Articles tagged with Skin
Researchers identified mutations in the KDSR gene, which disrupts ceramide production, leading to dry, scaly skin. Isotretinoin, a commonly used acne medication, counteracts this effect, allowing patients to produce ceramides and alleviate symptoms.
Researchers found that HDAC3 inhibitors increase expression of aquaporin-3, a channel that transports glycerin, helping to improve skin health and reducing inflammation. The study's findings suggest that HDAC inhibitors could be an effective therapy for psoriasis.
A new handheld scanner allows for non-invasive imaging of skin layers and blood vessels in psoriasis patients, enabling the assessment of disease severity and potential treatment options. The technology has the potential to improve diagnosis and therapy of other diseases such as skin cancer and diabetes.
Cosmetic makers are researching skin bacteria and active ingredients to promote helpful microbes and discourage harmful ones, but a baseline picture of a healthy skin microbiome is lacking. Companies have already marketed bacteria-based product lines, despite limited knowledge of the skin microbiome.
The Estée Lauder Companies Research & Development presents new findings in anti-aging skin and hair research, including the effects of pollen exposure and photo-aging. The studies aim to understand environmental and biological processes driving skin and hair aging.
Researchers at Hokkaido University identified the PNPLA1 gene as essential for acylceramide synthesis, a lipid that forms the skin barrier. The study sheds light on potential treatments for skin diseases like atopic dermatitis and ichthyosis.
Researchers at the University of Missouri have developed a new technique, sonoillumination, which uses ultrasonic pulsation to improve laser transmission through skin tissues. This technique has the potential to reduce safety concerns in laser dermatology and provide safer, more effective treatment options for patients.
Researchers found that acne is associated with an imbalance of skin bacteria, including increased levels of virulence-associated genes and reduced beneficial bacteria. Targeted treatments, such as probiotic supplementation or phage therapy, may be more effective than antibiotics in maintaining a healthy bacterial balance.
Scientists have found a new species of tyrannosaur dinosaur with a high degree of tactile sensitivity, similar to crocodiles. The discovery provides insight into the evolution and life appearance of tyrannosaurs, revealing that their faces were covered in scaly protective layers and highly touch-sensitive snouts.
Research published in BioDiscovery found that topical curcumin gel significantly reduces burn and scald severity, lessens pain, and improves healing with minimal scarring. Dr. Madalene Heng's study suggests curcumin's anti-inflammatory activity is key to its effectiveness.
Researchers developed two approaches to increase penicillin and cephalosporin use in hospitalized patients with penicillin allergy. Skin testing significantly increased favorable prescriptions, while a computerized guideline also improved antibiotic prescribing rates.
A new biomechanical eye model mimics mechanical stress on peri-orbital skin, showing how aged cells don't respond well to blinking movement. The study highlights the impact of cyclic mechanical stress on collagen production, energy, and cellular proliferation.
A new article published online by JAMA Dermatology estimates the global burden of skin disease, with dermatitis and acne vulgaris ranking among top causes. Skin diseases accounted for 1.79% of the global burden of disease in 2013, equivalent to 41.6 million DALYS.
A study published in The Journal of the American Osteopathic Association found that young adults with high melanin content skin are at increased risk of sunburn. Researchers suggest that targeted sunburn prevention programs, including apps that gamify protection, could help reduce this risk.
A Penn vet team has discovered two major players in the immune system's T cells that trigger chronic inflammation and lead to persistent leishmaniasis lesions. Blocking these pathways with existing FDA-approved drugs led to significant reductions in lesions in an animal model.
Researchers discovered two new antibiotics in harmless skin bacteria that effectively fought off Staphylococcus aureus, a common cause of skin infections. Personalized lotions with these friendly bacteria prevented colonization in patients with Atopic Dermatitis, offering a potential solution to frequent skin infections.
A new paper outlines expressions of skin conditions often misdiagnosed as brown recluse bites, including bacterial infections and deadly reactions. The authors introduce the NOT RECLUSE mnemonic device to help doctors accurately diagnose these cases.
A new skin-graft harvesting system has been shown to significantly accelerate the healing process of chronic wounds in high-risk patients. The minimally invasive approach resulted in faster recovery times and reduced healthcare costs, with an average savings of $1,153 per patient.
A large international survey found imperfections in primary and secondary prevention of skin cancer, with regional differences in sun protection behaviors. The study's results suggest that education level, gender, and socioeconomic status influence sun protection habits.
Researchers designed a new diagnostic tool that measures gene activity in skin samples to predict disease progression of autoimmune diseases like systemic sclerosis. The test, called the SSc Skin Severity Score, can distinguish between patients who are improving and those who are not 12 months after treatment begins.
Women are more susceptible to autoimmune diseases due to a new regulatory mechanism identified by researchers. The study found that the master regulator gene VGLL3 promotes autoimmunity in women, regardless of sex hormone involvement.
A Northwestern Medicine study shows that trained partners can catch far more mole irregularities than control group participants, growing their confidence and trust along the way. Common areas prone to developing fatal melanoma include hard-to-see spots on the body.
Researchers discovered that blocking IL-6 in psoriasis patients may not prevent skin inflammation, but its levels are central to thrombosis events triggered by skin inflammation. A compensatory 'workaround' mechanism involving other immune system molecules is proposed to explain the findings.
A study by Tohoku University found that air pollutants cause hypersensitivity to itch, leading to skin inflammation and allergic diseases like asthma. The research team discovered that AhR, a transcription factor activated by air pollutants, causes itchy sensations through the expression of neurotrophic factor artemin.
A wearable device measures key biomarkers in sweat to monitor health during exercise and detect diseases like cystic fibrosis. The low-cost, flexible device analyzes biomarker concentrations using colorimetric analysis and provides real-time results.
Fungal skin infections are commonly misdiagnosed due to difficulty distinguishing between various skin conditions. Misdiagnosis can result in incorrect therapy selection and worsening symptoms, according to a survey by GW dermatologist Adam Friedman.
Research suggests that skin bacteria Propionibacterium acnes produces a protective protein called RoxP, which shields against UV radiation-induced oxidative stress and potentially various skin diseases.
A new study suggests that identifying patients with higher risk factors, such as many moles or family history of melanoma, can improve the identification and treatment of those at higher risk. The study found that these patients were more likely to have melanoma on specific areas of their skin.
A study published in JAMA Dermatology found that patients with a family history of melanoma, multiple primary melanomas, or many moles are at higher risk for developing melanoma. The researchers recommend tailoring surveillance programs to individual risk factors to improve early detection and treatment.
Researchers discovered that thorny devils can extract significant quantities of water from soggy sand, but not enough from dew. The lizards' skin is covered with microscopic channels that take up water by capillary action, allowing them to drink without licking water.
A phase-1 clinical trial demonstrates that gene therapy can restore functional type-7 collagen protein expression and improve wound healing in patients with recessive dystrophic epidermolysis bullosa. The treatment appears safe and well-tolerated, with improved outcomes for patients who had not healed for five years.
Researchers have developed an innovative skin graft process that combines split thickness skin grafts with a specially engineered sheet of stem cells to maximize natural healing power. The new technique shows promising results in treating large or complicated burn injuries, preserving hair follicles and oil glands.
Physicians and patients utilized social media to diagnose cutaneous leishmaniasis in a youth travel group, leveraging posted images of skin lesions. The disease was effectively treated thanks to rapid recognition facilitated by the online community.
A team of scientists developed a new approach to visualize oxygen in tissue, using optoacoustic methods and a novel algorithm that corrects for light propagation effects. This non-invasive imaging method achieves high accuracy and resolution, enabling the study of various medical conditions such as tumor growth and metabolism.
A task force has been criticized for not recommending melanoma screening due to lack of evidence, but dermatologists believe early detection reduces risk of death from melanoma through visual inspections. The issue highlights the need for refined standards on skin cancer screenings with potential life-saving benefits.
Research found that 40% of top-rated sunscreens on Amazon don't adhere to AAD standards due to lack of water resistance. Consumers prioritize cosmetic aspects over photoprotection, highlighting the need for healthcare professionals to educate patients about sunscreen options.
A Northwestern University study found that 40% of top-selling sunscreens on Amazon.com fail to meet water or sweat resistance standards. Consumers spend up to 3,000% more for similar products, highlighting a need for affordable and effective options.
Research suggests that high levels of water hardness in homes may be linked to the development of eczema in early infancy. Living in a hard water area was associated with an up to 87% increased risk of eczema at three months of age, independent of domestic water chlorine content.
A 44-year-old man with confirmed Zika virus infection exhibited a diffuse papular rash, petechiae on the palate, and hyperemic sclerae. Early recognition of these mucocutaneous findings is crucial for healthcare providers to differentiate Zika from other erythematous skin eruptions.
A silicone-based polymer coating has been developed to mimic the mechanical and elastic properties of healthy skin. The material can temporarily tighten skin, reduce water loss from dry skin and provide long-lasting UV protection.
A RAND/Harvard study found that teledermatology improved access to dermatologists for Medicaid patients, with half of those receiving any dermatology care using the service. The collaboration between Direct Dermatology and Health Plan of San Joaquin achieved significant increases in patient visits with dermatologists.
A recent study found that human skin microbial communities remain highly stable over time, retaining unique signatures and resisting external perturbations. However, stability varied across individuals and sites, with oily areas showing more consistent bacterial and fungal communities.
A new study found that virtual dermatology care can nearly double the number of patients receiving dermatological care from a specialist. Teledermatology expanded access to younger and healthier patients with targeted skin conditions like acne and warts, while serving half of all enrollees who received any dermatology care.
Researchers found that dogs with atopic dermatitis have a sharp decrease in skin bacterial diversity, leading to impaired barrier function and increased Staphylococcus species. Antibiotic therapy restored normal levels, suggesting a correlation between skin barrier dysfunction and bacterial overgrowth.
Scleratrophic skin lesions like morphea, lichen sclerosus etatrophicus (LSA) and anetoderma are associated with Lyme borreliosis, with Borrelia DNA detected in up to 50% of patients. The response to antibiotic treatment varies, suggesting a heterogeneous origin for these dermatoses.
A new study published in JAMA Neurology found that even prediabetes can cause nerve damage in people with small fiber neuropathy, challenging the conventional wisdom of how nerves deteriorate. The research showed that patients with prediabetes lost about 10% of their nerve fiber density each year, similar to those with diabetes.
A team of researchers has solved a rare, debilitating disease by identifying a genetic mutation as its cause. The disease, Pyrin Associated Autoinflammation with Neutrphilic Dermatosis (PAAND), affects half of the children of patients who have the condition.
Researchers have identified the genetic mutation causing PAAND, a rare inflammatory disease, and found that repurposed anti-arthritis drug anakinra can effectively treat the condition. The treatment was tested on a volunteer from an English family with striking results.
Researchers at Duke University have identified a potential drug target in the skin for treating short-term itch. By targeting a specific ion channel protein called TRPV4, scientists hope to develop topical treatments that can suppress itch and inflammation.
Researchers at Ohio State University have identified a human gene product called MG53 that regulates wound healing and may control scarring. This discovery could help heal open wounds, decrease recovery time after surgery and reduce the spread of infections.
A large-scale study found a significant link between traffic-related air pollution and the formation of lentigenes (facial dark spots) on cheeks of Asian women over 50. The study also showed that exposure to nitrogen dioxide gas had a stronger impact on dark spot formation than particulate matter.
A national survey reveals that high school wrestlers are prone to skin infections, with the head and neck being the most frequent site. Most skin infections can be treated within three to six days, but some may have more serious eye and neurological involvement.
Researchers at Stanford University School of Medicine found that trimming the nails of laboratory mice can cure a common and life-threatening skin disease. The technique saved 93% of mice from ulcerative dermatitis, a condition that caused deep ulcers and led to animal euthanasia.
Researchers at NYU Langone developed an antiscarring paste that inhibits fibrosis caused by radiation therapy in mice. The study suggests the use of A2A receptor blockers as a potential therapeutic approach to prevent scarring and fibrosis in cancer patients.
Two studies investigated the relationship between skin disorders and endocrine diseases. The first study found a higher prevalence of insulin resistance among men with acne, while the second study identified hirsutism and acanthosis nigricans as key skin features of polycystic ovary syndrome (PCOS).
Once-weekly GLP-1RAs lack clear-cut benefits and harms, making it challenging to choose the most suitable medication. The medications share similar outcomes for blood pressure and lipids but have differences in terms of HbA1c reduction and body weight, as well as risk of nausea and heart rate increase.
A study by Temple University researchers found a significant association between psychological stress and various skin symptoms, including itchiness, hair loss, and acne-like rashes. The study suggests that healthcare providers should ask patients about their stress levels to better understand skin conditions.
Researchers at LSU have identified a new gene regulation pathway that prevents inflammation and speeds up the skin's healing process. A nanoparticle-carried small interference RNA blocks the Nax sodium sensor, enabling faster healing.
Researchers at the University of Pennsylvania School of Medicine used state-of-the-art techniques to survey the skin's virus population, or virome. Most DNA viruses on healthy human skin are viral 'dark matter' with never been described before.
A 125-million-year-old fossilized mammal named Spinolestes xenarthrosus has remarkably preserved fur, hair follicles, hedgehog-like spines, organs, and even a fungal hair infection. The study pushes back the earliest record of preserved mammalian hair structures by over 60 million years.