Articles tagged with Skin
Researchers created a single cell atlas of prenatal human skin, providing a molecular recipe for building skin. The study also led to the creation of a mini organ model that grows hair, offering insights into scarless skin repair and potential clinical applications in regenerative medicine.
Researchers have developed a new treatment for deep diabetic foot ulcers, using intact fish skin grafts to promote healing. The study found that this innovative approach showed promising results in improving wound closure and reducing infection rates.
Researchers at UC San Diego School of Medicine identified ZNF750 as a key player in controlling inflammation, shedding light on susceptibility to inflammatory skin diseases. The study paves the way for more effective therapies and broader insights into molecular biology of skin cells.
A new study suggests the hormone hepcidin may trigger psoriasis by causing iron overload in the skin. This excess iron amplifies the damaging effects of UV sunlight, leading to hyperproliferative chronic diseases like psoriasis. A potential treatment targeting hepcidin could improve treatment options for millions.
A new study demonstrates the potential of semaglutide in treating hidradenitis suppurative (HS) in people with obesity. The results show marked improvements in patient outcomes across several key measures, including reduced flare frequency, improved quality of life, and better glycaemic control.
A research team has successfully recreated wrinkle structures in biological tissue in vitro, revealing the mechanisms behind their formation. The study found that compressive forces and dehydration play a crucial role in wrinkle formation, mirroring aging skin effects.
A study by Min Deng and colleagues at UCLA identified two key dysregulated pathways in acne-affected skin: the GRN-SORT1 axis in TREM2 macrophages and the IL-13-IL-13RA1 axis in keratinocytes. These findings suggest modulating these pathways through gene therapy could lead to new acne treatments.
Researchers analyzed young and aged dermal fibroblasts, finding a significant decrease in protein secretion with age. The study also revealed an increase of over 60% in cytoplasmic protein accumulation, highlighting the cytoskeleton's crucial role in skin aging.
Researchers discovered a parasite protein that enhances wound healing in mice by stimulating immune cells to promote tissue regeneration and inhibit scarring. The protein, TGM, accelerates wound closure and improves skin regeneration.
A large-scale study investigated the relationship between childhood obesity and immune-mediated skin diseases (IMSDs), such as atopic dermatitis and psoriasis. The study found that obese children were more likely to develop these conditions, with changes in body weight affecting their risk of developing these diseases.
Research reveals the importance of exfoliation and improving skin metabolism for effective skin whitening treatments. Slower keratin metabolism in body skin can lead to dullness and pigmentation, making sun protection crucial.
Researchers found a Leishmania amazonensis strain resistant to amphotericin B, a widely used treatment for cutaneous leishmaniasis. The study highlights the urgent need for alternative drugs to combat the disease, which affects over 15,000 people in Brazil annually.
A clinical trial shows that JAK inhibitors improve autoimmune conditions such as alopecia areata, atopic dermatitis, and psoriasis in people with Down syndrome. The study also observed improvements in arthritis and decreased biomarkers of autoimmune thyroid disease.
A study found that collagen tripeptide and elastin peptide supplements significantly improved skin hydration, elasticity, and collagen content in middle-aged women. The combination of these peptides demonstrated enhanced anti-aging effects compared to a placebo group.
A new study from Boston University finds that sclerotherapy is safe and effective in patients with skin of color, but may cause post-inflammatory hyperpigmentation at a higher rate. The treatment is safe for all skin types when conducted by trained professionals.
Researchers from Tokyo Institute of Technology found that shark skin's denticles reduce drag at a wide range of speeds, allowing sharks to cruise efficiently and hunt effectively. The study suggests that extinct giant megalodons may have similar swimming speeds to white sharks.
Researchers developed a new method to map gene expression changes in sebocytes, providing insights into sebum production and its role in skin health. The study identifies key players in sebum production and suggests new ways to modulate it, with potential implications for acne, eczema, psoriasis, and infectious diseases.
Researchers engineered human skin bacteria to produce less lactic acid, attracting fewer mosquitoes to mice. The engineered microbes reduced mosquito attraction by up to 64.4% and also prevented bites.
Researchers have developed a new bioink that can mimic human skin constructs using 3D bioprinting. The bioink, based on thiol-norbornene-pullulan formulations, was effectively used to create epithelized dermal skin constructs with high cellular viability rates.
Following a Mediterranean diet and taking omega-3 fatty acid supplements, participants experienced significant reductions in inflammatory and non-inflammatory skin lesions. Those who reached target omega-3 levels showed the most substantial improvement in acne severity.
Researchers have detected anaerobic and aerobic bacteria in commercial tattoo and permanent makeup inks, indicating a potential source of human infections. The study found that around 35% of tattoo or permanent makeup inks sold in the US were contaminated with bacteria, highlighting the importance of monitoring these products.
A new study by Arizona State University reveals that initial phase sweating can be three times more effective than later phase sweating in terms of evaporation. The researchers developed a wind tunnel-shaped capsule with high-magnification video imagery to capture the dynamics of sweat droplet formation and evaporation on human skin.
Scientists identified Roseomonas mucosa as a beneficial bacterium that relieves eczema symptoms in adults and children. The probiotic is available over-the-counter and has shown significant improvement in eczema severity, skin barrier function, and quality of life.
A new study published in Environment International reveals that 15 out of 17 commonly used synthetic 'forever chemicals' can be absorbed through human skin. The researchers used 3D human skin equivalent models to investigate dermal bioavailability and found significant absorption rates for most substances.
A study conducted by Oregon Health & Science University and Lewis & Clark College found that increasing melanoma literacy combined with strengthening skin-check confidence is key to increasing early detection. Social media ads were used to boost knowledge and confidence, leading to improved survival rates when melanoma is caught early.
Researchers at Francis Crick Institute develop a new genetic therapy that silences mutated NRAS gene in cells with congenital melanocytic naevus syndrome (CMN), potentially reversing debilitating giant moles. The treatment has shown promising results in mice and could be used to reduce cancer risk in affected children and adults.
Researchers from Nagoya University have successfully treated rare genetic skin disorders epidermolytic ichthyosis (EI) and ichthyosis with confetti (IWC) by transplanting genetically healthy skin to inflamed areas. Transplantation of healthy skin has been used as a treatment option for severe burn injuries.
The study uses the Dermatological Vision Dataset and compares vision transformers with traditional CNNs, achieving an impressive 97.8% accuracy on validation sets. Integrating ViTs into dermatology represents a promising step toward more accurate diagnostics.
A new study combines bisphosphonates, commonly used for osteoporosis, with azole antifungals to treat fungal infections. The combination effectively targets dermatophytes and prevents resistance development.
Researchers found that eating more than one gram of sodium per day increases the likelihood of eczema flares by 22%, making it easier for patients to manage their symptoms. Eczema affects over 31 million people in the US and can be difficult to cope with when unpredictable.
A clinical trial discovered that the drug abrocitinib, approved for eczema treatment, significantly reduced symptoms of patients with severe itching diseases. Abrocitinib improved symptoms in both prurigo nodularis and chronic pruritus of unknown origin by 78% and 54%, respectively.
Researchers created a prototype of 'living bioelectronics', combining bacteria, sensors, and gel to integrate with living tissue. The device reduced inflammation and improved psoriasis-like symptoms in mice, offering potential for treating various skin conditions and injuries.
Scientists from Tokyo Medical and Dental University successfully generate autologous skin grafts by introducing mutations into mouse embryos, which then form sheets of epidermis containing hair follicles. These grafted skin patches survive up to 3 months and mimic mature epidermis structure.
Research published in the Journal of Investigative Dermatology reveals that UV exposure increases energy expenditure by inducing the 'browning' of subcutaneous fat, thereby preventing weight gain. This breakthrough discovery opens up new possibilities for treating obesity and metabolic disorders.
Researchers at Rice University developed a new material that mimics skin elasticity and motion types while preserving signal strength in electronics. The material, made by embedding ceramic nanoparticles into an elastic polymer, stabilizes radio-frequency communication and minimizes energy loss.
A large register-based study found that young adults with low stress resilience are more likely to develop psoriasis later in life. The study, based on data from over 1.6 million Swedish men, showed a significant link between stress resilience and the risk of developing severe cases of psoriasis.
A new study finds that the interleukin-17 pathway activates hypoxia-inducible factor 1-alpha in psoriasis, leading to increased sugar breakdown and lactate production. Blocking this pathway with an experimental drug may offer a new treatment option for inflammatory skin diseases.
A validation study on the WHO app using AI to detect skin diseases showed good reception amongst professionals in Ghana and Kenya. The app aims to improve diagnosis and treatment of neglected tropical diseases and common skin diseases.
A team of scientists at the University of Ottawa has developed a novel peptide-based hydrogel that can be used for on-the-spot repair to damaged organs and tissues. The material shows great potential for closing skin wounds, delivering therapeutics to damaged heart muscle, and reshaping and healing injured corneas.
Researchers have developed a new method to detect malignant melanoma using a microneedle patch that measures tyrosinase enzyme levels in the skin. This non-invasive technique has the potential to provide faster and more reliable results compared to traditional biopsies.
A self-adaptive temperature control system can improve wound healing by mimicking the skin's thermoregulatory functions. The system, developed by Zhu Meifang at Donghua University, uses an interactive thermoregulatory biomimetic electronic system to regulate temperature and promote dynamic healing processes.
Researchers have discovered that synchronization between the central circadian clock and peripheral clocks in muscle and skin is crucial for maintaining tissue function and preventing degenerative processes associated with aging. Time-restricted feeding can partially replace the central clock and enhance the autonomy of the muscle cloc...
Researchers developed a new experimental strategy to tackle scarring and fibrosis by releasing enough collagen to prevent tissue damage while protecting it from excessive amounts. The strategy, which uses molecules known as peptides to block the export of collagen from cells, shows promise in treating conditions such as scleroderma.
Researchers at Kobe University discovered a new gene, FDFT1, responsible for porokeratosis by identifying epigenetic silencing. Patients with localized lesions didn't have inherited damaged copies, leading to a hypothesis that epigenetic changes are the first hit. The findings have implications for treatment and counseling.
A study from the University of Gothenburg found that patient images are severely lacking in scientific articles on atopic dermatitis. This lack of visual aids hinders patients' ability to make informed decisions about their care, as they struggle to understand complex medical terminology and figures. The absence of images also affects ...
Researchers created a hydrogel that kills bacteria naturally, promotes cell growth and heals wounds more effectively than traditional gels. The gel is infused with amino acid polylysine and platelet-rich blood plasma to create properties well-suited for wound care.
Researchers at Boston University School of Medicine created a new scale for hyperpigmentation, the Post-inflammatory Dyspigmentation Area and Severity Index (PIDASI), which performs well in patients with varying skin tones.
Researchers developed a scoring system to distinguish between two serious skin diseases with similar symptoms. The study analyzed data from 117 patients and found the scoring system could help medical professionals quickly diagnose and choose appropriate treatment.
A study led by Leopold Eckhart found that the genetic programme controlling keratinized claws originated in a common ancestor of humans and frogs. The research team used the tropical clawed frog as an experimental model and discovered that important hair components, including keratins, share similarities with human hair.
Research found that wearing cosmetic foundation during aerobic exercise increased moisture in the skin, but did not significantly affect pore size. Additionally, oil levels decreased on the skin with makeup compared to without it.
Researchers analyzed published studies on AI in dermatology, finding significant shortcomings when applied to skin of color. Only 30% of AI programs had data specifically for skin of color, and current programs do worse at identifying skin lesions.
Researchers have discovered two genetic variants associated with generalized pustular psoriasis (GPP), a rare and serious condition characterized by widespread skin lesions and inflammation. These variants, found in the MEFV gene, may hold promise for new diagnostic and therapeutic approaches to GPP.
A new study published in PLOS ONE found that COVID-19 infections cause significant physiological differences between males and females. Males experience larger increases in skin temperature, breathing rate, and heart rate during infections, while also maintaining higher levels during recovery.
Researchers successfully printed full-thickness skin with potential for hair growth in rats, paving the way for more natural-looking reconstructive surgery outcomes. The bioprinting technology uses fat tissue and stem cells to create layered living skin and contains hair follicle precursors.
The new skin demonstrates excellent mechanical performance, self-adaptive camouflage capabilities, and long-term stability. It can quickly recognize and match the background by modulating optical signals in response to external stimuli.
A comprehensive study found pulse oximeters significantly overestimated oxygen saturation readings in individuals with darker skin tones. This could lead to missed treatments and incorrect diagnoses, as devices may not accurately reflect critical oxygen levels.
A study investigates the effects of mask-wearing and methylparaben exposure on skin health, revealing increased risk of oxidative damage and skin pro-inflammatory responses. The research highlights the need for reevaluating skincare routines to ensure skin health is not compromised by everyday practices.
Researchers at Aston University have discovered that aging skin exhibits distinct optical properties under polarised laser light. This finding could lead to the development of non-invasive light-based techniques for early detection and monitoring of skin conditions, including cancer.
A new study from MIT researchers found that doctors are less accurate in diagnosing skin diseases based on images of patients with darker skin. The researchers also discovered that an artificial intelligence algorithm can assist doctors in improving their diagnosis, although the improvements were more pronounced for lighter skin tones.
Researchers discovered that microRNA-29 can restore normal skin structure rather than producing a scar, promoting faster and more efficient wound healing. The release of microRNA-29 targets, particularly LAMC2, is crucial in this process, suggesting a potential new approach for treating large-area or deep wounds.