Articles tagged with Diastereomers
A team of researchers at The University of Osaka has found a novel method for creating diastereomers, which are structurally identical molecules with different biological activities. Their approach uses a group-14 allylatrane to control the reaction, resulting in the high-yield synthesis of complex molecules.
Researchers successfully synthesized isotopic atropisomers based on carbon isotope discrimination, exhibiting high rotational stability and stereochemical purity. The findings hold promise for fundamental understanding of isotopic atropisomers with implications in organic and medicinal chemistry.
Researchers at the University of Nebraska-Lincoln have discovered that the orientation of a single amino acid in peptides can direct activation to specific neurons, influencing communication among brain cells. This finding has far-reaching implications for understanding and regulating signaling processes in the brain.
Researchers have developed a novel catalytic approach to synthesize monocyclic 3-(pyrrol-1-yl)-azetidin-2-ones, which show potential as therapeutic agents. The method yields all four diastereomers with high selectivity and has been published in Current Organocatalysis.
A Japanese research team has synthesized isotopic atropisomers, a rare class of compounds, using ortho-CH3/CD3 discrimination. The resulting isotopic atropisomers exhibit high rotational stability and stereochemical purity.
Researchers at Nagoya University developed an organic catalyst that generates amino acid derivatives in high yields with precise stereochemical control. A slight structural change in the catalyst leads to inversion of a single stereocenter, enabling access to specific diastereomers.