Articles tagged with Kidney
A study published in the Journal of the American College of Surgeons found that morbidly obese patients undergoing Roux-en-Y gastric bypass surgery are at an increased risk of developing kidney stones as early as three months post-operation. The study suggests a possible link between the surgical procedure and changes in urinary electr...
Withdrawing calcineurin inhibitors after kidney transplantation can prolong survival, improve kidney function, and save money compared to lifelong medication use. The study found that treatment with sirolimus plus steroids may be more efficacious and less costly than regimens using calcineurin inhibitors.
A new study found that boiling cubed or shredded potato samples reduced potassium levels by 50% and 75%, respectively. Leaching had little effect on mineral content. Boiling thinly sliced potatoes can help renal failure patients reduce their mineral intake while maintaining other nutritional qualities.
Researchers have discovered a new kidney protein, NGAL, that can diagnose sudden kidney failure days sooner than current tests. A simple urine test for NGAL can help emergency department physicians accurately diagnose kidney failure and make evidence-based treatment decisions.
Researchers found that sirolimus can help protect against rejection in non-compliant kidney transplant patients, potentially extending their organ's lifespan. The study used an assay to measure immune function at 'trough' levels of immunosuppressive drugs.
A large US study found that sirolimus increases the risk of new-onset diabetes in kidney transplant recipients. The risk is higher when combined with other anti-rejection drugs and appears to be independent of other factors.
Patients with systolic dysfunction are nearly twice as likely to die than those without the condition, according to a study analyzing 2,718 kidney transplant candidates. This increased mortality risk is similar to that seen in patients with cardiac ischemia.
Researchers predict a rise in kidney stone disease due to global warming, with a potential cost of $1 billion annually by 2050. The southern US is expected to see an expansion of the
Leptospirosis is a major public health problem in South East Asia and South America, with over 500,000 severe cases every year. Researchers have discovered that bacteria can form biofilms, which protect them against harsh conditions and make them more resistant to antibiotics.
Researchers have identified genes that can cause enlarged hearts and kidney inflammation, leading to heart attacks and kidney failure. Understanding these genetic links may lead to new treatments for common heart diseases.
Research by Johns Hopkins Medicine found that African-American patients with chronic kidney disease continue to lose kidney function despite strict blood pressure control. The study suggests that treating CKD in this population may require a more comprehensive approach, considering other factors beyond just blood pressure.
A 10-year retrospective study found that even small increases in serum creatinine levels during hospitalization raise the risk of end-stage renal disease and mortality in elderly patients. The study also identified that larger changes in creatinine levels were associated with higher risks.
Research by Tufts University biologists reveals that early exposure to atrazine leads to deformed hearts, impaired kidneys, and digestive systems in tadpoles. The study found a significant increase in abnormalities in organs after 48 hours of exposure, with 57% of tadpoles having smaller-than-normal hearts.
Researchers found septic acute kidney injury (AKI) patients have higher acuity of illness, lower blood pressure, and worse pulmonary function compared to non-septic AKI. The study suggests septic AKI requires specific clinical interventions to reduce injury and promote kidney recovery.
Women with poor kidney filtering ability are at increased risk of sudden cardiac death, according to a new study published by the American Heart Association. The research found that those with advanced kidney dysfunction had a 3.16 times higher risk of SCD than women with normal kidney function.
Physiologists investigate nanoparticles' potential to cause diseases like atherosclerosis and kidney stones. Researchers are exploring how nanoparticles interact with cells and tissues to understand their role in these conditions.
Researchers identified two classes of small-molecule CFTR inhibitors that slowed cyst growth by over 80% and preserved kidney function. In mouse models, these inhibitors reduced cyst expansion and kidney enlargement.
A new study found that an iso-osmolar X-ray dye did not reduce the risk of kidney damage during percutaneous coronary intervention (PCI) in patients with chronic renal failure. The study compared two types of contrast medium and found no significant difference in rates of kidney injury or need for dialysis.
A new surgical approach, called bilateral nephron-sparing surgery, has shown promise in saving both kidneys of children with bilateral Wilms tumor. This procedure involves removing the malignant tumor while sparing as much healthy kidney tissue as possible.
A study found that elevated uric acid levels can precede significant changes in urine albumin levels, suggesting a potential early sign of diabetic kidney disease. Higher uric acid levels are associated with lower kidney function in patients with type 1 diabetes.
A simple laboratory test measures a biomarker called NGAL to predict acute kidney injury (AKI) risk up to three days before symptoms appear. The test has been shown to be highly accurate in identifying patients at risk of AKI and may enable timely treatment to prevent or improve outcomes.
Researchers at Albert Einstein College of Medicine found that aberrant Notch signaling plays a role in diabetic nephropathy and focal segmental glomerulosclerosis, two major causes of end-stage renal disease. They discovered that gamma secretase inhibitors can protect against kidney disease, sparking hope for new treatment options.
Researchers at Emory and Children's Healthcare of Atlanta are partnering with UCLA and Stanford hospitals to develop new ways to make kidney transplants more tolerable for children. The goal is to create a simple blood or urine test to inform doctors whether kidney rejection is 'revving up,' possibly avoiding painful biopsies.
Researchers have discovered a link between the bacteria Oxalobacter formigenes and a reduced risk of recurrent kidney stones. The study found that O. formigenes can metabolize oxalate, reducing the risk of calcium oxalate stone formation by up to 70%.
A new device containing human kidney cells has been shown to significantly reduce the risk of death from acute kidney injury. The device, called Renal Assist Device, was tested on 40 patients and found to improve recovery rates and reduce mortality by half.
A new screening questionnaire, SCORED, has been shown to be more accurate and efficient in identifying individuals with silent chronic kidney disease than current clinical practice guidelines. The test correctly identifies patients at risk for CKD 88-95% of the time and defines high-risk individuals 25% fewer times.
Researchers discovered that mice are more efficient at removing oxalate from the body, a crucial step in preventing kidney stones. This finding holds promise for developing improved treatments and paving the way for a mouse model of the disease.
Researchers studied 317 healthy teens aged 15-18 and found higher rates of albumin in the urine of black teens compared to their white counterparts, even with normal blood pressure. This suggests that kidney damage is apparent before hypertension develops in high-risk youths.
A rare case of colon duplication was diagnosed in an adult patient with hydronephrotic atrophy of the right kidney. The mass was successfully removed during a laparotomy, revealing a continuum of the duplicated colon. This exceptional case highlights the importance of accurate pre-operative diagnosis and surgical expertise.
A new study has found that kidney donor age is associated with increased aortic stiffness in recipients, which may explain higher rates of cardiovascular disease and death. The study suggests that targeted interventions after kidney transplantation could improve long-term results by reducing cardiovascular risk and mortality.
A large-scale study confirms that the cardiac surgery drug aprotinin increases death rates and damages kidney function. The study analyzed data from over 10,000 patients and found that those who received aprotinin had higher mortality rates and impaired kidney function compared to those who did not.
A study of acute kidney failure treatments found that intermittent hemodialysis and continuous kidney replacement therapy have similar clinical outcomes. No significant difference was seen in the risk of death or chronic dialysis treatment between the two therapies.
A new study suggests that taking N-acetylcysteine before a CT scan or angiogram can protect at-risk patients from kidney damage caused by iodine-containing contrast agents. The inexpensive drug, which is quick, convenient and widely available, appears to be the best choice for those with weakened kidneys.
Researchers at Yale University have received a $4 million NIH grant to study new biomarkers for detecting acute kidney injury (AKI) after cardiac surgery. The goal is to develop an earlier and more accurate diagnosis, reducing mortality rates.
Smart holograms can detect changes in blood-glucose levels, adrenaline levels, and other chemical imbalances, enabling patients to monitor their health more effectively. This new technology has wide applicability in various fields, including diabetes management, security, and smart packaging systems.
A new study by American Society of Nephrology confirms that intensive insulin therapy (IIT) protects kidneys in critically ill patients, reducing the risk of acute kidney injury (AKI) and death. IIT was found to be more effective in preventing AKI after surgery compared to medical ICU patients.
Researchers found that breakdown of self-cleaning mechanism in kidneys can lead to dysfunction and disease. The study suggests that defects in this clearance mechanism can cause accumulation of toxic substances, such as autoimmune antibodies, which can damage the kidney.
A new experimental protocol successfully induced immune tolerance to HLA-mismatched kidney transplants in four out of five patients. The treatment involved a combined organ and bone marrow transplant, followed by immunosuppressive drug withdrawal, resulting in normal kidney function for all patients.
A Stanford study has successfully enabled a patient to thrive for two years after stopping immunosuppressive drugs. The innovative technique, developed by Samuel Strober and his team, involves adjusting the patient's immune system and infusing blood cells from a compatible donor, boosting levels of regulatory T cells to prevent rejection.
Researchers are enrolling patients in a new study that transplants stem cells from a kidney donor's bone marrow into the recipient, with the goal of gradually eliminating the need for antirejection drugs. The study aims to improve post-transplant quality of life for recipients.
A study by Dr. Dorry L. Segev and colleagues found that severe obesity is associated with a lower chance of receiving a kidney transplant, even after adjusting for medical factors. Obese patients tend to wait longer and are more likely to be bypassed when a kidney becomes available.
A new Mayo Clinic study found that removing the entire kidney from younger patients with small kidney tumors may lead to decreased overall survival. In contrast, partial nephrectomy resulted in a 10-year overall survival rate of 93%. The study's findings highlight the importance of considering long-term health consequences for patients...
A Johns Hopkins study found that morbidly obese patients wait a median of five years on the transplant waiting list, while normal-weight patients wait two years less. The researchers argue that being overweight should not be a disqualifying factor for transplantation and call for guidelines to treat equally.
A newly identified molecular pathway involving the urokinase receptor (uPAR) appears to play a crucial role in the breakdown of kidney filtration structures, leading to proteinuria. The research suggests that targeting this pathway with antibodies or small molecule compounds could prevent or decrease proteinuria in animals.
Researchers found that a protein called hypoxia-inducible-factor (HIF-1) promotes the synthesis of fibrous connective tissue in kidneys, leading to reduced oxygenation and progression of chronic kidney disease. The study used mice with silenced HIF-1a to demonstrate the link between low oxygen conditions and CKD.
New research suggests transplanting kidneys from donors who died after cardiac arrest could increase the donor pool. A study found comparable short-term results between kidneys donated after cardiac death and brain death, with similar survival rates for patients and transplanted organs.
A study of over 300 live kidney donors found that they had good kidney function and tended to suffer a lower incidence of high blood pressure, diabetes, and heart-related deaths compared to the general population. Donors reported high satisfaction rates and would strongly encourage others to become donors if needed.
Smoking before or during pregnancy may decrease fertility in female offspring, according to a new mouse study. The study found that exposure to environmental toxins like polycyclic aromatic hydrocarbons (PAHs) can reduce the number of follicles in female mice, leading to reduced fertility.
A new study by the Medical College of Wisconsin suggests that captopril, an angiotensin-converting enzyme inhibitor, can reduce radiation injury to the kidneys in bone marrow transplant patients. This may lead to improved long-term kidney function and patient survival.
Using donated kidneys from older donors with health conditions can alleviate organ shortage among older adults, reducing waiting times and improving survival rates. Patient survival rates were similar across age groups, with 91% of patients over 60 receiving ECD kidneys surviving the transplant.
Researchers found that valproic acid reduces B cell activity by targeting histone deacetylases, preventing skin and kidney disease in mice with lupus. Mithramycin also shows promise by targeting Sp1, a transcription factor controlling genes involved in kidney disease, resulting in decreased kidney inflammation and protein levels.
Mayo Clinic researchers will study renal vascular disease caused by atherosclerosis to find new ways to diagnose and treat the condition. The study aims to develop novel imaging tools to predict, detect, and evaluate the disease, with the goal of preventing renal deterioration.
Chronic kidney disease is more common than previously thought, affecting over 13% of the US population, primarily those with diabetes and hypertension. The study highlights the importance of blood pressure control, blood sugar management, and avoiding toxic medications to slow disease progression.
Recent studies have linked widely used osteoporosis drugs and bowel prep solutions to kidney damage. Nephrologists must be aware of these emerging causes of kidney problems and take steps to prevent them.
A study found that black patients living in poorer neighborhoods were less likely to be placed on transplant waiting lists than white patients. Community poverty was a significant factor, rather than distance from transplant centers.
A recent study found that expanded criteria non-beating-heart kidney transplants from ECD donors are not suitable for elderly patients with ESRD. The risk of graft loss and death was significantly higher in these patients compared to brain-dead SCD donors.
A large-scale study has found no significant increase in cardiovascular risk for living kidney donors, but higher rates of high blood pressure were detected. The study analyzed data from 1,278 patients and compared them to 6,369 healthy adults.
Researchers developed a new mouse model to predict the loss of orally taken drugs due to metabolism by CYP3A, a key enzyme involved in first-pass metabolism. The study found that mice lacking functional CYP3A proteins accumulated docetaxol at higher levels, demonstrating the enzyme's role in intestinal metabolism.
Renal experts will discuss link between chronic kidney disease (CKD) and CVD, consequences of acute kidney injury, racial disparities in kidney disease outcomes, and treatment of anemia in kidney patients. The ASN's Public Policy News Briefing aims to improve health outcomes by highlighting significant research impacting public health.
Researchers suggest expanding kidney acceptance criteria and identify key factors improving transplant success. Matching donor and recipient ages and reducing waiting times may optimize results, while understanding risk factors like delayed graft function and acute rejection can aid preventive measures.