Articles tagged with Glycoproteins
A new study by SFU chemist Bingyun Sun and colleagues reveals that the number of sugars (N-Glycans) on membrane proteins correlates with their function in five animal species. The correlation has been conserved through evolution, suggesting a universal mechanism for stabilizing glycoproteins.
Researchers at Cornell University have engineered E. coli bacteria to produce glycoproteins for pharmaceuticals, reducing production time and cost. The method, called 'glycans by design,' uses enzymes to tailor sugar structures, leading to the development of cheaper and faster pharmaceuticals.
Researchers at Scripps Research Institute discover a way to stabilize proteins by attaching specific oligomeric arrays of sugars, potentially increasing the stability and reducing the cost of protein-based drugs. The new methodology has broad implications for the drug industry, particularly for glycoprotein-based drugs.
Scientists identified 28 glycoproteins in Italian Chardonnay, similar to known allergens, sparking hope for low-allergenic wine development. The discovery could lead to reduced allergy symptoms in millions of wine drinkers worldwide.
A non-human primate study generated antibodies capable of neutralizing diverse strains of HIV-1. The research found that methods to boost neutralizing antibody abundance in rectal and vaginal tissues are needed to prevent HIV-1 transmission.
Researchers have identified two new glycoproteins in spider web glue that can be used to develop a new generation of biobased adhesives. These proteins are produced from opposite strands of the same DNA sequence, making them a promising material for large-scale production and various applications.
Researchers have identified two new glycoproteins in spider web glue, which can be produced through opposite strands of the same DNA sequence. This discovery paves the way for large-scale production of biobased glues for various applications.
The PRAGUE-7 study, a randomized trial, investigated the effect of routine upfront administration of abciximab on outcomes in acute myocardial infarction (AMI) patients complicated by cardiogenic shock. The study found no significant benefit from this approach, with similar results seen between groups receiving standard or selective ab...
The HORIZONS AMI trial found that bivalirudin significantly reduces all-cause death, cardiac death, and major bleeding in heart attack patients. The use of bivalirudin also resulted in a 31% reduction in 1-year all cause mortality.
Scientists at The Wistar Institute have developed a novel vaccine design strategy that uses a herpes simplex protein to block a specific receptor molecule on antigen-presenting cells. This allows for a stronger immune response and potential protection against viral diseases like AIDS and cervical cancer.
A study found that routine upstream administration of platelet glycoprotein IIb/IIIa inhibitors reduced composite ischemia events, while deferred selective use resulted in fewer major bleeding complications. However, the criterion for noninferiority was not met.
A new cell surface profiling technique developed by Carolyn Bertozzi and her team could lead to the creation of a simple blood test for cancer diagnosis. The method involves tagging glycoproteins with a metabolic label and monitoring changes in O-linked protein glycosylation.
Researchers have discovered how defensins and mannan-binding lectin can prevent viruses from entering cells. Defensins block the influenza virus entry into cells by preventing membrane fusion, while mannan-binding lectin works in a similar way. These findings may lead to new strategies for preventing viral diseases.
A team of scientists at GlycoFi, Inc. and Dartmouth College reports the successful production of a human protein with complex glycosylation in genetically modified yeast. The achievement enables the generation of glycoprotein libraries for elucidating specific structure-function relationships and identifying efficacious molecules.
Researchers found a biochemical structure similarity between the Ebola virus outer protein shell and retroviruses carried by birds, suggesting possible bird transmission. This discovery raises health concerns for humans and encourages officials to be vigilant.
Researchers at Purdue University have simplified the outer shell of the Ebola virus, making it easier to produce in a lab and delivering genes to defective cells. This breakthrough could lead to treatments for diseases like cystic fibrosis and lung cancer.
A meta-analysis of six trials involving 31,400 patients found that anti-clotting drugs reduced death risk by 9% overall, but men showed a significant 19% reduction, while women saw no benefit. The treatment effect was greatest in high-risk patients.
Scientists have created a synthetic antifreeze protein that mimics the natural defense mechanism of Arctic and Antarctic fish, which can prevent ice growth in living organisms. The new compound has potential applications in frost protection for crops, preservation of human organs, and elimination of freezer burn.