Researchers found that dogs with atopic dermatitis have a sharp decrease in skin bacterial diversity, leading to impaired barrier function and increased Staphylococcus species. Antibiotic therapy restored normal levels, suggesting a correlation between skin barrier dysfunction and bacterial overgrowth.
Scleratrophic skin lesions like morphea, lichen sclerosus etatrophicus (LSA) and anetoderma are associated with Lyme borreliosis, with Borrelia DNA detected in up to 50% of patients. The response to antibiotic treatment varies, suggesting a heterogeneous origin for these dermatoses.
A new study published in JAMA Neurology found that even prediabetes can cause nerve damage in people with small fiber neuropathy, challenging the conventional wisdom of how nerves deteriorate. The research showed that patients with prediabetes lost about 10% of their nerve fiber density each year, similar to those with diabetes.
A team of researchers has solved a rare, debilitating disease by identifying a genetic mutation as its cause. The disease, Pyrin Associated Autoinflammation with Neutrphilic Dermatosis (PAAND), affects half of the children of patients who have the condition.
Researchers have identified the genetic mutation causing PAAND, a rare inflammatory disease, and found that repurposed anti-arthritis drug anakinra can effectively treat the condition. The treatment was tested on a volunteer from an English family with striking results.
Researchers at Duke University have identified a potential drug target in the skin for treating short-term itch. By targeting a specific ion channel protein called TRPV4, scientists hope to develop topical treatments that can suppress itch and inflammation.
Researchers at Ohio State University have identified a human gene product called MG53 that regulates wound healing and may control scarring. This discovery could help heal open wounds, decrease recovery time after surgery and reduce the spread of infections.
A large-scale study found a significant link between traffic-related air pollution and the formation of lentigenes (facial dark spots) on cheeks of Asian women over 50. The study also showed that exposure to nitrogen dioxide gas had a stronger impact on dark spot formation than particulate matter.
A national survey reveals that high school wrestlers are prone to skin infections, with the head and neck being the most frequent site. Most skin infections can be treated within three to six days, but some may have more serious eye and neurological involvement.
Researchers at Stanford University School of Medicine found that trimming the nails of laboratory mice can cure a common and life-threatening skin disease. The technique saved 93% of mice from ulcerative dermatitis, a condition that caused deep ulcers and led to animal euthanasia.
Researchers at NYU Langone developed an antiscarring paste that inhibits fibrosis caused by radiation therapy in mice. The study suggests the use of A2A receptor blockers as a potential therapeutic approach to prevent scarring and fibrosis in cancer patients.
Two studies investigated the relationship between skin disorders and endocrine diseases. The first study found a higher prevalence of insulin resistance among men with acne, while the second study identified hirsutism and acanthosis nigricans as key skin features of polycystic ovary syndrome (PCOS).
Once-weekly GLP-1RAs lack clear-cut benefits and harms, making it challenging to choose the most suitable medication. The medications share similar outcomes for blood pressure and lipids but have differences in terms of HbA1c reduction and body weight, as well as risk of nausea and heart rate increase.
A study by Temple University researchers found a significant association between psychological stress and various skin symptoms, including itchiness, hair loss, and acne-like rashes. The study suggests that healthcare providers should ask patients about their stress levels to better understand skin conditions.
Researchers at LSU have identified a new gene regulation pathway that prevents inflammation and speeds up the skin's healing process. A nanoparticle-carried small interference RNA blocks the Nax sodium sensor, enabling faster healing.
Researchers at the University of Pennsylvania School of Medicine used state-of-the-art techniques to survey the skin's virus population, or virome. Most DNA viruses on healthy human skin are viral 'dark matter' with never been described before.
A 125-million-year-old fossilized mammal named Spinolestes xenarthrosus has remarkably preserved fur, hair follicles, hedgehog-like spines, organs, and even a fungal hair infection. The study pushes back the earliest record of preserved mammalian hair structures by over 60 million years.
Researchers at OSU create a new approach to treat eczema and inflammatory skin disorders by identifying specific lipid deficiencies in each person. This system uses advanced science and mass spectrometry to develop personalized treatments.
Researchers from Uppsala University and IVPP in Beijing combined palaeontological and genomic data to determine that enamel originated in the skin and colonized the teeth much later. The study found that ganoine, an enamel-like tissue, is expressed in the skin of certain fish species, suggesting a possible connection between the two.
A small study found microfocused ultrasound to be safe and effective in treating laxity of the skin in adults with darker skin types. The treatment resulted in only three temporary adverse events, which resolved without complications.
A clinical trial at the VA Medical Center in Gainesville is testing maggot therapy for veterans with chronic diabetic ulcers. The treatment, which involves sterilized maggots feasting on dead tissue, has shown promise in clearing out wounds and reducing bacterial infections.
Researchers at the Buck Institute found that increased free radicals in mice accelerated wound healing in young animals but led to thin skin and poor wound healing as they aged. This study sheds light on current discrepancies regarding the role of free radicals in the aging process.
Researchers developed 3D human skin tissue models to detect sensitizers in medical devices, potentially replacing animal testing. The models showed ability to detect low levels of known skin sensitizers.
Researchers at Yale School of Medicine have successfully treated patients with moderate to severe eczema using a rheumatoid arthritis drug. Treatment led to dramatic improvement in itch, sleep, and skin redness, offering hope for a new standard of care for the chronic condition.
Researchers found that applying benzoyl peroxide to the skin before and after surgery significantly reduced P. acnes bacteria, potentially lowering the risk of postoperative infection. The study suggests using BPO as a tool to improve skin preparation and reduce bacterial contamination during shoulder surgery.
New UCLA research reveals that vitamin B12 can lead to pimple-prone skin by changing the activity of facial bacteria. This finding may help identify new treatments for acne by targeting specific mechanisms in the skin. The study, published in Science Translational Medicine, sheds light on one key role that B12 plays in acne development.
A Northwestern Medicine study found that many people are confused by sunscreen terminology, with only 43% understanding SPF values and 7% knowing how to protect against early skin aging. This confusion can lead to inadequate protection against sunburns and premature skin aging.
Researchers have identified a serotonin receptor, HTR7, as a key mediator of eczema and other forms of itch. The study suggests that targeting this receptor may lead to the development of powerful new therapies for chronic itch conditions.
MoleScope is an innovative hand-held tool that uses a smartphone to monitor skin for signs of cancer. The device has received approval from Health Canada and the FDA, and is expected to provide healthcare benefits in communities without access to medical specialists.
A novel survey of New Yorkers with tattoo-related complications found high rates of infection, itching and swelling that lasted longer than four months. Physicians warn of potential long-term consequences due to poorly understood chemical composition of colored inks.
Researchers found traditional teaching methods focus on factual knowledge rather than visual training, leading to improved results with perceptual training modules. Undergraduate students reached expertise in identifying skin cancers and benign lesions within two hours of training.
Researchers at Wake Forest Baptist Medical Center identified brain regions activated during mismatches between expected and experienced pain. The parietal lobe and insular cortex were found to be involved in processing real-time mismatches.
A Phase I/II trial has shown promising results for a new stem-cell based therapy in children with recessed dystrophic epidermolysis bullosa (RDEB), a painful skin condition. The treatment involves infusions of mesenchymal stromal cells, which improved pain scores and reduced the severity of the disease.
Researchers developed a gel filled with toxin-absorbing nanosponges that effectively treat skin and wound infections caused by MRSA without using antibiotics. The treatment keeps bacterial toxins under control, allowing the immune system to kill the bacteria more easily.
Researchers accelerate wound healing using electrical pulses, significantly reducing recovery time. The technology has potential to be applied to various situations where faster healing is desired.
Researchers developed a topical gene regulation technology that uses spherical nucleic acids (SNAs) to silence the gene that interferes with wound healing in diabetic animals. The treatment improved healing and blood circulation at the wound site, reducing recovery time by 50%.
Researchers found that papain breaks down skin cell connections, leading to increased skin permeability and inflammation. The enzyme can still trigger allergic reactions even when its enzymatic function is blocked.
Researchers report significant recovery after a single dose of an experimental treatment targeting interleukin-23, a key immune signaling protein in psoriasis. The study found nearly all patients experienced dramatic improvement in their symptoms, with an average 80% reduction in skin lesions.
The study identified two genetic variants associated with rosacea in people of European ancestry, located near the HLA-DRA and BTNL2 genes. The research used data from over 46,000 23andMe customers and confirmed the association through validation studies.
A study published in Cell Metabolism reveals that a high-salt diet can increase sodium accumulation in the skin, boosting the immune response to skin-infecting parasites. This finding suggests that dietary salt may have therapeutic potential in promoting host defense against microbial infections.
Hydrogen sulfide has been found to widen blood vessels in healthy young adults, which could lead to decreased blood pressure. The researchers plan to investigate further by examining the effects of hydrogen sulfide on hypertensive individuals and high blood pressure treatments.
Researchers have discovered that licorice extract's antioxidant active compound Licochalcone A strengthens the skin's defense systems, producing higher amounts of self-protecting molecules. This approach may provide superior sun protection by combining physical and biological defenses.
Researchers introduce a novel approach to stimulate the skin immune response using needle-free vaccination. The cyanoacrylate skin surface stripping (CSSS) method enhances penetration of vaccine particles into deeper skin layers, activating key immune cells.
A new study found that healthcare workers are 4.5 times more likely to suffer from irritant contact dermatitis after increased hand washing efforts, highlighting a potential counter-productive effect on infection reduction campaigns.
Scientists develop nanofibers from tilapia collagen and apply them to rat wounds, resulting in faster healing times and no immune reactions. The study suggests fish collagen could be a viable alternative for wound treatment, reducing the risk of transmitting diseases.
Researchers identified four proteins - stefin A1, slc25a5, serpinb3b, and KLK6 - that appear most likely to contribute to psoriasis. These findings advance efforts to understand the disease's causes and develop treatments.
Adults with eczema are more likely to experience health problems such as diabetes, high blood pressure, and insomnia due to the emotional toll of the disease. Physicians need to address these lifestyle risks alongside skin treatments.
Researchers found that specific commensal microbes like Staphylococcus epidermidis stimulate distinct immune cell responses without causing inflammation. This discovery helps clarify the role of skin commensals and may explain skin disorder variations.
Researchers found that increasing fruit surface wetness increases severity of skin spot, a disorder characterized by patches of small brownish dots on apples' skin. The study also showed that skin spot is positively correlated with the number of rainy days during the growing season.
Fat cells in the skin produce antimicrobial peptides that help protect against bacterial infections, contradicting previous assumptions about the immune response. The study's findings suggest that these peptides can provide a crucial first line of defense against infection.
Researchers found that bacterial infections due to Staphylococcus aureus aggravate neurodermatitis by triggering the formation of myeloid-derived suppressor cells, which suppress both harmful and beneficial immune responses in the skin. This can lead to chronic inflammation, itching, and social stigmatization in patients.
A new study suggests that skin sensitization to food proteins, triggered by pro-inflammatory molecules like TSLP and IL-25, can lead to food allergy development. The research found that mice exposed to food antigens through the skin developed severe allergic reactions when ingested.
Research reveals a significant association between psoriasis severity and uncontrolled hypertension, with patients having the greatest likelihood of uncontrolled hypertension experiencing more severe skin conditions. The study's findings suggest a need for effective management of blood pressure in these patients.
Researchers found that fermented milk produced with Lactococcus lactis H61 strain improved skin hydration and reduced sebum content in healthy young women. The study, published in the Journal of Dairy Science, suggests a potential health benefit of probiotic dairy products.
Researchers analyzed cultural and historical forces to estimate historic changes in UV exposure contributing to the rise in melanoma cases. Changes in fashion and clothing design, as well as increased leisure time and sun exposure, are identified as key factors.
A new paint-on, see-through 'smart' bandage glows to indicate tissue oxygenation concentration, enabling direct measurement for improved wound care. The bandage's phosphorescence emits light based on oxygen levels, allowing for non-invasive monitoring of wounds and burns.
Researchers found that using sweat-eating bacteria to metabolize ammonia improved skin condition and appearance in human volunteers. The study showed significant improvements, especially when the levels of AOB on the skin were high, suggesting potential modulation of the skin microbiota.
A new wearable medical device can quickly alert a person to cardiovascular trouble or skin dryness, using thousands of liquid crystals to sense heat. The device provides sub-millimeter spatial resolution for accurate monitoring of temperature and thermal transport characteristics.
Researchers challenged the long-held principle that separate groups of nerves and receptors are responsible for distinct components of touch. They found that all types of afferents contribute to the overall sensation, regardless of specific textures or shapes. This new understanding has far-reaching implications for the study of somato...
Patients with vitiligo experienced faster and better repigmentation after combining afamelanotide with narrowband UV-B phototherapy. The study found significant improvements in facial and upper extremity repigmentation rates compared to phototherapy alone.