Articles tagged with Skin
Researchers at the University of Córdoba have developed new molecules derived from cannabidiol, which induce the expression of heme oxygenase 1 and activate NRF2 to exhibit dual antioxidant activity. This mechanism has great potential for treating skin diseases like atopic dermatitis and epidermolysis bullosa.
Black and Hispanic children in the US experience more severe eczema than their white counterparts. Additionally, they are less likely to report overall excellent health. The disparities exist due to differences in how the condition appears on diverse skin tones, requiring individualized treatment approaches.
Researchers found that dietary intervention increased skin gene expression manifold, with raw food activating the immune defense system and increasing antioxidant production. This study suggests that a raw diet may help activate the immune defense of dogs, potentially reducing the risk of atopic dermatitis.
A challenging case study found that wearing a face mask with elastic bands worsened a man's existing skin allergies. Common allergens in masks and their components can trigger symptoms in people with pre-existing skin conditions.
Researchers have created a novel, allergen-depleted fragrance with anti-inflammatory properties that soothes xerotic skin. The fragrance, integrated into new Eucerin products, reduces skin redness and improves patient adherence to treatment.
A new analysis found that some COVID-19 patients experience persistent skin-related symptoms long after recovery. Researchers evaluated almost 1,000 cases and identified a previously unreported subset of patients with long-standing skin symptoms from COVID-19.
Researchers are developing an oral spray to treat severely painful blisters and scarring in EB patients. The spray contains anti-fibrotic molecules to prevent scarring and promote healing, aiming to improve symptoms such as eating difficulties and poor dental health.
The first international Wounds Week was a resounding success, bringing together experts to discuss wound infection, identification, prevention, and management of pressure. Key findings include the importance of antimicrobial stewardship and wound hygiene in preventing infections.
Burt's Bees presents research on bakuchiol, a natural alternative to retinol, with anti-inflammatory properties and improved skin health. The company also highlights the effectiveness of a natural lip balm containing turmeric in providing therapeutic benefits for dry or compromised lips.
Researchers at KIST extracted ganoderic acid from Ganoderma lucidum to treat skin conditions like atopic dermatitis. Optimal drying and extraction conditions were found to enhance anti-inflammatory, antioxidant, and anti-diabetic effects.
A new study has discovered that accumulated DNA damage in skin cells can be used to estimate the risk of deadly skin cancer. Researchers sequenced DNA from individual melanocytes and found a significant number of mutations associated with melanoma, even in people without visible moles.
Researchers at University of Reading and Newcastle University found planaria can be used as a reliable alternative for testing topical skin products without harming animals. The use of fluorescent dye mixed with potential skin products shows accurate interaction with living tissue.
An experimental probiotic treatment reduced eczema severity and improved quality of life for children as young as 3 years old. The treatment modified the skin microbiome and increased microbial diversity, reducing Staphylococcus aureus levels and promoting skin repair processes.
Research suggests that frequent use of high-strength corticosteroid creams for skin lightening can lead to impaired cortisol function and adrenal insufficiency. Women using these products may be at risk of developing severe health problems, including extreme fatigue and even death.
Two common gene variants in the KIF3A gene increase the risk of young children developing atopic dermatitis and food allergies. The study provides new insights into the genetic mechanisms underlying this condition, which affects up to 20% of all children.
Researchers found that two common genetic variations in the KIF3A gene impair skin barrier function, leading to increased water loss and development of atopic dermatitis. Genetic testing could help identify infants at risk, potentially preventing eczema and related allergic diseases.
Researchers develop siRNA-based treatment for psoriasis using ionic-liquid technology, reducing inflammation and symptoms without systemic side effects. The delivery method opens up new possibilities for treating debilitating dermatological disorders.
Researchers pinpointed a single gene biomarker, nitride oxide synthase 2 (NOS2), to distinguish between atopic dermatitis and psoriasis with 100% accuracy using adhesive tape strips. The study identifies distinct immune response markers for each disease.
A UCLA-led study found that dermatopathologists are motivated by both patient safety concerns and malpractice fears when ordering additional tests. The study surveyed 160 dermatopathologists in the US, who reported a strong emphasis on patient safety as a driving factor for their actions.
Researchers found that roflumilast cream significantly improved psoriasis signs and symptoms in as early as two weeks, with clear skin, itch reduction, and burden of disease improvement. The treatment showed promise for patients with plaque psoriasis lacking suitable options.
Researchers used synchrotron microtomography to visualize ancient fossils and found that acanthothoracid teeth were attached to jaw-bones like modern fish and land animals. This discovery challenges the common perception that sharks are primitive living vertebrates.
A new study from Binghamton University connects lipids and bacteria to aid in understanding eczema. Researchers found that decreased levels of ceramides can allow Staphylococcus aureus bacteria to penetrate the skin barrier, leading to inflammation and infection. Further research is needed to unlock the secrets of atopic dermatitis.
Researchers developed two dermascopes using smartphone-based cameras to image skin lesions, mapping differences between melanoma and erythema. The approach improves efficiency and efficacy of skin-lesion diagnostics with high precision and simplicity.
Researchers at the University of British Columbia have discovered a key enzyme that contributes to eczema's debilitating effects, offering new hope for treatment. By inhibiting Granzyme B, the study suggests a safer and more effective long-term treatment could prevent skin damage and reduce symptoms.
Researchers discovered an overabundance of KLK6 protein can produce skin inflammation in psoriasis, while normalizing its level can eliminate it. They also found that KLK6 plays a key role in damaging joints and bones in people with the disorder.
A new study from Umea University reveals that psoriasis patients with comorbid physical diseases experience increased mental health risks due to these associated somatic illnesses. The research indicates a higher risk of depression, anxiety, and suicide among psoriasis patients with other medical conditions.
BIOCAD presents results of clinical trial showing netakimab decreases disease activity and reduces skin manifestation of psoriatic arthritis through 24 weeks of therapy. The treatment was well-tolerated, with significant improvement in skin manifestations and quality of life.
Researchers from ETH Zurich have deconstructed the complex mechanisms that control tissue repair and scar formation, focusing on a signal molecule called activin. The study reveals how activin affects cell interactions and extracellular matrix composition, promoting wound healing but also causing scarring.
Researchers have developed UVC LEDs emitting at 230nm that can destroy microorganisms without allowing resistances to develop. The system achieves high irradiation power and uniformity, making it suitable for killing MDR pathogens and inactivating coronaviruses.
A new study revealed that 42.8% of medical staff treated COVID-19 patients experienced serious skin injuries related to personal protective equipment (PPE) use. The most common types of skin injuries were device-related pressure injuries, moist associated skin damage, and skin tears.
Researchers have created a novel vaccine delivery technology using a finger-tip sized patch with tiny needles that penetrate the skin, releasing molecules to prompt immune responses. The technology has shown improved immunogenicity, including cellular immune responses, and potential advantages in ease of fabrication and storage.
A study from North Carolina State University found that the protein periostin can directly activate itch-associated neurons in the skin, leading to increased itching in atopic dermatitis. Blocking periostin receptors reduced itch response in a mouse model of eczema.
A species of lipid DOPG has been found to aid healing of scratches on the cornea, even in humans with diabetes. The lipid stimulates cell growth and inhibits toll-like receptor activation, paving the way for potential clinical trials and treatment protocols.
Researchers at Georgia Institute of Technology have developed a new skin treatment using microscopic STAR particles that can deliver drugs directly to affected areas. The treatment, which involves rubbing the particles on the skin, has shown promising results in inhibiting tumor growth in mice.
Research published in the British Journal of Dermatology found that bereaved individuals have a 17% higher risk of dying from melanoma compared to non-bereaved persons. Those who had lost a partner were also 12% less likely to be diagnosed with melanoma, highlighting the importance of skin checks for early detection and improved survival.
Researchers identified how Staphylococcus aureus and Staphylococcus epidermidis promote skin inflammation and barrier damage in Netherton syndrome. The study provides a detailed genomic description of the skin microbiome and offers a potential new treatment target by targeting the microbiome.
A new study by the University of Nottingham found that daily moisturizer use cannot prevent childhood eczema in newborn babies. The research suggested a small increase in skin infection risk and early indications of potential food allergy connections.
A study by UC Davis Health researchers found that a Western diet rich in fat and sugar can induce inflammatory skin diseases like psoriasis. The diet's components, rather than obesity, may lead to skin inflammation and its development.
Researchers at Penn State are using a $2.8 million NIH grant to explore 3D bioprinting for craniomaxillofacial reconstruction. They will investigate bioprinting bone, skin, and other tissues directly during surgery to correct defects in the face, mouth, and skull.
Researchers found that 50% of lupus skin rashes contained high levels of Staphylococcus aureus bacteria. A protein called interferon increases the stickiness of staph to the skin. This discovery highlights the increased risk of infection and spreading in lupus patients.
Researchers at Oxford University Press USA have identified new ways to prevent skin scarring after injuries. The study suggests that pressure therapy, silicone treatment, and early laser intervention can reduce scar formation and improve therapeutic response. These findings offer promising hope for patients with hypertrophic scars.
A new handheld 3D skin printer has been developed to accelerate wound healing of large, severe burns. The device deposits sheets of skin using 'bio ink' made from mesenchymal stem cells, which promotes skin regeneration and reduces scarring.
A new handheld bioprinter has shown promising results in treating full-thickness burns by depositing bioink directly onto wounds. The device uses mesenchymal stromal cells to support local cell growth and reduce inflammation, scarring, and contraction.
Hives affect 1 in 5 people, and researchers used a mathematical model to recreate the patterns of hives. The study suggests that certain mechanisms may inhibit histamine release, adding complexity to the disease. The findings will help create a more detailed picture of how the skin disease develops.
A new study by Newcastle University scientists found that both UV and non-UV light from sunlight can damage the skin's cells, with visible and infrared rays causing greater harm at deeper levels. The research aims to improve sunscreen protection strategies against all three types of light.
A skin cream used to treat warts and skin cancer has been found to prevent infection from viral diseases like Zika and dengue when applied after a mosquito bite. The cream works by activating the skin's immune response, preventing the virus from spreading throughout the body.
Researchers at Indiana University have discovered a chemical compound found in essential oils that improves wound healing in mice when applied topically. The study shows increased cell growth and gene expression, suggesting potential for less scar formation and improved recovery.
Researchers found that a molecularly similar regulator to PD-1, PD-1H, can cause immune system attacks in lupus patients. This discovery suggests novel ways to restore function and provide new therapy for the disease.
Researchers used gene editing and stem cell reprogramming to correct mutations in a human genetic skin disorder, RDEB, in mice. The corrected skin grafts exhibited significant collagen VII deposition and integration, similar to wild-type skin.
Researchers found that a specific toxin in Staphylococcus aureus prevents tolerance and maintains the immune system's vigilance. Early-life exposure to commensal bacteria like S. epidermidis leads to immune tolerance, while later exposure to pathogenic S. aureus results in a vigorous immune response.
A Drexel University study found that rapamycin cream can reduce wrinkles, sagging, and improve skin tone in human subjects over 40. The drug blocks the TOR protein and has anti-aging effects by reducing senescent cells associated with skin aging.
Northwestern University researchers create a thin, wireless system that adds a sense of touch to virtual reality experiences, enabling new applications in social interactions, prosthetics, telemedicine, and entertainment. The device transmits touch patterns through miniature vibrating actuators embedded into a soft, flexible material.
Researchers identified genetic factors and parasite numbers that predict treatment success in cutaneous leishmaniasis. A small difference in parasite numbers makes a big difference in patient response.
A study found that shark skin microbiomes resist infection and maintain native bacterial communities even after injury. Regional differences were also detected in the microbial communities across different locations.
A new study found that chronic itch is significantly associated with clinical depression, suicidal ideation, and stress in dermatological patients. The study suggests providing access to a multidisciplinary team to prevent mental health problems.
A small proof-of-concept trial has shown promising results for a new therapy targeting the immune system to treat atopic dermatitis. The treatment, called etokimab, led to significant improvements in physical symptoms and a reduction in eosinophils in patients with severe eczema.
Columbia University researchers have captured the most detailed images yet of a temperature-sensing molecule in its open, intermediate, and closed states. The findings will help us understand the mechanics of hot and cold sensation, which could accelerate the development of drugs for inflammatory skin disease, itch, and pain.
A study published in the Journal of Investigative Dermatology found that ketogenic diets heavy in coconut oil and palm oils worsened psoriasiform-like skin inflammation in mice. In contrast, well-balanced ketogenic diets with long-chain triglycerides did not exacerbate skin inflammation.
Researchers used non-invasive tape strips to assess molecular signs of immune dysfunction and skin changes in young children with eczema. These biomarkers can predict response to medicine and development of associated conditions, paving the way for routine use in clinical trials.
A new study uses tape strips to analyze skin lesions and non-lesional skin in infants and young children with early-onset eczema, identifying biomarkers for immune and barrier abnormalities. The technique provides a non-invasive alternative to skin biopsies, which are often difficult to perform in children.