Articles tagged with T Cell Signaling
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Researchers at TUM have found a new link between IL-6 and pathogenic T cells in multiple sclerosis, shedding light on the disease's mechanisms. The discovery highlights the importance of blocking IL-6 signaling to prevent the formation of pathological cells.
La Jolla Institute researchers reveal a powerful arm of the immune system that drives maturation of helper T cells. Their study identifies activin A as a key factor, which could lead to more potent vaccines and treatments for autoimmune diseases.
A study published in the Journal of Experimental Medicine suggests that PD-1 does not directly cause T cell exhaustion. Instead, it helps regulate the balance between different T cell types, preserving a 'reserve force' that can fight on later. This finding has implications for cancer and antiviral therapies.
Researchers used mathematical models to predict immune response size based on T cell signaling, providing insights into manipulating immune responses for cancer treatment. The study also shed light on how 'errors' in immune response contribute to autoimmune disease.
Researchers at Johns Hopkins Medicine developed flattened football-shaped artificial particles that mimic immune cells, outperforming traditional basketball-shaped particles. These particles activated T-cells more effectively, leading to improved tumor reduction and increased survival rates in mice.
A new mouse model study reveals that interleukin-17 can stabilize atherosclerotic plaques by promoting their stability. This discovery provides crucial information on the role of the immune system in atherosclerosis and may lead to the development of new therapies.
Activated NK cells can excessively down-modulate the antiviral immune response in chronic HBV patients. Blocking the TRAIL pathway partially reconstitutes HBV-specific T cells, suggesting their vulnerability to apoptosis through this death ligand pathway.
By analyzing CD8+ T cells from healthy blood donors, researchers created a statistical model that accurately predicts the age and quality of T cells. This allows clinicians to transfer only young functional cells back into patients' bodies, potentially improving therapeutic outcomes for various cancers.
T cells decide on their identity when they begin expressing the Bcl11b gene, which acts as a transcription factor to control other genes. The activation of Bcl11b is crucial for T cells to maintain their identity and undergo the conversion process in the thymus.
Michelle Krogsgaard, a NYU Cancer Institute pathologist, has been awarded the NIH EUREKA grant to explore novel techniques in T-cell signaling. Her research aims to enhance the immune response in patients with HIV or cancer and diminish T-cell activation in autoimmune disease.
Researchers developed a technique to manipulate immunological synapses with molecular precision, revealing that spatial arrangement determines signal strength. This breakthrough may help develop treatments for autoimmune diseases and better understand cellular communication.
Researchers have developed a new tool that allows them to visualize cells in real-time, revealing details about their movement and behavior. The technique, called two-photon laser-scanning microscopy, has provided insights into the goal-oriented migration of activated T cells and the random wanderings of immature T cells.
Researchers found that old T cells weaken the immune system in older mice, causing impaired B cell activation and antibody production. However, infusing young T cells into old mice restored B cell function, suggesting a key role for helper T cells in maintaining immune capacity with age.
Researchers found that estrogen deficiency triggers the expression of interferon gamma, which stimulates T cell activation and TNF production. Estrogen treatment increases TGFb levels in bone marrow, leading to bone preservation.
A new study published in Science proposes a potential design principle for vaccines targeting difficult-to-destroy viruses like HIV and smallpox. The research found that a double-punch approach, targeting both pathways to activate killer cells, could provide more efficient protection against viruses.
A new hypothesis suggests that autoimmunity is triggered by insufficient immune stimulation, leading to a decrease in T cells and an overactive expansion of the remaining population. This condition, known as lymphopenia, can cause diseases like Type 1 diabetes and rheumatoid arthritis.
Researchers found damaged T cells arose from a particular cell lineage in tumor environments, leading to immune dysfunction. Targeting novel properties can prevent or reverse the defects, providing new insights into the relationship between tumors and defective T cells.
Researchers found that a chemical signal from the nervous system can redirect immune actions, affecting conditions like arthritis and asthma. The discovery suggests potential for developing drugs to regulate the immune response and improve defenses.