Articles tagged with Skin
A multi-year strategic partnership aims to advance longevity science, understanding the connection between skin ageing and systemic health indicators. The collaboration seeks insights into how skin influences overall quality of life.
This viewpoint discusses how inflammation can coexist with hyperpigmentation, particularly in individuals with darker skin tones. The authors propose an approach where hyperpigmentation prompts continued assessment for persistent inflammation, addressing the potential underrecognition of this condition.
Lip cosmetics products are routinely ingested and absorbed through lip tissue, but existing frameworks were never designed to assess this dual-pathway exposure route. Researchers found significant gaps in testing and regulation, including inadequate absorption data and outdated ingestion assumptions.
A new extraction method concentrates antioxidant compounds from medicinal plants, but the resulting ingredient's safety and effectiveness depend on various factors. The researchers found that a crude herbal extract was more biologically safe than a highly enriched fraction, despite having lower antioxidant potency.
Researchers at Hiroshima University have developed a new way to detect subtle, early-stage changes in human skin collagen using advanced optical imaging and chiroptical spectroscopy. The study reveals that the molecular organization and supramolecular chirality of dermal collagen collapses prior to visible fiber thinning or fragmentation.
A new compound called ampyrone safely increases melanin production in human skin, offering a potential treatment for hypopigmentation disorders. The discovery could improve visual function and enhance patient quality of life for those with severe genetic forms of albinism.
The novel bionic cooling skin bridges the gap between comfort and functionality by combining a hierarchical Janus nanofiber structure with visible light-responsive metal–organic frameworks. It achieves passive thermal management, on-demand antibacterial action, and skin-like mechanical compatibility, resulting in 97.1% antibacterial ef...
Researchers found basking shark denticles are massive and arranged in 'paver blocks,' allowing for stretching during filter feeding. This unique arrangement may promote flexibility and repel parasites.
Researchers developed a method to analyze compounds pulled in cupping jars, detecting changes in 13 volatile compounds before and after treatment. These findings suggest that cupping therapy may have measurable physiological effects, which can be studied with modern analytical techniques.
The study reveals that hair follicles contain specialized sentinel cells that monitor environmental exposure and microbial presence, potentially linking immune detection to sensory signaling. The discovery may have implications for understanding skin infections, immune disorders, and topical therapeutics.
A new study found that AI applications enhance consumer understanding of skin conditions by increasing accuracy and confidence. However, imperfect guessing accuracy remains, highlighting the need for further design improvements to facilitate better comprehension.
Researchers identified distinct genetic sequences that propel critical memories into years-long timeframes underpinning chronic disease. The study provides valuable inroads for developing new therapeutic strategies for chronic inflammation.
Researchers created a comprehensive mapping of over 1 million cells in normal adult human skin, identifying 45 unique cell types that vary across composition and arrangement. This study brings scientists closer to developing more targeted treatments for skin diseases like eczema and psoriasis.
Researchers have developed a painless skin patch that samples key immune cells from the skin, offering a new way to monitor immune health. The device detects inflammatory signals and collects immune cells without invasive procedures.
Researchers at the University of British Columbia have developed a topical CRISPR-based therapy that can correct faulty genes in human skin, potentially treating genetic skin conditions like ARCI and eczema. The treatment, using lipid nanoparticle technology, restores up to 30% of normal skin function.
A landmark study found that consuming vitamin C-rich foods like kiwifruit boosts plasma and skin vitamin C levels, improving skin thickness and stimulating renewal. Increasing daily vitamin C intake is recommended to support optimal skin function.
A Nigerian survey found that 80% of children exposed to skin bleaching products were under 2 years old, with mothers citing aesthetic preferences and social benefits as primary reasons for use. The study highlights the need for policy interventions to safeguard children's health from the risks associated with skin lightening products.
Nanoemulsions in cosmetics provide efficient carriers for active ingredients, maintaining product efficacy and bioavailability. Their stability ensures sustained release of actives, reducing the need for frequent application.
A major study has found that people with eczema can bathe either daily or weekly without affecting their symptoms. The study, published in the British Journal of Dermatology, involved 438 participants and showed no significant difference in eczema symptoms between the two groups.
The congress will focus on key mechanisms of skin ageing, including cellular senescence, mitochondrial dysfunction, and microbiome-skin interactions. Top experts in dermatology and longevity science will present new strategies for enhancing skin vitality and combating age-related decline.
A new Cochrane review found that immediate skin-to-skin contact between newborns and their mothers significantly improves exclusive breastfeeding rates, optimal body temperature, breathing, and heart rate. The review suggests that skin-to-skin contact should be the global standard of care for all babies after birth.
A recent study published in Integrative and Comparative Biology found that bonnethead sharks' skin undergoes significant changes as they mature, with younger sharks having fewer ridges on their denticles. These changes likely improve swimming performance and protect the skin from predators or injuries.
Researchers at University of California San Diego School of Medicine discovered that quorum sensing in S. aureus delays wound healing and found targeting the agr system could disarm bacteria without antibiotics, preserving healthy skin bacteria to enhance recovery.
A topical formulation has been shown to reduce the incidence of hand-foot neuropathy in cancer patients undergoing chemotherapy, improving quality of life. The cream, developed at UMH, acts directly on neurosensory pain receptors, reducing hypersensitivity and tolerance to chemotherapy.
Scientists found that stretching the skin stimulates immune cells and increases its ability to absorb large molecules, including vaccines. This approach resulted in higher antibody levels against the H1N1 flu antigen compared to traditional needle-free delivery methods.
A cohort study suggests nicotinamide reduces skin cancer risk, with greatest effect seen after initial skin cancer diagnosis, indicating potential chemopreventive properties of the vitamin B3 derivative
Researchers suggest that phototherapy for newborn jaundice may require adjustments based on a baby's skin tone. The study found that darker-skinned infants may receive up to 5.7 times less effective light dose under identical settings, leading to predicted bilirubin reductions of about 40.8 percent compared to lighter-skinned infants.
Researchers at Penn State developed a wearable sensor that accurately measures chloride ion levels in sweat, enabling early diagnosis of cystic fibrosis. The sensor uses multiple types of hydrogel to track small fluctuations in chloride ion levels, providing real-time information on an individual's health.
A parasitic worm has evolved to suppress neurons in the skin to evade detection, reducing its own survival. Researchers discovered that the worm produces molecules blocking TRPV1+ activity, essential for pain sensation and immune responses, allowing it to infect the skin undetected.
The conference will explore the latest breakthroughs in skin ageing research, targeting molecular mechanisms and real-world applications. Key findings include the importance of understanding skin ageing's intrinsic and extrinsic factors to develop comprehensive solutions.
Researchers discovered that components in young human blood serum can restore youthful properties to skin when combined with bone marrow cells. This study highlights the role of bone marrow in supporting skin health and may lead to novel approaches to address age-related changes.
Researchers at the University of Michigan have identified a complete sensory pathway for sensing cool temperatures, which is separate from the pathway for hot temperatures. This discovery provides insight into how the skin detects its surroundings and responds to environmental changes.
This review synthesizes mechanisms, clinical manifestations, and management strategies for biologics targeting TNF-α, IL-17, IL-12/23, IL-4/13, and PD-1/PD-L1. Immune drift leads to Th2 dominance, Th2/Th22 imbalance, compensatory Th2 activation, unchecked Th1/Th17 expansion, and epidermal dyshomeostasis.
Researchers found that ChatGPT-4 performed better across demographic groups, while LLaVA showed significant sex-related biases in diagnosing skin diseases from medical images. The study emphasizes the need to address these biases to ensure AI models are safe and effective for all patients.
A study published in Journal of the Mechanical Behavior of Biomedical Materials found that wrinkled skin is caused by its tendency to buckle under pressure due to age-related changes in its mechanical properties. As people age, their skin becomes more prone to wrinkles as it stretches and contracts in different directions.
Researchers discovered a unique nanostructure in blue shark skin that produces their iconic blue coloration, which also suggests a potential capacity for color change. Tiny changes in guanine crystal spacing can alter the shark's body color to suit its environment.
A compound called NSC51349 has shown promise as an antiviral treatment against cutaneous human papillomaviruses (HPVs), reducing viral load without harming host cells. The discovery offers new potential for treating skin infections and cancers in immunocompromised individuals.
Researchers from Binghamton University confirm the long-held 'urban myth' that saltwater dries out skin, increasing tissue stiffness and stress. A simple solution to alleviate tightness is taking a shower after coming out of the ocean.
A groundbreaking review identifies the skin as a central hub for systemic inflammation regulation, linking it to multiple organs through bidirectional crosstalk. The study reveals IL-17A as a master regulator of multi-organ crosstalk, driving various diseases simultaneously.
Researchers discover certain skin bacteria metabolize cis-urocanic acid using enzyme urocanase, fine-tuning immune response to UV radiation. This finding opens the door to microbiome-aware sun protection, where resident microbes are considered in sun protection strategies.
New research from Binghamton University reveals that the topography patterns of wrinkled fingers remain constant after multiple immersions. The study found that blood vessels beneath the skin contract and move in relation to other vessels, resulting in consistent wrinkles.
Recent high-quality deepfake videos can feature realistic heartbeats and minute changes in face color, making them challenging to detect. Researchers found that even small variations in skin tone and facial motion can replicate the original pulse in deepfakes.
A randomized clinical trial found no association between immediate skin-to-skin contact and improved neurodevelopmental outcomes in very preterm neonates. However, the intervention was shown to enhance breastfeeding practices up to 12 months compared to standard care.
Prolonged sitting impairs forearm cutaneous vascular function, but alternating local skin cooling and heating alleviates this effect. This study found that ambient temperature modulation can mitigate the decline in cutaneous vascular function.
Researchers at the University of Maryland discovered a way to predict treatment success for cutaneous leishmaniasis, a devastating skin infection. By analyzing a patient's immune system, they identified a distinctive pattern that distinguishes responders from non-responders, with 90% accuracy.
The device uses AI technology to detect potential heart problems and provides real-time health insights. It has multiple points touching the skin near the heart, allowing for more accurate tracking even during movement.
Researchers found that ultrafine bubble showers significantly suppressed inflammation in mice with atopic dermatitis caused by external factors. The treatment also improved skin protective barrier proteins. However, no significant effects were seen in mice with atopic dermatitis caused by genetic factors.
Compound K exhibits anti-aging properties by enhancing skin barrier function, preventing photoaging, and regulating autophagy. It also protects against mitochondrial dysfunction and promotes tight junctions between keratinocytes.
Researchers found that disrupting bacterial metabolism can help the body tolerate infection and heal more effectively. By inhibiting a specific metabolic pathway, they successfully reduced tissue damage in a mouse model of necrotizing skin infection.
Researchers from UMass Amherst have discovered that epithelial cells communicate with slow electrical signals, 1,000 times slower than nerve impulses. This finding could enable new applications in wearable sensors, wound healing and more.
Researchers at NIH identified characteristic symptoms of topical steroid withdrawal (TSW), including elevated nicotinamide adenine dinucleotide (NAD+) levels, which can be diagnosed using provisional criteria. TSW treatment may involve mitochondrial complex I-blocking drugs, such as metformin or berberine.
A study co-led by the University of Zurich has shown that gluconolactone significantly increases the number and function of regulatory T cells in both mice and humans, promoting a more balanced immune environment. This effect was observed in lupus patients as well, with visible improvements in clinical studies after just two weeks.
A team of researchers from Aalto University developed a hydrogel with a unique structure that combines high stiffness with flexibility and self-healing capabilities. The material uses exceptionally large and ultra-thin specific clay nanosheets, allowing it to self-heal via entanglement.
Researchers have identified a new starting point for therapy by targeting SSAT enzyme in psoriasis, restoring regulatory T cell function and breaking inflammation cycle. This approach could lead to a promising alternative treatment option with fewer side effects.
Dermatology researchers have identified a novel skin disease in a male patient with erythroderma, a rare and severe inflammation that causes widespread redness and scaling. Targeted treatment with biologic inhibitors reversed symptoms, providing a promising diagnostic tool for precision-medicine.
Researchers discovered that a topical ABT-263 treatment effectively reduces aged skin senescence markers, priming the skin for improved subsequent wound healing. The treatment also triggered inflammation, which surprisingly helped the healing process by 'waking up' the skin's repair systems.
Researchers have identified a targeted therapy that could bring relief to people living with lichen planus, a chronic inflammatory skin condition. The treatment, baricitinib, selectively blocks specific inflammatory pathways, reducing inflammation and suppressing the overactive immune response that contributes to the disease.
A recent study found that electric fans provide little cooling relief for older adults indoors during extreme heat due to their limited sweat production. Dr. Fergus O'Connor from Griffith University suggests using air conditioning at a higher temperature in conjunction with a fan to provide effective cooling and reduce operating costs.
A new study explains how scratching aggravates inflammation and swelling in a type of eczema called allergic contact dermatitis. Scratching activates mast cells, which drive itchiness and inflammation, but also triggers the release of substance P, which protects against bacteria.
Research on preservative mechanisms aims to develop improved preservation methods and identify effective antimicrobial compounds. Factors such as concentration, exposure time, and specific microorganism targeting influence preservative effectiveness, making targeted modifications crucial for enhanced antimicrobial properties.