Articles tagged with Skin
Infants have a unique homing property that directs certain immune cells to the skin at birth, protecting them from disease-causing bacteria. This skin-homing ability is crucial for lifelong immunity and local tissue development.
Researchers tracked the evolution of Staphylococcus aureus in patients with eczema, discovering rapid mutations in a gene that enables the bacteria to grow faster on the skin. These findings could lead to targeted treatments by targeting variants of S. aureus associated with eczema symptoms.
Researchers at Salk Institute discover that mechanical and chemical itch sensations are encoded by different brain pathways, which act together to drive chronic itch. The study reveals key molecules regulating these pathways and opens avenues for new therapies.
Researchers found that cocklebur fruit extracts encouraged collagen production, sped wound healing, and exerted a protective effect against UVB radiation. However, high doses of the extract can be harmful and further research is needed to determine its safe use in cosmetic applications.
A team of researchers developed a transfer-tattoo-like cell sheet that can be directly applied to targeted surfaces, facilitating cutaneous wound healing and promoting skin tissue regeneration. The system leverages natural cell migration between surfaces, eliminating the need for external stimuli and detachment processes.
A new study published in the New England Journal of Medicine found that lebrikizumab was effective in treating moderate to severe atopic dermatitis, improving skin clarity and reducing itching. The study involved two phase 3 trials with over 700 participants and showed promising results for the treatment.
A team of dermatologists developed an AI model to detect complications from bacterial or viral infections in atopic dermatitis patients. The model distinguishes between eczema and skin lesions caused by blood cancer, improving patient management and health outcomes.
A novel rare mutation in the ABCA12 gene was identified as a cause of Harlequin Ichthyosis through BGI genetic tests. The mutation leads to a severely dysfunctional protein responsible for the disease's serious phenotype.
A study found that individuals with a history of atopic diseases, such as allergic asthma or rhinitis, had significantly lower rates of melanoma and skin cancer compared to non-atopic individuals. The risk of melanoma was up to 50% lower in atopic patients, and the overall risk of skin cancer was also reduced.
Researchers at City University of Hong Kong developed a wireless, soft e-skin for interactive touch communication in the virtual world. The e-skin can detect and deliver the sense of touch, enabling one-to-multiuser interaction and overcoming the limitations of space and distance.
Researchers at the University of South Australia are developing new biomarkers to improve melanoma detection and avoid delayed treatment. The current markers used in clinical practice are not always sensitive or specific, leading to fatal consequences if cancerous cells are missed.
Researchers developed a neural network model that uses terahertz time-domain spectroscopy data to predict burn healing outcomes with high accuracy. The new approach improves upon existing methods by reducing training data requirements, making it more practical for processing large clinical trials.
Researchers from TIBI have developed an advanced electronic skin patch that provides simultaneous, continuous monitoring of multiple bodily parameters. The new E-skin patch offers enhanced flexibility, thermal cooling abilities, and fluid absorption over conventional substrates while demonstrating excellent biocompatibility and biodegr...
Using artificial human skin, researchers have successfully blocked invasive growth in a skin cancer model by targeting the TGF beta pathway. The study aims to develop new skin cancer therapies using existing drugs that can block these signalling pathways.
Researchers developed an artificial skin with superior sensing capabilities, detecting pressure and approach signals for various applications. The innovation has potential in human-machine interfaces, artificial intelligence, prosthesis, and augmented reality.
Researchers have developed a new peptide drug that silences genes responsible for skin inflammation, suppressing lesions and healing skin without side effects. The topical treatment is being tested in a clinical trial for patients with eczema, offering hope for more effective treatments.
A new classification system, MPATH-Dx Version 2.0, has been developed to simplify diagnoses of melanocytic skin lesions. The system categorizes lesions into four classes, providing guidance on treatment and surveillance for patients.
A six-year study involving 146 patients found that antivenom reduced the risk of skin necrosis in those bitten by brown recluse spiders. Administration of the substance was safe with minimal adverse effects, particularly when given within 48 hours of the incident.
Regular use of vitamin D supplements was associated with a significantly reduced risk of melanoma and better skin cancer classification compared to non-users. However, the study did not find a significant association between vitamin D use and other skin changes or severity of photoaging.
Researchers from City University of Hong Kong developed an advanced wireless haptic interface system called WeTac. The system provides a vivid touch experience with personalized tactile sensation data and overcomes the shortcomings of existing bulky gloves.
Researchers highlight recent progress in organotypic models, which offer a balance between the accessibility and control of in vitro context. These models have been used to study various aging-related phenotypes, including skin, gut, and skeletal muscle, providing valuable insights into the underlying mechanisms.
Research by Uppsala University and Swedish University of Agricultural Sciences links atopic dermatitis in dogs to specific genome regions. The study identifies genes coinciding with human atopic eczema, including the filaggrin gene region.
Early application of skin moisturizers is an effective strategy for preventing atopic dermatitis (AD) in high-risk infants. A systematic review and network meta-analysis found that three types of emollients, including cream, emulsion, and mixed types, are comparable in preventing AD; however, emollient emulsion may be the optimal option.
Researchers at UNIST developed a subcutaneously implantable electromagnetic biosensor system for continuous glucose monitoring. The new technology eliminates the need for frequent finger pricking, providing more accurate blood glucose level tracking and improved patient care.
UCF researchers are developing a wearable, wireless health monitor to track physiological response to heat stress in firefighters. The device aims to identify correlations between heat stress and skin thermal activity for the first time, providing insight into the link between heat stress and serious medical issues.
Urban-living Indigenous children and young people in high-income countries are disproportionately affected by atopic dermatitis and bacterial skin infections, which can lead to serious complications. This systematic review highlights the need for co-designed research with Indigenous communities to address these health inequities.
Eczema affects 10-20% of Canadian infants, making it a common condition to manage. Optimally managing atopic dermatitis in infants is crucial, as it impacts the whole family.
The 13th International Conference on Skin Ageing & Challenges will be held in Lisbon, Portugal, with over 61 communications and innovations presented. Key findings include the impact of olfactory receptors on microbiota & wound healing, as well as recent artificial intelligence developments for skin cancer detection.
Researchers have discovered a way to reactivate a fetal repair pathway in adults to improve healing of diabetic wounds. The study used tissue nanotransfection technology to deliver a gene that activates the protein NPGPx, which is active in fetuses but largely inactive in adults and absent in diabetic adults.
The 13th Annual Meeting on Skin Challenges 2022 will address key skin ageing and challenges such as skin microbiome, cancer, inflammation, wound healing, and more. The event will feature experts from industry and academia presenting their research on these topics.
Researchers found that knockdown of secreted frizzled-related protein 4 (SFRP4) suppresses SASP and improves age-related skin phenotypes. This suggests a potential candidate for the development of new skin rejuvenation therapies.
A study published in BMJ Open found that quad bike injuries among children are significantly more severe and common than car injuries. The research highlights the need for public education campaigns to educate on ATV-related injuries, particularly in young riders.
A new project aims to create more race-inclusive AI in medicine by developing a distributed, inclusive data collection and learning framework that relies on smartphone apps. The framework uses federated learning, which allows models to be trained on device data while protecting user privacy.
A randomized clinical trial involving over 1,600 patients found that two antiseptic solutions are equally effective in preventing post-surgical infections. The study provides reassurance to orthopedic surgeons and helps improve practice of evidence-based medicine.
Researchers found a drastic decrease in bacterial abundance on the skin of patients with graft-versus-host disease, while an increased occurrence of staphylococci was observed. This discovery may lead to improved treatment measures for GVHD, which affects approximately 30-70% of stem cell transplant recipients.
A UC Riverside-led study found that acute THS exposure initiates mechanisms of inflammatory skin disease and elevates urinary biomarkers of oxidative harm. The researchers discovered elevated molecular biomarkers in blood associated with early-stage activation of contact dermatitis, psoriasis, and other skin conditions.
A new skin-stretching device called EASApprox has been successfully used to treat large scalp defects in 12 patients, providing enough skin for direct closure using sutures or gradual healing. The procedure showed good functional and cosmetic results with acceptable scarring and no serious complications.
A Phase I/II study found tofacitinib effective in improving skin and organ issues in systemic sclerosis patients. The drug was well-tolerated, with minimal impact on T-cells, suggesting potential repurposing for treatment.
A large randomized clinical trial demonstrated Octagam 10% as an efficacious and well-tolerated treatment option for adult dermatomyositis patients. The study showed improved outcomes in patients with this rare disease, providing a much-needed treatment alternative.
A study by MedUni Vienna's Department of Dermatology reveals that tick saliva inhibits the skin's defense function, making it easier for pathogens to multiply. Climate change increases the danger from ticks, which now pose a threat in higher-altitude regions of Austria and well into late autumn.
A team of researchers at Juntendo University has identified a biomolecule called human-β-defensin-3 (hBD-3) that can mitigate eczema in mice by regulating autophagy and the aryl hydrocarbon receptor signaling pathway. This discovery provides new insights into the pathogenesis of atopic dermatitis and potential therapeutic solutions.
Lenabasum has been shown to improve skin symptoms in patients with amyopathic dermatomyositis, demonstrating significant reductions in inflammation and disease severity. The study's findings suggest that lenabasum is a well-tolerated treatment option for refractory skin disease.
A new survey of 17,000 Europeans found that 8 in 10 believe tans are attractive and healthy, despite decades of awareness campaigns linking sun exposure to skin cancer and aging. The study also revealed low levels of adherence to sun protection habits, with only 1 in 10 using all forms of protection.
A new imaging technique called LC-OCT significantly improved the accuracy of basal cell carcinoma (BCC) diagnosis by 12% compared to clinical and dermoscopic examinations. The technique provided detailed 3D images at a cellular level, enabling more accurate differentiation between BCCs and other skin conditions.
Researchers identified an immune biomarker in newborns that can predict the onset and severity of pediatric atopic eczema. The Barrier dysfunction in Atopic newBorns (BABY) study found elevated levels of TARC at 2 months to be more than twice as likely to develop eczema by age 2.
Extracellular vesicles and exosomes are membrane-bound vesicles that facilitate intercellular exchange of proteins, lipids, and genetic material. They will be highlighted in upcoming events focusing on mitochondrial quality control, skin ageing, and microbiota.
A UC Davis Health study found that tecovirimat appears to be safe and effective for treating monkeypox symptoms and skin lesions. The study, which included 25 patients with confirmed monkeypox infection, showed that 92% of patients had lesions in their genital or anal area, while 40% healed from their lesions within a week of treatment.
Researchers found that lidocaine injections reduced Psoriasis Area and Severity Index scores by 35-70% and maintained improvements for at least 24 weeks. The study suggests targeting sensory nerves as a potential therapeutic strategy for psoriasis treatment.
Researchers at NTU Singapore and Cuprina have developed a new clinical-grade collagen made from discarded bullfrog skin, which is leapfrogging from the lab bench to clinics soon. This sustainable innovation aims to reduce waste and provide an affordable yet effective wound-care solution.
Researchers analyzed ancient proteins in high-status Viking graves to identify beaver fur, supporting the idea that it was a luxury item. The discovery suggests that wearing exotic fur was an obvious visual statement of affluence and social status during the Viking Age.
The 13th Annual Meeting on Skin Challenges 2022 will highlight the roles of extracellular vesicles in skin ageing and age-related diseases. Therapeutic strategies and anti-ageing potential of these vesicles from various sources, including stem cells and commensal bacteria, will be addressed.
Researchers found that an elephant's folded skin plays a crucial role in its flexible and strong trunk, enabling it to grasp fragile vegetation and rip apart tree trunks. The study suggests that wrapping soft robotics with a skin-like structure could give machines protection and strength while maintaining flexibility.
The 13th Annual Meeting on Skin Challenges 2022 will discuss recent advances in skin ageing, focusing on extracellular vesicles and their therapeutic potential. Experts will also share findings on the skin microbiome and its role in age-related diseases.
A new study published in the British Journal of Dermatology found that taking Vitamin D supplements during pregnancy can substantially reduce the chances of babies developing atopic eczema. Babies who were breastfed for more than a month showed a lower risk of eczema, suggesting that supplementation may have long-lasting benefits.
Researchers at Hokkaido University identified over 1,300 types of ceramides in the top layer of human skin, including their chain lengths and fatty acid compositions. The discovery could improve understanding of skin barrier function and disease pathology.
A new study from Oregon State University suggests that the gelatin in Pacific whiting skin has anti-aging properties, preventing wrinkles caused by ultraviolet radiation. The researchers found a positive response in a human cell model system, providing evidence for further research.
Researchers identified DNA damage-inducible transcript 4 (DDIT4) as a critical factor regulated by histone deacetylase 4 (HDAC4) in skin aging. Overexpression of HDAC4 rescued cells from senescence, while DDIT4 overexpression reversed changes associated with aging.
Researchers have developed a method to create living human skin on robots, providing a realistic texture and self-healing properties. The skin is made up of collagen and human dermal fibroblasts, which conform to the robot's surface and can even repair wounds with the help of a collagen bandage.
Researchers discovered that dermal contact with nicotine concentrations found in thirdhand smoke and electronic cigarette spills can impair wound healing, increase susceptibility to skin infections, and cause oxidative stress in skin cells. The study suggests that even a short exposure of 24 hours is sufficient to cause skin damage.
A Monash University study found that microbial fermentation of dietary fibre in the gut protects against allergic skin disease. The researchers used mice with a diet high in fermentable fibre or purified SCFAs, showing that butyrate enhances the metabolism of keratinocytes and fortifies the skin barrier.