Articles tagged with Skin
A gene mutation causes wrinkled skin and hair loss; turning off that mutation restores the mouse to normal appearance. The study reveals an important role for mitochondria in skin health, with reversed mitochondrial dysfunction leading to restored smooth skin and thick fur.
Researchers found that cancer patients developing skin diseases after anti-PD-1 therapy can do so even after treatment has concluded. The median time to develop skin disease was four months after starting treatment, but in one case, it took over three years.
A fourth-generation retinoid, trifarotene, has been found to target only one particular retinoic acid receptor, reducing side effects. The study suggests that trifarotene may be particularly useful for treating large skin surface areas, such as the back and chest.
A new study led by University of Pennsylvania researchers has discovered the underlying factors causing ichthyosis, a skin barrier disorder that leads to thick layers of scales. The team developed a topical therapy using a lotion that restored the skin's natural lipid envelope, improving symptoms in affected dogs.
The NHS treats over 2 million wounds annually at a cost of £5.3 billion. Professor Peter Vowden highlights the need for improved systems of care to reduce this burden.
Researchers found that prurigo nodularis disproportionately affects African-Americans, particularly between ages 50 and 65. The study also identified associations with HIV infection, diabetes, chronic kidney disease, and clinical depression.
Scientists have developed a new technique using nanoparticles called NanoFlares to quickly and accurately predict excessive scarring. The method involves applying the nanoparticles to closed wounds and using a fluorescence microscope to detect signals given out by the nanoparticles' interaction with target biomarkers.
The Estée Lauder Companies presents research on autophagy's role in skin aging, as well as the impact of ozone pollution and blue light on skin cells. This study reveals that exposure to blue light at night can disrupt circadian rhythm and accelerate skin aging.
A research team at UT Southwestern Medical Center has found that inhibiting glucose transport may be a safe and effective treatment for skin diseases like psoriasis. By targeting the metabolic requirements of hyperproliferative skin diseases, researchers were able to reduce disease-associated skin overgrowth and inflammation in mice.
Researchers found that topical treatment with live Roseomonas mucosa was safe and associated with reduced disease severity in adults and children with eczema. The study's findings support further evaluation of this potential new therapy for atopic dermatitis, a condition linked to increased risks of asthma, hay fever, and food allergy.
Researchers at the University of Bristol are developing a realistic model of human skin on artificial robotic muscles. This innovation could lead to more successful transplants for burns patients and revolutionize healthcare.
A Northwestern University study links infant skin exposure and genetics to food allergy development, providing potential ways to intervene early. Limiting use of infant wipes with soap and washing hands before handling babies may help avoid developing food allergy.
Scientists at Osaka University developed a new topical gel to treat skin lesions in TSC, a rare inherited disease. The drug's approval marks a world first and offers a painless, safe, and easy-to-use solution for patients suffering from cosmetic issues.
Scientists have developed a new vaccine technology that induces strong immunity and improved disease symptoms in immunized animals. The platform has achieved proof-of-concepts in veterinary medical use, including treatments for insect-bite hypersensitivity in horses and atopic dermatitis in dogs.
Researchers found that gingival mesenchymal stem cells release more proteins, including IL-1RA, which blocks proinflammatory cytokines, accelerating wound healing in mucosal tissues. The study suggests potential therapeutic applications for delayed wound healing in diabetic patients.
Researchers discovered that retinoid-related orphan receptor alpha (RORα) in skin Tregs regulates immune response. Removing RORα from Tregs led to an increase in inflammatory cells and worsened eczema symptoms. The study suggests boosting RORα or targeting related pathways may be effective treatments.
Research suggests that medical school textbooks widely used in North America contribute to racial bias through underrepresentation of dark skin tones. The study analyzed over 4,000 human images and found that only a few percent of photos featured dark skin tones.
Eczema patients' skin shows shorter lipids that protect less effectively, allowing irritants to enter and setting the stage for lesions. An allergic immune response shortens lipids, making skin more susceptible to eczematous lesions.
The Estée Lauder Companies presents research on new anti-aging compounds, including hydroxypinacolone retinoate (HPR) that improves skin appearance without irritation. Caffeine enhances epidermal hydration by increasing the transepithelial electric potential and electro-osmosis.
Researchers at University of Cambridge have discovered the neural circuit controlling cuttlefish's dynamic skin papillae, enabling 3D camouflage. The discovery opens up new avenues for biologically-inspired material design and may shed light on cephalopod perception.
Scientists discovered a motor nerve dedicated to papillary and skin tension control in the stellate ganglion, allowing papillae to hold shape for over an hour. The study also found similarities between the neural circuit controlling papillae and squid skin iridescence.
Researchers discovered a protective mechanism in the immune system that shields against recurrent bacterial skin infections caused by Staphylococcus aureus. Gamma delta T cells, which account for less than 1% of lymph node cells before infection, multiply and provide protection against subsequent infections.
Researchers found patients and doctors disagree on surgical scarring evaluation 28% of the time, with patients focusing on depth and physicians on coloration and texture. This highlights the need for better assessment methods and improved preoperative counseling.
Researchers have discovered a potential new therapy for eczema that also reduces asthma severity, offering hope for effective treatments for both conditions. The study found that alleviating skin inflammation can significantly reduce asthma symptoms.
Researchers found that beneficial bacteria on mouse skin work with the immune system to defend against disease-causing microbes and accelerate wound healing. This study suggests untangling similar mechanisms in humans may improve approaches to managing skin wounds and treating other damaged tissues.
LJI researchers reveal LIGHT, a tumor necrosis factor super family member, drives skin inflammation in atopic dermatitis. The discovery provides a novel therapeutic target for the treatment of severe eczema. Therapies blocking LIGHT signaling may halt disease symptoms and reverse symptoms.
Researchers discovered snakes use unique skin movement to propel themselves forward in a straight line. This rectilinear locomotion gives them an advantage in confined spaces and could inform robotics for search-and-rescue operations and underwater inspections.
Terra firma-forme dermatosis is a hyperpigmented skin disease with a dirt-like appearance, found on trunks of 28% patients and extremities of 27%. Recognizing the condition helps avoid unnecessary testing and treatment.
Researchers at Chapman University found that hagfish skin is not puncture-resistant due to its flaccid nature. The slime released after attack plays a crucial role in defending against shark bites, showcasing the unique defensive strategy of these ancient eel-like animals.
Scientists at King's College London have discovered a seaweed compound that can protect human skin from UV radiation without harming marine ecosystems. The mycosporine-like amino acid, palythine, has been shown to absorb harmful rays and offer antioxidant protection against cellular damage.
Researchers identified specific gene expression patterns in women who appear younger than their chronologic age, suggesting that genetic changes may slow down skin aging. The study revealed accelerated changes in pathways related to oxidative stress, energy metabolism, and senescence with increasing age.
A new technique using machine learning can improve the diagnosis of melanoma by identifying the optimal amount of context around skin lesions. By segmenting images into two parts, separating the lesion from surrounding skin, researchers found that a limited border beyond the lesion enhances classification performance.
Researchers found that shark skin's dermal denticles develop from neural crest cells, just like teeth, supporting the theory that these primitive scales were carried into jawed vertebrates to form teeth. This discovery suggests a deep evolutionary relationship between ancient fish scales and vertebrate teeth.
A new Northwestern Medicine study found that water baths were just as effective as bleach baths in reducing eczema symptoms, with no added benefits to using bleach. Regular bathing can help control bacterial infections and prevent dryness, making it a better alternative for patients with eczema.
The study identifies a protein called IL-36 as a key player in inducing skin inflammation in response to bacteria on the skin surface. This finding has significant implications for developing alternative treatments for atopic dermatitis, a condition affecting 20% of children and 5% of adults.
Researchers at Johns Hopkins Medicine have developed a topical gel made from common blood pressure pills that block inflammation pathways, speeding up the healing of chronic skin wounds. The gel was shown to be effective in accelerating wound healing in mice and pigs, with one concentration showing significant benefits.
A new treatment reduced disease burden in patients with skin-predominant dermatomyositis, improving patient-reported quality of life and symptom assessments. The treatment, anabasum, was well-tolerated with mild side effects.
Research reveals that wounds heal more than twice as fast in skin with prior inflammatory experience, thanks to sensitized stem cells. These cells remain active long after the initial inflammation has subsided and are better equipped to migrate into the wound.
Researchers identified four key themes in mannequin design, including flexible vocal cords, realistic color change, step-by-step training, and more natural movements. The findings aim to improve clinical competency and optimal clinical outcomes for pediatric residents.
Researchers found that fire ant venom compounds can reduce skin thickening and inflammation in a mouse model of psoriasis. The solenopsin analogs, similar to ceramides, can restore the skin's barrier function and decrease immune cell infiltration.
A CWRU researcher has received a five-year, $3.9 million grant from the National Institutes of Health to explore ways to augment the body's immune system after exposure to toxic chemicals, including mustard gas. The goal is to reduce skin swelling and pain while enhancing tissue repair.
A Northwestern Medicine study reveals that many 'fragrance-free' and 'hypoallergenic' moisturizers contain allergens, making it difficult for patients to find affordable and safe options. The study found that only 12% of the top-selling moisturizers were free of common skin allergens.
A new study found that Zika virus preferentially replicates in the female reproductive tract after vaginal transmission, suggesting a higher risk of fetal Zika disease. The research used rhesus macaques to investigate the effects of mosquito and sexual transmission on Zika infection.
A James Cook University scientist has discovered an alcohol-free antiseptic solution that is safe and effective for minor surgical procedures. The study found a slightly lower infection rate with the new solution compared to traditional water-based antiseptics.
Engineered skin grafts from stem cells can regulate blood glucose levels and reverse insulin resistance in diabetic mice. The approach, using CRISPR gene editing, has shown promise for potential long-term treatment of human patients with diabetes.
Researchers at the University of Chicago have developed a novel gene therapy approach that uses skin transplants to treat type-2 diabetes and obesity. The method uses CRISPR technology to deliver a hormone that stimulates insulin production, reducing blood glucose levels and promoting weight loss.
A new study reveals that fish-scale geckos have a hidden strength in their fragile skin, containing bony deposits known as osteoderms. The geckos' ability to drop their skin as a defense mechanism is paradoxically paired with the presence of armor-like osteoderms.
Researchers from Hokkaido University successfully treated mice with atopic dermatitis using HLA-G1, a protein that inhibits immune responses. The treatment showed marked improvement in skin lesions and reduced immune response compared to untreated mice.
Researchers at Kumamoto University developed a photothermal ablation system to enhance transdermal delivery of protein-based drugs. The system, using gold nanorods and near-infrared light, increased skin permeability and successfully delivered proteins in both in vitro and in vivo experiments.
A new study from the University of Pennsylvania challenges common advice given to breast cancer patients, suggesting that antiperspirants can be used safely during radiotherapy. The study found no significant difference in radiation skin dose absorbed by patients with or without antiperspirants.
Researchers have developed a hypoallergenic electronic sensor that can be worn on the skin for up to a week without causing inflammation or irritation. The device uses breathable nanoscale meshes and has been tested on 20 subjects, demonstrating its reliability as an electrode for continuous health monitoring.
Researchers have identified a new target for treating inflammatory skin conditions by depleting the RIPK1 protein. This finding offers a potential 'upstream' approach to treating conditions such as psoriasis, which currently rely on immune suppressant treatments with potential complications.
Researchers at Nagoya University have identified a new category of genetic skin diseases characterized by autoinflammatory responses. These conditions reflect an uncontrolled primitive immune response that does not depend on external irritants, emphasizing the need for better understanding and effective treatments.
A new clinical trial found that high doses of vitamin D can reduce skin redness, swelling, and inflammation after a sunburn. Vitamin D at doses of 50,000-200,000 IU was shown to have long-lasting benefits in reducing skin inflammation and promoting skin barrier repair.
Researchers at Penn found that a perturbed skin microbiome can be transmitted to uninfected mice, leading to heightened inflammatory responses and more severe disease. The study also hints at the potential for practical implications in treating people with leishmaniasis.
A Swedish study found that biological treatments for psoriasis have a long-lasting positive impact on skin clearance and quality of life, even after switching between different medications. The study followed 583 individuals for up to 10 years and analyzed the effectiveness of treatments using three different measurements.
New consensus recommendations suggest that isotretinoin treatment does not significantly increase the risk of abnormal scarring or delayed wound healing associated with skin procedures. The review article analyzed 32 relevant articles and concluded that manual dermabrasion and fully ablative laser procedures are not currently recommended.
A computer model developed by neuroscientists at the University of Chicago can simulate the entire nerve response of the hand to any pattern of touch stimulation, providing insights into how the nervous system perceives touch. This tool will enable scientists to create realistic touch sensations in bionic hands for amputees.
A study by Penn researchers found that antibiotics can significantly change the skin microbiome, leading to lingering effects even after treatment is stopped. Antiseptics, on the other hand, had a less durable impact and did not significantly alter the skin's microbial communities.
Researchers at Nagoya University identified a mosaic skin disease caused by sperm cell transmission of keratin mutation. The mutation was found to be identical in the affected daughter and her father, confirming germline transmission. Genetic counseling is crucial for predicting disease risk in future children.