Articles tagged with Hedgehog Pathway
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Researchers discovered that blocking the Hedgehog pathway kills cancer cells while leaving healthy liver tissue intact. This finding offers hope for targeted treatments and diagnostic tests for liver cancer.
Researchers found a novel gene critical for regulating Hh signaling in mammals, revealing the first clear difference in conserved signaling pathway function between species. The discovery suggests that multi-component pathways evolve by inserting new proteins into existing pathways.
Researchers have successfully treated Down syndrome in mice by restoring nerve growth in the cerebellum, a key brain region affected by the condition. The treatment, which stimulates the Hedgehog pathway, restored normal cell division rates and numbers in granule cell precursors.
Researchers found two sequences in Gli1 protein that prevent its degradation, leading to accelerated tumorigenesis and shorter tumor latency. This discovery may represent a novel anticancer therapy by modulating Gli protein stability.
A study found that the Hh pathway in insects determines whether adult stem cells are fated for fat or bone, with implications for treating osteoporosis, diabetes, and obesity. The researchers also discovered that drugs targeting this pathway could potentially build stronger bones while reducing fat.
UT Southwestern researchers found that activating hedgehog signaling pathway blocks fat formation in mammals, while inhibiting it stimulates fat cell creation. The study opens avenues for potential therapy in humans for obesity, diabetes and osteoporosis.
Researchers uncover new insights into Hedgehog signaling, revealing the primary cilium's crucial role in connecting Smoothened to downstream signaling. This discovery has significant implications for understanding cancer and birth defect causes, as well as advancing stem cell research.
Researchers have identified a subset of tumor cells that resist inhibition of the Hedgehog signaling pathway, leading to cancer recurrence. However, targeting these residual cell populations could lead to effective treatment of basal cell carcinoma.
Researchers found that beta-arrestin2 activates the hedgehog signaling pathway, which can lead to cancerous tumors. The study suggests potential new drugs to block tumor growth by disrupting beta-arrestin2's function.
Researchers found that Hedgehog signaling is greatly activated in prostate cancers, distinguishing them from benign ones. The study's findings suggest that targeting the Hedgehog pathway may lead to new treatments for human disease.
Researchers found that Hedgehog activity in localized prostate tumors is significantly lower than in metastatic cancers. Blocking the Hedgehog signal with cyclopamine slowed tumor growth and even reversed aggressive cancer progression in mice experiments.
Researchers found that pancreatic cancer growth can be arrested by blocking the Hedgehog signaling pathway, which is active in human embryonic development. This pathway has been linked to several other types of cancer and may offer a new treatment avenue for pancreatic cancer.
Scientists used RNA interference to identify four new genes involved in passing along Hedgehog's signal in fruit fly cells. The study suggests that human versions of these genes may be involved in diseases characteristic of abnormal Hedgehog activity, including birth defects and cancers.
Researchers at Johns Hopkins Medicine discovered a primitive cellular pathway, Sonic Hedgehog, that stays active in some lung cancers. The pathway's activation leads to excessive cell growth and cancer. Researchers are testing drugs on mice and plan to explore human clinical trials in the future.
Researchers at Howard Hughes Medical Institute found that a plant compound called cyclopamine effectively killed cultured mouse medulloblastoma cells and human tumors. The study showed promising results, with all seven tested human medulloblastomas responding dramatically to the treatment.
Scientists have discovered a new hedgehog blocker that stops medulloblastoma tumor growth and kills cancer cells in mice and human patients. The study provides hope for the development of new treatments for this deadly childhood brain cancer.