Articles tagged with Skin
Researchers at Kobe University discovered a new gene, FDFT1, responsible for porokeratosis by identifying epigenetic silencing. Patients with localized lesions didn't have inherited damaged copies, leading to a hypothesis that epigenetic changes are the first hit. The findings have implications for treatment and counseling.
A study from the University of Gothenburg found that patient images are severely lacking in scientific articles on atopic dermatitis. This lack of visual aids hinders patients' ability to make informed decisions about their care, as they struggle to understand complex medical terminology and figures. The absence of images also affects ...
Researchers created a hydrogel that kills bacteria naturally, promotes cell growth and heals wounds more effectively than traditional gels. The gel is infused with amino acid polylysine and platelet-rich blood plasma to create properties well-suited for wound care.
Researchers at Boston University School of Medicine created a new scale for hyperpigmentation, the Post-inflammatory Dyspigmentation Area and Severity Index (PIDASI), which performs well in patients with varying skin tones.
Researchers developed a scoring system to distinguish between two serious skin diseases with similar symptoms. The study analyzed data from 117 patients and found the scoring system could help medical professionals quickly diagnose and choose appropriate treatment.
A study led by Leopold Eckhart found that the genetic programme controlling keratinized claws originated in a common ancestor of humans and frogs. The research team used the tropical clawed frog as an experimental model and discovered that important hair components, including keratins, share similarities with human hair.
Research found that wearing cosmetic foundation during aerobic exercise increased moisture in the skin, but did not significantly affect pore size. Additionally, oil levels decreased on the skin with makeup compared to without it.
Researchers analyzed published studies on AI in dermatology, finding significant shortcomings when applied to skin of color. Only 30% of AI programs had data specifically for skin of color, and current programs do worse at identifying skin lesions.
Researchers have discovered two genetic variants associated with generalized pustular psoriasis (GPP), a rare and serious condition characterized by widespread skin lesions and inflammation. These variants, found in the MEFV gene, may hold promise for new diagnostic and therapeutic approaches to GPP.
A new study published in PLOS ONE found that COVID-19 infections cause significant physiological differences between males and females. Males experience larger increases in skin temperature, breathing rate, and heart rate during infections, while also maintaining higher levels during recovery.
Researchers successfully printed full-thickness skin with potential for hair growth in rats, paving the way for more natural-looking reconstructive surgery outcomes. The bioprinting technology uses fat tissue and stem cells to create layered living skin and contains hair follicle precursors.
The new skin demonstrates excellent mechanical performance, self-adaptive camouflage capabilities, and long-term stability. It can quickly recognize and match the background by modulating optical signals in response to external stimuli.
A comprehensive study found pulse oximeters significantly overestimated oxygen saturation readings in individuals with darker skin tones. This could lead to missed treatments and incorrect diagnoses, as devices may not accurately reflect critical oxygen levels.
A study investigates the effects of mask-wearing and methylparaben exposure on skin health, revealing increased risk of oxidative damage and skin pro-inflammatory responses. The research highlights the need for reevaluating skincare routines to ensure skin health is not compromised by everyday practices.
Researchers at Aston University have discovered that aging skin exhibits distinct optical properties under polarised laser light. This finding could lead to the development of non-invasive light-based techniques for early detection and monitoring of skin conditions, including cancer.
A new study from MIT researchers found that doctors are less accurate in diagnosing skin diseases based on images of patients with darker skin. The researchers also discovered that an artificial intelligence algorithm can assist doctors in improving their diagnosis, although the improvements were more pronounced for lighter skin tones.
Researchers discovered that microRNA-29 can restore normal skin structure rather than producing a scar, promoting faster and more efficient wound healing. The release of microRNA-29 targets, particularly LAMC2, is crucial in this process, suggesting a potential new approach for treating large-area or deep wounds.
A study published in the Journal of Investigative Dermatology found that patients with vitiligo incur significantly higher healthcare costs than those without the condition. The research analyzed direct and indirect healthcare costs associated with vitiligo, revealing an unmet need for cost-effective treatments.
A KAIST research team has developed a stretchable and adhesive microneedle sensor that can detect physiological signals without being affected by sweat and dead skin. The sensor allows for long-term stable control of wearable robots, enabling precise movement recognition for rehabilitation treatments.
Researchers identify successful treatment of granulomas in the skin with mTOR inhibitor sirolimus, which showed partial complete remission of symptoms in 7 out of 10 patients. The study suggests targeting both immune and non-immune cells in granulomas may prevent recurrence.
Researchers have revealed CD4+ T cells can work effectively on their own to control melanoma, challenging conventional understanding. Harnessing their potential therapeutically holds great promise for improving current cancer immunotherapies.
Researchers introduce trehalose into hydrogels to form hydrogen bond interactions, improving dehydration resistance, lubrication performance, mechanical properties, and manufacturing accuracy. This discovery proposes a new design principle for high-precision manufacturing of hydrogel materials.
A study by researchers at University of California - San Diego reveals a connection between the skin microbiome and signs of aging, including crow's feet wrinkles. The analysis found positive associations with diverse skin microbiomes and negative correlations with moisture loss, suggesting potential new directions for skincare solutions.
Researchers found a clear dose-response relationship between long-term topical corticosteroid use and elevated risks of osteoporosis and major osteoporotic fractures. Women under 50 had higher risks compared to men and other age groups, emphasizing the importance of careful treatment.
Recent research has identified the gut-skin axis as a critical factor in atopic dermatitis, with alterations to gut microbiome composition contributing to disease severity. The review article highlights promising therapeutic approaches, including diet, probiotics, and fecal transplants.
Researchers from Tokyo University of Science developed a novel, low-cost hydrogel using seaweed extract that prevents wound expansion and promotes healing. The hydrogel demonstrates significantly lower adhesion and swelling compared to conventional hydrogels, making it an excellent alternative for treating skin wounds.
Researchers developed a method to measure microvascular changes in the skin using AI and optoacoustic imaging technology, enabling non-invasive assessment of diabetes severity. The study identified 32 significant changes in blood vessels, which can be used to monitor disease progression.
A study by Brigham researchers found that individuals with darker skin tones and more severe acne face greater stigma in social and professional settings. Participants were less likely to want to be friends or post photos with those having severe acne, particularly if they had a darker skin tone.
Researchers found a significant increase in extracellular vesicles released by aged keratinocytes, which were also enriched with specific microRNAs. These EVs impaired young keratinocyte proliferation and organogenesis, mimicking aged skin defects.
A new study at the University of Turku discovered that plixorafenib inhibits multiple signaling pathways in cutaneous squamous cell carcinoma, showing promise for treatment. The drug was originally developed for melanoma and lung cancer, but its effectiveness against cSCC is significant.
Researchers at Harvard Medical School have discovered a novel mechanism behind itch, revealing that Staphylococcus aureus single-handedly causes itch by instigating a molecular chain reaction. The study found that the bacterium's enzyme protease V8 activates protein PAR1 on skin neurons, leading to the sensation of itch.
A systematic review found that only 203 images of 60 patients were included in 152 studies on psoriasis treatment outcomes over 20 years. The low image sharing rate complicates patient understanding and highlights the need for more clinical images.
Researchers at Rensselaer Polytechnic Institute have successfully created hair follicles in human skin tissue using 3D-bioprinting techniques. This innovation has potential applications in regenerative medicine, drug testing, and understanding the complex interactions between skin and topical products.
Two cases report flaxseed as an allergen causing severe reactions, including facial rashes and contact dermatitis. Flaxseed is increasingly used in baked goods, cereals, and oil paints, highlighting the need for awareness about its potential to trigger allergic reactions.
Researchers studied shark and skate skin mucus to understand its unique biochemistry. They found a thin, neutral mucus layer with properties similar to human mucus, suggesting potential biomedical applications for wound care and treatment.
Researchers at George Washington University discovered a potential new treatment for cutaneous lupus erythematosus, a severe autoimmune skin disease, using anandamide nanoparticles. The study found that the treatment reduced the size and severity of skin lesions in mice with the disease.
Scientists developed a synthetic melanin that accelerates wound healing and protects against sun damage. The cream also quiets the immune system, allowing for continuous repair and reducing inflammation.
Researchers developed a low-cost anti-inflammatory hydrogel containing annexin A1 that accelerated complete skin wound healing in mice with induced type 1 diabetes. The hydrogel modulated the wound microenvironment and favored tissue regeneration, reducing inflammation and improving blood vessel formation.
Scientists at Imperial College London have found that cells within hair follicles can detect touch and release neurotransmitters serotonin and histamine. This discovery may help understand histamine's role in inflammatory skin diseases like eczema.
Research by Hokkaido University's Masayo Soma found that Java sparrows show increased swelling in their eye rings when paired with a preferred mate. This change serves as a rapid indicator of mating readiness and plays a crucial role in communication between pair-bonded birds.
The brain natriuretic peptide (BNP) is a peptide that plays a crucial role in activating atopic dermatitis, or eczema. In a mouse model of AD, mice without BNP exhibited reduced thickened skin and itching compared to control mice with BNP.
Researchers at UCSF found a feedback loop between immune protein IL-31 and nerve cells, which dials back nearby inflammation and promotes skin healing. This discovery could lead to new treatments for conditions like eczema, allergies, and asthma by targeting the nervous system's role in regulating the immune response.
A new AI software has achieved a 100% detection rate for melanoma, significantly improving skin cancer detection accuracy. The software correctly identified 99.5% of all skin cancers and 92.5% of pre-cancerous lesions, with potential to reduce face-to-face consultations and enhance dermatology triage.
A new study finds that faces with acne, especially adult female acne, are perceived as less attractive, trustworthy, confident, successful, dominant, and happy. The study also highlights the emotional and psychological burden experienced by individuals with acne.
Researchers at Johns Hopkins University have developed a new algorithm to filter out unwanted signals in medical images of darker skin tones, producing significantly sharper images. This breakthrough aims to mitigate bias in imaging technologies and improve surgical navigation and medical diagnostics for patients with diverse skin tones.
A major European study found that almost all patients with skin diseases face embarrassment, leading to a huge psychological toll. The study also revealed that stigmatization is a major impact of skin diseases on personal and professional life.
Researchers have identified viral components of the skin's microbiome that drive the development of innovative therapies for atopic dermatitis. Bacteriophages, or 'bacteria eaters', were found to help certain bacteria grow faster in AD patients, contributing to the overpopulation of the skin microbiome.
Studies show that shrinking and swelling of skin layers cause mechanoreceptors to fire off signals to the brain, leading to a feeling of skin tightness. The researchers developed a predictive model that accurately predicted human subjects' reported feelings, opening up new possibilities for improving cosmetics formulations.
The study reveals that applying cleansers or moisturizers to the skin can alter its state, activating mechanoreceptors and feeding information to the central nervous system. Strong correlations were found between physical stress on the stratum corneum and subjective reports of 'tightness' in surveys of thousands of participants.
A new study from the University of Pennsylvania School of Medicine found a significant link between inflammatory bowel disease (IBD) and atopic dermatitis (AD), with adults having a 34% increased risk and children having a 44% increased risk. The severity of AD was also associated with an increased risk of developing IBD.
Researchers have identified novel therapeutic targets using single-cell and spatially resolved omics, including cannabidiol for colorectal tumors, Cux1 as a potential target for dry skin diseases, and microglia communication for Alzheimer's disease. These studies offer hope for future treatments.
A global team of experts outlines a roadmap for creating a comprehensive and inclusive reference work on human skin cell composition. The proposed Human Skin Cell Atlas will provide a standardized framework for semi-automated mapping of patient-specific changes in skin diseases, supporting personalized medicine.
The Estee Lauder Companies' New Incubation Ventures has launched a breakthrough prize for innovative active ingredient companies, R&D labs and scientists pushing the boundaries of Indian consumers. The prize program aims to discover and support the next generation of Indian beauty brands.
A recent study published in Frontiers reveals that holidaymakers who engage in short, intense sun-seeking behaviors experience a rapid reduction in Proteobacteria abundance, which decreases skin microbiota diversity. However, the bacterial community structure recovers rapidly after returning to less sunny climates.
A recent study found that increased skin cancer screening is not enough to address racial disparities in melanoma survival rates. Researchers suggest that educating physicians about presentation of melanoma in skin of color and making sure people have access to a dermatologist when they have a suspicious lesion could be more effective.
Researchers have uncovered a novel mechanism of cell death regulation, shedding light on its significance during conditions such as SARS-CoV infection and skin injury. The study reveals that the cleavage of cFLIP restrains cell death during viral infection and tissue injury, favoring tissue repair.
Researchers found that daily consumption of dealcoholized muscadine wine for six weeks improved skin elasticity and barrier function, while reducing inflammation and oxidative stress. Although wrinkles were not significantly affected, participants showed significant improvements in skin smoothness.
A combination of Lactobacillus acidophilus and Lacticaseibacillus rhamnosus strains successfully inhibited the production of superantigens causing toxic shock syndrome. Probiotics may also prevent growth of Staphylococcus aureus, a virulent strain that produces proteins triggering the disease.
Researchers from Binghamton University found that collagen fibers in skin become more tightly packed together, leading to increased stiffness and tissue hardness. This study sheds light on the biological mechanisms behind sun-induced skin changes.
Researchers discovered a novel peptide, T14, that is detectable in human keratinocytes and inversely related to age, with higher levels found in chronically photosensitive individuals. The study suggests that monitoring T14 levels may offer insights into the link between degenerative diseases and epidermal cell profiles.