suggests that targeted interventions after kidney transplantation could improve long-term results by reducing cardiovascular risk and mortality.
A large-scale study confirms that the cardiac surgery drug aprotinin increases death rates and damages kidney function. The study analyzed data from over 10,000 patients and found that those who received aprotinin had higher mortality rates and impaired kidney function compared to those who did not.
A study of acute kidney failure treatments found that intermittent hemodialysis and continuous kidney replacement therapy have similar clinical outcomes. No significant difference was seen in the risk of death or chronic dialysis treatment between the two therapies.
A new study suggests that taking N-acetylcysteine before a CT scan or angiogram can protect at-risk patients from kidney damage caused by iodine-containing contrast agents. The inexpensive drug, which is quick, convenient and widely available, appears to be the best choice for those with weakened kidneys.
Researchers at Yale University have received a $4 million NIH grant to study new biomarkers for detecting acute kidney injury (AKI) after cardiac surgery. The goal is to develop an earlier and more accurate diagnosis, reducing mortality rates.
Smart holograms can detect changes in blood-glucose levels, adrenaline levels, and other chemical imbalances, enabling patients to monitor their health more effectively. This new technology has wide applicability in various fields, including diabetes management, security, and smart packaging systems.
A new study by American Society of Nephrology confirms that intensive insulin therapy (IIT) protects kidneys in critically ill patients, reducing the risk of acute kidney injury (AKI) and death. IIT was found to be more effective in preventing AKI after surgery compared to medical ICU patients.
Researchers found that breakdown of self-cleaning mechanism in kidneys can lead to dysfunction and disease. The study suggests that defects in this clearance mechanism can cause accumulation of toxic substances, such as autoimmune antibodies, which can damage the kidney.
A new experimental protocol successfully induced immune tolerance to HLA-mismatched kidney transplants in four out of five patients. The treatment involved a combined organ and bone marrow transplant, followed by immunosuppressive drug withdrawal, resulting in normal kidney function for all patients.
A Stanford study has successfully enabled a patient to thrive for two years after stopping immunosuppressive drugs. The innovative technique, developed by Samuel Strober and his team, involves adjusting the patient's immune system and infusing blood cells from a compatible donor, boosting levels of regulatory T cells to prevent rejection.
Researchers are enrolling patients in a new study that transplants stem cells from a kidney donor's bone marrow into the recipient, with the goal of gradually eliminating the need for antirejection drugs. The study aims to improve post-transplant quality of life for recipients.
A study by Dr. Dorry L. Segev and colleagues found that severe obesity is associated with a lower chance of receiving a kidney transplant, even after adjusting for medical factors. Obese patients tend to wait longer and are more likely to be bypassed when a kidney becomes available.
A new Mayo Clinic study found that removing the entire kidney from younger patients with small kidney tumors may lead to decreased overall survival. In contrast, partial nephrectomy resulted in a 10-year overall survival rate of 93%. The study's findings highlight the importance of considering long-term health consequences for patients...
A Johns Hopkins study found that morbidly obese patients wait a median of five years on the transplant waiting list, while normal-weight patients wait two years less. The researchers argue that being overweight should not be a disqualifying factor for transplantation and call for guidelines to treat equally.
A newly identified molecular pathway involving the urokinase receptor (uPAR) appears to play a crucial role in the breakdown of kidney filtration structures, leading to proteinuria. The research suggests that targeting this pathway with antibodies or small molecule compounds could prevent or decrease proteinuria in animals.
Researchers found that a protein called hypoxia-inducible-factor (HIF-1) promotes the synthesis of fibrous connective tissue in kidneys, leading to reduced oxygenation and progression of chronic kidney disease. The study used mice with silenced HIF-1a to demonstrate the link between low oxygen conditions and CKD.
New research suggests transplanting kidneys from donors who died after cardiac arrest could increase the donor pool. A study found comparable short-term results between kidneys donated after cardiac death and brain death, with similar survival rates for patients and transplanted organs.
A study of over 300 live kidney donors found that they had good kidney function and tended to suffer a lower incidence of high blood pressure, diabetes, and heart-related deaths compared to the general population. Donors reported high satisfaction rates and would strongly encourage others to become donors if needed.
Smoking before or during pregnancy may decrease fertility in female offspring, according to a new mouse study. The study found that exposure to environmental toxins like polycyclic aromatic hydrocarbons (PAHs) can reduce the number of follicles in female mice, leading to reduced fertility.
A new study by the Medical College of Wisconsin suggests that captopril, an angiotensin-converting enzyme inhibitor, can reduce radiation injury to the kidneys in bone marrow transplant patients. This may lead to improved long-term kidney function and patient survival.
Using donated kidneys from older donors with health conditions can alleviate organ shortage among older adults, reducing waiting times and improving survival rates. Patient survival rates were similar across age groups, with 91% of patients over 60 receiving ECD kidneys surviving the transplant.
Researchers found that valproic acid reduces B cell activity by targeting histone deacetylases, preventing skin and kidney disease in mice with lupus. Mithramycin also shows promise by targeting Sp1, a transcription factor controlling genes involved in kidney disease, resulting in decreased kidney inflammation and protein levels.
Mayo Clinic researchers will study renal vascular disease caused by atherosclerosis to find new ways to diagnose and treat the condition. The study aims to develop novel imaging tools to predict, detect, and evaluate the disease, with the goal of preventing renal deterioration.
Chronic kidney disease is more common than previously thought, affecting over 13% of the US population, primarily those with diabetes and hypertension. The study highlights the importance of blood pressure control, blood sugar management, and avoiding toxic medications to slow disease progression.
A recent study found that expanded criteria non-beating-heart kidney transplants from ECD donors are not suitable for elderly patients with ESRD. The risk of graft loss and death was significantly higher in these patients compared to brain-dead SCD donors.
Recent studies have linked widely used osteoporosis drugs and bowel prep solutions to kidney damage. Nephrologists must be aware of these emerging causes of kidney problems and take steps to prevent them.
A study found that black patients living in poorer neighborhoods were less likely to be placed on transplant waiting lists than white patients. Community poverty was a significant factor, rather than distance from transplant centers.
A large-scale study has found no significant increase in cardiovascular risk for living kidney donors, but higher rates of high blood pressure were detected. The study analyzed data from 1,278 patients and compared them to 6,369 healthy adults.
Researchers developed a new mouse model to predict the loss of orally taken drugs due to metabolism by CYP3A, a key enzyme involved in first-pass metabolism. The study found that mice lacking functional CYP3A proteins accumulated docetaxol at higher levels, demonstrating the enzyme's role in intestinal metabolism.
Renal experts will discuss link between chronic kidney disease (CKD) and CVD, consequences of acute kidney injury, racial disparities in kidney disease outcomes, and treatment of anemia in kidney patients. The ASN's Public Policy News Briefing aims to improve health outcomes by highlighting significant research impacting public health.
Researchers suggest expanding kidney acceptance criteria and identify key factors improving transplant success. Matching donor and recipient ages and reducing waiting times may optimize results, while understanding risk factors like delayed graft function and acute rejection can aid preventive measures.
Researchers at UT Southwestern Medical Center have identified a likely cause of kidney transplant rejection: antibodies attacking MICA antigens. The study found that patients who showed the most marked effect from these antibodies were those considered high-risk for clinical transplantation.
Researchers have identified potential targets for ALS treatment by studying SOD1 gene mutations. Additionally, a new study on Candida parapsilosis has revealed that lipase is an essential virulence factor. Further research suggests that the timing of treatment with immune-modifying drugs can significantly impact viral infection outcomes.
Researchers at UT Southwestern Medical Center found that patients with metabolic syndrome have highly acidic urine, which increases the risk of developing uric-acid kidney stones. This association was independent of age and renal function, suggesting a link between metabolic syndrome components and increased acidity in urine.
Scientists at Lund University have found a genetic basis for severe urinary tract infections, suggesting a gene that regulates the immune system may be used as a risk marker. This discovery could enable early detection of susceptible individuals, potentially reducing unnecessary examinations and treatment.
Scientists discovered that genetic variations do not negatively affect the efficacy of fluvastatin in renal transplant patients. Additionally, researchers created synthetic lipids called pseudoceramides to treat skin diseases and found them to significantly increase protein production when skin cells differentiate.
A study found that individuals with suppressed immune systems, such as kidney transplant patients and those with HIV, have a higher incidence of squamous cell eye cancer. Residence in subtropical regions and prior history of skin cancer were also associated with increased risk.
Research suggests that female gender is associated with slower progression rates in certain renal diseases, possibly due to the protective effects of estrogen on kidney health. Estrogen inhibits the activity of transforming growth factor beta (TGF-β), which promotes scarring in the kidneys.
Women with diabetes lose protective effect of estrogen on kidneys, which normally reduces risk of chronic kidney disease. Research suggests that hormone ratio rather than absolute levels determines impact on diabetic kidney disease.
The Indiana University School of Medicine has been awarded a five-year, $6 million grant to continue developing advanced light microscopy systems for kidney research. The center will incorporate four core projects, including the development of quantitative analysis tools and techniques to image deeper tissues.
Researchers found radiofrequency ablation to be 93% effective in eradicating malignant kidney tumors, with minimal discomfort and no serious complications. The study's lead author suggests this treatment is an excellent option for patients who are not good operative candidates or have multiple renal tumors.
Researchers have identified a potential biomarker, urinary neutrophil gelatinase-associated lipocalin (uNGAL), to predict acute kidney injury (AKI) in critically ill children. The study found that uNGAL levels increased 48 hours before a jump in serum creatinine levels, suggesting its potential as an early warning system for AKI preven...
Researchers have discovered that combining two blood pressure-lowering drugs with enzyme replacement therapy can slow the progression of kidney disease in patients with severe Fabry disease. The study found significant reductions in proteinuria and minimal decline in kidney function after an average of two and a half years' treatment.
Researchers have identified a gene, GLIS2, that protects against a serious kidney disease called nephronopthisis. Mutations in this gene cause the disease, which leads to kidney degeneration and failure.
Researchers at the University at Buffalo discovered that high levels of cystatin C can predict an increased risk of developing pre-diabetes. The study, based on the Western New York Health Study, found a three-fold association between cystatin C levels and progression to pre-diabetes.
Researchers found that thousands of tiny particles are released during angioplasty and stenting, which can impair kidney function. The study suggests that new devices may prevent debris release and improve patient outcomes.
Endurance exercise experts recommend limiting fluid intake during prolonged activities to prevent exercise-induced hyponatremia (EAH), a potentially lethal water intoxication. Excess drinking can lead to diluted sodium levels in the blood, posing risk to athletes engaging in 4-hour or longer endurance events.
Two studies identify interactions between heart disease and kidney disease, revealing that anemia, microalbuminuria, and declining eGFR are associated with increased cardiovascular risk. The findings highlight the importance of screening and intervention for patients at high risk of kidney disease.
A new algorithm developed by Carnegie Mellon University researchers can create matches for three- and four-way kidney exchanges, increasing the efficiency of kidney exchanges. The algorithm has already been used by the Alliance for Paired Donation, a kidney exchange program, to identify potential transplants and improve transplant rates.
A new imaging technique using Indocyanine Green (ICG) dye helps surgeons precisely remove cancerous tumors from the kidney while sparing as much healthy tissue as possible. This innovation allows for more effective treatment and better patient outcomes.
Researchers developed a treatment strategy for hereditary inclusion body myopathy, a rare muscle disease, based on clues from transgenic mice. The approach also may benefit patients with certain kidney disorders.
Researchers found that early treatment with ACE inhibitors can preserve kidney function and reduce the risk of irreversible damage in young patients with early-stage IgA nephropathy. The study suggests that starting treatment early may limit the need for renal replacement therapy.
Researchers found that while both treatments showed promise, treatment 2 was associated with a higher risk of disease recurrence and shingles. The study suggests that patients should be thoroughly informed about the pros and cons of each treatment to make an informed decision.
A recent study found that obesity is a significant barrier to living kidney donation among African Americans, with over 30% of black donors excluded due to obesity. Social reasons, including failure to complete the donor evaluation process, also contribute to the low rates of donation.
The study found that females have higher levels of nitric oxide synthase, which may contribute to their lower risk of kidney disease. In contrast, males have more AT1 receptors that enable angiotensin 2 to cause damage, leading to a greater risk of hypertension and kidney injury.