Articles tagged with Skin
Researchers at the University of Chicago have developed a novel gene therapy approach that uses skin transplants to treat type-2 diabetes and obesity. The method uses CRISPR technology to deliver a hormone that stimulates insulin production, reducing blood glucose levels and promoting weight loss.
Researchers at Kumamoto University developed a photothermal ablation system to enhance transdermal delivery of protein-based drugs. The system, using gold nanorods and near-infrared light, increased skin permeability and successfully delivered proteins in both in vitro and in vivo experiments.
A new study from the University of Pennsylvania challenges common advice given to breast cancer patients, suggesting that antiperspirants can be used safely during radiotherapy. The study found no significant difference in radiation skin dose absorbed by patients with or without antiperspirants.
Researchers have developed a hypoallergenic electronic sensor that can be worn on the skin for up to a week without causing inflammation or irritation. The device uses breathable nanoscale meshes and has been tested on 20 subjects, demonstrating its reliability as an electrode for continuous health monitoring.
Researchers have identified a new target for treating inflammatory skin conditions by depleting the RIPK1 protein. This finding offers a potential 'upstream' approach to treating conditions such as psoriasis, which currently rely on immune suppressant treatments with potential complications.
Researchers at Nagoya University have identified a new category of genetic skin diseases characterized by autoinflammatory responses. These conditions reflect an uncontrolled primitive immune response that does not depend on external irritants, emphasizing the need for better understanding and effective treatments.
A new clinical trial found that high doses of vitamin D can reduce skin redness, swelling, and inflammation after a sunburn. Vitamin D at doses of 50,000-200,000 IU was shown to have long-lasting benefits in reducing skin inflammation and promoting skin barrier repair.
Researchers at Penn found that a perturbed skin microbiome can be transmitted to uninfected mice, leading to heightened inflammatory responses and more severe disease. The study also hints at the potential for practical implications in treating people with leishmaniasis.
New consensus recommendations suggest that isotretinoin treatment does not significantly increase the risk of abnormal scarring or delayed wound healing associated with skin procedures. The review article analyzed 32 relevant articles and concluded that manual dermabrasion and fully ablative laser procedures are not currently recommended.
A Swedish study found that biological treatments for psoriasis have a long-lasting positive impact on skin clearance and quality of life, even after switching between different medications. The study followed 583 individuals for up to 10 years and analyzed the effectiveness of treatments using three different measurements.
A computer model developed by neuroscientists at the University of Chicago can simulate the entire nerve response of the hand to any pattern of touch stimulation, providing insights into how the nervous system perceives touch. This tool will enable scientists to create realistic touch sensations in bionic hands for amputees.
A study by Penn researchers found that antibiotics can significantly change the skin microbiome, leading to lingering effects even after treatment is stopped. Antiseptics, on the other hand, had a less durable impact and did not significantly alter the skin's microbial communities.
Researchers at Nagoya University identified a mosaic skin disease caused by sperm cell transmission of keratin mutation. The mutation was found to be identical in the affected daughter and her father, confirming germline transmission. Genetic counseling is crucial for predicting disease risk in future children.
Researchers identified mutations in the KDSR gene, which disrupts ceramide production, leading to dry, scaly skin. Isotretinoin, a commonly used acne medication, counteracts this effect, allowing patients to produce ceramides and alleviate symptoms.
A new handheld scanner allows for non-invasive imaging of skin layers and blood vessels in psoriasis patients, enabling the assessment of disease severity and potential treatment options. The technology has the potential to improve diagnosis and therapy of other diseases such as skin cancer and diabetes.
Researchers found that HDAC3 inhibitors increase expression of aquaporin-3, a channel that transports glycerin, helping to improve skin health and reducing inflammation. The study's findings suggest that HDAC inhibitors could be an effective therapy for psoriasis.
Cosmetic makers are researching skin bacteria and active ingredients to promote helpful microbes and discourage harmful ones, but a baseline picture of a healthy skin microbiome is lacking. Companies have already marketed bacteria-based product lines, despite limited knowledge of the skin microbiome.
The Estée Lauder Companies Research & Development presents new findings in anti-aging skin and hair research, including the effects of pollen exposure and photo-aging. The studies aim to understand environmental and biological processes driving skin and hair aging.
Researchers at Hokkaido University identified the PNPLA1 gene as essential for acylceramide synthesis, a lipid that forms the skin barrier. The study sheds light on potential treatments for skin diseases like atopic dermatitis and ichthyosis.
Researchers at the University of Missouri have developed a new technique, sonoillumination, which uses ultrasonic pulsation to improve laser transmission through skin tissues. This technique has the potential to reduce safety concerns in laser dermatology and provide safer, more effective treatment options for patients.
Researchers found that acne is associated with an imbalance of skin bacteria, including increased levels of virulence-associated genes and reduced beneficial bacteria. Targeted treatments, such as probiotic supplementation or phage therapy, may be more effective than antibiotics in maintaining a healthy bacterial balance.
Scientists have found a new species of tyrannosaur dinosaur with a high degree of tactile sensitivity, similar to crocodiles. The discovery provides insight into the evolution and life appearance of tyrannosaurs, revealing that their faces were covered in scaly protective layers and highly touch-sensitive snouts.
Research published in BioDiscovery found that topical curcumin gel significantly reduces burn and scald severity, lessens pain, and improves healing with minimal scarring. Dr. Madalene Heng's study suggests curcumin's anti-inflammatory activity is key to its effectiveness.
A new biomechanical eye model mimics mechanical stress on peri-orbital skin, showing how aged cells don't respond well to blinking movement. The study highlights the impact of cyclic mechanical stress on collagen production, energy, and cellular proliferation.
Researchers developed two approaches to increase penicillin and cephalosporin use in hospitalized patients with penicillin allergy. Skin testing significantly increased favorable prescriptions, while a computerized guideline also improved antibiotic prescribing rates.
A new article published online by JAMA Dermatology estimates the global burden of skin disease, with dermatitis and acne vulgaris ranking among top causes. Skin diseases accounted for 1.79% of the global burden of disease in 2013, equivalent to 41.6 million DALYS.
A study published in The Journal of the American Osteopathic Association found that young adults with high melanin content skin are at increased risk of sunburn. Researchers suggest that targeted sunburn prevention programs, including apps that gamify protection, could help reduce this risk.
A Penn vet team has discovered two major players in the immune system's T cells that trigger chronic inflammation and lead to persistent leishmaniasis lesions. Blocking these pathways with existing FDA-approved drugs led to significant reductions in lesions in an animal model.
Researchers discovered two new antibiotics in harmless skin bacteria that effectively fought off Staphylococcus aureus, a common cause of skin infections. Personalized lotions with these friendly bacteria prevented colonization in patients with Atopic Dermatitis, offering a potential solution to frequent skin infections.
A new paper outlines expressions of skin conditions often misdiagnosed as brown recluse bites, including bacterial infections and deadly reactions. The authors introduce the NOT RECLUSE mnemonic device to help doctors accurately diagnose these cases.
A new skin-graft harvesting system has been shown to significantly accelerate the healing process of chronic wounds in high-risk patients. The minimally invasive approach resulted in faster recovery times and reduced healthcare costs, with an average savings of $1,153 per patient.
A large international survey found imperfections in primary and secondary prevention of skin cancer, with regional differences in sun protection behaviors. The study's results suggest that education level, gender, and socioeconomic status influence sun protection habits.
Researchers designed a new diagnostic tool that measures gene activity in skin samples to predict disease progression of autoimmune diseases like systemic sclerosis. The test, called the SSc Skin Severity Score, can distinguish between patients who are improving and those who are not 12 months after treatment begins.
Women are more susceptible to autoimmune diseases due to a new regulatory mechanism identified by researchers. The study found that the master regulator gene VGLL3 promotes autoimmunity in women, regardless of sex hormone involvement.
A Northwestern Medicine study shows that trained partners can catch far more mole irregularities than control group participants, growing their confidence and trust along the way. Common areas prone to developing fatal melanoma include hard-to-see spots on the body.
Researchers discovered that blocking IL-6 in psoriasis patients may not prevent skin inflammation, but its levels are central to thrombosis events triggered by skin inflammation. A compensatory 'workaround' mechanism involving other immune system molecules is proposed to explain the findings.
A study by Tohoku University found that air pollutants cause hypersensitivity to itch, leading to skin inflammation and allergic diseases like asthma. The research team discovered that AhR, a transcription factor activated by air pollutants, causes itchy sensations through the expression of neurotrophic factor artemin.
A wearable device measures key biomarkers in sweat to monitor health during exercise and detect diseases like cystic fibrosis. The low-cost, flexible device analyzes biomarker concentrations using colorimetric analysis and provides real-time results.
Fungal skin infections are commonly misdiagnosed due to difficulty distinguishing between various skin conditions. Misdiagnosis can result in incorrect therapy selection and worsening symptoms, according to a survey by GW dermatologist Adam Friedman.
Research suggests that skin bacteria Propionibacterium acnes produces a protective protein called RoxP, which shields against UV radiation-induced oxidative stress and potentially various skin diseases.
A new study suggests that identifying patients with higher risk factors, such as many moles or family history of melanoma, can improve the identification and treatment of those at higher risk. The study found that these patients were more likely to have melanoma on specific areas of their skin.
A study published in JAMA Dermatology found that patients with a family history of melanoma, multiple primary melanomas, or many moles are at higher risk for developing melanoma. The researchers recommend tailoring surveillance programs to individual risk factors to improve early detection and treatment.
Researchers discovered that thorny devils can extract significant quantities of water from soggy sand, but not enough from dew. The lizards' skin is covered with microscopic channels that take up water by capillary action, allowing them to drink without licking water.
A phase-1 clinical trial demonstrates that gene therapy can restore functional type-7 collagen protein expression and improve wound healing in patients with recessive dystrophic epidermolysis bullosa. The treatment appears safe and well-tolerated, with improved outcomes for patients who had not healed for five years.
Researchers have developed an innovative skin graft process that combines split thickness skin grafts with a specially engineered sheet of stem cells to maximize natural healing power. The new technique shows promising results in treating large or complicated burn injuries, preserving hair follicles and oil glands.
Physicians and patients utilized social media to diagnose cutaneous leishmaniasis in a youth travel group, leveraging posted images of skin lesions. The disease was effectively treated thanks to rapid recognition facilitated by the online community.
A team of scientists developed a new approach to visualize oxygen in tissue, using optoacoustic methods and a novel algorithm that corrects for light propagation effects. This non-invasive imaging method achieves high accuracy and resolution, enabling the study of various medical conditions such as tumor growth and metabolism.
A task force has been criticized for not recommending melanoma screening due to lack of evidence, but dermatologists believe early detection reduces risk of death from melanoma through visual inspections. The issue highlights the need for refined standards on skin cancer screenings with potential life-saving benefits.
A Northwestern University study found that 40% of top-selling sunscreens on Amazon.com fail to meet water or sweat resistance standards. Consumers spend up to 3,000% more for similar products, highlighting a need for affordable and effective options.
Research found that 40% of top-rated sunscreens on Amazon don't adhere to AAD standards due to lack of water resistance. Consumers prioritize cosmetic aspects over photoprotection, highlighting the need for healthcare professionals to educate patients about sunscreen options.
Research suggests that high levels of water hardness in homes may be linked to the development of eczema in early infancy. Living in a hard water area was associated with an up to 87% increased risk of eczema at three months of age, independent of domestic water chlorine content.
A 44-year-old man with confirmed Zika virus infection exhibited a diffuse papular rash, petechiae on the palate, and hyperemic sclerae. Early recognition of these mucocutaneous findings is crucial for healthcare providers to differentiate Zika from other erythematous skin eruptions.
A silicone-based polymer coating has been developed to mimic the mechanical and elastic properties of healthy skin. The material can temporarily tighten skin, reduce water loss from dry skin and provide long-lasting UV protection.
A RAND/Harvard study found that teledermatology improved access to dermatologists for Medicaid patients, with half of those receiving any dermatology care using the service. The collaboration between Direct Dermatology and Health Plan of San Joaquin achieved significant increases in patient visits with dermatologists.
A recent study found that human skin microbial communities remain highly stable over time, retaining unique signatures and resisting external perturbations. However, stability varied across individuals and sites, with oily areas showing more consistent bacterial and fungal communities.
A new study found that virtual dermatology care can nearly double the number of patients receiving dermatological care from a specialist. Teledermatology expanded access to younger and healthier patients with targeted skin conditions like acne and warts, while serving half of all enrollees who received any dermatology care.
Researchers found that dogs with atopic dermatitis have a sharp decrease in skin bacterial diversity, leading to impaired barrier function and increased Staphylococcus species. Antibiotic therapy restored normal levels, suggesting a correlation between skin barrier dysfunction and bacterial overgrowth.
Scleratrophic skin lesions like morphea, lichen sclerosus etatrophicus (LSA) and anetoderma are associated with Lyme borreliosis, with Borrelia DNA detected in up to 50% of patients. The response to antibiotic treatment varies, suggesting a heterogeneous origin for these dermatoses.
A new study published in JAMA Neurology found that even prediabetes can cause nerve damage in people with small fiber neuropathy, challenging the conventional wisdom of how nerves deteriorate. The research showed that patients with prediabetes lost about 10% of their nerve fiber density each year, similar to those with diabetes.
A team of researchers has solved a rare, debilitating disease by identifying a genetic mutation as its cause. The disease, Pyrin Associated Autoinflammation with Neutrphilic Dermatosis (PAAND), affects half of the children of patients who have the condition.