Predicting treatment outcome for leishmaniasis
Researchers identified genetic factors and parasite numbers that predict treatment success in cutaneous leishmaniasis. A small difference in parasite numbers makes a big difference in patient response.
Skin
Articles tagged with Skin
'Epidermal VR' gives technology a human touch
Northwestern University researchers create a thin, wireless system that adds a sense of touch to virtual reality experiences, enabling new applications in social interactions, prosthetics, telemedicine, and entertainment. The device transmits touch patterns through miniature vibrating actuators embedded into a soft, flexible material.
Shark skin microbiome resists infection
A study found that shark skin microbiomes resist infection and maintain native bacterial communities even after injury. Regional differences were also detected in the microbial communities across different locations.
SourceKing Abdullah University of Science & Technology (KAUST)·JournalAnimal Microbiome·DateNov 4, 2019
Increased depression, suicidal thoughts and stress are reported in patients with chronically itchy skin
A new study found that chronic itch is significantly associated with clinical depression, suicidal ideation, and stress in dermatological patients. The study suggests providing access to a multidisciplinary team to prevent mental health problems.
Promising therapy for common form of eczema identified in early-stage trial
A small proof-of-concept trial has shown promising results for a new therapy targeting the immune system to treat atopic dermatitis. The treatment, called etokimab, led to significant improvements in physical symptoms and a reduction in eosinophils in patients with severe eczema.
Images offer most detailed glimpse yet into how skin senses temperature
Columbia University researchers have captured the most detailed images yet of a temperature-sensing molecule in its open, intermediate, and closed states. The findings will help us understand the mechanics of hot and cold sensation, which could accelerate the development of drugs for inflammatory skin disease, itch, and pain.
SourceColumbia University Irving Medical Center·JournalNature Structural & Molecular Biology·DateOct 21, 2019
How do ketogenic diets affect skin inflammation?
A study published in the Journal of Investigative Dermatology found that ketogenic diets heavy in coconut oil and palm oils worsened psoriasiform-like skin inflammation in mice. In contrast, well-balanced ketogenic diets with long-chain triglycerides did not exacerbate skin inflammation.
Painless tape strips used to detect molecular changes in skin of children with eczema
Researchers used non-invasive tape strips to assess molecular signs of immune dysfunction and skin changes in young children with eczema. These biomarkers can predict response to medicine and development of associated conditions, paving the way for routine use in clinical trials.
Use of tape strips in early onset pediatric atopic dermatitis
A new study uses tape strips to analyze skin lesions and non-lesional skin in infants and young children with early-onset eczema, identifying biomarkers for immune and barrier abnormalities. The technique provides a non-invasive alternative to skin biopsies, which are often difficult to perform in children.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalJAMA Dermatology·DateOct 9, 2019
Burt's Bees presents clinical data demonstrating proven efficacy of natural skin care
Burt's Bees research highlights the effectiveness of natural ingredients like bakuchiol in addressing anti-aging concerns and protecting skin from environmental damage. Clinical studies demonstrate improved skin health, reduced sensitivity, and enhanced lip barrier function with nature-based skincare regimens.
New species of parasite is identified in fatal case of visceral leishmaniasis
Researchers identified a new species of parasite causing a disease similar to visceral leishmaniasis, resistant to current treatments. The parasite was found to infect both internal organs and skin, leading to severe symptoms and death in patients.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalEmerging Infectious Diseases·DateOct 1, 2019
Emerging parasitic disease mimics the symptoms of visceral leishmaniasis in people
A new study reveals a parasitic disease that mimics visceral leishmaniasis symptoms in people, but doesn't respond to standard treatments. Researchers found the parasite was more closely related to Crithidia fasciculata, which usually infects mosquitoes.
SourceNIH/National Institute of Allergy and Infectious Diseases·JournalEmerging Infectious Diseases·DateOct 1, 2019
Heart, kidney disease risk factors for adverse effects from gout medication
A study published in CMAJ found that heart disease increases the risk of hospitalization for allopurinol-related severe skin reactions. People with specific genetic markers, such as HLA-B*5801, are at higher risk. The risk is further increased when combined with kidney disease.
Smoothing wrinkles in mice -- without needles
Researchers developed a needle-free 'exosome' treatment that reduces wrinkles in UV-exposed mice, improving skin health and collagen production. The treatment uses a jet of air to deliver medications deep into the skin, providing a more youthful appearance.
Needle-free flu vaccine patch effective in early study
A new needle-free flu vaccine patch has been developed that effectively stimulates the immune system without negative side effects. The patch uses a synthetic peptide to disrupt the skin barrier, allowing the flu vaccine virus to be delivered, and has shown promise in early human trials.
SourceUniversity of Rochester Medical Center·JournalJournal of Investigative Dermatology·DateSep 16, 2019
Elaborate Komodo dragon armor defends against other dragons
Researchers at the University of Texas at Austin discovered that Komodo dragon armor is designed to protect against other dragons, not predators. The unique bone structure, featuring four distinct shapes, provides extensive coverage and suggests that young Komodo dragons do not have armor until adulthood.
Skin patch could painlessly deliver vaccines, cancer medications in one minute
Researchers developed a fast-acting skin patch that efficiently delivers medication to attack melanoma cells, producing nine times the antibody level compared to traditional injections. The patch technology has widespread applications for other vaccines and could be used to deliver vaccines against infectious diseases.
Scientists use skin's microbiome to develop health index for children with eczema
A new index developed from the skin microbiome of children can identify eczema and predict treatment response. The Microbial Index of Skin Health (MiSH) achieved high accuracy in identifying skin conditions across different cities, paving the way for precise skin care.
Shedding light on the reaction mechanism of PUVA light therapy for skin diseases
Researchers analyzed the reaction mechanism of PUVA therapy using time-resolved laser spectroscopy. The process involves two stages: initial binding and cyclobutane ring formation, which triggers programmed cell death and destroys diseased cells.
SourceHeinrich-Heine University Duesseldorf·JournalJournal of the American Chemical Society·DateAug 20, 2019
New pain organ discovered in the skin
Researchers at Karolinska Institutet have discovered a new sensory organ in the skin that detects painful mechanical damage, such as pricks and pressure. This discovery changes our understanding of the cellular mechanisms of physical sensation and may be significant in the understanding of chronic pain.
Mode of delivery at birth may play key role in shaping the child's skin microbiome
A study published in the Journal of Investigative Dermatology found that children's skin microbiomes are similar to their mothers' and can be affected by mode of delivery. The research suggests that vaginal delivery is associated with a stronger bacterial similarity to mothers, while Caesarian section may lead to differences.
Pain and gain: Skin nerves anticipate and fight infection, Pitt research finds
Scientists at the University of Pittsburgh School of Medicine found that pain-sensing nerves in the skin can detect pathogens and initiate an immune response to fight infection. The discovery reveals a new nerve-driven protective mechanism called anticipatory immunity, which prevents infections from spreading.
Time heals all wounds, but this adhesive can help
Researchers have developed an active adhesive dressing that contracts in response to body heat, speeding up wound healing. The dressings, inspired by embryonic skin, use thermoresponsive polymers and silver nanoparticles to prevent bacterial growth, making them a promising alternative to traditional treatments.
SourceWyss Institute for Biologically Inspired Engineering at Harvard·JournalScience Advances·DateJul 24, 2019
Patients treated for visceral leishmaniasis can still transmit the disease, study shows
A study by the Drugs for Neglected Diseases Initiative found that nearly 60% of patients with PKDL passed on parasites to sandflies, which can then infect others. Early treatment of PKDL patients is crucial to prevent transmission of leishmaniasis in South Asia.
Inexpensive equipment and training can improve melanoma detection and reduce biopsies
Research suggests that primary care physicians trained in dermatoscopy can detect melanoma earlier and more accurately, reducing the need for invasive biopsies. The study found that a dermatoscope can improve diagnosis by four times compared to unaided eye inspection.
SourceAmerican Osteopathic Association·JournalThe Journal of the American Osteopathic Association·DateJul 1, 2019
Burt's Bees presents research on the proven power of naturals at the 2019 WCD
Burt's Bees presents clinical research demonstrating the protective abilities of botanical antioxidants, improving barrier function, and modulating sebum and the skin microbiome. The studies highlight the role of nature-based regimens in reducing oxidative damage, decreasing skin sensitivity, and promoting overall skin health.
People with benign skin condition willing to trade time, money to cure disorder
Researchers found that patients with benign hyperpigmentation are willing to spend significant time and money to be cured. The study suggests that these conditions have a substantial impact on quality of life, particularly when facial skin is involved.
The Estée Lauder Companies showcases new research on combating aging at 2019 SID Meeting
The Estée Lauder Companies' research focuses on defending skin from environmental stressors and aging, demonstrating the antioxidant benefit of eucalyptus extract. The team discovered that activating sirtuins with key ingredients increases skin fibroblast activity to combat aging.
Discovery may help explain why women get autoimmune diseases far more often than men
Researchers have discovered that amplifying the amount of VGLL3 in skin cells pushes the immune system into overdrive, leading to autoimmune responses. This finding may help explain why women are more likely to develop autoimmune diseases like lupus and could lead to new treatments.
Ginkgo seed extracts show antibacterial activity on skin pathogens
Researchers at Emory University found that Ginkgo seed extracts inhibit the growth of skin pathogens like Cutibacterium acnes, Staphylococcus aureus, and Streptococcus pyogenes. The study suggests ginkgo seeds could be used as a topical antimicrobial treatment for skin disorders.
Zinc oxide reduces body odor caused by bacteria and aids wound healing
A study found that zinc oxide reduces armpit odour by killing responsible bacteria, while also assisting in wound healing. The compound's antimicrobial effects were confirmed through a double-blind trial involving 30 healthy volunteers.
UC Davis designer receives STEM grant from Johnson & Johnson
Katia Vega, a UC Davis design professor, has received the Johnson & Johnson WiSTEM2D Scholars Award for her innovative work in integrating technology into wearable cosmetics. The $150,000 grant provides three years of mentorship and aims to fuel development of female STEM leaders.
How can we improve skin care in residential care homes?
A new study aims to develop a standardized skin care guidance for elderly people in residential care, addressing common skin problems and improving quality of life. The SKINCARE study will investigate the effectiveness of the new program and provide training for care workers.
Sunscreen use could lead to better blood vessel health
Researchers found that sunscreen and sweat on the skin can protect blood vessel function from UVR exposure, preserving nitric oxide levels. This protective effect may benefit individuals who spend extended periods outdoors, reducing the risk of skin vascular dysfunction.
Mystery of how beetles that live in aquifers breathe solved
Researchers found that subterranean beetles breathe through their skin, absorbing oxygen from the surrounding water, which limits their size. This discovery sheds light on the unique adaptations of these tiny creatures living in underground aquifers.
Dermatology students improve Wikipedia entries on skin disease
A group of medical students from the University of Colorado Anschutz Medical Campus improved Wikipedia articles on skin-related diseases, increasing their visibility by millions of views. They added evidence-based information from Cochrane Reviews to make the articles more complete and accurate.
SourceUniversity of Colorado Anschutz Medical Campus·JournalJournal of the American Academy of Dermatology·DateApr 3, 2019
Wearable sensors mimic skin to help with wound healing process
Researchers at Binghamton University have developed skin-inspired electronics to monitor lactate and oxygen levels on the skin, enabling long-term, high-performance wound monitoring. The sensor's bio-mimicry structure allows for invisible integration with biological tissue, reducing inflammation and evoking no response.
Illinois professor contributes to improved care for NICU babies
Researchers developed a wireless, battery-free sheath that can be laid on the skin and gently peeled off when needed. The patch gathers medical data and processes it locally to reduce information sent wirelessly. Since deployment at two hospitals, 90 babies have used the patches, validating them as a feasible alternative to current tec...
Skin diseases are more common than we think
A recent study found that at least one skin abnormality affects 64.5% of the adult population, with men being more frequently affected than women. The prevalence of skin diseases increases with age and is associated with significant economic burdens.
New potential approach to treat atopic dermatitis
Researchers found that a small yeast species called Malassezia strengthens the body's defenses against pathogens, but its balance with the immune system is key to preventing atopic dermatitis. A new potential treatment targets this balance by neutralizing interleukin-17 cytokine production.
Proof of pimple: Mouse model validates how 'good' and 'bad' bacteria affect acne
Researchers have developed a new mouse model that closely resembles human acne by adding synthetic sebum, allowing them to directly compare 'good' and 'bad' strains of Propionibacterium acnes bacteria. The study found that acne-associated strains caused inflammation and lesions, while health-associated strains had minimal effect.
No wires, more cuddles: Sensors are first to monitor babies in the NICU without wires
Researchers developed soft, flexible wireless sensors to monitor premature babies in the NICU. These sensors allow physical bonding between baby and parent while providing clinical-grade measurements, replacing traditional wire-based sensors that pose a barrier to skin-to-skin contact.
Dermal disruption: Amphibian skin bacteria is more diverse in cold, variable environments
A global survey of frog skin bacteria reveals that diverse microbial communities thrive in cold, variable environments. Fast-growing bacteria are often outcompeted by slower-dormant types in temperate climates.
Salt could be a key factor in allergic immune reactions
Researchers found elevated salt concentrations in the skin of patients with atopic dermatitis, which can lead to Th2 cell activation and increased production of IL-4 and IL-13. The study suggests a link between salt intake and the occurrence of atopic dermatitis.
Scientists identify unique subtype of eczema linked to food allergy
Researchers found structural and molecular differences in skin near eczema lesions of children with both conditions, suggesting an elevated risk for developing food allergies. These differences may help identify children at elevated risk and inform early intervention strategies.
SourceNIH/National Institute of Allergy and Infectious Diseases·JournalScience Translational Medicine·DateFeb 20, 2019
A deeper look at the relationship between dermatitis and food allergy, in pediatric patients
Food allergies are associated with unique skin properties and abnormalities in pediatric patients with atopic dermatitis. The study found decreased filaggrin, elevated type 2 immune responses, and increased keratin expression in skin samples from patients with food allergy and dermatitis.
SourceAmerican Association for the Advancement of Science (AAAS)·JournalScience Translational Medicine·DateFeb 20, 2019
How the brain responds to texture
New research reveals that neurons in the brain's somatosensory cortex respond differently to various features of a surface, creating a high-dimensional representation of texture. This complex neural landscape allows for the rich sensation of texture, enabling us to distinguish between subtle differences.
SourceUniversity of Chicago Medical Center·JournalProceedings of the National Academy of Sciences·DateFeb 8, 2019
VAT fat may cause pathogenic obesity
Visceral adipose tissue prioritizes over subcutaneous fat storage, leading to chronic inflammation and insulin resistance. Early life malnutrition and modern diets contribute to VAT accumulation.
SourceSmithsonian Tropical Research Institute·JournalProceedings of the National Academy of Sciences·DateJan 11, 2019
Investigational cream may help patients with inflammatory skin disease
A study published in the British Journal of Dermatology found that an investigational nonsteroidal topical cream, PAC-14028, improved clinical symptoms and signs in adults with mild to moderate atopic dermatitis. The cream blocks a specific ion channel involved in pain perception and inflammation.
Yale experts treat severe, disfiguring sarcoidosis with novel therapy
Researchers successfully treated a patient with disfiguring sarcoidosis using a drug approved for rheumatoid arthritis. The treatment showed promising results in reducing skin lesions and halting the activation of the Jak-STAT pathway.
E-bandage generates electricity, speeds wound healing in rats
Researchers have developed a self-powered bandage that converts skin movements into an electric field, accelerating wound healing in rats. The e-bandage reduces healing time by up to 75% compared to traditional bandages.
Using light to stop itch
Scientists at EMBL Rome have discovered a way to treat itchy skin conditions like eczema by using near-infrared light to bind to specialized nerve cells. This method has shown promising results in mice with eczema and amyloidosis, offering new hope for potential human treatments.
Wound care revolution: Put away your rulers and reach for your phone
A new app called Swift Skin and Wound measures wounds accurately, providing a way to clearly document and quantify wound size. The app is being used by clinicians and healthcare professionals at the McGill University Health Centre in Montreal to improve clinical management and patient outcomes for diabetic patients.
Building an AI to predict if you carry a killer on your skin
Researchers developed an AI model to predict the risk of developing a serious infection from Staphylococcus epidermidis genomic features. The model uses large-scale population genomics and machine learning to identify high-risk genotypes, which could lead to proactive identification of individuals at risk before surgical procedures.
The naked eye alone is not enough to ensure the accurate diagnosis of skin cancer, say experts
A systematic review of research has concluded that visual inspection alone is not sufficient to diagnose skin cancer accurately. Key findings include the limited effectiveness of smartphone applications in detecting melanomas and the potential benefits of dermoscopy and teledermatology.
It's not a shock: Better bandage promotes powerful healing
Researchers developed a new wound dressing that applies gentle electrical pulses using energy from body motions, significantly speeding up healing times in rodent tests.
Researchers regrow hair on wounded skin
A team of researchers at NYU Langone Health has successfully regrown hair strands on damaged skin by stimulating fibroblasts to secrete collagen through the sonic hedgehog signaling pathway. The study offers new hope for treating hair loss and may lead to the development of more effective drugs.
SourceNYU Langone Health / NYU Grossman School of Medicine·JournalNature Communications·DateNov 28, 2018
Researchers discover why some parts of the body have hair and others don't
A study by University of Pennsylvania researchers reveals that Dickkopf 2 (DKK2) is a naturally occurring protein that blocks the WNT pathway, controlling hair growth. The discovery has significant implications for hair loss treatment and wound healing.
The potentially deadly bacterium that's on everyone's skin
Researchers have identified a set of genes that enable S. epidermidis to cause disease in certain circumstances, making it a major concern for those undergoing surgery. The study aims to identify patients at high risk of infection before surgery, reducing the risk of post-operative infections.
Lipid that aids normal skin turnover may help psoriasis
Researchers have discovered a lipid called phosphatidylglycerol (PG) that may help restore healthy skin turnover in people with psoriasis. PG reduced inflammation and raised skin lesions when applied topically to a mouse model of psoriasis, suggesting it could be a new treatment option.
SourceMedical College of Georgia at Augusta University·JournalJournal of Investigative Dermatology·DateNov 27, 2018