Articles tagged with Skin
A study by University of Pennsylvania researchers reveals that Dickkopf 2 (DKK2) is a naturally occurring protein that blocks the WNT pathway, controlling hair growth. The discovery has significant implications for hair loss treatment and wound healing.
Researchers have identified a set of genes that enable S. epidermidis to cause disease in certain circumstances, making it a major concern for those undergoing surgery. The study aims to identify patients at high risk of infection before surgery, reducing the risk of post-operative infections.
A team of researchers at NYU Langone Health has successfully regrown hair strands on damaged skin by stimulating fibroblasts to secrete collagen through the sonic hedgehog signaling pathway. The study offers new hope for treating hair loss and may lead to the development of more effective drugs.
Researchers have discovered a lipid called phosphatidylglycerol (PG) that may help restore healthy skin turnover in people with psoriasis. PG reduced inflammation and raised skin lesions when applied topically to a mouse model of psoriasis, suggesting it could be a new treatment option.
The LEO Foundation Skin Immunology Research Center will bring together leading researchers to provide new knowledge for better diagnoses and treatments of psoriasis and eczema. The center aims to strengthen the immune system's fight against over 3,000 known skin diseases.
A medically challenging case presented at the American College of Allergy, Asthma and Immunology Annual Scientific Meeting found that allergy shots provided significant benefits to a patient with severe eczema. The treatment successfully reduced the need for high-dose steroid therapy and improved symptoms such as itching and dry skin.
Researchers developed a gene-suppressing drug that, when combined with an over-the-counter gel, accelerated wound healing in mice. The treatment, tested on mice with skin excisions or burns, showed significant improvements in healing outcomes, including regeneration of hair follicles and collagen networks.
A new treatment for lymphedema symptoms has been found to be effective in restoring skin health and reducing swelling. Ketoprofen, an anti-inflammatory drug, has shown promising results in two clinical trials, with participants experiencing significant improvements in skin thickness and appearance.
A new study from the University of Pennsylvania found that cancer patients can safely use topical skin treatments during radiation therapy without increasing the radiation dose to their skin. The study challenged common advice given to patients and debunked the myth that these treatments increase radiation damage.
A recent study published in JAMA Facial Plastic Surgery found that e-cigarette vaping negatively impacts wound healing, causing damage comparable to traditional cigarette smoking. The researchers discovered increased tissue death and delayed wound healing in experimental models exposed to both e-cigarettes and traditional cigarettes.
The study found that female participants preferred more cooling during exercise, while males did not experience similar changes in body temperature. After exercising, females' skin temperatures fell rapidly, but they continued to seek neck cooling due to elevated core temperatures.
A new study published by the Keck School of Medicine of USC found that an online care delivery model is equivalent to in-person care for improving psoriasis symptoms. Patients with chronic skin diseases need ongoing care, and depending on where they live, their access to dermatological care can be variable.
A new study found significant disparities in the use of outpatient dermatology services among different ethnic groups and socioeconomic statuses. Patients with lower incomes and education levels were less likely to receive care, while those with higher incomes and education levels had better access to specialized services.
Scientists at the Salk Institute have developed a technique to directly convert cells in an open wound into new skin cells, promoting healing and countering the effects of aging. The approach, which relies on reprogramming cells to a stem-cell-like state, shows promising results in treating large ulcers and skin damage.
Researchers have made significant progress in developing an acne vaccine by targeting a toxin secreted from Propionibacterium acnes bacteria. The vaccine has shown promise in reducing inflammation in human acne lesions. Future studies aim to engineer a non-toxic chemical or targeted vaccine formulation for its human application.
Scientists developed a flexible, high-density artificial retina using 2D materials that mimics the human eye. The device has shown promising results in laboratory and animal studies, and could potentially restore sight to millions of people with retinal diseases.
Researchers have discovered that lupus patients' skin cells produce an excessive amount of interferon kappa, leading to increased sensitivity to UV light. The team's findings suggest that blocking this protein may help alleviate photosensitivity symptoms and potentially new treatments for the condition.
A gene mutation causes wrinkled skin and hair loss; turning off that mutation restores the mouse to normal appearance. The study reveals an important role for mitochondria in skin health, with reversed mitochondrial dysfunction leading to restored smooth skin and thick fur.
Researchers found that cancer patients developing skin diseases after anti-PD-1 therapy can do so even after treatment has concluded. The median time to develop skin disease was four months after starting treatment, but in one case, it took over three years.
A fourth-generation retinoid, trifarotene, has been found to target only one particular retinoic acid receptor, reducing side effects. The study suggests that trifarotene may be particularly useful for treating large skin surface areas, such as the back and chest.
A new study led by University of Pennsylvania researchers has discovered the underlying factors causing ichthyosis, a skin barrier disorder that leads to thick layers of scales. The team developed a topical therapy using a lotion that restored the skin's natural lipid envelope, improving symptoms in affected dogs.
The NHS treats over 2 million wounds annually at a cost of £5.3 billion. Professor Peter Vowden highlights the need for improved systems of care to reduce this burden.
Researchers found that prurigo nodularis disproportionately affects African-Americans, particularly between ages 50 and 65. The study also identified associations with HIV infection, diabetes, chronic kidney disease, and clinical depression.
Scientists have developed a new technique using nanoparticles called NanoFlares to quickly and accurately predict excessive scarring. The method involves applying the nanoparticles to closed wounds and using a fluorescence microscope to detect signals given out by the nanoparticles' interaction with target biomarkers.
The Estée Lauder Companies presents research on autophagy's role in skin aging, as well as the impact of ozone pollution and blue light on skin cells. This study reveals that exposure to blue light at night can disrupt circadian rhythm and accelerate skin aging.
A research team at UT Southwestern Medical Center has found that inhibiting glucose transport may be a safe and effective treatment for skin diseases like psoriasis. By targeting the metabolic requirements of hyperproliferative skin diseases, researchers were able to reduce disease-associated skin overgrowth and inflammation in mice.
Researchers found that topical treatment with live Roseomonas mucosa was safe and associated with reduced disease severity in adults and children with eczema. The study's findings support further evaluation of this potential new therapy for atopic dermatitis, a condition linked to increased risks of asthma, hay fever, and food allergy.
Researchers at the University of Bristol are developing a realistic model of human skin on artificial robotic muscles. This innovation could lead to more successful transplants for burns patients and revolutionize healthcare.
A Northwestern University study links infant skin exposure and genetics to food allergy development, providing potential ways to intervene early. Limiting use of infant wipes with soap and washing hands before handling babies may help avoid developing food allergy.
Scientists at Osaka University developed a new topical gel to treat skin lesions in TSC, a rare inherited disease. The drug's approval marks a world first and offers a painless, safe, and easy-to-use solution for patients suffering from cosmetic issues.
Scientists have developed a new vaccine technology that induces strong immunity and improved disease symptoms in immunized animals. The platform has achieved proof-of-concepts in veterinary medical use, including treatments for insect-bite hypersensitivity in horses and atopic dermatitis in dogs.
Researchers found that gingival mesenchymal stem cells release more proteins, including IL-1RA, which blocks proinflammatory cytokines, accelerating wound healing in mucosal tissues. The study suggests potential therapeutic applications for delayed wound healing in diabetic patients.
Researchers discovered that retinoid-related orphan receptor alpha (RORα) in skin Tregs regulates immune response. Removing RORα from Tregs led to an increase in inflammatory cells and worsened eczema symptoms. The study suggests boosting RORα or targeting related pathways may be effective treatments.
Research suggests that medical school textbooks widely used in North America contribute to racial bias through underrepresentation of dark skin tones. The study analyzed over 4,000 human images and found that only a few percent of photos featured dark skin tones.
Eczema patients' skin shows shorter lipids that protect less effectively, allowing irritants to enter and setting the stage for lesions. An allergic immune response shortens lipids, making skin more susceptible to eczematous lesions.
The Estée Lauder Companies presents research on new anti-aging compounds, including hydroxypinacolone retinoate (HPR) that improves skin appearance without irritation. Caffeine enhances epidermal hydration by increasing the transepithelial electric potential and electro-osmosis.
Researchers at University of Cambridge have discovered the neural circuit controlling cuttlefish's dynamic skin papillae, enabling 3D camouflage. The discovery opens up new avenues for biologically-inspired material design and may shed light on cephalopod perception.
Scientists discovered a motor nerve dedicated to papillary and skin tension control in the stellate ganglion, allowing papillae to hold shape for over an hour. The study also found similarities between the neural circuit controlling papillae and squid skin iridescence.
Researchers discovered a protective mechanism in the immune system that shields against recurrent bacterial skin infections caused by Staphylococcus aureus. Gamma delta T cells, which account for less than 1% of lymph node cells before infection, multiply and provide protection against subsequent infections.
Researchers found patients and doctors disagree on surgical scarring evaluation 28% of the time, with patients focusing on depth and physicians on coloration and texture. This highlights the need for better assessment methods and improved preoperative counseling.
Researchers have discovered a potential new therapy for eczema that also reduces asthma severity, offering hope for effective treatments for both conditions. The study found that alleviating skin inflammation can significantly reduce asthma symptoms.
Researchers found that beneficial bacteria on mouse skin work with the immune system to defend against disease-causing microbes and accelerate wound healing. This study suggests untangling similar mechanisms in humans may improve approaches to managing skin wounds and treating other damaged tissues.
LJI researchers reveal LIGHT, a tumor necrosis factor super family member, drives skin inflammation in atopic dermatitis. The discovery provides a novel therapeutic target for the treatment of severe eczema. Therapies blocking LIGHT signaling may halt disease symptoms and reverse symptoms.
Researchers discovered snakes use unique skin movement to propel themselves forward in a straight line. This rectilinear locomotion gives them an advantage in confined spaces and could inform robotics for search-and-rescue operations and underwater inspections.
Terra firma-forme dermatosis is a hyperpigmented skin disease with a dirt-like appearance, found on trunks of 28% patients and extremities of 27%. Recognizing the condition helps avoid unnecessary testing and treatment.
Researchers at Chapman University found that hagfish skin is not puncture-resistant due to its flaccid nature. The slime released after attack plays a crucial role in defending against shark bites, showcasing the unique defensive strategy of these ancient eel-like animals.
Scientists at King's College London have discovered a seaweed compound that can protect human skin from UV radiation without harming marine ecosystems. The mycosporine-like amino acid, palythine, has been shown to absorb harmful rays and offer antioxidant protection against cellular damage.
A new technique using machine learning can improve the diagnosis of melanoma by identifying the optimal amount of context around skin lesions. By segmenting images into two parts, separating the lesion from surrounding skin, researchers found that a limited border beyond the lesion enhances classification performance.
Researchers identified specific gene expression patterns in women who appear younger than their chronologic age, suggesting that genetic changes may slow down skin aging. The study revealed accelerated changes in pathways related to oxidative stress, energy metabolism, and senescence with increasing age.
Researchers found that shark skin's dermal denticles develop from neural crest cells, just like teeth, supporting the theory that these primitive scales were carried into jawed vertebrates to form teeth. This discovery suggests a deep evolutionary relationship between ancient fish scales and vertebrate teeth.
A new Northwestern Medicine study found that water baths were just as effective as bleach baths in reducing eczema symptoms, with no added benefits to using bleach. Regular bathing can help control bacterial infections and prevent dryness, making it a better alternative for patients with eczema.
The study identifies a protein called IL-36 as a key player in inducing skin inflammation in response to bacteria on the skin surface. This finding has significant implications for developing alternative treatments for atopic dermatitis, a condition affecting 20% of children and 5% of adults.
Researchers at Johns Hopkins Medicine have developed a topical gel made from common blood pressure pills that block inflammation pathways, speeding up the healing of chronic skin wounds. The gel was shown to be effective in accelerating wound healing in mice and pigs, with one concentration showing significant benefits.
A new treatment reduced disease burden in patients with skin-predominant dermatomyositis, improving patient-reported quality of life and symptom assessments. The treatment, anabasum, was well-tolerated with mild side effects.
Research reveals that wounds heal more than twice as fast in skin with prior inflammatory experience, thanks to sensitized stem cells. These cells remain active long after the initial inflammation has subsided and are better equipped to migrate into the wound.
Researchers identified four key themes in mannequin design, including flexible vocal cords, realistic color change, step-by-step training, and more natural movements. The findings aim to improve clinical competency and optimal clinical outcomes for pediatric residents.
Researchers found that fire ant venom compounds can reduce skin thickening and inflammation in a mouse model of psoriasis. The solenopsin analogs, similar to ceramides, can restore the skin's barrier function and decrease immune cell infiltration.
A CWRU researcher has received a five-year, $3.9 million grant from the National Institutes of Health to explore ways to augment the body's immune system after exposure to toxic chemicals, including mustard gas. The goal is to reduce skin swelling and pain while enhancing tissue repair.
A Northwestern Medicine study reveals that many 'fragrance-free' and 'hypoallergenic' moisturizers contain allergens, making it difficult for patients to find affordable and safe options. The study found that only 12% of the top-selling moisturizers were free of common skin allergens.
A new study found that Zika virus preferentially replicates in the female reproductive tract after vaginal transmission, suggesting a higher risk of fetal Zika disease. The research used rhesus macaques to investigate the effects of mosquito and sexual transmission on Zika infection.