Articles tagged with Hedgehog Pathway
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Researchers found that inhibiting the sonic hedgehog pathway restricts feather bud outgrowth and branching in chickens. Temporarily modified Shh expression resulted in proto-featherlike structures, highlighting the pathway's importance in feather development.
Researchers have discovered that a specific gene pathway is crucial for feather formation, dating back to the origins of proto-feathers in dinosaurs. The study provides insights into how genetic interactions evolved to allow for the emergence of complex structures like feathers.
A Mount Sinai-led research team has identified stem cell populations and mechanisms underlying age-related degeneration in meibomian glands, which secrete lipid-rich meibum to prevent tear evaporation. The findings suggest that targeting Hh and EGFR signaling could be a potential therapeutic option for evaporative dry eye disease.
A recent study suggests that tiny antenna-like structures on cells called primary cilia could be a potential therapeutic target for Amyotrophic Lateral Sclerosis (ALS). Researchers have identified mutations in the C21orf2 gene, which impair primary cilia formation and structure, leading to motor neuron death.
A recent study has identified a blood protein called fibrin as the root cause of developmental delays and brain damage in preterm infants. The researchers found that fibrin interferes with a cell-signaling pathway essential for neuron creation, particularly in the cerebellum.
Researchers propose targeting non-canonical HH/GLI signaling to improve response rate and durability of therapeutic effects exerted by SMO inhibition in melanoma. The findings suggest that combined targeting of hedgehog signaling and BRD4 could provide a novel therapeutic option against melanoma.
Researchers have made significant breakthroughs in understanding the molecular mechanisms of supratentorial ependymoma, a rare and aggressive form of childhood brain cancer. By targeting the Hedgehog signaling pathway and primary cilia formation, scientists discovered new potential treatments that overcame resistance to existing drugs.
Researchers identified toll-like receptor (TLR) signaling as a novel pathway regulating GLI3 expression, which plays a role in inflammatory cytokine production and cancer. They found that IRF3 directly binds to the GLI3 promoter region, increasing its expression upon TLR4 stimulation.
A new study identified the Cnpy4 gene as a crucial modulator of the Hedgehog signaling pathway, which regulates growth and development during embryonic stages. This discovery could lead to potential new treatments for cancers related to Hedgehog signaling and birth defects involving extra fingers or toes.
Researchers at The Graduate Center, CUNY, found that increased signaling of the sonic hedgehog protein can inhibit LID in animal models of Parkinson's disease. This could lead to a potential therapeutic solution for most Parkinson's patients.
Scientists have identified two new candidate genes, ULK4 and PTTG1, that positively influence the development of an embryo by restoring a strong Sonic Hedgehog signaling pathway. This finding provides new insights into the causes of holoprosencephaly, a congenital malformation affecting around one to four in every 1,000 unborns.
Researchers found that the drug Vismodegib altered tumor-associated macrophage metabolism, shifting them from immunosuppressive M2 macrophages to pro-inflammatory M1 macrophages. This shift led to a decrease in tumor-promoting properties and improved immune response.
Researchers at Baylor College of Medicine discover a protein signaling mechanism driving joint and tendon dysfunction in OI, finding that inhibiting this pathway can prevent tendinopathy problems. The study used mouse models with deleted Fkpb10 gene, leading to contracture, joint inflammation, and cartilage piece formation.
A study on Saudi Arabian breast cancer patients identified somatic mutations in tumor suppressor genes, including BRCA1, BRCA2, and PIK3CA. The findings highlight the importance of routine genetic sequencing for precision therapies in the region. Novel mutations were also discovered, with potential implications for targeted treatments.
Researchers at UMass Amherst have identified a key protein component of the Hedgehog signaling pathway as an important player in phenotypic plasticity, allowing cells to sense and respond to environmental inputs. This finding provides insights into how genes and environment interact to shape anatomical traits.
Researchers found that melanoma cells secrete extracellular vesicles via the hedgehog signalling pathway, intensifying malignant properties in target cells. This discovery can help develop better treatment and diagnostics for melanoma.
Researchers have found that the Wnt pathway likely functions upstream of and activates the Hh pathway in response to injury, enabling proper tissue regeneration. The study suggests a new mechanism for appendage regeneration, with implications for human limb repair and regeneration.
Researchers used advanced cryo-EM technology to determine the structure of a molecular complex implicated in birth defects and several cancers. The study revealed that two Patched-1 molecules simultaneously engage a single Hedgehog molecule, forming a unique 2-to-1 ratio PTCH1-HH complex required for efficient Hedgehog signaling.
Researchers found that Hedgehog signaling proteins keep cancer stem cells alive and are required for their survival. The study suggests targeting the Hedgehog pathway could eliminate cancer stem cells and prevent recurrence.
Researchers at WashU Medicine identified a way to prevent fat cells from growing larger, leading to weight gain and obesity. By activating a specific protein pathway in mice, they found that high-fat diets did not lead to obesity.
Researchers at St. Jude Children's Research Hospital have discovered a promising target for precision medicines to block the Sonic Hedgehog signaling pathway, which drives cell proliferation in medulloblastoma. Inhibiting this pathway using an investigational drug INK128 significantly extended the lives of mice with the tumor.
Scientists at UCSF discover primary cilia, found on fat-forming cells in muscle, regulate fat formation and tissue renewal. The study provides new insights into muscle aging and disease, potentially leading to improved muscle regeneration.
Researchers have identified an enzyme called Phospholipase A2 that triggers the movement of Smoothened into primary cilia, amplifying signaling activity. This discovery opens new avenues for developing drugs to treat developmental disorders and cancers associated with Sonic Hedgehog pathway hyperactivation.
Xiaoyen Zheng, a GW researcher, has received a $1.7 million grant to continue studying the Hedgehog receptor's mechanisms. Her research aims to understand the role of ciliary trafficking in regulating the Patched component.
Recent advances in understanding regulatory mechanisms of HH pathway and chemical regulation are discussed. CAS scientists propose a hypothetical model for endogenous chemical modulation and suggest precise interventions for better therapeutic outcomes.
Researchers from the University of Copenhagen have made significant progress in understanding how primary cilia receive and transmit signals, shedding light on their role in regulating cellular behaviors and preventing diseases such as ciliopathies.
Researchers at Stanford University School of Medicine have discovered that diabetes impairs the activity of bone stem cells, leading to impaired fracture healing. A newly identified protein stimulates the activity of skeletal stem cells, counteracting this decrease and promoting efficient fracture repair.
Researchers at Penn State University have identified Speckle-type POZ Protein (Spop) as a key regulator of bone development. The study reveals that Spop positively regulates Hedgehog signaling during bone formation, leading to reduced bone density and brachydactyly-like symptoms.
The Hedgehog signaling pathway is required to maintain and replenish taste buds and taste papillae in mouse models. Disruptions in the pathway can lead to rapid disappearance of taste buds, highlighting its importance in taste organ homeostasis.
The study reveals that the loss of cilia on facial cells impairs the function of developmental repressors, leading to increased Hedgehog signaling and facial widening. This discovery provides insights into the mechanisms of midfacial development and sheds light on the underlying causes of ciliopathies.
Researchers at Indiana University have identified the genetic pathways that control physical traits in horned beetles based on nutritional conditions during development. The study reveals a complex relay system transmitting information about external circumstances to the cell nucleus, allowing organisms to produce different traits in r...
Researchers found that transient activation of the Hedgehog pathway after irradiation rescued salivary gland dysfunction by preserving stem/progenitor cells and parasympathetic innervation. Shh gene transfer improved saliva flow rates in mice, while also preserving acini marker Aqp5 expression.
Lomonosov Moscow State University scientists discovered that skin cancer basal cell carcinoma contains gene mutations linked to other cancer types, including melanoma. The study found that 85% of BCC cases contain Sonic hedgehog signaling pathway gene mutations, which resist anticancer therapy.
The sonic hedgehog gene plays a crucial role in maintaining the normal physiological state and repair process of an adult healthy lung. In contrast to previous reports, hedgehog signaling decreases after lung injury, which correlates with the loss of cells that normally express the sonic hedgehog gene.
Research at Rensselaer Polytechnic Institute suggests a link between zinc deficiency and activation of the Hedgehog signaling pathway in many diseases. Zinc inhibits the autoprocessing reaction, leading to enhanced production of the Hedgehog ligand and uncontrolled cell growth.
Scientists at MD Anderson Cancer Center identified a long non-coding RNA called BCAR4 as playing a key role in the hedgehog signaling pathway's contribution to breast cancer metastasis. The study suggests that targeting this pathway with locked nucleic acids may provide a new approach for treating aggressive breast cancers.
Two UT Southwestern doctors have received grants to test the effectiveness of itraconazole on lung cancer pathways and growth. The researchers aim to disrupt communication between tumor cells and their surrounding environment, slowing cancer growth.
Researchers have found that the menin protein suppresses signaling in the Hedgehog pathway in endocrine organs, leading to increased cell proliferation. Inhibiting this pathway using drugs reduces tumor growth in an animal model of human MEN1 syndrome.
GW researcher Xiaoyan Zheng is studying the mechanism involved in the hedgehog signaling pathway's regulation of cell-cell adhesion and segregation. The goal is to find better ways to treat diseases related to these interactions, such as cancer.
Researchers at Stanford University School of Medicine have identified a new way to block the Hedgehog pathway in skin cancers, which become resistant to treatment. The discovery offers a promising new approach for treating basal cell carcinoma and potentially improving patient outcomes.
Researchers have identified a novel signalling pathway controlling cellular energy metabolism, independent of the known hedgehog pathway. This discovery suggests that substances targeting this pathway could provide an easy and safe adjunct therapy for diabetes and obesity, resolving complications induced by cancer treatments.
Researchers found that common polymorphisms in the T2R38 gene were correlated with the incidence of bacterial sinus infections, demonstrating a genetic link to individual differences in respiratory infection susceptibility. In companion pieces, studies on PSD-95 expression and progranulin deficiency shed light on potential therapeutic ...
Researchers found that combining GDC-0449 with standard chemotherapy improved response rates and progression-free survival for patients with advanced pancreatic cancer. The treatment targets the desmoplastic stroma and pancreatic cancer stem cells, which contribute to disease resistance.
Researchers found that activating a cholesterol pathway may enhance chemotherapy's effectiveness against pancreatic cancer. The study used a cholesterol derivative to block the Hedgehog pathway, which is linked to both cancer and heart disease.
Researchers identify non-canonical activation of Gli1 protein through the mTOR pathway, promoting esophageal cancer development. A combination of RAD-001 and GDC-0449 inhibits tumor growth by targeting both pathways.
Researchers have identified a new cellular mechanism underlying hydronephrosis by studying kidney development in mice. Genetic mutations in the Hedgehog signaling pathway impaired urine flow from the kidney to the bladder, leading to hydronephrosis.
Researchers found that arsenic trioxide inhibits the growth of medulloblastoma and Ewing sarcoma cell lines by blocking the Hedgehog/GLI1 signaling pathway. The compound improved survival in a mouse model of medulloblastoma, suggesting its potential as a therapeutic option.
A Stanford study found that arsenic trioxide can block the Hedgehog pathway, a signaling cascade involved in various cancers. The compound inhibits the expression of certain genes, making it harder for cancer cells to mutate and evade treatment.
Researchers discovered Sonic hedgehog gene presence in ectoderm of mice limb buds, indicating a new role in digit formation and possible implications for human birth defects. Disrupting this signaling led to extra digits forming.
Atoh1, a transcription factor critical for fetal development, is necessary for the development of many forms of medulloblastoma. Shutting down Atoh1 in susceptible brain cells prevented medulloblastoma from developing in mice, suggesting it as a potential target for new drug treatments.
Scientists at the University of Wisconsin-Madison School of Medicine and Public Health have identified a critical link between two signaling pathways that contribute to the development of colorectal tumors. The study reveals how CRD-BP binds to and increases GLI1 messenger RNA, leading to cancer-promoting gene activation.
Cells in developing tissue consider their history of signaling exposure to determine location, challenging the widely held hypothesis that morphogens are the primary source of positional information. Researchers found that cells require a 'memory' of past exposure to morphogen signals to adopt specific gene expression patterns.
Researchers at UCSF discovered a tiny filament extending from brain cells, known as primary cilia, may play a role in the most common malignant brain tumor in children. The study found that primary cilia are present in some tumors but absent in others, suggesting they may be used by cancer cells to grow.
Researchers identified a novel strategy to inhibit the hedgehog (Hh) signaling pathway, which is involved in various physiological processes but also stimulates cancer development. By activating the liver X receptor (LXR), they were able to block tumor cell growth and prevent cancer formation in animal studies.
The concentration of Hedgehog determines whether the right hand thumb grows on the left hand side, a mechanism controlled by different concentrations of the molecule. The study found that cells use various molecular mechanisms to interpret different Hedgehog concentrations.
Researchers at the University of Edinburgh studied the Hedgehog signalling pathway in colon cells to find new treatments for inflammatory bowel disease. They discovered that a defective GLI1 protein may calm inflammation, but is only half as active in IBD patients.
Scientists at Karolinska Institutet discovered skin stem cells can divide actively and transport themselves through skin tissue, contradicting previous assumptions. The study's findings also suggest a link between hedgehog signaling and the development of basal cell carcinoma, the most common form of skin cancer.
The study sheds light on the complex interactions between genes and environmental factors that cause holoprosencephaly, a developmental malformation affecting the anterior brain and face. Researchers found that a gene called Six3 plays a crucial role in regulating fetal brain development.
Research suggests that hedgehog antagonists, used to treat certain cancers, can worsen cardiac function and lead to death in mice with heart disease. The study highlights the need to monitor patients' cardiovascular health when using these drugs.
Researchers Philip A. Beachy and Clifford J. Tabin received the 2008 March of Dimes Prize for their work on hedgehog genes and their role in embryonic development, including limb formation and organ development.