Articles tagged with Mouse Strains
Research links oral bacteria to Parkinson's disease via the gut-brain axis, finding Streptococcus mutans produces metabolite imidazole propionate that contributes to disease progression. Targeting the oral-gut microbiome may offer a new therapeutic approach for Parkinson's treatment.
Aging individuals experience bone loss despite physical activity, highlighting the importance of MSCs in regulating bone mechanoresponse. The new 3D bone marrow analog reveals that trabecular volume affects MSC response to mechanical signals, with higher strains associated with older densities and increased F-actin production
Researchers at Weill Cornell Medicine develop two strains of mycobacteria with 'kill switches' that can be triggered to stop the bacteria after they activate an immune response. The new approach aims to accelerate vaccine development and overcome safety concerns.
Researchers from JAX used mice with different genetic backgrounds to identify factors influencing eye aging, leading to a better understanding of age-related eye diseases. The study found that genetics play a key role in retinal aging and predicts common age-related eye diseases.
A new study using a novel mouse strain expressing Halo-tagged SOCS1 reveals that the inhibitor needs to exceed a threshold level to suppress GM-CSF and IFN-gamma signaling. The findings emphasize SOCS1's crucial function in modulating cytokine signaling.
A six-year study examining 38 clinical isolates of Cryptococcus found genes and gene alleles associated with disease severity. The research aims to develop new treatments targeting these genetic variations, predicting disease outcomes and improving patient care.
Scientists at The Jackson Laboratory have identified the CAST/EiJ mouse as a highly susceptible model for studying severe COVID-19. This genetically pure background allows researchers to investigate the virus's impact without artificial receptor modifications, mirroring human responses. Initial trials using antiviral treatments show pr...
Scientists at the Jackson Laboratory created a mouse model for late-onset Alzheimer’s disease by introducing genetic variants associated with the illness into mice. They used transcriptomics to analyze brain tissue and identify key biological signatures, paving the way for testing new therapeutics.
Researchers have identified a novel type of T cell that can recognize and respond to multiple bacterial strains in the gut. This breakthrough finding has significant implications for treating diseases such as cancer and inflammatory bowel disease. The discovery was made by Kazuki Nagashima, winner of the NOSTER & Science Microbiome Prize.
Researchers at The Jackson Laboratory have developed new laboratory-grade research mouse strains that better reflect human genetic variation. These wild-derived strains, detailed in PLoS Genetics, introduce millions of novel genetic variants and provide a powerful resource for modeling human traits and diseases.
A new study has discovered that bank voles in southern Sweden carry a virus that can cause hemorrhagic fever in humans, spreading the disease further south than previously known. The virus strain is closely related to strains from Finland and Karelia.
Researchers at ETH Zurich have identified a virus called Paride that can infect and destroy dormant bacteria, including Pseudomonas aeruginosa. The study found that the combination of Paride and an antibiotic called meropenem was effective in killing bacteria in both laboratory cultures and mice with chronic infections.
Researchers from Kumamoto University found that synchronizing ovulation and mating in
Researchers at Texas Biomedical Research Institute have found that adding an antibody to the widely-used TB vaccine significantly improves its long-term effectiveness. The combination of the vaccine and an IL-10 blocker allows for better control of TB infection in mice, with improved lung health and increased memory immune cells.
Scientists have identified two new candidate genes, ULK4 and PTTG1, that positively influence the development of an embryo by restoring a strong Sonic Hedgehog signaling pathway. This finding provides new insights into the causes of holoprosencephaly, a congenital malformation affecting around one to four in every 1,000 unborns.
Researchers created a new reporter mouse strain to visualize and manipulate P2X2-expressing cells, revealing their expression in specific subsets of sensory nerves. The study sheds light on the selective targeting of therapeutic approaches to address sensory nerve dysfunction.
Researchers developed a web tool to estimate the impact of genetic modification of mice, which can complicate biomedical research interpretation. The tool aids in explaining controversies and improving translation from lab animals to humans.
Researchers found a genetic trade-off between female sexual maturation and longevity, where delayed reproduction is associated with longer life. Mice with lower IGF1 levels reached sexual maturity later and lived longer.
Researchers have created a genome-wide map of most inbred mouse strains, finding that they represent only limited genetic diversity. The team hopes to expand this diversity by adding wild mouse populations, which could lead to more effective translation of experimental results to humans.
The study of 15 mouse strains' genetic makeup reveals potential causes of environmental diseases. Researchers can now compare genetic variations to determine individual susceptibility to toxins in humans.
Researchers found that the genetic variation in laboratory mice is vastly greater than previously thought, with 8.3 million variations described. The pedigrees of the 15 mouse strains studied differ from each other to a far greater degree than previously assumed.
Researchers have sequenced the DNA of 15 commonly used mouse strains, discovering over 8.3 million single nucleotide polymorphisms. This data will help understand complex genetic traits and their relation to human diseases, such as Parkinson's, cancer, and asthma.
Researchers have identified two Bifidobacterium strains that exhibit potent antimicrobial properties, protecting the intestinal tract from lethal infection with salmonella. These strains, CA1 and F9, decrease bacterial numbers, prevent entry into cells, and work in concert with gut lining enzymes to produce a barrier against infection.
A new study contradicts the long-held assumption that the Helicobacter pylori bacterium has been with humans forever. Researchers analyzed DNA from over 500 strains from five continents and found that strains from Peru resemble those from Spain, not those from eastern Asia.
Researchers have created a mutant strain of Mycobacterium tuberculosis that fails to establish a lethal chronic infection in mice. Targeting the pcaA gene, which codes for an enzyme essential for virulence, may lead to breakthroughs in TB treatment.
Researchers found that mice lacking centromere protein B (CENP-B) suffer from reproductive failure due to defects in the uterus. The study suggests CENP-B plays a role in cell divisions that remodel the uterine lining during estrus and pregnancy.
Researchers found that genetic variation significantly impacts an individual's sensitivity to estrogen, challenging traditional laboratory-animal-based safety tests. The study suggests that genetic makeup should be considered when prescribing estrogen and related hormones for medical purposes.
A team of researchers from the University of Cincinnati and other institutions has identified the first gene responsible for age-related hearing loss in mice. The Ahl gene is located on mouse Chromosome 10 and appears to be a single, recessive trait that causes significant hearing losses in older mice.
Researchers found synergy in two strains of Enterococcus faecalis when combining trovafloxacin and ampicillin/sulbactam, but not in other tested strains. Combination antibiotic treatment remains the only effective means to eliminate vancomycin-resistant enterococcal infections.