Articles tagged with Skin
Researchers found that lidocaine injections reduced Psoriasis Area and Severity Index scores by 35-70% and maintained improvements for at least 24 weeks. The study suggests targeting sensory nerves as a potential therapeutic strategy for psoriasis treatment.
Researchers at NTU Singapore and Cuprina have developed a new clinical-grade collagen made from discarded bullfrog skin, which is leapfrogging from the lab bench to clinics soon. This sustainable innovation aims to reduce waste and provide an affordable yet effective wound-care solution.
Researchers analyzed ancient proteins in high-status Viking graves to identify beaver fur, supporting the idea that it was a luxury item. The discovery suggests that wearing exotic fur was an obvious visual statement of affluence and social status during the Viking Age.
The 13th Annual Meeting on Skin Challenges 2022 will highlight the roles of extracellular vesicles in skin ageing and age-related diseases. Therapeutic strategies and anti-ageing potential of these vesicles from various sources, including stem cells and commensal bacteria, will be addressed.
Researchers found that an elephant's folded skin plays a crucial role in its flexible and strong trunk, enabling it to grasp fragile vegetation and rip apart tree trunks. The study suggests that wrapping soft robotics with a skin-like structure could give machines protection and strength while maintaining flexibility.
The 13th Annual Meeting on Skin Challenges 2022 will discuss recent advances in skin ageing, focusing on extracellular vesicles and their therapeutic potential. Experts will also share findings on the skin microbiome and its role in age-related diseases.
A new study published in the British Journal of Dermatology found that taking Vitamin D supplements during pregnancy can substantially reduce the chances of babies developing atopic eczema. Babies who were breastfed for more than a month showed a lower risk of eczema, suggesting that supplementation may have long-lasting benefits.
Researchers at Hokkaido University identified over 1,300 types of ceramides in the top layer of human skin, including their chain lengths and fatty acid compositions. The discovery could improve understanding of skin barrier function and disease pathology.
A new study from Oregon State University suggests that the gelatin in Pacific whiting skin has anti-aging properties, preventing wrinkles caused by ultraviolet radiation. The researchers found a positive response in a human cell model system, providing evidence for further research.
Researchers identified DNA damage-inducible transcript 4 (DDIT4) as a critical factor regulated by histone deacetylase 4 (HDAC4) in skin aging. Overexpression of HDAC4 rescued cells from senescence, while DDIT4 overexpression reversed changes associated with aging.
Researchers have developed a method to create living human skin on robots, providing a realistic texture and self-healing properties. The skin is made up of collagen and human dermal fibroblasts, which conform to the robot's surface and can even repair wounds with the help of a collagen bandage.
Researchers discovered that dermal contact with nicotine concentrations found in thirdhand smoke and electronic cigarette spills can impair wound healing, increase susceptibility to skin infections, and cause oxidative stress in skin cells. The study suggests that even a short exposure of 24 hours is sufficient to cause skin damage.
A Monash University study found that microbial fermentation of dietary fibre in the gut protects against allergic skin disease. The researchers used mice with a diet high in fermentable fibre or purified SCFAs, showing that butyrate enhances the metabolism of keratinocytes and fortifies the skin barrier.
A study has found that there is no single best moisturiser for children with eczema, highlighting the importance of patient education and choice. The trial, funded by the National Institute for Health and Care Research, compared four types of moisturisers and found that reactions were common regardless of type.
Researchers studied naked mole-rats' skin using single-cell RNA-seq to understand its remarkable stability against aging. They found no changes in epidermal gene expression with age and a unique keratinocyte differentiation trajectory that remained intact.
Recent studies found that pathologists perceive an overdiagnosis of melanoma, with many diagnosing cases as non-invasive melanoma despite variability in diagnoses. A study involving over 100 dermatopathologists showed a majority agree on the issue, but awareness may not be enough to reduce overdiagnosis.
Researchers at Binghamton University have discovered that human skin's unique structure allows it to maximize both durability and flexibility. The team created artificial skin membranes that mimicked the structure of mammalian skin, testing their puncture toughness and deformability.
Researchers found a 1000-fold increase in skin microbiota and larger lesions after smallpox vaccination, but all groups had equal protection from re-infection. The study suggests that manipulating commensal skin microbiota might enhance the efficacy of intradermal vaccines.
Researchers at the University of Bristol created a 3D-printed artificial fingertip that produces nerve signals similar to those from human tactile nerves. The innovation could improve robot dexterity and prosthetic hand performance by giving them an in-built sense of touch.
A new study led by Yale University shows that one in three patients with a severe skin disease called alopecia areata were able to regrow hair after being treated with a common arthritis drug. The Phase 3 clinical trials used baricitinib, a Janus kinase inhibitor, to treat the condition.
Researchers from the University of Nottingham have created a detailed molecular map of the skin's stratum corneum using 3D mass spectrometry imaging. This discovery provides fundamental understanding in skin biology and enables the development of new skin products and treatments.
Researchers developed a microneedle treatment that increased desensitization rates to peanut allergy in mice, outperforming existing immunotherapy methods. The novel approach achieved significant results using lower doses of allergen, offering new hope for millions suffering from peanut allergy.
A UC Davis Health study found that taking bile acids or treatments regulating their production levels can help control psoriasis inflammation. Bile acids inhibited skin inflammation by stopping immune T cells from producing proinflammatory protein IL-17A and blocking immune cell movement to the site.
Researchers have developed a cream that prevents frostbite injuries in mice when applied to the skin before severe cold exposure. The cream, called SynAFP, reduces frostbite wound size and speeds healing compared to no treatment. Further studies are needed to determine its effects on humans.
A new algorithm, FusionM4Net, has been developed to classify skin lesions with improved diagnostic accuracy. The algorithm uses a multi-stage data fusion process and outperforms previous state-of-the-art algorithms.
A pioneering test called AMBLor has been developed to predict the spread or return of skin cancer. By analyzing primary tumor biopsies, the test identifies patients at low risk of disease progression, providing them with more accurate information and personalized prognosis.
Researchers identify eleven rare genetic variants associated with eczema, accounting for over 20% of the disease's heritability. The variants are found in genes that code for proteins involved in inflammatory reactions, providing promising targets for new therapeutic approaches.
Researchers developed a new fabrication method for wearable pressure sensors that enhance durability, sensitivity and transparency. The sensors can detect various body movements and health indicators, such as pulse, sweat, and temperature.
Researchers discovered that wound macrophages undergo different metabolic programs to coordinate tissue repair, including the use of reactive oxygen radicals for blood vessel growth. Macrophages also utilize a different type of mitochondrial exchange for anti-inflammatory and reparative functions in late-stage wound healing.
Researchers at A*STAR's Institute of Molecular and Cell Biology have discovered a novel protein therapy using Agrin to promote wound healing and repair. The study found that timely induction or exogenous supplementation of Agrin accelerates the healing process, preserving the mechanical architecture of injured skin layers.
A new virtual histology technology may reduce the need for invasive skin biopsies, providing a biopsy-free solution for rapid diagnosis of malignant skin tumors. The technology uses deep-learning frameworks to transform images of intact skin into detailed, virtually stained images.
Researchers have identified specific skin microbiome bacteria and their pathways as contributing to ageing skin. The study, published in PLOS ONE, used a novel approach to chart host-microbe co-metabolism in skin aging.
Researchers found that nearly 75% of pregnant women with stretch marks reported moderate to prominent embarrassment, which impacted their social activities, self-esteem, and clothing choices. The study highlights the need for open discussions about stretch marks to normalize them and identify potential mental health issues.
Scientists from Japan discover IL-36Ra plays a pivotal role in wound healing, and Cl-amidine normalizes exacerbated I/R injury. The study's findings suggest IL-36Ra as a potential therapeutic target for cutaneous I/R injuries.
Researchers identified two distinct clusters of patients with Prurigo nodularis: those with increased inflammation and those with a higher likelihood of spinal disease. This study suggests that personalized treatment approaches can be tailored to specific patient profiles.
A new study revealed that global guidance for preventing Surgical Site Infections (SSI) is not effective and needs revision. The FALCON trial found no superiority of interventions like alcoholic chlorhexidine skin preparation and triclosan coated sutures over lower-cost alternatives.
Scientists have shown that applying an electric field to the skin affects collagen pathways, temporarily reducing production and increasing degradation. This opens new therapeutic perspectives for the topical treatment of skin fibrosis characterized by excessive collagen deposition.
Researchers identified a bacterium on healthy cats that produces antibiotics against severe skin infections in humans and pets. The discovery may lead to new treatments for MRSP infections in dogs and potentially other inflammatory skin diseases.
A new trial has found that vaginal laser therapy treatments claim to reduce negative vaginal symptoms of menopause – experienced by about half of all women – by up to 100 per cent. However, the study shows they might not work at all, with no difference found between the laser treatment and a placebo.
Researchers found glycerin, a natural ingredient in many skin lotions, reduces psoriasis symptoms by calming scaly patches and promoting healthy skin cell maturation. The study's results support anecdotal reports from patients with psoriasis, providing objective evidence of glycerin's effectiveness in combatting the condition.
A UCI-led study identifies a new molecular pathway that promotes wound healing in the skin by relaxing cell-cell adhesions between migrating keratinocytes. This finding may improve understanding of wound healing biology and lead to new therapies for non-healing wounds like diabetic ulcers.
A team of scientists at McGill University has invented a smart device for personalized skin care inspired by the male diving beetle. The device collects and monitors body fluids while sticking to the skin's surface, paving the way for more accurate diagnostics and treatment for skin diseases like acne.
A Michigan Medicine study found that altering interferon kappa levels in mice with psoriasis-like lesions reduced disease severity. The research suggests using therapies to modulate interferon states may limit inflammation in psoriasis patients.
Researchers at Johns Hopkins Medicine have discovered an enzyme inhibitor, Q-VD-OPH, that boosts the immune system to fight antibiotic-resistant MRSA and other skin infections. The treatment works by reducing apoptosis of neutrophils and monocytes, leaving them in plentiful numbers to remove bacteria.
A study by Massachusetts General Hospital found that COVID-19 vaccine skin reactions are rare, affecting approximately 1.9% of recipients after the first dose. The majority of these reactions did not recur after a second dose, providing critical reassurance to individuals with concerns about vaccination.
A study published in the Journal of Investigative Dermatology found that a Western diet rich in sugar and fat disrupts gut microorganisms, leading to psoriasis flares. Switching to a balanced diet restores gut health and suppresses skin inflammation, offering a potential solution for managing the condition.
A research team from City University of Hong Kong has designed a simple electromechanical device that can detect skin disorders such as psoriasis by measuring tissue stiffness. The device provides real-time evaluations of deep tissue stiffness, allowing for accurate targeting of lesions and monitoring of skin health status.
The researchers developed a biomaterial made from discarded bullfrog skin and fish scales that acts as a scaffold for bone-forming cells to multiply, leading to the formation of new bone. The biomaterial has shown low risk of triggering an inflammatory response and could be used to assist with bone growth around surgical implants.
Scientists at UC San Diego School of Medicine discovered two enzymes, histone deacetylases (HDACs), that inhibit the body's inflammatory response in the skin. These enzymes allow the skin to tolerate certain microbes living on its surface while preventing a constant rash from developing elsewhere.
Studies show distinct neuron populations control itching in hairy and hairless skin, offering hope for targeted therapies. Researchers aim to develop treatments that block itch-inducing neurons, improving quality of life for patients with chronic skin itch conditions.
A ceremonial tsantsa was authenticated and repatriated to Ecuador in 2019, with researchers confirming its origins using CT scans and assessing 33 criteria. The artefact's unique features, such as a distinctive hairstyle and three holes in the lips, matched those of SAAWC culture group members.
A study of 582 participants found that over two-thirds have developed hand dermatitis due to increased hand washing and use of alcohol-based rubs during COVID-19. The study suggests that skin barrier function can help identify suitable modifications to prevent hand eczema.
A modified 5:2 diet has shown promising results in reducing scaling and thickness of skin symptoms in psoriasis patients. The study found a significant reduction in Psoriasis severity after following the MIF diet, with 30% of patients reporting a decrease in itching.
Researchers discovered that strawberry geranium (Saxifraga stolonifera) suppresses excessive immune response mediated by Toll-like receptor 2, reducing skin inflammation. This finding offers a potential alternative to conventional antibiotics and steroid-like compounds used to control dermatitis.
A new study found that short-term exposure to hazardous air quality from wildfire smoke can harm skin health, particularly for those with eczema. The research, conducted during the Camp Fire in 2018, saw a significant increase in patients visiting clinics with concerns of eczema and general itch.
A new care bundle has been shown to reduce the incidence of facial pressure injuries in frontline COVID-19 healthcare workers. The study found that approximately 29% of respondents developed a facial pressure injury prior to using the care bundle, compared to just 8% after its implementation.
Dr. Kelly Haas is studying the structure, stability, and resilience of the hand microbiome in collaboration with GOJO Industries. Her goal is to understand how the hand microbiome responds to hand hygiene events and develop new products that minimize the trade-off between public health and personal hand health.
Delayed injection-site reactions can occur in some patients who received the Moderna mRNA-1273 vaccine, researchers say. Most symptoms clear up after a week, and completion of the second dose should not be discouraged.
A new study has identified a universal strain of bacteria derived from healthy human skin that can treat the most common type of eczema. In a Phase I clinical trial, two-thirds of participants showed significant improvements in symptoms, including reduced itchiness and inflammation.
A neural network system analyzes photographs to rank and distinguish suspicious skin lesions, suggesting it can aid clinicians in spotting precancerous marks during clinical visits. The platform's performance was demonstrated with a sensitivity and specificity of 90.3% and 89.9%, respectively, in identifying 'ugly duckling' lesions.